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Roles and regulatory mechanisms of miR‑30b in cancer, cardiovascular disease, and metabolic disorders (Review)

  • Authors:
    • Qing Zhang
    • Shousheng Liu
    • Jie Zhang
    • Xuefeng Ma
    • Mengzhen Dong
    • Baokai Sun
    • Yongning Xin
  • View Affiliations / Copyright

    Affiliations: Department of Infectious Disease, Qingdao Municipal Hospital, Qingdao University, Qingdao, Shandong 266011, P.R. China, Clinical Research Center, Qingdao Municipal Hospital, Qingdao University, Qingdao, Shandong 266011, P.R. China
    Copyright: © Zhang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 44
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    Published online on: November 17, 2020
       https://doi.org/10.3892/etm.2020.9475
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Abstract

MicroRNAs (miRNAs) are non‑coding RNAs 21‑23 nucleotides in length that regulate gene expression, and thereby modulate signaling pathways and protein synthesis in both physiological and pathogenic processes. miR‑30b inhibits cell proliferation, migration, invasion and epithelial‑mesenchymal transformation in multiple types of cancer. In addition to its role in several types of neoplasias, miR‑30b has been shown to exhibit essential roles in cardiovascular and metabolic diseases. In the present review, an overview of the biological functions of miR‑30b and its role in the pathogenesis of neoplastic, cardiovascular and metabolic diseases is provided. miR‑30b is a potential candidate for clinical development as a diagnostic and prognostic biomarker, therapeutic agent and drug target. However, further research is required to elucidate its role in health and disease and to harness its potential clinical utility.
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1 

Kim VN, Han J and Siomi MC: Biogenesis of small RNAs in animals. Nat Rev Mol Cell Biol. 10:126–139. 2009.PubMed/NCBI View Article : Google Scholar

2 

Hammond SM: An overview of microRNAs. Adv Drug Deliv Rev. 87:3–14. 2015.PubMed/NCBI View Article : Google Scholar

3 

Lee Y, Ahn C, Han J, Choi H, Kim J, Yim J, Lee J, Provost P, Rådmark O, Kim S and Kim VN: The nuclear RNase III Drosha initiates microRNA processing. Nature. 425:415–419. 2003.PubMed/NCBI View Article : Google Scholar

4 

Morlando M, Ballarino M, Gromak N, Pagano F, Bozzoni I and Proudfoot NJ: Primary microRNA transcripts are processed co-transcriptionally. Nat Struct Mol Biol. 15:902–909. 2008.PubMed/NCBI View Article : Google Scholar

5 

Yang JS, Phillips MD, Betel D, Mu P, Ventura A, Siepel AC, Chen KC and Lai EC: Widespread regulatory activity of vertebrate microRNA* species. RNA. 17:312–326. 2011.PubMed/NCBI View Article : Google Scholar

6 

Fabian MR and Sonenberg N: The mechanics of miRNA-mediated gene silencing: A look under the hood of miRISC. Nat Struct Mol Biol. 19:586–593. 2012.PubMed/NCBI View Article : Google Scholar

7 

Pfaff J and Meister G: Argonaute and GW182 proteins: An effective alliance in gene silencing. Biochem Soc Trans. 41:855–860. 2013.PubMed/NCBI View Article : Google Scholar

8 

Selbach M, Schwanhausser B, Thierfelder N, Fang Z, Khanin R and Rajewsky N: Widespread changes in protein synthesis induced by microRNAs. Nature. 455:58–63. 2008.PubMed/NCBI View Article : Google Scholar

9 

Yates LA, Norbury CJ and Gilbert RJ: The long and short of microRNA. Cell. 153:516–519. 2013.PubMed/NCBI View Article : Google Scholar

10 

Greenhill C: Adipose tissue: Exosomal microRNAs-novel adipokines. Nat Rev Endocrinol. 13(188)2017.PubMed/NCBI View Article : Google Scholar

11 

Guay C and Regazzi R: Circulating microRNAs as novel biomarkers for diabetes mellitus. Nat Rev Endocrinol. 9:513–521. 2013.PubMed/NCBI View Article : Google Scholar

12 

Lian JB, Stein GS, van Wijnen AJ, Stein JL, Hassan MQ, Gaur T and Zhang Y: MicroRNA control of bone formation and homeostasis. Nat Rev Endocrinol. 8:212–227. 2012.PubMed/NCBI View Article : Google Scholar

13 

Cheng G: Circulating miRNAs: Roles in cancer diagnosis, prognosis and therapy. Adv Drug Deliv Rev. 81:75–93. 2015.PubMed/NCBI View Article : Google Scholar

