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Androgen receptor gene mutations in 258 Han Chinese patients with polycystic ovary syndrome

  • Authors:
    • Lifeng Tian
    • Yang Zou
    • Jun Tan
    • Yaoqing Wang
    • Jia Chen
    • Leizhen Xia
    • Lixian Xu
    • Ge Chen
    • Qiongfang Wu
    • Ouping Huang
  • View Affiliations / Copyright

    Affiliations: Department of Gynecology and Obstetrics, Jiangxi Medical College, Graduate School of Nanchang University, Nanchang, Jiangxi 330031, P.R. China, Key Laboratory of Women's Reproductive Health of Jiangxi Province, Jiangxi Provincial Maternal and Child Health Hospital, Nanchang, Jiangxi 330006, P.R. China, Reproductive Medicine Center, Jiangxi Provincial Maternal and Child Health Hospital, Nanchang, Jiangxi 330006, P.R. China
    Copyright: © Tian et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 31
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    Published online on: November 11, 2020
       https://doi.org/10.3892/etm.2020.9463
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Abstract

Polycystic ovary syndrome (PCOS) affects 8‑13% of reproductive‑age females worldwide and mutations or aberrant expression of androgen receptor (AR) may cause the onset of this disease. In the present study, 258 samples from Han Chinese patients with PCOS were analyzed for the presence of AR mutations via sequencing of all coding exons of the AR gene. A total of five heterozygous missense mutations, namely p.V3M, p.Q72R, p.S158L, p.S176R and p.G396R, were identified in five of the patients. Among these, p.S158L was a novel mutation that, to the best of our knowledge, has not been reported previously. Although the remaining four mutations have been reported previously, they existed at low frequencies or were absent in the control subjects and in the Exome Aggregation Consortium database. The results of evolutionary conservation and in silico analysis revealed that the p.V3M, p.S158L and p.S176R mutations were pathogenic, whereas the p.Q72R and p.G396R mutations were benign. Compared with the patients with PCOS without AR mutations or with benign AR mutations, markedly lower estrogen levels on the day of human chorionic gonadotropin injection were observed in the three patients with PCOS with potentially pathogenic mutations. In addition, patients with PCOS with pathogenic mutations had lower numbers of oocytes; however, the difference was not statistically significant. Of note, these observations should be interpreted with caution due to the relatively small sample size in the present study. Therefore, a larger number of samples should be collected to validate the results of the present study in future studies. In summary, the present study identified three potential pathogenic mutations in 258 Han Chinese patients with PCOS and these mutations may have an implication in the pathogenesis of PCOS.
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1 

Teede H, Deeks A and Moran L: Polycystic ovary syndrome: A complex condition with psychological, reproductive and metabolic manifestations that impacts on health across the lifespan. BMC Med. 8(41)2010.PubMed/NCBI View Article : Google Scholar

2 

Azziz R, Carmina E, Chen Z, Dunaif A, Laven JS, Legro RS, Lizneva D, Natterson-Horowtiz B, Teede HJ and Yildiz BO: Polycystic ovary syndrome. Nat Rev Dis Primers. 2(16057)2016.PubMed/NCBI View Article : Google Scholar

3 

Azziz R, Carmina E, Dewailly D, Diamanti-Kandarakis E, Escobar-Morreale HF, Futterweit W, Janssen OE, Legro RS, Norman RJ, Taylor AE, et al: Androgen Excess Society: Positions statement: Criteria for defining polycystic ovary syndrome as a predominantly hyperandrogenic syndrome: An Androgen Excess Society guideline. J Clin Endocrinol Metab. 91:4237–4245. 2006.PubMed/NCBI View Article : Google Scholar

4 

Chang WY, Knochenhauer ES, Bartolucci AA and Azziz R: Phenotypic spectrum of polycystic ovary syndrome: Clinical and biochemical characterization of the three major clinical subgroups. Fertil Steril. 83:1717–1723. 2005.PubMed/NCBI View Article : Google Scholar

