Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Experimental and Therapeutic Medicine
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-0981 Online ISSN: 1792-1015
Journal Cover
January-2021 Volume 21 Issue 1

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
January-2021 Volume 21 Issue 1

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article

Assessment of three successive treatments of ranibizumab on neovascular macular degeneration by OCT angiography

  • Authors:
    • Juming Zhu
    • Qing Peng
    • Tu Su
    • Minli Wang
    • Fang Wang
  • View Affiliations / Copyright

    Affiliations: Department of Ophthalmology, Nanjing Medical University, Nanjing, Jiangsu 210029, P.R. China, Department of Ophthalmology, Tenth People's Hospital, Shanghai 200072, P.R. China
  • Article Number: 59
    |
    Published online on: November 19, 2020
       https://doi.org/10.3892/etm.2020.9491
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

In the present study, the efficacy of three consecutive anti‑VEGF treatments in patients with neovascular macular degeneration (nAMD) was assessed by optical coherence tomography angiography (OCT‑A). A total of 23 eyes with nAMD were treated with intravitreal injections (IVIs) of ranibizumab once a month for three consecutive months. There were eight follow‑up time‑points: Prior to the initial IVI and on days 1, 3, 7, 14, 30, 60 and 90 after the first IVI. The follow‑up examinations consisted of measurements of the best‑corrected visual acuity (BCVA), the height of retinal pigmented epithelium detachment (RPED), the greatest linear dimension (GLD), choroidal neovascularization (CNV) flow area, whole retinal thickness and four‑quadrant retinal thickness. The results indicated that, when compared with the baseline, the BCVA gradually improved after IVI and improved significantly on days 60 and 90 (P<0.05); the RPED and GLD improved after IVI, with a significant improvement on days 30, 60 and 90 (all, P<0.05); the CNV flow area was gradually shortened in the early stage after IVI but rebounded on day 30, while the difference was statistically significant on day 14 (P<0.05). The temporal retinal thickness was statistically significant on day 30 (P<0.05) and there were statistically significant differences in nasal and inferior retinal thickness on days 14 and 30 compared with prior to IVI (all, P<0.05). The BCVA was positively correlated with the RPED, GLD, CNV flow area and nasal retinal thickness (all, P<0.05). In conclusion, OCT‑A may provide an effective reference to guide the evaluation, treatment and monitoring of nAMD. The present study was registered in the Chinese Clinical Trial Registry (CChiTR; no. ChiCTR1900023607; http://www.chictr.org.cn/listbycreater.aspx).
View Figures

Figure 1

Figure 2

View References

1 

Ambati J, Ambati BK, Yoo SH, Ianchulev S and Adamis AP: Age-related macular degeneration: Etiology, pathogenesis, and therapeutic strategies. Surv Ophthalmol. 48:257–293. 2003.PubMed/NCBI View Article : Google Scholar

2 

Anderson DH, Mullins RF, Hageman GS and Johnson LV: A role for local inflammation in the formation of drusen in the aging eye. Am J Ophthalmol. 134:411–431. 2002.PubMed/NCBI View Article : Google Scholar

3 

Jager RD, Mieler WF and Miller JW: Age-related macular degeneration. N Engl J Med. 358:2606–2617. 2008.PubMed/NCBI View Article : Google Scholar

4 

Ardeljan C, Ardeljan D, Abu-Asab M and Chan CC: Inflammation and cell death in age-related macular degeneration: An immunopathological and ultrastructural model. J Clin Med. 3:1542–1560. 2014.PubMed/NCBI View Article : Google Scholar

5 

Cho Y, Cao X, Shen D, Tuo J, Parver LM, Rickles FR and Chan CC: Evidence for enhanced tissue factor expression in age-related macular degeneration. Lab Investig. 91:519–526. 2011.PubMed/NCBI View Article : Google Scholar

6 

MacHalińska A, Kłos P, Safranow K, Dziedziejko V, Rudnicki M, Paczkowska E, Karczewicz D and Machaliński B: Neural stem/progenitor cells circulating in peripheral blood of patients with neovascular form of AMD: A novel view on pathophysiology. Graefes Arch Clin Exp Ophthalmol. 249:1785–1794. 2011.PubMed/NCBI View Article : Google Scholar