14 

Song CL, Liu B, Wang JP, Zhang BL, Zhang JC, Zhao LY, Shi YF, Li YX, Wang G, Diao HY, et al: Anti-apoptotic effect of microRNA-30b in early phase of rat myocardial ischemia-reperfusion injury model. J Cell Biochem. 116:2610–2619. 2015.PubMed/NCBI View Article : Google Scholar

15 

Zhu ED, Li N, Li BS, Li W, Zhang WJ, Mao XH, Guo G, Zou QM and Xiao B: miR-30b, down-regulated in gastric cancer, promotes apoptosis and suppresses tumor growth by targeting plasminogen activator inhibitor-1. PLoS One. 9(e106049)2014.PubMed/NCBI View Article : Google Scholar

16 

Mazzeo A, Beltramo E, Lopatina T, Gai C, Trento M and Porta M: Molecular and functional characterization of circulating extracellular vesicles from diabetic patients with and without retinopathy and healthy subjects. Exp Eye Res. 176:69–77. 2018.PubMed/NCBI View Article : Google Scholar

17 

Gu D, Zou X, Ju G, Zhang G, Bao E and Zhu Y: Mesenchymal stromal cells derived extracellular vesicles ameliorate acute renal ischemia reperfusion injury by inhibition of mitochondrial fission through miR-30. Stem Cells Int. 2016(2093940)2016.PubMed/NCBI View Article : Google Scholar

18 

Serafin A, Foco L, Zanigni S, Blankenburg H, Picard A, Zanon A, Giannini G, Pichler I, Facheris MF, Cortelli P, et al: Overexpression of blood microRNAs 103a, 30b, and 29a in L-dopa-treated patients with PD. Neurology. 84:645–653. 2015.PubMed/NCBI View Article : Google Scholar

19 

Zheng Y, Wang Z, Tu Y, Shen H, Dai Z, Lin J and Zhou Z: miR-101a and miR-30b contribute to inflammatory cytokine-mediated β-cell dysfunction. Lab Invest. 95:1387–1397. 2015.PubMed/NCBI View Article : Google Scholar

20 

Wa Q, He P, Huang S, Zuo J, Li X, Zhu J, Hong S, Lv G, Cai D, Xu D, et al: miR-30b regulates chondrogenic differentiation of mouse embryo-derived stem cells by targeting SOX9. Exp Ther Med. 14:6131–6137. 2017.PubMed/NCBI View Article : Google Scholar

21 

Han F, Huo Y, Huang CJ, Chen CL and Ye J: MicroRNA-30b promotes axon outgrowth of retinal ganglion cells by inhibiting Semaphorin3A expression. Brain Res. 1611:65–73. 2015.PubMed/NCBI View Article : Google Scholar

22 

Howe GA, Kazda K and Addison CL: MicroRNA-30b controls endothelial cell capillary morphogenesis through regulation of transforming growth factor beta 2. PLoS One. 12(e0185619)2017.PubMed/NCBI View Article : Google Scholar

23 

Besteiro S, Brooks CF, Striepen B and Dubremetz JF: Autophagy protein Atg3 is essential for maintaining mitochonrial integrity and for normal intracellular development of Toxoplasma gondii tachyzoites. PLoS Pathog. 7(e1002416)2011.PubMed/NCBI View Article : Google Scholar

24 

Parzych KR and Klionsky DJ: An overview of autophagy: Morphology, mechanism, and regulation. Antioxid Redox Signal. 20:460–473. 2014.PubMed/NCBI View Article : Google Scholar

25 

Li SP, He JD, Wang Z, Yu Y, Fu SY, Zhang HM, Zhang JJ and Shen ZY: miR-30b inhibits autophagy to alleviate hepatic ischemia-reperfusion injury via decreasing the Atg12-Atg5 conjugate. World J Gastroenterol. 22:4501–4514. 2016.PubMed/NCBI View Article : Google Scholar

26 

Wang J, Sun YT, Xu TH, Sun W, Tian BY, Sheng ZT, Sun L, Liu LL, Ma JF, Wang LN and Yao L: MicroRNA-30b regulates high phosphorus level-induced autophagy in vascular smooth muscle cells by targeting BECN1. Cell Physiol Biochem. 42:530–536. 2017.PubMed/NCBI View Article : Google Scholar

27 

Chen Z, Jin T and Lu Y: AntimiR-30b Inhibits TNF-α mediated apoptosis and attenuated cartilage degradation through enhancing autophagy. Cell Physiol Biochem. 40:883–894. 2016.PubMed/NCBI View Article : Google Scholar

28 

Naqvi AR, Fordham JB and Nares S: MicroRNA target Fc receptors to regulate Ab-dependent Ag uptake in primary macrophages and dendritic cells. Innate Immun. 22:510–521. 2016.PubMed/NCBI View Article : Google Scholar

