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Diagnostic values of NLR and miR‑141 in patients with osteoarthritis and their association with severity of knee osteoarthritis

  • Authors:
    • Chengchen Cai
    • Ruojing Zhang
    • Xiaoli Xu
    • Guowen Li
    • Haixin Gou
  • View Affiliations / Copyright

    Affiliations: Department of Traditional Chinese Medicine, Huadong Hospital, Fudan University, Shanghai 200040, P.R. China, Department of Scientific Research, Shanghai TCM‑Integrated Hospital, Shanghai University of TCM, Shanghai 200082, P.R. China
    Copyright: © Cai et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 74
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    Published online on: November 25, 2020
       https://doi.org/10.3892/etm.2020.9506
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Abstract

The present study aimed to explore the diagnostic values of neutrophil‑lymphocyte ratio (NLR) and microRNA (miR)‑141 in patients with osteoarthritis and their association with the severity of knee osteoarthritis. In total 142 patients with osteoarthritis (the study group) admitted to Shanghai TCM‑Integrated Hospital, Shanghai University of TCM from January 2017 to January 2019 and 150 healthy controls (the control group) were enrolled in the present study. NLR and miR‑141 in peripheral blood and their diagnostic values for osteoarthritis were compared between the two groups. The two indicators in the study group were significantly increased (P<0.001), and their combined detection had a better diagnostic value for the disease (P<0.001). Moreover, they were closely associated to the progression of the disease and were independent risk factors (P<0.001). To sum up, NLR and miR‑141 were significantly increased in the peripheral blood of patients with osteoarthritis. Their combined detection exhibited a good diagnostic value for the disease and may become a potential therapeutic target osteoarthritis in the future.
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1 

Malfait AM: Osteoarthritis year in review 2015: Biology. Osteoarthritis Cartilage. 24:21–26. 2016.PubMed/NCBI View Article : Google Scholar

2 

Loeser RF, Collins JA and Diekman BO: Ageing and the pathogenesis of osteoarthritis. Nat Rev Rheumatol. 12:412–420. 2016.PubMed/NCBI View Article : Google Scholar

3 

Nelson AE: Osteoarthritis year in review 2017: Clinical. Osteoarthritis Cartilage. 26:319–325. 2018.PubMed/NCBI View Article : Google Scholar

4 

Palazzo C, Nguyen C, Lefevre-Colau MM, Rannou F and Poiraudeau S: Risk factors and burden of osteoarthritis. Ann Phys Rehabil Med. 59:134–138. 2016.PubMed/NCBI View Article : Google Scholar

5 

Yu D, Jordan KP, Bedson J, Englund M, Blyth F, Turkiewicz A, Prieto-Alhambra D and Peat G: Population trends in the incidence and initial management of osteoarthritis: Age-period-cohort analysis of the clinical practice research Datalink, 1992-2013. Rheumatology (Oxford). 56:1902–1917. 2017.PubMed/NCBI View Article : Google Scholar

6 

Mathiessen A and Conaghan PG: Synovitis in osteoarthritis: Current understanding with therapeutic implications. Arthritis Res Ther. 19(18)2017.PubMed/NCBI View Article : Google Scholar

7 

Sharma L: Osteoarthritis year in review 2015: Clinical. Osteoarthritis Cartilage. 24:36–48. 2016.PubMed/NCBI View Article : Google Scholar

8 

Collins NJ, Prinsen CA, Christensen R, Bartels EM, Terwee CB and Roos EM: Knee injury and osteoarthritis outcome score (KOOS): Systematic review and meta-analysis of measurement properties. Osteoarthritis Cartilage. 24:1317–1329. 2016.PubMed/NCBI View Article : Google Scholar

9 

Wallace IJ, Worthington S, Felson DT, urmain RD, Wren KT, Maijanen H, Woods RJ and Lieberman DE: Knee osteoarthritis has doubled in prevalence since the mid-20th century. Proc Natl Acad Sci USA. 114:9332–9336. 2017.PubMed/NCBI View Article : Google Scholar

