Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Experimental and Therapeutic Medicine
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-0981 Online ISSN: 1792-1015
Journal Cover
January-2021 Volume 21 Issue 1

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
January-2021 Volume 21 Issue 1

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article

Application of antibiotics before 3 years of age increases the risk of childhood overweight and obesity

  • Authors:
    • Jiuzhen Tian
    • Honghua Liu
    • Hua Guo
    • Weiping Han
    • Hui Ding
    • Tong Chen
  • View Affiliations / Copyright

    Affiliations: Department of Pediatrics, Dongying People's Hospital, Dongying, Shandong 257000, P.R. China, Operation Room, Dongying People's Hospital, Dongying, Shandong 257000, P.R. China
  • Article Number: 56
    |
    Published online on: November 19, 2020
       https://doi.org/10.3892/etm.2020.9488
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Childhood obesity and antibiotics abuse have become global health problems. It is necessary to explore the correlation between application of antibiotics for children under 3 and the risk of overweight and obesity in children. In the present study, young children aged 3 (36‑38 months) were investigated using a face‑to‑face questionnaire survey. These children were admitted to Dongying City Children's Hospital from December 2017 to May 2019, and the effective sample size was 4,258. According to the body mass index (BMI), young children were divided into two groups, including emaciation and normal group as well as overweight and obesity group. Univariate analysis was performed to identify the possible influencing factors between the two groups using chi‑square test. A difference of P<0.05 indicated statistical significance of a certain factor between the two groups, which could be adopted as an influencing factor in Logistic regression analysis. In addition, odds ratios (ORs) and the corresponding 95% confidence intervals (CIs) were employed to quantify the correlation of antibiotic application with the risk of overweight and obesity. A total of 3,322 young children (78.0%) were included in the antibiotic group while the remaining 936 (22.0%) were enrolled in the non‑antibiotic group. Logistic regression analysis revealed that antibiotic application increased the risk of overweight and obesity among the 3‑year‑old young children (OR, 1.44; 95% CI, 1.03‑2.01). In addition, application of antibiotics for five times or higher significantly increased the risk of overweight and obesity (OR, 1.73; 95% CI, 1.07‑2.80), and such risks were more significant in children who were administered antibiotics for the first time within 6 months of age (OR, 1.71; 95% CI, 1.08‑2.69). The application of antibiotics in infants and young children was thus revealed to increase the risk of overweight and obesity at the age of 3 in a frequency‑dependent manner.
View Figures
View References

1 

Zhang T, Smith MA, Camp PG, Shajari S, MacLeod SM and Carleton BC: Prescription drug dispensing profiles for one million children: A population-based analysis. Eur J Clin Pharmacol. 69:581–588. 2013.PubMed/NCBI View Article : Google Scholar

2 

Seekatz AM and Young VB: Clostridium difficile and the microbiota. J Clin Invest. 124:4182–4189. 2014.PubMed/NCBI View Article : Google Scholar

3 

Tilg H and Adolph TE: Influence of the human intestinal microbiome on obesity and metabolic dysfunction. Curr Opin Pediatr. 27:496–501. 2015.PubMed/NCBI View Article : Google Scholar

4 

Bailey LC, Forrest CB, Zhang P, Richards TM, Livshits A and DeRusso PA: Association of antibiotics in infancy with early childhood obesity. JAMA Pediatr. 168:1063–1069. 2014.PubMed/NCBI View Article : Google Scholar

5 

Saari A, Virta LJ, Sankilampi U, Dunkel L and Saxen H: Antibiotic exposure in infancy and risk of being overweight in the first 24 months of life. Pediatrics. 135:617–626. 2015.PubMed/NCBI View Article : Google Scholar

6 

GBD 2015 Obesity Collaborators. Afshin A, Forouzanfar MH, Reitsma MB, Sur P, Estep K, Lee A, Marczak L, Mokdad AH, Moradi-Lakeh M, et al: Health effects of overweight and obesity in 195 countries over 25 years. N Engl J Med. 377:13–27. 2017.PubMed/NCBI View Article : Google Scholar

7 

Kyrgiou M, Kalliala I, Markozannes G, Gunter MJ, Paraskevaidis E, Gabra H, Martin-Hirsch P and Tsilidis KK: Adiposity and cancer at major anatomical sites: Umbrella review of the literature. BMJ. 356(j477)2017.PubMed/NCBI View Article : Google Scholar