29 

Naqvi AR, Fordham JB and Nares S: miR-24, miR-30b, and miR-142-3p regulate phagocytosis in myeloid inflammatory cells. J Immunol. 194:1916–1927. 2015.PubMed/NCBI View Article : Google Scholar

30 

Fordham JB, Naqvi AR and Nares S: Regulation of miR-24, miR-30b, and miR-142-3p during macrophage and dendritic cell differentiation potentiates innate immunity. J Leukoc Biol. 98:195–207. 2015.PubMed/NCBI View Article : Google Scholar

31 

Sun Y, Guo D, Liu B, Yin X, Wei H, Tang K and Bi H: Regulatory role of rno-miR-30b-5p in IL-10 and Toll-like receptor 4 expressions of T lymphocytes in experimental autoimmune uveitis in vitro. Mediators Inflamm. 2018(2574067)2018.PubMed/NCBI View Article : Google Scholar

32 

Duan ZQ, Shi JD, Wu MN, Hu NZ and Hu YZ: Influence of miR-30b regulating humoral immune response by genetic difference. Immunol Res. 64:181–190. 2016.PubMed/NCBI View Article : Google Scholar

33 

Liu H, Zhang N and Tian D: miR-30b is involved in methylglyoxal-induced epithelial-mesenchymal transition of peritoneal mesothelial cells in rats. Cell Mol Biol Lett. 19:315–329. 2014.PubMed/NCBI View Article : Google Scholar

34 

Xiong Y, Wang Y, Wang L, Huang Y, Xu Y, Xu L, Guo Y, Lu J, Li X, Zhu M and Qian H: MicroRNA-30b targets Snail to impede epithelial-mesenchymal transition in pancreatic cancer stem cells. J Cancer. 9:2147–2159. 2018.PubMed/NCBI View Article : Google Scholar

35 

Sun X, Zhao S, Li H, Chang H, Huang Z, Ding Z, Dong L, Chen J, Zang Y and Zhang J: MicroRNA-30b suppresses epithelial-mesenchymal transition and metastasis of hepatoma cells. J Cell Physiol. 232:625–634. 2017.PubMed/NCBI View Article : Google Scholar

36 

Van Cutsem E, Sagaert X, Topal B, Haustermans K and Prenen H: Gastric cancer. Lancet. 388:2654–2664. 2016.PubMed/NCBI View Article : Google Scholar

37 

Siegel RL, Miller KD and Jemal A: Cancer statistics, 2019. CA Cancer J Clin. 69:7–34. 2019.PubMed/NCBI View Article : Google Scholar

38 

Qiao F, Zhang K, Gong P, Wang L, Hu J, Lu S and Fan H: Decreased miR-30b-5p expression by DNMT1 methylation regulation involved in gastric cancer metastasis. Mol Biol Rep. 41:5693–5700. 2014.PubMed/NCBI View Article : Google Scholar

39 

Tian SB, Yu JC, Liu YQ, Kang WM, Ma ZQ, Ye X and Yan C: miR-30b suppresses tumor migration and invasion by targeting EIF5A2 in gastric cancer. World J Gastroenterol. 21:9337–9347. 2015.PubMed/NCBI View Article : Google Scholar

40 

Xi Z, Si J and Nan J: LncRNA MALAT1 potentiates autophagy-associated cisplatin resistance by regulating the microRNA30b/autophagy-related gene 5 axis in gastric cancer. Int J Oncol. 54:239–248. 2019.PubMed/NCBI View Article : Google Scholar

41 

Huang YH, Lin KH, Chen HC, Chang ML, Hsu CW, Lai MW, Chen TC, Lee WC, Tseng YH and Yeh CT: Identification of postoperative prognostic microRNA predictors in hepatocellular carcinoma. PLoS One. 7(e37188)2012.PubMed/NCBI View Article : Google Scholar

42 

Qin X, Chen J, Wu L and Liu Z: miR-30b-5p acts as a tumor suppressor, repressing cell proliferation and cell cycle in human hepatocellular carcinoma. Biomed Pharmacother. 89:742–750. 2017.PubMed/NCBI View Article : Google Scholar

43 

Hur K, Toiyama Y, Boland CR and Goel A: Identification of a novel metastasis-specific microRNA signature in human colorectal cancer. Gastroenterology. 142:S525–S526. 2012.

44 

Perez-Villamil B, Paz-Cabezas M, Calvo-López T, Ogando-Castro J, Sastre J, Mañes S and Díaz-Rubio E: microRNA(miR) subtypes correlates with colorectal cancer(CRC) molecular subtypes: Validation of miR-30b interaction with genes up-regulated in the high-stroma subtype. Ann Oncol. 28 (Suppl 5):v194–v195. 2017.

