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Pediatric autoimmune neuropsychiatric disorders associated with streptococcal infections (Review)

  • Authors:
    • Dalia Dop
    • Iulia Rahela Marcu
    • Rodica Padureanu
    • Carmen  Elena Niculescu
    • Vlad Padureanu
  • View Affiliations / Copyright

    Affiliations: Department of Pediatrics, University of Medicine and Pharmacy of Craiova, Craiova 200349, Romania, Department of Physical and Rehabilitation Medicine, University of Medicine and Pharmacy of Craiova, Craiova 200349, Romania, Department of Biochemistry, University of Medicine and Pharmacy of Craiova, Craiova 200349, Romania, Department of Internal Medicine, University of Medicine and Pharmacy of Craiova, Craiova 200349, Romania
    Copyright: © Dop et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 94
    |
    Published online on: November 26, 2020
       https://doi.org/10.3892/etm.2020.9526
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Abstract

Pediatric autoimmune neuropsychiatric disorders associated with streptococcal infections (PANDAS) are clinically characterized by the sudden onset of obsessive‑compulsive manifestations, motor and verbal tics, as well as other behavioral symptoms in a group of children with B‑hemolytic streptococcal infection. PANDAS are considered autoimmune diseases because the streptococcal infection and response can be demonstrated. The most frequent physiopathological mechanism is molecular mimicry: A foreign antigen shares sequence or structural similarities with self‑antigens. A thorough review of the literature was carried out using the PubMed database and SCOPUS, searching for immunological, clinical and microbiological aspects, as well as the treatment of the PANDAS syndrome. The diagnosis is clinical and it requires a careful medical history and a thorough physical examination, while the treatment is complex. Untreated or unrecognized manifestations of PANDAS can increase the risk of obsessive‑compulsive manifestations and tics during adulthood. Taking this into consideration, further studies are required to establish the best method of therapy.
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1 

Swedo SE, Leonard HL, Garvey M, Mittleman B, Allen AJ, Perlmutter S, Lougee L, Dow S, Zamkoff J and Dubbert BK: Pediatric autoimmune neuropsychiatric disorders associated with streptococcal infections: Clinical description of the first 50 cases. Am J Psychiatry. 155:264–271. 1998.PubMed/NCBI View Article : Google Scholar

2 

Swedo SE, Leckman JF and Rose NR: From research subgroup to clinical syndrome: Modifying the PANDAS criteria to describe PANS (pediatric acute-onset neuropsychiatric syndrome). Pediatr Therapeut. 2:1–8. 2012.

3 

Kirvan CA, Swedo SE, Kurahara D and Cunningham MW: Streptococcal mimicry and antibody-mediated cell signaling in the pathogenesis of Sydenham's chorea. Autoimmunity. 39:21–29. 2006.PubMed/NCBI View Article : Google Scholar

4 

Siloşi CA, Siloşi I, Pădureanu V, Bogdan M, Mogoantă SŞ, Ciurea ME, Cojocaru M, Boldeanu L, Avrămescu CS, Boldeanu MV and Popa DG: Sepsis and identification of reliable biomarkers for postoperative period prognosis. Rom J Morphol Embryol. 59:77–91. 2018.PubMed/NCBI

5 

Kirvan CA, Swedo SE, Snider LA and Cunningham MW: Antibody-mediated neuronal cell signaling in behavior and movement disorders. J Neuroimmunol. 179:173–179. 2006.PubMed/NCBI View Article : Google Scholar

6 

Kirvan CA, Swedo SE, Heuser JS and Cunningham MW: Mimicry and autoantibody-mediated neuronal cell signaling in Sydenham chorea. Nat Med. 9:914–920. 2003.PubMed/NCBI View Article : Google Scholar

7 

Cox CJ, Sharma M, Leckman JF, Zuccolo J, Zuccolo A, Kovoor A, Swedo SE and Cunningham MW: Brain human monoclonal autoantibody from Sydenham chorea targets dopaminergic neurons in transgenic mice and signals dopamine D2 receptor: Implications in human disease. J Immunol. 191:5524–5541. 2013.PubMed/NCBI View Article : Google Scholar

8 

Kirvan CA, Cox CJ, Swedo SE and Cunningham MW: Tubulin is a neuronal target of autoantibodies in Sydenham's chorea. J Immunol. 178:7412–7421. 2007.PubMed/NCBI View Article : Google Scholar

9 

Brimberg L, Benhar I, Mascaro-Blanco A, Alvarez K, Lotan D, Winter C, Klein J, Moses AE, Somnier FE, Leckman JF, et al: Behavioral, pharmacological, and immunological abnormalities after streptococcal exposure: A novel rat model of Sydenham chorea and related neuropsychiatric disorders. Neuropsychopharmacology. 37:2076–2087. 2012.PubMed/NCBI View Article : Google Scholar