8 

Ajslev TA, Andersen CS, Gamborg M, Sørensen TI and Jess T: Childhood overweight after establishment of the gut microbiota: The role of delivery mode, pre-pregnancy weight and early administration of antibiotics. Int J Obes (Lond). 35:522–529. 2011.PubMed/NCBI View Article : Google Scholar

9 

Trasande L, Blustein J, Liu M, Corwin E, Cox LM and Blaser MJ: Infant antibiotic exposures and early-life body mass. Int J Obes (Lond). 37:16–23. 2013.PubMed/NCBI View Article : Google Scholar

10 

Edmonson MB and Eickhoff JC: Weight gain and obesity in infants and young children exposed to prolonged antibiotic prophylaxis. JAMA Pediatr. 171:150–156. 2017.PubMed/NCBI View Article : Google Scholar

11 

Wang W: Pediatrics. 9th edition. People's Medical Publishing House, 2018.

12 

Li H, Ji CY, Zong XN and Zhang YQ: Body mass index growth curves for Chinese children and adolescents aged 0 to 18 years. Zhonghua Er Ke Za Zhi. 47:493–498. 2009.PubMed/NCBI(In Chinese).

13 

Shi CM, Li XL, Dong J, Zhang CM, Tong ML, Guo XR and Zhang M: A survey of 1~7 year old children's eating behavior and its association with children's physical development. Zhonghua Shi Yong Er Ke Lin Chuang Za Zhi. 31:840–845. 2016.(In Chinese).

14 

Obesity: Preventing and managing the global epidemic. Report of a WHO consultation. World Health Organ Tech Rep Ser. 894:i–xii, 1-253. 2000.PubMed/NCBI

15 

Ogden CL, Carroll MD, Kit BK and Flegal KM: Prevalence of obesity and trends in body mass index among US children and adolescents, 1999-2010. JAMA. 307:483–490. 2012.PubMed/NCBI View Article : Google Scholar

16 

Mbakwa CA, Scheres L, Penders J, Mommers M, Thijs C and Arts IC: Early life antibiotic exposure and weight development in children. J Pediatr. 176:105–113.e2. 2016.PubMed/NCBI View Article : Google Scholar

17 

Azad MB, Bridgman SL, Becker AB and Kozyrskyj AL: Infant antibiotic exposure and the development of childhood overweight and central adiposity. Int J Obes (Lond). 38:1290–1298. 2014.PubMed/NCBI View Article : Google Scholar

18 

Grijalva CG, Nuorti JP and Griffin MR: Antibiotic prescription rates for acute respiratory tract infections in US ambulatory settings. JAMA. 302:758–766. 2009.PubMed/NCBI View Article : Google Scholar

19 

Paul IM, Maselli JH, Hersh AL, Boushey HA, Nielson DW and Cabana MD: Antibiotic prescribing during pediatric ambulatory care visits for asthma. Pediatrics. 127:1014–1021. 2011.PubMed/NCBI View Article : Google Scholar

20 

Dubos R, Savage D and Schaedler R: Biological Freudianism. Lasting effects of early environmental influences. Pediatrics. 38:789–800. 1966.PubMed/NCBI

21 

Koren O, Goodrich JK, Cullender TC, Spor A, Laitinen K, Bäckhed HK, Gonzalez A, Werner JJ, Angenent LT, Knight R, et al: Host remodeling of the gut microbiome and metabolic changes during pregnancy. Cell. 150:470–480. 2012.PubMed/NCBI View Article : Google Scholar

22 

Gaskins HR, Collier CT and Anderson DB: Antibiotics as growth promotants: Mode of action. Anim Biotechnol. 13:29–42. 2002.PubMed/NCBI View Article : Google Scholar

23 

Cho I, Yamanishi S, Cox L, Methé BA, Zavadil J, Li K, Gao Z, Mahana D, Raju K, Teitler I, et al: Antibiotics in early life alter the murine colonic microbiome and adiposity. Nature. 488:621–626. 2012.PubMed/NCBI View Article : Google Scholar

24 

Cox LM, Yamanishi S, Sohn J, Alekseyenko AV, Leung JM, Cho I, Kim SG, Li H, Gao Z, Mahana D, et al: Altering the intestinal microbiota during a critical developmental window has lasting metabolic consequences. Cell. 158:705–721. 2014.PubMed/NCBI View Article : Google Scholar