45 

van den Braak RRC, Sieuwerts AM, Lalmahomed ZS, Smid M, de Weerd V, van der Vlugt-Daane M, van Galen A, Xiang S, Biermann K, Foekens JA, et al: Validation and pathway analysis of a metastasis-specific microRNA signature in primary colon cancer. Cancer Res. 77 (13 Suppl)(S2530)2017.

46 

Coebergh van den Braak RRJ, Sieuwerts AM, Lalmahomed ZS, Smid M, Wilting SM, Bril SI, Xiang S, van der Vlugt-Daane M, de Weerd V, van Galen A, et al: Confirmation of a metastasis-specific microRNA signature in primary colon cancer. Sci Rep. 8(5242)2018.PubMed/NCBI View Article : Google Scholar

47 

Tryndyak V, Kindrat I, McDannell B, Beland FA and Pogribny IP: A microRNA signature panel predicts differential sensitivity of liver cancer cells to chemotherapeutic drugs. Cancer Res. 78 (13 Suppl)(S5887)2018.

48 

Zhuo LJ, Chen H, Wu MX, Gao MQ, Chen SP and Huang AM: Morphology and microRNA expression profiles of drug-resistant cells in hepatocellular carcinoma. Zhonghua Bing Li Xue Za Zhi. 42:604–608. 2013.PubMed/NCBI(In Chinese).

49 

Yeh CT and Huang YH: Extraneous delivery of anti-miR-30b by polyethyleneimine or antagomir-based strategies inhibits hepatoma growth in a xenograft model. J Gastroenterol Hepatol (Australia). 31 (Suppl 3)(S419)2016.

50 

Ferlay J, Soerjomataram I, Dikshit R, Eser S, Mathers C, Rebelo M, Parkin DM, Forman D and Bray F: Cancer incidence and mortality worldwide: Sources, methods and major patterns in GLOBOCAN 2012. Int J Cancer. 136:E359–E386. 2015.PubMed/NCBI View Article : Google Scholar

51 

Yilmaz U, Yilmaz N, Ergen A, Aksakal N and Zeybek U: Expression levels of Micrornas related to autophaphy pathway in tumor and adjacent normal tissues of colorectal cancer patients. Acta Physiologica. 221(36)2017.

52 

Yoon SM, Park SY, Bae JA, Ko YS, Kim HG and Kim KK: A strategy to screen and subsequently identify therapeutically valuable microRNAs that target a clinically established KITENIN oncogene in colorectal cancer. Eur J Cancer. 50 (Suppl 5)(S189)2014.

53 

Park SY, Kim H, Yoon S, Bae JA, Choi SY, Jung YD and Kim KK: KITENIN-targeting microRNA-124 suppresses colorectal cancer cell motility and tumorigenesis. Mol Ther. 22:1653–1664. 2014.PubMed/NCBI View Article : Google Scholar

54 

Liao WT, Ye YP, Zhang NJ, Li TT, Wang SY, Cui YM, Qi L, Wu P, Jiao HL, Xie YJ, et al: MicroRNA-30b functions as a tumour suppressor in human colorectal cancer by targeting KRAS, PIK3CD and BCL2. J Pathol. 232:415–427. 2014.PubMed/NCBI View Article : Google Scholar

55 

Zhao H, Xu Z, Qin H, Gao Z and Gao L: miR-30b regulates migration and invasion of human colorectal cancer via SIX1. Biochem J. 460:117–125. 2014.PubMed/NCBI View Article : Google Scholar

56 

Wu P, Ye Y, Ding Y and Liao W: The function of miR-30b in colorectal cancer metastasis. Chin J Clin Oncol. 41:679–683. 2014.

57 

Bray F, Ferlay J, Soerjomataram I, Siegel RL, Torre LA and Jemal A: Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 68:394–424. 2018.PubMed/NCBI View Article : Google Scholar

58 

Hu L, Ai J, Long H, Liu W, Wang X, Zuo Y, Li Y, Wu Q and Deng Y: Integrative microRNA and gene profiling data analysis reveals novel biomarkers and mechanisms for lung cancer. Oncotarget. 7:8441–8454. 2016.PubMed/NCBI View Article : Google Scholar

59 

Zhong K, Chen K, Han L and Li B: MicroRNA-30b/c inhibits non-small cell lung cancer cell proliferation by targeting Rab18. BMC Cancer. 14(703)2014.PubMed/NCBI View Article : Google Scholar

60 

Chen S, Li P, Yang R, Cheng R, Zhang F, Wang Y, Chen X, Sun Q, Zang W, Du Y, et al: microRNA-30b inhibits cell invasion and migration through targeting collagen triple helix repeat containing 1 in non-small cell lung cancer. Cancer Cell Int. 15(85)2015.PubMed/NCBI View Article : Google Scholar

