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Article

Clinical efficacy of duodenoscopy combined with laparoscopy in the treatment of patients with severe acute pancreatitis and pancreatic pseudocyst, and the effects on IL‑6 and CRP

  • Authors:
    • Lianhua Zheng
    • Shasha Huang
    • Fengji Liu
    • Juan Yang
  • View Affiliations / Copyright

    Affiliations: Medical Record Room, Weifang People's Hospital, Weifang, Shandong 261041, P.R. China, Department of Weifang City Disinfection Supply Quality Control Center, Weifang People's Hospital, Weifang, Shandong 261041, P.R. China, Department of General Surgery, Weifang People's Hospital, Weifang, Shandong 261041, P.R. China
  • Article Number: 55
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    Published online on: November 19, 2020
       https://doi.org/10.3892/etm.2020.9487
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Abstract

The study aimed to investigate the clinical efficacy of duodenoscopy combined with laparoscopy in the treatment of patients with severe acute pancreatitis (SAP) and pancreatic pseudocyst (PP), and its effects on serum inflammatory factors. Altogether 94 patients complicated with SAP and PP who were admitted to Weifang People's Hospital (Weifang, China) from September 2015 to December 2018 were included. Based on the different operation methods, 49 patients who underwent traditional laparotomy under laparoscopic surgery were included in group A, and 45 patients who underwent duodenoscopy and laparoscopy under duodenoscope to treat the drainage of nipple and pancreatic pseudocysts were included in group B. The expression levels of related serum indexes and serum stress indexes before and at 48 h after surgery, the postoperative nausea, vomiting and abdominal pain scores, as well as the clinical efficacy, perioperative related indexes, recovery and complications were compared between the two groups. The prognostic factors in both groups were assessed via Logistic univariate and multivariate analyses. C‑reactive protein (CRP), tumor necrosis factor‑α (TNF‑α), interleukin‑6 (IL‑6), interleukin‑β (IL‑β), endotoxin and nuclear factor κB (NF‑κB) were significantly lower in group B than those in group A (P<0.001). Upregulating cortisol and norepinephrine in group B was lower than that in group A (P<0.001). The total effective rate in group B was higher than that in group A (P<0.05). The perioperative related indexes, recovery, and postoperative complications in group B were better than those in group A (P<0.05). Scores of abdominal pain, nausea and vomiting in group B were markedly lower than those in group A (P<0.001). Multivariate Logistic regression analysis showed that CRP, TNF‑α, IL‑6, IL‑β and surgical methods were independent risk factors for the prognosis of patients with SAP and PP. In conclusion, the combined treatment with duodenoscopy and laparoscopic surgery has little inflammatory and stress reaction, and it is highly safe, worthy to be popularized.
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Copy and paste a formatted citation
Spandidos Publications style
Zheng L, Huang S, Liu F and Yang J: Clinical efficacy of duodenoscopy combined with laparoscopy in the treatment of patients with severe acute pancreatitis and pancreatic pseudocyst, and the effects on IL‑6 and CRP. Exp Ther Med 21: 55, 2021.
APA
Zheng, L., Huang, S., Liu, F., & Yang, J. (2021). Clinical efficacy of duodenoscopy combined with laparoscopy in the treatment of patients with severe acute pancreatitis and pancreatic pseudocyst, and the effects on IL‑6 and CRP. Experimental and Therapeutic Medicine, 21, 55. https://doi.org/10.3892/etm.2020.9487
MLA
Zheng, L., Huang, S., Liu, F., Yang, J."Clinical efficacy of duodenoscopy combined with laparoscopy in the treatment of patients with severe acute pancreatitis and pancreatic pseudocyst, and the effects on IL‑6 and CRP". Experimental and Therapeutic Medicine 21.1 (2021): 55.
Chicago
Zheng, L., Huang, S., Liu, F., Yang, J."Clinical efficacy of duodenoscopy combined with laparoscopy in the treatment of patients with severe acute pancreatitis and pancreatic pseudocyst, and the effects on IL‑6 and CRP". Experimental and Therapeutic Medicine 21, no. 1 (2021): 55. https://doi.org/10.3892/etm.2020.9487
Copy and paste a formatted citation
x
Spandidos Publications style
Zheng L, Huang S, Liu F and Yang J: Clinical efficacy of duodenoscopy combined with laparoscopy in the treatment of patients with severe acute pancreatitis and pancreatic pseudocyst, and the effects on IL‑6 and CRP. Exp Ther Med 21: 55, 2021.
APA
Zheng, L., Huang, S., Liu, F., & Yang, J. (2021). Clinical efficacy of duodenoscopy combined with laparoscopy in the treatment of patients with severe acute pancreatitis and pancreatic pseudocyst, and the effects on IL‑6 and CRP. Experimental and Therapeutic Medicine, 21, 55. https://doi.org/10.3892/etm.2020.9487
MLA
Zheng, L., Huang, S., Liu, F., Yang, J."Clinical efficacy of duodenoscopy combined with laparoscopy in the treatment of patients with severe acute pancreatitis and pancreatic pseudocyst, and the effects on IL‑6 and CRP". Experimental and Therapeutic Medicine 21.1 (2021): 55.
Chicago
Zheng, L., Huang, S., Liu, F., Yang, J."Clinical efficacy of duodenoscopy combined with laparoscopy in the treatment of patients with severe acute pancreatitis and pancreatic pseudocyst, and the effects on IL‑6 and CRP". Experimental and Therapeutic Medicine 21, no. 1 (2021): 55. https://doi.org/10.3892/etm.2020.9487
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