Open Access

Roles and regulatory mechanisms of miR‑30b in cancer, cardiovascular disease, and metabolic disorders (Review)

  • Authors:
    • Qing Zhang
    • Shousheng Liu
    • Jie Zhang
    • Xuefeng Ma
    • Mengzhen Dong
    • Baokai Sun
    • Yongning Xin
  • View Affiliations

  • Published online on: November 17, 2020     https://doi.org/10.3892/etm.2020.9475
  • Article Number: 44
  • Copyright: © Zhang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

MicroRNAs (miRNAs) are non‑coding RNAs 21‑23 nucleotides in length that regulate gene expression, and thereby modulate signaling pathways and protein synthesis in both physiological and pathogenic processes. miR‑30b inhibits cell proliferation, migration, invasion and epithelial‑mesenchymal transformation in multiple types of cancer. In addition to its role in several types of neoplasias, miR‑30b has been shown to exhibit essential roles in cardiovascular and metabolic diseases. In the present review, an overview of the biological functions of miR‑30b and its role in the pathogenesis of neoplastic, cardiovascular and metabolic diseases is provided. miR‑30b is a potential candidate for clinical development as a diagnostic and prognostic biomarker, therapeutic agent and drug target. However, further research is required to elucidate its role in health and disease and to harness its potential clinical utility.
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January-2021
Volume 21 Issue 1

Print ISSN: 1792-0981
Online ISSN:1792-1015

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Copy and paste a formatted citation
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Spandidos Publications style
Zhang Q, Liu S, Zhang J, Ma X, Dong M, Sun B and Xin Y: Roles and regulatory mechanisms of miR‑30b in cancer, cardiovascular disease, and metabolic disorders (Review). Exp Ther Med 21: 44, 2021
APA
Zhang, Q., Liu, S., Zhang, J., Ma, X., Dong, M., Sun, B., & Xin, Y. (2021). Roles and regulatory mechanisms of miR‑30b in cancer, cardiovascular disease, and metabolic disorders (Review). Experimental and Therapeutic Medicine, 21, 44. https://doi.org/10.3892/etm.2020.9475
MLA
Zhang, Q., Liu, S., Zhang, J., Ma, X., Dong, M., Sun, B., Xin, Y."Roles and regulatory mechanisms of miR‑30b in cancer, cardiovascular disease, and metabolic disorders (Review)". Experimental and Therapeutic Medicine 21.1 (2021): 44.
Chicago
Zhang, Q., Liu, S., Zhang, J., Ma, X., Dong, M., Sun, B., Xin, Y."Roles and regulatory mechanisms of miR‑30b in cancer, cardiovascular disease, and metabolic disorders (Review)". Experimental and Therapeutic Medicine 21, no. 1 (2021): 44. https://doi.org/10.3892/etm.2020.9475