5 

Livadas S, Pappas C, Karachalios A, Marinakis E, Tolia N, Drakou M, Kaldrymides P, Panidis D and Diamanti-Kandarakis E: Prevalence and impact of hyperandrogenemia in 1,218 women with polycystic ovary syndrome. Endocrine. 47:631–638. 2014.PubMed/NCBI View Article : Google Scholar

6 

Owens LA, Kristensen SG, Lerner A, Christopoulos G, Lavery S, Hanyaloglu AC, Hardy K, Yding Andersen C and Franks S: Gene expression in granulosa cells from small antral follicles from women with or without polycystic ovaries. J Clin Endocrinol Metab. 104:6182–6192. 2019.PubMed/NCBI View Article : Google Scholar

7 

Younas K, Quintela M, Thomas S, Garcia-Parra J, Blake L, Whiteland H, Bunkheila A, Francis LW, Margarit L, Gonzalez D, et al: Delayed endometrial decidualisation in polycystic ovary syndrome; the role of AR-MAGEA11. J Mol Med (Berl). 97:1315–1327. 2019.PubMed/NCBI View Article : Google Scholar

8 

Xu G, Wang Q, Zhang AD, Liu JD, Feng JW and Chen YL: Effect of electroacupuncture at different acupoints on steroid hormones and ovarian androgen receptor expression in polycystic ovary syndrome rats. Zhen Ci Yan Jiu. 43:543–549. 2018.PubMed/NCBI View Article : Google Scholar

9 

Li X, Pishdari B, Cui P, Hu M, Yang HP, Guo YR, Jiang HY, Feng Y, Billig H and Shao R: Regulation of androgen receptor expression alters AMPK phosphorylation in the endometrium: In vivo and in vitro studies in women with polycystic ovary syndrome. Int J Biol Sci. 11:1376–1389. 2015.PubMed/NCBI View Article : Google Scholar

10 

Caldwell AS, Edwards MC, Desai R, Jimenez M, Gilchrist RB, Handelsman DJ and Walters KA: Neuroendocrine androgen action is a key extraovarian mediator in the development of polycystic ovary syndrome. Proc Natl Acad Sci USA. 114:E3334–E3343. 2017.PubMed/NCBI View Article : Google Scholar

11 

Rajender S, Carlus SJ, Bansal SK, Negi MP, Sadasivam N, Sadasivam MN and Thangaraj K: Androgen receptor CAG repeats length polymorphism and the risk of polycystic ovarian syndrome (PCOS). PLoS One. 8(e75709)2013.PubMed/NCBI View Article : Google Scholar

12 

Peng CY, Xie HJ, Guo ZF, Nie YL, Chen J, Zhou JM and Yin J: The association between androgen receptor gene CAG polymorphism and polycystic ovary syndrome: A case-control study and meta-analysis. J Assist Reprod Genet. 31:1211–1219. 2014.PubMed/NCBI View Article : Google Scholar

13 

Schüring AN, Welp A, Gromoll J, Zitzmann M, Sonntag B, Nieschlag E, Greb RR and Kiesel L: Role of the CAG repeat polymorphism of the androgen receptor gene in polycystic ovary syndrome (PCOS). Exp Clin Endocrinol Diabetes. 120:73–79. 2012.PubMed/NCBI View Article : Google Scholar

14 

Ibáñez L, Ong KK, Mongan N, Jääskeläinen J, Marcos MV, Hughes IA, De Zegher F and Dunger DB: Androgen receptor gene CAG repeat polymorphism in the development of ovarian hyperandrogenism. J Clin Endocrinol Metab. 88:3333–3338. 2003.PubMed/NCBI View Article : Google Scholar

15 

Kim JJ, Choung SH, Choi YM, Yoon SH, Kim SH and Moon SY: Androgen receptor gene CAG repeat polymorphism in women with polycystic ovary syndrome. Fertil Steril. 90:2318–2323. 2008.PubMed/NCBI View Article : Google Scholar

16 

Xia Y, Che Y, Zhang X, Zhang C, Cao Y, Wang W, Xu P, Wu X, Yi L, Gao Q, et al: Polymorphic CAG repeat in the androgen receptor gene in polycystic ovary syndrome patients. Mol Med Rep. 5:1330–1334. 2012.PubMed/NCBI View Article : Google Scholar