61 

Park G, Son B, Kang J, Lee S, Jeon J, Kim JH, Yi GR, Youn H, Moon C, Nam SY and Youn B: LDR-induced miR-30a and miR-30b target the PAI-1 pathway to control adverse effects of NSCLC radiotherapy. Mol Ther. 27:342–354. 2019.PubMed/NCBI View Article : Google Scholar

62 

Li C, Qin F, Hu F, Xu H, Sun G, Han G, Wang T and Guo M: Characterization and selective incorporation of small non-coding RNAs in non-small cell lung cancer extracellular vesicles. Cell Biosci. 8(2)2018.PubMed/NCBI View Article : Google Scholar

63 

Hojbjerg JA, Ebert EBF, Clement MS, Winther-Larsen A, Meldgaard P and Sorensen B: Circulating miR-30b and miR-30c predict erlotinib response in EGFR-mutated non-small cell lung cancer patients. Lung Cancer. 135:92–96. 2019.PubMed/NCBI View Article : Google Scholar

64 

Gu YF, Zhang H, Su D, Mo ML, Song P, Zhang F and Zhang SC: miR-30b and miR-30c expression predicted response to tyrosine kinase inhibitors as first line treatment in non-small cell lung cancer. Chin Med J (Engl). 126:4435–4439. 2013.PubMed/NCBI

65 

Qi Z, Zhang B, Zhang J, Hu Q, Xu F, Chen B and Zhu C: MicroRNA-30b inhibits non-small cell lung cancer cell growth by targeting the epidermal growth factor receptor. Neoplasma. 65:192–200. 2018.PubMed/NCBI View Article : Google Scholar

66 

Garofalo M, Romano G, Di Leva G, Nuovo G, Jeon YJ, Ngankeu A, Sun J, Lovat F, Alder H, Condorelli G, et al: EGFR and MET receptor tyrosine kinase-altered microRNA expression induces tumorigenesis and gefitinib resistance in lung cancers. Nat Med. 18:74–82. 2011.PubMed/NCBI View Article : Google Scholar

67 

Chen JC, Su YH, Chiu CF, Chang YW, Yu YH, Tseng CF, Chen HA and Su JL: Suppression of Dicer increases sensitivity to gefitinib in human lung cancer cells. Ann Surg Oncol. 21 (Suppl 4):S555–S563. 2014.PubMed/NCBI View Article : Google Scholar

68 

Donagh LM, Gray S, Cuffe S, Finn S, Fitzgerald N, Young V, Ryan R, Nicholson S, Leonard N, O'Byrne K and Barr M: MA02.02 A novel 5-miR signature shows promise as a diagnostic tool and as a predictor of cisplatin response in NSCLC. J Thorac Oncol. 12 (1 Suppl):S348–S349. 2017.

69 

Antoni S, Ferlay J, Soerjomataram I, Znaor A, Jemal A and Bray F: Bladder cancer incidence and mortality: A global overview and recent trends. Eur Urol. 71:96–108. 2017.PubMed/NCBI View Article : Google Scholar

70 

Wszolek MF, Gould JJ, Kenney PA, Rieger-Christ KM, Neto BS, LaVoie AK, Libertino JA, Lavoie K, Libertino JA and Summerhayes IC: A microrna expression profile involved in the invasive bladder tumor phenotype. J Urol. 181(347)2009.PubMed/NCBI View Article : Google Scholar

71 

Mahdavinezhad A, Mousavibahar SH, Poorolajal J, Yadegarazari R, Jafari M, Shabab N and Saidijam M: Association between tissue miR-141, miR-200c and miR-30b and bladder cancer: A matched case-control study. Urol J. 12:2010–2013. 2015.PubMed/NCBI

72 

Mahdavinezhad A, Mousavi-Bahar SH, Poorolajal J, Yadegarazari R, Jafari M, Shabab N and Saidijam M: Evaluation of miR-141, miR-200c, miR-30b expression and clinicopathological features of bladder cancer. Int J Mol Cell Med. 4:32–39. 2015.PubMed/NCBI

73 

Wei S, Yao Y, Gupta PK and Bing Z: miRNA expression in lower and upper urothelial carcinoma and the potential clinical application. Lab Investigation. 93(A257)2013.

74 

Brisuda A, Pospíšilová Š, Soukup V, Hrbáček J, Čapoun O, Mareš J, Pazourková E, Korabečná M, Hořínek T A, Hanuš T and Babjuk M: C221: The differences in expression of microRNA in urine of bladder cancer patients and healthy controls. Eur Urol Suppl. 13:e1385–e1385a. 2014.

