Signalling pathways implicated in the pathogenesis of rheumatic heart disease (Review)

Xian,Shenglin; Zeng,Zhiyu

doi:10.3892/etm.2020.9508

Signalling pathways implicated in the pathogenesis of rheumatic heart disease (Review)

Authors:
- Shenglin Xian
- Zhiyu Zeng
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Affiliations: Department of Cardiology, The First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi 530021, P.R. China
Published online on: November 25, 2020 https://doi.org/10.3892/etm.2020.9508
Article Number: 76
Copyright: © Xian et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Rheumatic heart disease (RHD) is frequently encountered in underdeveloped areas and primarily affects patients under the age of 40 years old. The pathogenesis of RHD has yet to be fully elucidated and surgical treatment remains the only option, which is expensive and technically demanding for patients in less developed areas. Signalling pathways are crucial for the occurrence and development of several diseases, and researchers worldwide have made progress in elucidating the signalling pathways associated with the pathogenesis of RHD. The aim of the present review was to discuss 6 signalling pathways implicated in the pathogenesis of RHD, summarize the methods and progress of these studies and propose future research directions. Important information on the pathogenesis of RHD according to the current progress of signalling pathway studies was also summarized, in the hope that this review may serve as a reference for future research on the signalling pathways involved in the pathogenesis of RHD.

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