17 

Möhlig M, Jürgens A, Spranger J, Hoffmann K, Weickert MO, Schlösser HW, Schill T, Brabant G, Schüring A, Pfeiffer AF, et al: The androgen receptor CAG repeat modifies the impact of testosterone on insulin resistance in women with polycystic ovary syndrome. Eur J Endocrinol. 155:127–130. 2006.PubMed/NCBI View Article : Google Scholar

18 

Hu DG, Hickey TE, Irvine C, Wijayakumara DD, Lu L, Tilley WD, Selth LA and Mackenzie PI: Identification of androgen receptor splice variant transcripts in breast cancer cell lines and human tissues. Horm Cancer. 5:61–71. 2014.PubMed/NCBI View Article : Google Scholar

19 

Wang F, Pan J, Liu Y, Meng Q, Lv P, Qu F, Ding GL, Klausen C, Leung PC, Chan HC, et al: Alternative splicing of the androgen receptor in polycystic ovary syndrome. Proc Natl Acad Sci USA. 112:4743–4748. 2015.PubMed/NCBI View Article : Google Scholar

20 

Walters KA and Handelsman DJ: Androgen receptor splice variants and polycystic ovary syndrome: Cause or effect? Asian J Androl. 18:442–443. 2016.PubMed/NCBI View Article : Google Scholar

21 

Wadosky KM and Koochekpour S: Androgen receptor splice variants and prostate cancer: From bench to bedside. Oncotarget. 8:18550–18576. 2017.PubMed/NCBI View Article : Google Scholar

22 

Hickey TE, Irvine CM, Dvinge H, Tarulli GA, Hanson AR, Ryan NK, Pickering MA, Birrell SN, Hu DG, Mackenzie PI, et al: Expression of androgen receptor splice variants in clinical breast cancers. Oncotarget. 6:44728–44744. 2015.PubMed/NCBI View Article : Google Scholar

23 

Nam H, Kim CH, Cha MY, Kim JM, Kang BM and Yoo HW: Polycystic ovary syndrome woman with heterozygous androgen receptor gene mutation who gave birth to a child with androgen insensitivity syndrome. Obstet Gynecol Sci. 58:179–182. 2015.PubMed/NCBI View Article : Google Scholar

24 

Rotterdam ESHRE/ASRM-Sponsored PCOS Consensus Workshop Group. Revised 2003 consensus on diagnostic criteria and long-term health risks related to polycystic ovary syndrome. Fertil Steril. 81:19–25. 2004.PubMed/NCBI View Article : Google Scholar

25 

Hatch R, Rosenfield RL, Kim MH and Tredway D: Hirsutism: Implications, etiology, and management. Am J Obstet Gynecol. 140:815–830. 1981.PubMed/NCBI View Article : Google Scholar

26 

Balen AH, Laven JS, Tan SL and Dewailly D: Ultrasound assessment of the polycystic ovary: International consensus definitions. Hum Reprod Update. 9:505–514. 2003.PubMed/NCBI View Article : Google Scholar

27 

Wu J, Zou Y, Luo Y, Guo JB, Liu FY, Zhou JY, Zhang ZY, Wan L and Huang OP: Prevalence and clinical significance of mediator complex subunit 12 mutations in 362 Han Chinese samples with uterine leiomyoma. Oncol Lett. 14:47–54. 2017.PubMed/NCBI View Article : Google Scholar

28 

Li GX, Jiao XH and Cheng XB: Correlations between blood uric acid and the incidence and progression of type 2 diabetes nephropathy. Eur Rev Med Pharmacol Sci. 22:506–511. 2018.PubMed/NCBI View Article : Google Scholar

29 

Adzhubei IA, Schmidt S, Peshkin L, Ramensky VE, Gerasimova A, Bork P, Kondrashov AS and Sunyaev SR: A method and server for predicting damaging missense mutations. Nat Methods. 7:248–249. 2010.PubMed/NCBI View Article : Google Scholar

30 

Schwarz JM, Cooper DN, Schuelke M and Seelow D: MutationTaster2: Mutation prediction for the deep-sequencing age. Nat Methods. 11:361–362. 2014.PubMed/NCBI View Article : Google Scholar