75 

Wszolek MF, Rieger-Christ KM, Kenney PA, Gould JJ, Silva Neto B, LaVoie AK, Logvinenko T and Summerhayes IC: A MicroRNA expression profile defining the invasive bladder tumor phenotype. Urol Oncol. 29:794–801.e1. 2011.PubMed/NCBI View Article : Google Scholar

76 

Pospisilova S, Pazzourkova E, Horinek A, Brisuda A, Svobodova I, Soukup V, Hrbacek J, Capoun O, Hanus T, Mares J, et al: MicroRNAs in urine supernatant as potential non-invasive markers for bladder cancer detection. Neoplasma. 63:799–808. 2016.PubMed/NCBI View Article : Google Scholar

77 

Torre LA, Islami F, Siegel RL, Ward EM and Jemal A: Global cancer in women: Burden and trends. Cancer Epidemiol Biomarkers Prev. 26:444–457. 2017.PubMed/NCBI View Article : Google Scholar

78 

Hafez MM, Hassan ZK, Zekri AR, Gaber AA, Al Rejaie SS, Sayed-Ahmed MM and Al Shabanah O: MicroRNAs and metastasis-related gene expression in Egyptian breast cancer patients. Asian Pac J Cancer Prev. 13:591–598. 2012.PubMed/NCBI View Article : Google Scholar

79 

Zhang K, Wang YW, Wang YY, Song Y, Zhu J, Si PC and Ma R: Identification of microRNA biomarkers in the blood of breast cancer patients based on microRNA profiling. Gene. 619:10–20. 2017.PubMed/NCBI View Article : Google Scholar

80 

Ribas G, Peña-Chilet M, Sanchis SO, Martinez MT, Lluch A and Ayala G: Differential microRNA expression in breast cancer patients aged 35 years or younger. Ann Oncol. 26 (Suppl 3)(iii12)2015.

81 

Croset M, Pantano F, Kan CWS, Bonnelye E, Descotes F, Alix-Panabieres C, Lecellier CH, Bachelier R, Allioli N, Hong SS, et al: miRNA-30 family members inhibit breast cancer invasion, osteomimicry, and bone destruction by directly targeting multiple bone metastasis-associated genes. Cancer Res. 78:5259–5273. 2018.PubMed/NCBI View Article : Google Scholar

82 

Luo J, Zhao Q, Zhang W, Zhang Z, Gao J, Zhang C, Li Y and Tian Y: A novel panel of microRNAs provides a sensitive and specific tool for the diagnosis of breast cancer. Mol Med Rep. 10:785–791. 2014.PubMed/NCBI View Article : Google Scholar

83 

Costa B, Amorim I, Gärtner F and Vale N: Understanding breast cancer: From conventional therapies to repurposed drugs. Eur J Pharm Sci. 151(105401)2020.PubMed/NCBI View Article : Google Scholar

84 

Espin E, Perez-Fidalgo JA, Tormo E, Pineda B, Cejalvo JM, Sabbaghi MA, Alonso E, Rovira A, Rojo F, Albanell J, et al: Effect of trastuzumab on the antiproliferative effects of PI3K inhibitors in HER2+ breast cancer cells with de novo resistance to trastuzumab. J Clin Oncol. 33 (Suppl 15)(e11592)2015.

85 

Guo QS, Wang P, Huang Y, Guo YB, Zhu MY and Xiong YC: Regulatory effect of miR-30b on migration and invasion of pancreatic cancer stem cells. Zhonghua Yi Xue Za Zhi. 99:3019–3023. 2019.PubMed/NCBI View Article : Google Scholar : (In Chinese).

86 

Li Q, Zhang X, Li N, Liu Q and Chen D: miR-30b inhibits cancer cell growth, migration, and invasion by targeting homeobox A1 in esophageal cancer. Biochem Biophys Res Commun. 485:506–512. 2017.PubMed/NCBI View Article : Google Scholar

87 

Xu J, Lv H, Zhang B, Xu F, Zhu H, Chen B, Zhu C and Shen J: miR-30b-5p acts as a tumor suppressor microRNA in esophageal squamous cell carcinoma. J Thorac Dis. 11:3015–3029. 2019.PubMed/NCBI View Article : Google Scholar

88 

Liu W, Li H, Wang Y, Zhao X, Guo Y, Jin J and Chi R: miR-30b-5p functions as a tumor suppressor in cell proliferation, metastasis and epithelial-to-mesenchymal transition by targeting G-protein subunit α-13 in renal cell carcinoma. Gene. 626:275–281. 2017.PubMed/NCBI View Article : Google Scholar

89 

Reddemann K, Gola D, Schillert A, Knief J, Kuempers C, Ribbat-Idel J, Ber S, Schemme J, Bernard V, Gebauer N, et al: Dysregulation of microRNAs in angioimmunoblastic T-cell lymphoma. Anticancer Res. 35:2055–2061. 2015.PubMed/NCBI

