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Article

Ascites symptom inventory-7 is a valuable tool for evaluating the effectiveness of tolvaptan in patients with cirrhotic ascites

  • Authors:
    • Hideto Kawaratani
    • Kei Moriya
    • Tadashi Namisaki
    • Naotaka Shimozato
    • Kosuke Kaji
    • Hiroaki Takaya
    • Yukihisa Fujinaga
    • Yasuhiko Sawada
    • Shinya Sato
    • Soichiro Saikawa
    • Takuya Kubo
    • Takemi Akahane
    • Hiroshi Fukui
    • Hitoshi Yoshiji
  • View Affiliations / Copyright

    Affiliations: Third Department of Internal Medicine, Nara Medical University, Kashihara, Nara 634-8522, Japan
  • Article Number: 30
    |
    Published online on: November 10, 2020
       https://doi.org/10.3892/etm.2020.9462
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Abstract

Patients with liver cirrhosis frequently experience non‑specific symptoms and report severe reductions in their quality of life (QOL). The underlying mechanisms of the disease are multifactorial that may be specific to the disease or directly related to the liver. The major concern of liver cirrhosis with ascites, however, is the decreased QOL. Therefore, in the present study, the Ascites Symptom Inventory‑7 (ASI‑7) questionnaire was applied to subjectively evaluate the symptoms in patients with cirrhotic ascites following tolvaptan administration. In total, 69 patients with liver cirrhosis with ascites hospitalized to Nara Medical University were evaluated after being treated with tolvaptan (3.75‑7.5 mg/day) and conventional diuretics between December 2013 and April 2018. A follow‑up assessment was conducted 7 days after tolvaptan treatment, whilst ASI‑7 was used on days 1 and 8 of the study. After an uneventful 7‑day tolvaptan treatment regimens, 49 patients (71.0%) lost >1.5 kg of their body weight, who were referred to as responders, with the change in the ASI‑7 score being found to correlate with the body weight change. By contrast, changes in urine volume did not correlate with those in the ASI‑7 score. The responders experienced a greater reduction in the ASI‑7 score after 7 days compared with those in the non‑responders (P<0.01). ASI‑7 scores were also found to correlate with body weight after tolvaptan administration. In conclusion, ASI‑7 accurately reflected changes in body weight but not urine volume and results of the study highlighted the value of ASI‑7 in the evaluation of ascitic volume and effectiveness of tolvaptan in cirrhotic ascites. The present clinical trial was registered onto the UMIN‑Clinical Trial Registry on 1st March 2014 (registration no. UMIN000013095).
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Copy and paste a formatted citation
Spandidos Publications style
Kawaratani H, Moriya K, Namisaki T, Shimozato N, Kaji K, Takaya H, Fujinaga Y, Sawada Y, Sato S, Saikawa S, Saikawa S, et al: Ascites symptom inventory-7 is a valuable tool for evaluating the effectiveness of tolvaptan in patients with cirrhotic ascites. Exp Ther Med 21: 30, 2021.
APA
Kawaratani, H., Moriya, K., Namisaki, T., Shimozato, N., Kaji, K., Takaya, H. ... Yoshiji, H. (2021). Ascites symptom inventory-7 is a valuable tool for evaluating the effectiveness of tolvaptan in patients with cirrhotic ascites. Experimental and Therapeutic Medicine, 21, 30. https://doi.org/10.3892/etm.2020.9462
MLA
Kawaratani, H., Moriya, K., Namisaki, T., Shimozato, N., Kaji, K., Takaya, H., Fujinaga, Y., Sawada, Y., Sato, S., Saikawa, S., Kubo, T., Akahane, T., Fukui, H., Yoshiji, H."Ascites symptom inventory-7 is a valuable tool for evaluating the effectiveness of tolvaptan in patients with cirrhotic ascites". Experimental and Therapeutic Medicine 21.1 (2021): 30.
Chicago
Kawaratani, H., Moriya, K., Namisaki, T., Shimozato, N., Kaji, K., Takaya, H., Fujinaga, Y., Sawada, Y., Sato, S., Saikawa, S., Kubo, T., Akahane, T., Fukui, H., Yoshiji, H."Ascites symptom inventory-7 is a valuable tool for evaluating the effectiveness of tolvaptan in patients with cirrhotic ascites". Experimental and Therapeutic Medicine 21, no. 1 (2021): 30. https://doi.org/10.3892/etm.2020.9462
Copy and paste a formatted citation
x
Spandidos Publications style
Kawaratani H, Moriya K, Namisaki T, Shimozato N, Kaji K, Takaya H, Fujinaga Y, Sawada Y, Sato S, Saikawa S, Saikawa S, et al: Ascites symptom inventory-7 is a valuable tool for evaluating the effectiveness of tolvaptan in patients with cirrhotic ascites. Exp Ther Med 21: 30, 2021.
APA
Kawaratani, H., Moriya, K., Namisaki, T., Shimozato, N., Kaji, K., Takaya, H. ... Yoshiji, H. (2021). Ascites symptom inventory-7 is a valuable tool for evaluating the effectiveness of tolvaptan in patients with cirrhotic ascites. Experimental and Therapeutic Medicine, 21, 30. https://doi.org/10.3892/etm.2020.9462
MLA
Kawaratani, H., Moriya, K., Namisaki, T., Shimozato, N., Kaji, K., Takaya, H., Fujinaga, Y., Sawada, Y., Sato, S., Saikawa, S., Kubo, T., Akahane, T., Fukui, H., Yoshiji, H."Ascites symptom inventory-7 is a valuable tool for evaluating the effectiveness of tolvaptan in patients with cirrhotic ascites". Experimental and Therapeutic Medicine 21.1 (2021): 30.
Chicago
Kawaratani, H., Moriya, K., Namisaki, T., Shimozato, N., Kaji, K., Takaya, H., Fujinaga, Y., Sawada, Y., Sato, S., Saikawa, S., Kubo, T., Akahane, T., Fukui, H., Yoshiji, H."Ascites symptom inventory-7 is a valuable tool for evaluating the effectiveness of tolvaptan in patients with cirrhotic ascites". Experimental and Therapeutic Medicine 21, no. 1 (2021): 30. https://doi.org/10.3892/etm.2020.9462
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