31 

Kumar S, Stecher G and Tamura K: MEGA7: Molecular evolutionary genetics analysis version 7.0 for bigger datasets. Mol Biol Evol. 33:1870–1874. 2016.PubMed/NCBI View Article : Google Scholar

32 

Walters KA, Rodriguez Paris V, Aflatounian A and Handelsman DJ: Androgens and ovarian function: translation from basic discovery research to clinical impact. J Endocrinol. 242:R23–R50. 2019.PubMed/NCBI View Article : Google Scholar

33 

Walters KA and Handelsman DJ: Role of androgens in the ovary. Mol Cell Endocrinol. 465:36–47. 2018.PubMed/NCBI View Article : Google Scholar

34 

Baculescu N: The role of androgen receptor activity mediated by the CAG repeat polymorphism in the pathogenesis of PCOS. J Med Life. 6:18–25. 2013.PubMed/NCBI

35 

Lim JJ, Lima PDA, Salehi R, Lee DR and Tsang BK: Regulation of androgen receptor signaling by ubiquitination during folliculogenesis and its possible dysregulation in polycystic ovarian syndrome. Sci Rep. 7(10272)2017.PubMed/NCBI View Article : Google Scholar

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Copy and paste a formatted citation
Spandidos Publications style
Tian L, Zou Y, Tan J, Wang Y, Chen J, Xia L, Xu L, Chen G, Wu Q, Huang O, Huang O, et al: Androgen receptor gene mutations in 258 Han Chinese patients with polycystic ovary syndrome. Exp Ther Med 21: 31, 2021.
APA
Tian, L., Zou, Y., Tan, J., Wang, Y., Chen, J., Xia, L. ... Huang, O. (2021). Androgen receptor gene mutations in 258 Han Chinese patients with polycystic ovary syndrome. Experimental and Therapeutic Medicine, 21, 31. https://doi.org/10.3892/etm.2020.9463
MLA
Tian, L., Zou, Y., Tan, J., Wang, Y., Chen, J., Xia, L., Xu, L., Chen, G., Wu, Q., Huang, O."Androgen receptor gene mutations in 258 Han Chinese patients with polycystic ovary syndrome". Experimental and Therapeutic Medicine 21.1 (2021): 31.
Chicago
Tian, L., Zou, Y., Tan, J., Wang, Y., Chen, J., Xia, L., Xu, L., Chen, G., Wu, Q., Huang, O."Androgen receptor gene mutations in 258 Han Chinese patients with polycystic ovary syndrome". Experimental and Therapeutic Medicine 21, no. 1 (2021): 31. https://doi.org/10.3892/etm.2020.9463
Copy and paste a formatted citation
x
Spandidos Publications style
Tian L, Zou Y, Tan J, Wang Y, Chen J, Xia L, Xu L, Chen G, Wu Q, Huang O, Huang O, et al: Androgen receptor gene mutations in 258 Han Chinese patients with polycystic ovary syndrome. Exp Ther Med 21: 31, 2021.
APA
Tian, L., Zou, Y., Tan, J., Wang, Y., Chen, J., Xia, L. ... Huang, O. (2021). Androgen receptor gene mutations in 258 Han Chinese patients with polycystic ovary syndrome. Experimental and Therapeutic Medicine, 21, 31. https://doi.org/10.3892/etm.2020.9463
MLA
Tian, L., Zou, Y., Tan, J., Wang, Y., Chen, J., Xia, L., Xu, L., Chen, G., Wu, Q., Huang, O."Androgen receptor gene mutations in 258 Han Chinese patients with polycystic ovary syndrome". Experimental and Therapeutic Medicine 21.1 (2021): 31.
Chicago
Tian, L., Zou, Y., Tan, J., Wang, Y., Chen, J., Xia, L., Xu, L., Chen, G., Wu, Q., Huang, O."Androgen receptor gene mutations in 258 Han Chinese patients with polycystic ovary syndrome". Experimental and Therapeutic Medicine 21, no. 1 (2021): 31. https://doi.org/10.3892/etm.2020.9463
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