7 

Faridi A, Jia Y, Gao SS, Huang D and Bhavsar KV: Sensitivity and Speci fi city of OCT angiography to detect choroidal neovascularization. Ophthalmol Retin. 1:294–303. 2017.PubMed/NCBI View Article : Google Scholar

8 

Schneider EW and Fowler SC: Optical coherence tomography angiography in the management of age-related macular degeneration. Curr Opin Ophthalmol. 29:217–225. 2018.PubMed/NCBI View Article : Google Scholar

9 

Lupidi M, Cerquaglia A, Chhablani J, Fiore T, Singh SR, Cardillo Piccolino F, Corbucci R, Coscas F, Coscas G and Cagini C: Optical coherence tomography angiography in age-related macular degeneration: The game changer. Eur J Ophthalmol. 28:349–357. 2018.PubMed/NCBI View Article : Google Scholar

10 

Kaszubski PA, Ben Ami T, Saade C, Nabati C, Kumar V, Santos AR, Silva R, Cachulo ML, Cunha-Vaz JG and Smith RT: Changes in reticular pseudodrusen area in eyes that progressed from early to late age-related macular degeneration. Int Ophthalmol. 38:503–511. 2018.PubMed/NCBI View Article : Google Scholar

11 

Aggarwal K, Agarwal A, Sharma A, Sharma K and Gupta V: OCTA Study Group. Detection of type 1 choroidal neovascular membranes using optical coherence tomography angiography in tubercular posterior uveitis. Retina. 39:1595–1606. 2018.

12 

Nesper PL, Soetikno BT, Treister AD and Fawzi AA: Volume-rendered projection-resolved OCT angiography: 3D lesion complexity is associated with therapy response in wet age-related macular degeneration. Investig Ophthalmol Vis Sci. 59:1944–1952. 2018.PubMed/NCBI View Article : Google Scholar

13 

Pilotto E, Frizziero L, Daniele AR, Convento E, Longhin E, Guidolin F, Parrozzani R, Cavarzeran F and Midena E: Early OCT angiography changes of type 1 CNV in exudative AMD treated with anti-VEGF. Br J Ophthalmol. 103:67–71. 2019.PubMed/NCBI View Article : Google Scholar

14 

Fauser S, Schwabecker V and Muether PS: Suppression of intraocular vascular endothelial growth factor during aflibercept treatment of age-related macular degeneration. Am J Ophthalmol. 158:532–536. 2014.PubMed/NCBI View Article : Google Scholar

15 

Heier JS, Brown DM, Chong V, Korobelnik JF, Kaiser PK, Nguyen QD, Kirchhof B, Ho A, Ogura Y, Yancopoulos GD, et al: Intravitreal aflibercept (VEGF trap-eye) in wet age-related macular degeneration. Ophthalmology. 119:2537–2548. 2012.PubMed/NCBI View Article : Google Scholar

16 

Liu F, Ding X, Yang Y, Li J, Tang M, Yuan M, Hu A, Zhan Z, Li Z and Lu L: Aqueous humor cytokine profiling in patients with wet AMD. Mol Vis. 22:352–361. 2016.PubMed/NCBI

17 

Nowak JZ: Age-related macular degeneration (AMD): Pathogenesis and therapy. Pharmacol Rep. 58:353–363. 2006.PubMed/NCBI

18 

Hollyfield JG, Bonilha VL, Rayborn ME, Yang X, Shadrach KG, Lu L, Ufret RL, Salomon RG and Perez VL: Oxidative damage-induced inflammation initiates age-related macular degeneration. Nat Med. 14:194–198. 2008.PubMed/NCBI View Article : Google Scholar

19 

Chen M and Xu H: Parainflammation, chronic inflammation, and age-related macular degeneration. J Leukoc Biol. 98:713–725. 2015.PubMed/NCBI View Article : Google Scholar

20 

Xu H, Chen M and Forrester JV: Para-inflammation in the aging retina. Prog Retin Eye Res. 28:348–368. 2009.PubMed/NCBI View Article : Google Scholar