10 

Wang Y, Teichtahl AJ and Cicuttini FM: Osteoarthritis year in review 2015: Imaging. Osteoarthritis Cartilage. 24:49–57. 2016.PubMed/NCBI View Article : Google Scholar

11 

Rupaimoole R and Slack FJ: MicroRNA therapeutics: Towards a new era for the management of cancer and other diseases. Nat Rev Drug Discov. 16:203–222. 2017.PubMed/NCBI View Article : Google Scholar

12 

Feinberg MW and Moore KJ: MicroRNA regulation of atherosclerosis. Circ Res. 118:703–720. 2016.PubMed/NCBI View Article : Google Scholar

13 

Yang S, Zhang W, Cai M, Zhang Y, Jin F, Yan S, Baloch Z, Fang Z, Xue S, Tang R, et al: Suppression of bone resorption by miR-141 in aged rhesus monkeys. J Bone Miner Res. 33:1799–1812. 2018.PubMed/NCBI View Article : Google Scholar

14 

Hu H, Zhang G, Tian G, Lv G and Jin Y: miRNA profiling reveals the upregulation of Osteogenesis-associated miRNAs in ovariectomy osteoporosis mice. Clin Exp Obstet Gynecol. 45:817–822. 2018.

15 

Balta S, Celik T, Mikhailidis DP, Ozturk C, Demirkol S, Aparci M and Iyisoy A: The relation between atherosclerosis and the neutrophil-lymphocyte ratio. Clin Appl Thromb Hemost. 22:405–411. 2016.PubMed/NCBI View Article : Google Scholar

16 

Fu X, Li T, Dai Y and Li J: Preoperative systemic inflammation score (SIS) is superior to neutrophil to lymphocyte ratio (NLR) as a predicting indicator in patients with esophageal squamous cell carcinoma. BMC Cancer. 19(721)2019.PubMed/NCBI View Article : Google Scholar

17 

Glyn-Jones S, Palmer AJ, Agricola R, Price AJ, Vincent TL, Weinans H and Carr AJ: Osteoarthritis. Lancet. 386:376–387. 2015.PubMed/NCBI View Article : Google Scholar

18 

Tichopad A, Kitchen R, Riedmaier I, Becker C, Ståhlberg A and Kubista M: Design and optimization of reverse-transcription quantitative PCR experiments. Clin Chem. 55:1816–1823. 2009.PubMed/NCBI View Article : Google Scholar

19 

Lysholm J and Gillquist J: Evaluation of knee ligament surgery results with special emphasis on use of a scoring scale. Am J Sports Med. 10:150–154. 1982.PubMed/NCBI View Article : Google Scholar

20 

McConnell S, Kolopack P and Davis AM: The western ontario and mcmaster universities osteoarthritis index (WOMAC): A review of its utility and measurement Properties. Arthritis Rheum. 45:453–461. 2001.PubMed/NCBI View Article : Google Scholar

21 

Wewers ME and Lowe NK: A critical review of visual analogue scales in the measurement of clinical phenomena. Res Nurs Health. 13:227–236. 1990.PubMed/NCBI View Article : Google Scholar

22 

Johnson VL and Hunter DJ: The epidemiology of osteoarthritis. Best Pract Res Clin Rheumatol. 28:5–15. 2014.PubMed/NCBI View Article : Google Scholar

23 

Thakur M, Dickenson AH and Baron R: Osteoarthritis pain: Nociceptive or neuropathic? Nat Rev Rheumatol. 10(374)2014.PubMed/NCBI View Article : Google Scholar

24 

Li W, Du C, Wang H and Zhang C: Increased serum ADAMTS-4 in knee osteoarthritis: A potential indicator for the diagnosis of osteoarthritis in early stages. Genet Mol Res. 13:9642–9649. 2014.PubMed/NCBI View Article : Google Scholar