10 

Lotan D, Benhar I, Alvarez K, Mascaro-Blanco A, Brimberg L, Frenkel D, Cunningham MW and Joel D: Behavioral and neural effects of intra-striatal infusion of anti-streptococcal antibodies in rats. Brain Behav Immun. 38:249–262. 2014.PubMed/NCBI View Article : Google Scholar

11 

Chang K, Frankovich J, Cooperstock M, Cunningham MW, Latimer ME, Murphy TK, Pasternack M, Thienemann M, Williams K, Walter J, et al: Clinical evaluation of youth with pediatric acute-onset neuropsychiatric syndrome (PANS): Recommendations from the 2013 PANS consensus conference. J Child Adolesc Psychopharmacol. 25:3–13. 2015.PubMed/NCBI View Article : Google Scholar

12 

Singer HS, Mascaro-Blanco A, Alvarez K, Morris-Berry C, Kawikova I, Ben-Pazi H, Thompson CB, Ali SF, Kaplan EL and Cunningham MW: Neuronal antibody biomarkers for Sydenham's chorea identify a new group of children with chronic recurrent episodic acute exacerbations of tic and obsessive compulsive symptoms following a streptococcal infection. PLoS One. 10(e0120499)2015.PubMed/NCBI View Article : Google Scholar

13 

Morris-Berry CM, Pollard M, Gao S and Thompson C: Tourette Syndrome Study Group and Singer HS. Anti-streptococcal, tubulin, and dopamine receptor 2 antibodies in children with PANDAS and Tourette syndrome: Single-point and longitudinal assessments. J Neuroimmunol. 264:106–113. 2013.PubMed/NCBI View Article : Google Scholar

14 

Gilbert DL, Mink JW and Singer HS: A pediatric neurology perspective on pediatric autoimmune neuropsychiatric disorder associated with streptococcal infection and pediatric acute-onset neuropsychiatric syndrome. J Pediatr. 199:243–251. 2018.PubMed/NCBI View Article : Google Scholar

15 

Singer HS, Gause C, Morris C and Lopez P: Tourette Syndrome Study Group. Serial immune markers do not correlate with clinical exacerbations in pediatric autoimmune neuropsychiatric disorders associated with streptococcal infections. Pediatrics. 121:1198–1205. 2008.PubMed/NCBI View Article : Google Scholar

16 

Dale RC: Tics and tourette: A clinical, pathophysiological and etiological review. Curr Opin Pediatr. 29:665–673. 2017.PubMed/NCBI View Article : Google Scholar

17 

Chain JL, Alvarez K, Mascaro-Blanco A, Reim S, Bentley R, Hommer R, Grant P, Leckman JF, Kawikova I, Williams K, et al: Autoantibody biomarkers for basal ganglia encephalitis in sydenham chorea and pediatric autoimmune neuropsychiatric disorder associated with streptococcal infections. Front Psychiatry. 11(564)2020.PubMed/NCBI View Article : Google Scholar

18 

Hesselmark E and Bejerot S: Biomarkers for diagnosis of Pediatric Acute Neuropsychiatric Syndrome (PANS)-sensitivity and specificity of the Cunningham panel. J Neuroimmunol. 312:31–37. 2017.PubMed/NCBI View Article : Google Scholar

19 

Frankovich J, Thienemann M, Pearlstein J, Crable A, Brown K and Chang K: Multidisciplinary clinic dedicated to treating youth with pediatric acute-onset neuropsychiatric syndrome: Presenting characteristics of the first 47 consecutive patients. J Child Adolesc Psychopharmacol. 25:38–47. 2015.PubMed/NCBI View Article : Google Scholar

20 

Murphy TK, Snider LA, Mutch PJ, Harden E, Zaytoun A, Edge PJ, Storch EA, Yang MCK, Mann G, Goodman WK and Swedo SE: Relationship of movements and behaviors to group A streptococcus infections in elementary school children. Biol Psychiatry. 61:279–284. 2007.PubMed/NCBI View Article : Google Scholar

21 

Giedd JN, Rapoport JL, Garvey MA, Perlmutter S and Swedo SE: MRI assessment of children with obsessive-compulsive disorder or tics associated with streptococcal infection. Am J Psychiatry. 157:281–283. 2000.PubMed/NCBI View Article : Google Scholar

22 

Niculescu EC, Dop D, Diaconu R, Stepan AE, Gheonea C and Stănescu GL: Vertical transmission of HIV/TB in newborns: A case report. Rom J Morphol Embryol. 55:1473–1476. 2014.PubMed/NCBI

23 

Snider LA, Lougee L, Slattery M, Grant   and Swedo SE: Antibiotic prophylaxis with azithromycin or penicillin for childhood-onset neuropsychiatric disorders. Biol Psychiatry. 57:788–792. 2005.PubMed/NCBI View Article : Google Scholar

24 

Mihailovici AR, Padureanu V, Albu CV, Dinescu VC, Pirlog MC, Dinescu SN, Malin RD and Calborean V: Myocardial noncompaction. Rev Chim (Bucharest). 69:2209–2212. 2018.