21 

CATT Research Group. Martin DF, Maguire MG, Ying GS, Grunwald JE, Fine SL and Jaffe GJ: Ranibizumab and bevacizumab for neovascular age-related macular degeneration. N Engl J Med. 364:1897–1908. 2011.PubMed/NCBI View Article : Google Scholar

22 

Comparison of Age-related Macular Degeneration Treatments Trials (CATT) Research Group; Writing Committee. Martin DF, Maguire MG, Fine SL, Ying GS, Jaffe GJ, Grunwald JE, Toth C, Redford M and Ferris FL III. Ranibizumab and bevacizumab for treatment of neovascular age-related macular degeneration. Ophthalmology. 127 (Suppl):S135–S145. 2020.PubMed/NCBI View Article : Google Scholar

23 

Shah ND and Barkmeier AJ: Risk of systemic adverse events following intravitreal bevacizumab, ranibizumab, and aflibercept in routine clinical practice. Ophthalmology: Aug 8, 2020 2020 (Epub ahead of print).

24 

Sun X, Xu X and Zhang X: Counterfeit bevacizumab and endophthalmitis. N Engl J Med. 365:378–379. 2011.PubMed/NCBI View Article : Google Scholar

25 

Wang F, Yu S, Liu K, Chen FE, Song Z, Zhang X, Xu X and Sun X: Acute intraocular inflammation caused by endotoxin after intravitreal injection of counterfeit bevacizumab in Shanghai China. Ophthalmology. 120:355–361. 2013.PubMed/NCBI View Article : Google Scholar

26 

Huang HB, Pan Y and Liu T: Shanghai eye treatment outbreak: Bevacizumab therapy for AMD in China. Clin Exp Optom. 96:106–108. 2013.PubMed/NCBI View Article : Google Scholar

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Zhu J, Peng Q, Su T, Wang M and Wang F: Assessment of three successive treatments of ranibizumab on neovascular macular degeneration by OCT angiography. Exp Ther Med 21: 59, 2021.
APA
Zhu, J., Peng, Q., Su, T., Wang, M., & Wang, F. (2021). Assessment of three successive treatments of ranibizumab on neovascular macular degeneration by OCT angiography. Experimental and Therapeutic Medicine, 21, 59. https://doi.org/10.3892/etm.2020.9491
MLA
Zhu, J., Peng, Q., Su, T., Wang, M., Wang, F."Assessment of three successive treatments of ranibizumab on neovascular macular degeneration by OCT angiography". Experimental and Therapeutic Medicine 21.1 (2021): 59.
Chicago
Zhu, J., Peng, Q., Su, T., Wang, M., Wang, F."Assessment of three successive treatments of ranibizumab on neovascular macular degeneration by OCT angiography". Experimental and Therapeutic Medicine 21, no. 1 (2021): 59. https://doi.org/10.3892/etm.2020.9491
Copy and paste a formatted citation
x
Spandidos Publications style
Zhu J, Peng Q, Su T, Wang M and Wang F: Assessment of three successive treatments of ranibizumab on neovascular macular degeneration by OCT angiography. Exp Ther Med 21: 59, 2021.
APA
Zhu, J., Peng, Q., Su, T., Wang, M., & Wang, F. (2021). Assessment of three successive treatments of ranibizumab on neovascular macular degeneration by OCT angiography. Experimental and Therapeutic Medicine, 21, 59. https://doi.org/10.3892/etm.2020.9491
MLA
Zhu, J., Peng, Q., Su, T., Wang, M., Wang, F."Assessment of three successive treatments of ranibizumab on neovascular macular degeneration by OCT angiography". Experimental and Therapeutic Medicine 21.1 (2021): 59.
Chicago
Zhu, J., Peng, Q., Su, T., Wang, M., Wang, F."Assessment of three successive treatments of ranibizumab on neovascular macular degeneration by OCT angiography". Experimental and Therapeutic Medicine 21, no. 1 (2021): 59. https://doi.org/10.3892/etm.2020.9491
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team