Open Access

Investigational drugs with dual activity against HBV and HIV (Review)

  • Authors:
    • Shiyu Sun
    • Qing Yang
    • Yunjian Sheng
    • Yi Fu
    • Changfeng Sun
    • Cunliang Deng
  • View Affiliations

  • Published online on: November 11, 2020     https://doi.org/10.3892/etm.2020.9467
  • Article Number: 35
  • Copyright: © Sun et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Chronic hepatitis B (CHB) and acquired immunodeficiency syndrome (AIDS) are global public health problems that pose a significant health burden. Human immunodeficiency virus (HIV) and hepatitis B virus (HBV) coinfection is common, as these viruses have similar transmission routes, such as blood transmission, sexual transmission and mother‑to‑child transmission. Coinfection frequently leads to accelerated disease progression. For individuals coinfected with HIV/HBV, combination antiretroviral therapy containing dual anti‑HBV drugs is recommended. Certain studies have also indicated the benefits of antiretroviral drugs with anti‑HBV activity in patients with coinfection. A total of four Food and Drug Administration‑approved HIV drugs also have anti‑HBV activity; namely, emtricitabine, lamivudine, tenofovir disoproxil fumarate and tenofovir alafenamide, which are all nucleoside reverse transcriptase inhibitors. However, various issues, including drug resistance and side effects, limit their application. Therefore, it is necessary to develop more drugs with dual activity against HBV and HIV. The present review outlines the mechanisms, safety and efficacy of certain drugs that have been investigated for this purpose.
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January-2021
Volume 21 Issue 1

Print ISSN: 1792-0981
Online ISSN:1792-1015

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Copy and paste a formatted citation
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Spandidos Publications style
Sun S, Yang Q, Sheng Y, Fu Y, Sun C and Deng C: Investigational drugs with dual activity against HBV and HIV (Review). Exp Ther Med 21: 35, 2021
APA
Sun, S., Yang, Q., Sheng, Y., Fu, Y., Sun, C., & Deng, C. (2021). Investigational drugs with dual activity against HBV and HIV (Review). Experimental and Therapeutic Medicine, 21, 35. https://doi.org/10.3892/etm.2020.9467
MLA
Sun, S., Yang, Q., Sheng, Y., Fu, Y., Sun, C., Deng, C."Investigational drugs with dual activity against HBV and HIV (Review)". Experimental and Therapeutic Medicine 21.1 (2021): 35.
Chicago
Sun, S., Yang, Q., Sheng, Y., Fu, Y., Sun, C., Deng, C."Investigational drugs with dual activity against HBV and HIV (Review)". Experimental and Therapeutic Medicine 21, no. 1 (2021): 35. https://doi.org/10.3892/etm.2020.9467