25 

Murphy TK, Parker-Athill EC, Lewin AB, Storch EA and Mutch PJ: Cefdinir for recent-onset pediatric neuropsychiatric disorders: A pilot randomized trial. J Child Adolesc Psychopharmacol. 25:57–64. 2015.PubMed/NCBI View Article : Google Scholar

26 

Albu CV, Padureanu V, Boldeanu MV, Bumbea AM, Enescu AS, Albulescu DM, Silosi CA and Enescu A: Vascular neurocognitive disorders and the vascular risk factors. J Mind Med Sci. 5:7–15. 2018.

27 

Franklin ME, Sapyta J, Freeman JB, Khanna M, Compton S, Almirall D, Moore P, Choate-Summers M, Garcia A, Edson AL, et al: Cognitive behaviour therapy augmentation of pharmacotherapy in pediatric obsessive-compulsive disorder: The pediatric OCD treatment study II (POTS II) randomized controlled trial. JAMA. 306:1224–1232. 2011.PubMed/NCBI View Article : Google Scholar

28 

Swedo SE, Frankovich J and Murphy TK: Overview of treatment of pediatric acute-onset neuropsychiatric syndrome. J Child Adolesc Psychopharmacol. 27:562–565. 2017.PubMed/NCBI View Article : Google Scholar

29 

Sigra S, Hesselmark E and Bejerot S: Treatment of PANDAS and PANS: A systematic review. Neurosci Biobehav Rev. 86:51–65. 2018.PubMed/NCBI View Article : Google Scholar

30 

Frankovich J, Swedo S, Murphy T, Dale RC, Agalliu D, Williams K, Daines M, Mady Hornig M, Chugani H, Sanger T, et al: Clinical management of pediatric acute-onset neuropsychiatric syndrome: Part II-use of immunomodulatory therapies. J Child Adolesc Psychopharmacol. 27:574–593. 2017.PubMed/NCBI View Article : Google Scholar

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Copy and paste a formatted citation
Spandidos Publications style
Dop D, Marcu IR, Padureanu R, Niculescu CE and Padureanu V: Pediatric autoimmune neuropsychiatric disorders associated with streptococcal infections (Review). Exp Ther Med 21: 94, 2021.
APA
Dop, D., Marcu, I.R., Padureanu, R., Niculescu, C.E., & Padureanu, V. (2021). Pediatric autoimmune neuropsychiatric disorders associated with streptococcal infections (Review). Experimental and Therapeutic Medicine, 21, 94. https://doi.org/10.3892/etm.2020.9526
MLA
Dop, D., Marcu, I. R., Padureanu, R., Niculescu, C. E., Padureanu, V."Pediatric autoimmune neuropsychiatric disorders associated with streptococcal infections (Review)". Experimental and Therapeutic Medicine 21.1 (2021): 94.
Chicago
Dop, D., Marcu, I. R., Padureanu, R., Niculescu, C. E., Padureanu, V."Pediatric autoimmune neuropsychiatric disorders associated with streptococcal infections (Review)". Experimental and Therapeutic Medicine 21, no. 1 (2021): 94. https://doi.org/10.3892/etm.2020.9526
Copy and paste a formatted citation
x
Spandidos Publications style
Dop D, Marcu IR, Padureanu R, Niculescu CE and Padureanu V: Pediatric autoimmune neuropsychiatric disorders associated with streptococcal infections (Review). Exp Ther Med 21: 94, 2021.
APA
Dop, D., Marcu, I.R., Padureanu, R., Niculescu, C.E., & Padureanu, V. (2021). Pediatric autoimmune neuropsychiatric disorders associated with streptococcal infections (Review). Experimental and Therapeutic Medicine, 21, 94. https://doi.org/10.3892/etm.2020.9526
MLA
Dop, D., Marcu, I. R., Padureanu, R., Niculescu, C. E., Padureanu, V."Pediatric autoimmune neuropsychiatric disorders associated with streptococcal infections (Review)". Experimental and Therapeutic Medicine 21.1 (2021): 94.
Chicago
Dop, D., Marcu, I. R., Padureanu, R., Niculescu, C. E., Padureanu, V."Pediatric autoimmune neuropsychiatric disorders associated with streptococcal infections (Review)". Experimental and Therapeutic Medicine 21, no. 1 (2021): 94. https://doi.org/10.3892/etm.2020.9526
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