NK/T‑cell non‑Hodgkin lymphoma: Case report and review of the literature

Lungu,Mihaiela; Telehuz,Anca; Voinescu,Doina Carina; Sapira,Violeta; Trifan,Angel; Elkan,Eva Maria; Fătu,Ana; Creangă,Valerica Zărnescu; Polinschi,Mihai; Stoleriu,Gabriela; Niculet,Elena

doi:10.3892/etm.2020.9523

NK/T‑cell non‑Hodgkin lymphoma: Case report and review of the literature

Authors:
- Mihaiela Lungu
- Anca Telehuz
- Doina Carina Voinescu
- Violeta Sapira
- Angel Trifan
- Eva Maria Elkan
- Ana Fătu
- Valerica Zărnescu Creangă
- Mihai Polinschi
- Gabriela Stoleriu
- Elena Niculet
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Affiliations: Clinical Department, Faculty of Medicine and Pharmacy, ‘Dunarea de Jos’ University of Galati, 800008 Galati, Romania, Research Center of Medical and Pharmaceutical Sciences, Faculty of Medicine and Pharmacy, ‘Dunarea de Jos’ University of Galati, 800008 Galati, Romania, Department of Morphological and Functional Sciences, Faculty of Medicine and Pharmacy, ‘Dunarea de Jos’ University of Galati, 800008 Galati, Romania
Published online on: November 26, 2020 https://doi.org/10.3892/etm.2020.9523
Article Number: 91
Copyright: © Lungu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Natural killer (NK)/T‑cell lymphomas represent a rare type of lymphoid malignancy with mostly extranodal involvement, having NK cell or (rare) T cell lineage, classified by the World Health Organization into several subtypes which can involve the head and neck region, with the most frequent one being the nasal type. This article presents the case of a 31‑year‑old patient who presented at the Emergency Unit of Saint Andrew Emergency Clinical Hospital of Galati suffering from mycosis fungoides‑like cutaneous lesions, associated with partial left eyelid ptosis of unknown etiology, as well as a poor health status with fever and respiratory failure. The final diagnosis was NK/T‑cell non‑Hodgkin lymphoma, possibly nasal type with medium sized T cells. The complexity of the rare diagnosis, associated with the unusual rapid patient evolution towards exitus 3 months after diagnosis, the intra‑orbital metastatic involvement and the absence of a standardized treatment are case peculiarities, some of which are consistent with current literature data.

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