25 

Angelakis E, Merhej V and Raoult D: Related actions of probiotics and antibiotics on gut microbiota and weight modification. Lancet Infect Dis. 13:889–899. 2013.PubMed/NCBI View Article : Google Scholar

26 

Esposito S, Castellazzi L and Garbarino F: Can probiotic administration during pregnancy and the first year of life effectively reduce the risk of infections and allergic diseases in childhood? J Biol Regul Homeost Agents. 28:565–573. 2014.PubMed/NCBI

27 

Barczynska R, Bandurska K, Slizewska K, Litwin M, Szalecki M, Libudzisz Z and Kapusniak J: Intestinal Microbiota, obesity and prebiotics. Pol J Microbiol. 64:93–100. 2015.PubMed/NCBI

28 

Million M, Angelakis E, Paul M, Armougom F, Leibovici L and Raoult D: Comparative meta-analysis of the effect of Lactobacillus species on weight gain in humans and animals. Microb Pathog. 53:100–108. 2012.PubMed/NCBI View Article : Google Scholar

29 

Yin YN, Yu QF, Fu N, Liu XW and Lu FG: Effects of four Bifidobacteria on obesity in high-fat diet induced rats. World J Gastroenterol. 16:3394–3401. 2010.PubMed/NCBI View Article : Google Scholar

30 

Park DY, Ahn YT, Park SH, Huh CS, Yoo SR, Yu R, Sung MK, McGregor RA and Choi MS: Supplementation of Lactobacillus curvatus HY7601 and Lactobacillus plantarum KY1032 in diet-induced obese mice is associated with gut microbial changes and reduction in obesity. PLoS One. 8(e59470)2013.PubMed/NCBI View Article : Google Scholar

31 

Mekkes MC, Weenen TC, Brummer RJ and Claassen E: The development of probiotic treatment in obesity: A review. Benef Microbes. 5:19–28. 2014.PubMed/NCBI View Article : Google Scholar

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Tian J, Liu H, Guo H, Han W, Ding H and Chen T: Application of antibiotics before 3 years of age increases the risk of childhood overweight and obesity. Exp Ther Med 21: 56, 2021.
APA
Tian, J., Liu, H., Guo, H., Han, W., Ding, H., & Chen, T. (2021). Application of antibiotics before 3 years of age increases the risk of childhood overweight and obesity. Experimental and Therapeutic Medicine, 21, 56. https://doi.org/10.3892/etm.2020.9488
MLA
Tian, J., Liu, H., Guo, H., Han, W., Ding, H., Chen, T."Application of antibiotics before 3 years of age increases the risk of childhood overweight and obesity". Experimental and Therapeutic Medicine 21.1 (2021): 56.
Chicago
Tian, J., Liu, H., Guo, H., Han, W., Ding, H., Chen, T."Application of antibiotics before 3 years of age increases the risk of childhood overweight and obesity". Experimental and Therapeutic Medicine 21, no. 1 (2021): 56. https://doi.org/10.3892/etm.2020.9488
Copy and paste a formatted citation
x
Spandidos Publications style
Tian J, Liu H, Guo H, Han W, Ding H and Chen T: Application of antibiotics before 3 years of age increases the risk of childhood overweight and obesity. Exp Ther Med 21: 56, 2021.
APA
Tian, J., Liu, H., Guo, H., Han, W., Ding, H., & Chen, T. (2021). Application of antibiotics before 3 years of age increases the risk of childhood overweight and obesity. Experimental and Therapeutic Medicine, 21, 56. https://doi.org/10.3892/etm.2020.9488
MLA
Tian, J., Liu, H., Guo, H., Han, W., Ding, H., Chen, T."Application of antibiotics before 3 years of age increases the risk of childhood overweight and obesity". Experimental and Therapeutic Medicine 21.1 (2021): 56.
Chicago
Tian, J., Liu, H., Guo, H., Han, W., Ding, H., Chen, T."Application of antibiotics before 3 years of age increases the risk of childhood overweight and obesity". Experimental and Therapeutic Medicine 21, no. 1 (2021): 56. https://doi.org/10.3892/etm.2020.9488
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team