25 

Park YM, Kim SJ, Lee KJ, Yang SS, Min BH and Yoon HC: Detection of CTX-II in serum and urine to diagnose osteoarthritis by using a Fluoro-microbeads guiding chip. Biosens Bioelectron. 67:192–199. 2015.PubMed/NCBI View Article : Google Scholar

26 

Li D, Liu J, Guo B, Liang C, Dang L, Lu C, He X, Cheung HY, Xu L, Lu C, et al: Osteoclast-derived exosomal miR-214-3p inhibits osteoblastic bone formation. Nat Commun. 7(10872)2016.PubMed/NCBI View Article : Google Scholar

27 

Wu Y, Zhang Y, Zhang Y and Wang JJ: CircRNA hsa_circ_0005105 upregulates NAMPT expression and promotes chondrocyte extracellular matrix degradation by sponging miR-26a. Cell Biol Int. 41:1283–1289. 2017.PubMed/NCBI View Article : Google Scholar

28 

Zhou X, Ye F, Yin C, Zhuang Y, Yue G and Zhang G: The interaction between MiR-141 and lncRNA-H19 in regulating cell proliferation and migration in gastric cancer. Cell Physiol Biochem. 36:1440–1452. 2015.PubMed/NCBI View Article : Google Scholar

29 

Tejero R, Navarro A, Campayo M, Viñolas N, Marrades RM, Cordeiro A, Ruíz-Martínez M, Santasusagna S, Molins L, Ramirez J, et al: miR-141 and miR-200c as markers of overall survival in early stage non-small cell lung cancer adenocarcinoma. PLoS One. 9(e101899)2014.PubMed/NCBI View Article : Google Scholar

30 

Dong Y, Si JW, Li WT, Liang L, Zhao J, Zhou M, Li D and Li T: miR-200a/miR-141 and miR-205 upregulation might be associated with hormone receptor status and prognosis in endometrial carcinomas. Int J Clin Exp Pathol. 8:2864–2875. 2015.PubMed/NCBI

31 

Gundogdu G and Gundogdu K: A novel biomarker in patients with knee osteoarthritis: Adropin. Clin Rheumatol. 37:2179–2186. 2018.PubMed/NCBI View Article : Google Scholar

32 

Sangani R, Periyasamy-Thandavan S, Kolhe R, Bhattacharyya MH, Chutkan N, Hunter M, Isales C, Hamrick M, Hill WD and Fulzele S: MicroRNAs-141 and 200a regulate the SVCT2 transporter in bone marrow stromal cells. Mol Cell Endocrinol. 410:19–26. 2015.PubMed/NCBI View Article : Google Scholar

33 

Karlsson C, Dehne T, Lindahl A, Brittberg M, Pruss A, Sittinger M and Ringe J: Genome-wide expression profiling reveals new candidate genes associated with osteoarthritis. Osteoarthritis Cartilage. 18:581–592. 2010.PubMed/NCBI View Article : Google Scholar

34 

Sunbul M, Gerin F, Durmus E, Kivrak T, Sari I, Tigen K and Cincin A: Neutrophil to lymphocyte and platelet to lymphocyte ratio in patients with dipper versus non-dipper hypertension. Clin Exp Hypertens. 36:217–221. 2014.PubMed/NCBI View Article : Google Scholar

35 

Han R, Wu D, Deng S, Liu T, Zhang T and Xu Y: NLRP3 inflammasome induces pyroptosis in lung tissues of radiation-induced lung injury in mice. Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi. 33:1206–1211. 2017.PubMed/NCBI(In Chinese).