90 

Oduor CI, Kaymaz Y, Chelimo K, Otieno JA, Ong'echa JM, Moormann AM and Bailey JA: Integrative microRNA and mRNA deep-sequencing expression profiling in endemic Burkitt lymphoma. BMC Cancer. 17(761)2017.PubMed/NCBI View Article : Google Scholar

91 

Xu G and Li JY: Differential expression of PDGFRB and EGFR in microvascular proliferation in glioblastoma. Tumour Biol. 37:10577–10586. 2016.PubMed/NCBI View Article : Google Scholar

92 

Li Z, Guo J, Ma Y, Zhang L and Lin Z: Oncogenic role of MicroRNA-30b-5p in glioblastoma through targeting proline-rich transmembrane protein 2. Oncol Res. 26:219–230. 2018.PubMed/NCBI View Article : Google Scholar

93 

Zhang D, Liu Z, Zheng N, Wu H, Zhang Z and Xu J: miR-30b-5p modulates glioma cell proliferation by direct targeting MTDH. Saudi J Biol Sci. 25:947–952. 2018.PubMed/NCBI View Article : Google Scholar

94 

Jian Y, Xu CH, Li YP, Tang B, Xie SH and Zeng EM: Down-regulated microRNA-30b-3p inhibits proliferation, invasion and migration of glioma cells via inactivation of the AKT signaling pathway by up-regulating RECK. Biosci Rep. 39(BSR20182226)2019.PubMed/NCBI View Article : Google Scholar

95 

Hu Y, Zhang X, Cui M, Su Z, Wang M, Liao Q and Zhao Y: Verification of candidate microRNA markers for parathyroid carcinoma. Endocrine. 60:246–254. 2018.PubMed/NCBI View Article : Google Scholar

96 

Li L and Wang B: Overexpression of microRNA-30b improves adenovirus-mediated p53 cancer gene therapy for laryngeal carcinoma. Int J Mol Sci. 15:19729–19740. 2014.PubMed/NCBI View Article : Google Scholar

97 

Wang N, Xiang X, Chen K, Liu P and Zhu A: Targeting of NT5E by miR-30b and miR-340 attenuates proliferation, invasion and migration of gallbladder carcinoma. Biochimie. 146:56–67. 2018.PubMed/NCBI View Article : Google Scholar

98 

Cui H, Miao S, Esworthy T, Zhou X, Lee SJ, Liu C, Yu ZX, Fisher JP, Mohiuddin M and Zhang LG: 3D bioprinting for cardiovascular regeneration and pharmacology. Adv Drug Deliv Rev. 132:252–269. 2018.PubMed/NCBI View Article : Google Scholar

99 

Li T, Sun ZL and Xie QY: Protective effect of microRNA-30b on hypoxia/reoxygenation-induced apoptosis in H9C2 cardiomyocytes. Gene. 561:268–275. 2015.PubMed/NCBI View Article : Google Scholar

100 

Li F, Chen Q, Song X, Zhou L and Zhang J: miR-30b is involved in the homocysteine-induced apoptosis in human coronary artery endothelial cells by regulating the expression of caspase 3. Int J Mol Sci. 16:17682–17695. 2015.PubMed/NCBI View Article : Google Scholar

101 

Li B, Hu J and Chen X: MicroRNA-30b protects myocardial cell function in patients with acute myocardial ischemia by targeting plasminogen activator inhibitor-1. Exp Ther Med. 15:5125–5132. 2018.PubMed/NCBI View Article : Google Scholar

102 

Shen Y, Shen Z, Miao L, Xin X, Lin S, Zhu Y, Guo W and Zhu YZ: miRNA-30 family inhibition protects against cardiac ischemic injury by regulating cystathionine-γ-lyase expression. Antioxid Redox Signal. 22:224–240. 2015.PubMed/NCBI View Article : Google Scholar

103 

Wei C, Li L and Gupta S: NF-KB-mediated miR-30b regulation in cardiomyocytes cell death by targeting Bcl-2. Mol Cell Biochem. 387:135–141. 2014.PubMed/NCBI View Article : Google Scholar

104 

Ma F, Li T, Zhang H and Wu G: miR-30s family inhibit the proliferation and apoptosis in human coronary artery endothelial cells through targeting the 3'UTR region of ITGA4 and PLCG1. J Cardiovasc Pharmacol. 68:327–333. 2016.PubMed/NCBI View Article : Google Scholar

105 

Kim NH, Ahn J, Choi YM, Son HJ, Choi WH, Cho HJ, Yu JH, Seo JA, Jang YJ, Jung CH and Ha TY: Differential circulating and visceral fat microRNA expression of non-obese and obese subjects. Clin Nutr. 39:910–916. 2020.PubMed/NCBI View Article : Google Scholar

