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Investigation of the relationship between chronic montelukast treatment, asthma and depression‑like behavior in mice

  • Authors:
    • Banu Cahide Tel
    • Gokcen Telli
    • Sevgen Onder
    • Emirhan Nemutlu
    • Turgut Emrah Bozkurt
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    Affiliations: Department of Pharmacology, Hacettepe University Faculty of Pharmacy, Ankara, Sihhiye 06100, Turkey, Department of Pathology, Hacettepe University Faculty of Medicine, Ankara, Sihhiye 06100, Turkey, Department of Analytical Chemistry, Hacettepe University Faculty of Pharmacy, Ankara, Sihhiye 06100, Turkey
    Copyright: © Tel et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 27
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    Published online on: November 9, 2020
       https://doi.org/10.3892/etm.2020.9459
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Abstract

In 2008, the Food and Drug Administration of the US issued a warning about the neuropsychiatric side effects of montelukast. Previous clinical studies on montelukast have reported conflicting results and, to the best of our knowledge, no experimental studies concerning these side effects had been conducted. In the current study, the effect of montelukast on depression‑like behavior in an ovalbumin (OVA)‑induced mouse model was investigated. A total of 3 OVA challenges were applied at 2 week intervals for the persistence of asthma. Depression‑like behavior was assessed using forced swim tests following each challenge and locomotor activities were evaluated using open field tests. At the end of the current study, plasma montelukast concentrations were measured and the development of asthma and effect of montelukast treatment were histopathologically examined. Inflammation scores that were increased in the OVA mice following all challenges were indicated to be reduced by montelukast treatment. The immobility time of mice increased beginning with the first challenge and this was also reduced by montelukast treatment. Montelukast administration to the control mice did not alter immobility times. Moreover, motor activity of the OVA and montelukast‑treated mice were not altered. The results indicated there was no association between chronic montelukast treatment and depression. Furthermore, the chronic administration of montelukast to non‑asthmatic mice did not increase immobility. However, depressive behavior increased at all time points in the OVA mice. These results indicated that chronic montelukast treatment is not associated with depression‑like behavior and confirmed the association between asthma and depression. Further studies are required to provide an improved understanding of the neuropsychiatric side effects of montelukast.
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Copy and paste a formatted citation
Spandidos Publications style
Tel B, Telli G, Onder S, Nemutlu E and Bozkurt T: Investigation of the relationship between chronic montelukast treatment, asthma and depression‑like behavior in mice. Exp Ther Med 21: 27, 2021.
APA
Tel, B., Telli, G., Onder, S., Nemutlu, E., & Bozkurt, T. (2021). Investigation of the relationship between chronic montelukast treatment, asthma and depression‑like behavior in mice. Experimental and Therapeutic Medicine, 21, 27. https://doi.org/10.3892/etm.2020.9459
MLA
Tel, B., Telli, G., Onder, S., Nemutlu, E., Bozkurt, T."Investigation of the relationship between chronic montelukast treatment, asthma and depression‑like behavior in mice". Experimental and Therapeutic Medicine 21.1 (2021): 27.
Chicago
Tel, B., Telli, G., Onder, S., Nemutlu, E., Bozkurt, T."Investigation of the relationship between chronic montelukast treatment, asthma and depression‑like behavior in mice". Experimental and Therapeutic Medicine 21, no. 1 (2021): 27. https://doi.org/10.3892/etm.2020.9459
Copy and paste a formatted citation
x
Spandidos Publications style
Tel B, Telli G, Onder S, Nemutlu E and Bozkurt T: Investigation of the relationship between chronic montelukast treatment, asthma and depression‑like behavior in mice. Exp Ther Med 21: 27, 2021.
APA
Tel, B., Telli, G., Onder, S., Nemutlu, E., & Bozkurt, T. (2021). Investigation of the relationship between chronic montelukast treatment, asthma and depression‑like behavior in mice. Experimental and Therapeutic Medicine, 21, 27. https://doi.org/10.3892/etm.2020.9459
MLA
Tel, B., Telli, G., Onder, S., Nemutlu, E., Bozkurt, T."Investigation of the relationship between chronic montelukast treatment, asthma and depression‑like behavior in mice". Experimental and Therapeutic Medicine 21.1 (2021): 27.
Chicago
Tel, B., Telli, G., Onder, S., Nemutlu, E., Bozkurt, T."Investigation of the relationship between chronic montelukast treatment, asthma and depression‑like behavior in mice". Experimental and Therapeutic Medicine 21, no. 1 (2021): 27. https://doi.org/10.3892/etm.2020.9459
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