SARS‑CoV‑2, multiple sclerosis, and focal deficit in a postpartum woman: A case report
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- Published online on: November 26, 2020 https://doi.org/10.3892/etm.2020.9524
- Article Number: 92
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Abstract
SARS‑CoV‑2 infections raise many practical concerns in a woman with multiple sclerosis (MS) during the perinatal period. On the other hand, the impact of COVID-19 on patients with MS and disease‑modifying therapies (DMTs) is unknown. We report on a female patient who was treated with interferon beta 1a (IFNB‑1a) for many years for relapsing‑remitting multiple sclerosis (RRMS) until December 2018. She developed COVID 19 infection in April 2020, after giving birth to a healthy baby girl, five weeks before. She developed a mild right hemiparesis 2 weeks later, without cold symptoms. On admission, PCR for SARS‑CoV‑2 was positive, and she received antivirals and corticotherapy. One month later, specific IgG and IgM antibodies were negative. The patient did not develop immunity to COVID-19 infection. This report raises several problems. The focal deficit could be a real relapse or a pseudo‑relapse due to SARS‑CoV‑2 and postpartum patient vulnerability. The treatment options in this particular case raise many challenges. The absence of antibodies after a SARS‑CoV‑2 infection raises a big question over the acquired immunity, the increased risk of reinfection, and the subsequent evolution of MS. The standard of care for a woman with MS and COVID-19 infection during the postpartum period must be explored and more precise recommendations must be established in the future.