106 

Kirby TJ, Walton RG, Finlin B, Zhu B, Unal R, Rasouli N, Peterson CA and Kern PA: Integrative mRNA-microRNA analyses reveal novel interactions related to insulin sensitivity in human adipose tissue. Physiol Genomics. 48:145–153. 2016.PubMed/NCBI View Article : Google Scholar

107 

Stepien EL, Durak-Kozica M, Kaminska A, Targosz-Korecka M, Libera M, Tylko G, Opalinska A, Kapusta M, Solnica B, Georgescu A, et al: Circulating ectosomes: Determination of angiogenic microRNAs in type 2 diabetes. Theranostics. 8:3874–3890. 2018.PubMed/NCBI View Article : Google Scholar

108 

Zang J, Maxwell AP, Simpson DA and McKay GJ: Differential expression of urinary exosomal microRNAs miR-21-5p and miR-30b-5p in individuals with diabetic kidney disease. Sci Rep. 9(10900)2019.PubMed/NCBI View Article : Google Scholar

109 

Dai LL, Li SD, Ma YC, Tang JR, Lv JY, Zhang YQ, Miu YL, Ma YQ, Li CM, Chu YY, et al: MicroRNA-30b regulates insulin sensitivity by targeting SERCA2b in non-alcoholic fatty liver disease. Liver Int. 39:1504–1513. 2019.PubMed/NCBI View Article : Google Scholar

110 

Latorre J, Moreno-Navarrete JM, Mercader JM, Sabater M, Rovira O, Girones J, Ricart W, Fernández-Real JM and Ortega FJ: Decreased lipid metabolism but increased FA biosynthesis are coupled with changes in liver microRNAs in obese subjects with NAFLD. Int J Obes (Lond). 41:620–630. 2017.PubMed/NCBI View Article : Google Scholar

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Copy and paste a formatted citation
Spandidos Publications style
Zhang Q, Liu S, Zhang J, Ma X, Dong M, Sun B and Xin Y: Roles and regulatory mechanisms of miR‑30b in cancer, cardiovascular disease, and metabolic disorders (Review). Exp Ther Med 21: 44, 2021.
APA
Zhang, Q., Liu, S., Zhang, J., Ma, X., Dong, M., Sun, B., & Xin, Y. (2021). Roles and regulatory mechanisms of miR‑30b in cancer, cardiovascular disease, and metabolic disorders (Review). Experimental and Therapeutic Medicine, 21, 44. https://doi.org/10.3892/etm.2020.9475
MLA
Zhang, Q., Liu, S., Zhang, J., Ma, X., Dong, M., Sun, B., Xin, Y."Roles and regulatory mechanisms of miR‑30b in cancer, cardiovascular disease, and metabolic disorders (Review)". Experimental and Therapeutic Medicine 21.1 (2021): 44.
Chicago
Zhang, Q., Liu, S., Zhang, J., Ma, X., Dong, M., Sun, B., Xin, Y."Roles and regulatory mechanisms of miR‑30b in cancer, cardiovascular disease, and metabolic disorders (Review)". Experimental and Therapeutic Medicine 21, no. 1 (2021): 44. https://doi.org/10.3892/etm.2020.9475
Copy and paste a formatted citation
x
Spandidos Publications style
Zhang Q, Liu S, Zhang J, Ma X, Dong M, Sun B and Xin Y: Roles and regulatory mechanisms of miR‑30b in cancer, cardiovascular disease, and metabolic disorders (Review). Exp Ther Med 21: 44, 2021.
APA
Zhang, Q., Liu, S., Zhang, J., Ma, X., Dong, M., Sun, B., & Xin, Y. (2021). Roles and regulatory mechanisms of miR‑30b in cancer, cardiovascular disease, and metabolic disorders (Review). Experimental and Therapeutic Medicine, 21, 44. https://doi.org/10.3892/etm.2020.9475
MLA
Zhang, Q., Liu, S., Zhang, J., Ma, X., Dong, M., Sun, B., Xin, Y."Roles and regulatory mechanisms of miR‑30b in cancer, cardiovascular disease, and metabolic disorders (Review)". Experimental and Therapeutic Medicine 21.1 (2021): 44.
Chicago
Zhang, Q., Liu, S., Zhang, J., Ma, X., Dong, M., Sun, B., Xin, Y."Roles and regulatory mechanisms of miR‑30b in cancer, cardiovascular disease, and metabolic disorders (Review)". Experimental and Therapeutic Medicine 21, no. 1 (2021): 44. https://doi.org/10.3892/etm.2020.9475
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