36 

Goldring MB and Otero M: Inflammation in osteoarthritis. Curr Opin Rheumatol. 23:471–478. 2011.PubMed/NCBI View Article : Google Scholar

37 

Adamski JK, Kelsey A and Brennan B: Inflammatory myofibroblastic tumors following the treatment of malignancy in Childhood: Case reports. J Pediatr Hematol Oncol. 36:159–162. 2014.PubMed/NCBI View Article : Google Scholar

38 

Diaz-Martinez J, Campa A, Delgado-Enciso I, Hain D, George F, Huffman F and Baum M: The relationship of blood neutrophil-to-lymphocyte ratio with nutrition markers and health outcomes in hemodialysis patients. Int Urol Nephrol. 51:1239–1247. 2019.PubMed/NCBI View Article : Google Scholar

39 

Koolwal D: Anticoagulant EDTA induced storage effect (Artifacts) on peripheral blood cells. Clin Lab Haematol. 27:336–342. 2018.

40 

Niazi S, Krogh Nielsen M, Sørensen TL and Subhi Y: Neutrophil-to-lymphocyte ratio in age-related macular degeneration: A systematic review and meta-analysis. Acta Ophthalmol. 97:558–566. 2019.PubMed/NCBI View Article : Google Scholar

41 

Soysal P, Stubbs B, Lucato P, Luchini C, Solmi M, Peluso R, Sergi G, Isik AT, Manzato E, Maggi S, et al: Inflammation and frailty in the elderly: A systematic review and meta-analysis. Ageing Res Rev. 31:1–8. 2016.PubMed/NCBI View Article : Google Scholar

42 

Lunebourg A, Parratte S, Gay A, Ollivier M, Garcia-Parra K and Argenson JN: Lower function, quality of life, and survival rate after total knee arthroplasty for posttraumatic arthritis than for primary arthritis. Acta Orthop. 86:189–194. 2015.PubMed/NCBI View Article : Google Scholar

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Copy and paste a formatted citation
Spandidos Publications style
Cai C, Zhang R, Xu X, Li G and Gou H: Diagnostic values of NLR and miR‑141 in patients with osteoarthritis and their association with severity of knee osteoarthritis. Exp Ther Med 21: 74, 2021.
APA
Cai, C., Zhang, R., Xu, X., Li, G., & Gou, H. (2021). Diagnostic values of NLR and miR‑141 in patients with osteoarthritis and their association with severity of knee osteoarthritis. Experimental and Therapeutic Medicine, 21, 74. https://doi.org/10.3892/etm.2020.9506
MLA
Cai, C., Zhang, R., Xu, X., Li, G., Gou, H."Diagnostic values of NLR and miR‑141 in patients with osteoarthritis and their association with severity of knee osteoarthritis". Experimental and Therapeutic Medicine 21.1 (2021): 74.
Chicago
Cai, C., Zhang, R., Xu, X., Li, G., Gou, H."Diagnostic values of NLR and miR‑141 in patients with osteoarthritis and their association with severity of knee osteoarthritis". Experimental and Therapeutic Medicine 21, no. 1 (2021): 74. https://doi.org/10.3892/etm.2020.9506
Copy and paste a formatted citation
x
Spandidos Publications style
Cai C, Zhang R, Xu X, Li G and Gou H: Diagnostic values of NLR and miR‑141 in patients with osteoarthritis and their association with severity of knee osteoarthritis. Exp Ther Med 21: 74, 2021.
APA
Cai, C., Zhang, R., Xu, X., Li, G., & Gou, H. (2021). Diagnostic values of NLR and miR‑141 in patients with osteoarthritis and their association with severity of knee osteoarthritis. Experimental and Therapeutic Medicine, 21, 74. https://doi.org/10.3892/etm.2020.9506
MLA
Cai, C., Zhang, R., Xu, X., Li, G., Gou, H."Diagnostic values of NLR and miR‑141 in patients with osteoarthritis and their association with severity of knee osteoarthritis". Experimental and Therapeutic Medicine 21.1 (2021): 74.
Chicago
Cai, C., Zhang, R., Xu, X., Li, G., Gou, H."Diagnostic values of NLR and miR‑141 in patients with osteoarthritis and their association with severity of knee osteoarthritis". Experimental and Therapeutic Medicine 21, no. 1 (2021): 74. https://doi.org/10.3892/etm.2020.9506
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