Periodontal effects of two innovative oral rinsing substances in oncologic patients

Kappenberg‑Niţescu,Diana Cristala; Luchian,Ionut; Mârțu,Ioana; Solomon,Sorina-Mihaela; Mârţu,Silvia; Păsărin,Liliana; Mârțu,Alexandra; Sioustis,Ioana-Andreea; Goriuc,Ancuța; Tatarciuc,Monica

doi:10.3892/etm.2020.9530

Periodontal effects of two innovative oral rinsing substances in oncologic patients

Authors:
- Diana Cristala Kappenberg‑Niţescu
- Ionut Luchian
- Ioana Mârțu
- Sorina-Mihaela Solomon
- Silvia Mârţu
- Liliana Păsărin
- Alexandra Mârțu
- Ioana-Andreea Sioustis
- Ancuța Goriuc
- Monica Tatarciuc
View Affiliations

Affiliations: Department of Periodontology, ‘Grigore T. Popa’ University of Medicine and Pharmacy, Iasi 700115, Romania, Department of Dental Technology, Faculty of Dental Medicine, ‘Grigore T. Popa’ University of Medicine and Pharmacy, Iasi 700115, Romania, Department of Biochemistry, ‘Grigore T. Popa’ University of Medicine and Pharmacy, Iasi 700115, Romania
Published online on: November 26, 2020 https://doi.org/10.3892/etm.2020.9530
Article Number: 98
Copyright: © Kappenberg‑Niţescu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )

Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )

Cited By (CrossRef): 0 citations Loading Articles...

Abstract

Chemotherapy often presents side effects, including oral adverse effects that may interfere with the completion of the oncology treatment, threatening the outcome of the treatment and significantly affecting the quality of life of the patient. The aim of the present study was to evaluate two antiseptic, antimicrobial and antifungal substances that may be used in order to achieve improved oral hygiene and to lower the prevalence of side effects during chemotherapy. Patients were randomly divided into three groups: Placebo, oral rinse with cetrimide and mouth coating with a pharmacy‑made compound (nystatin, neomycin and metronidazole). Their oral hygiene and periodontal parameters were determined at baseline and 14 days of use. It was revealed that the most effective clinical results were achieved in the group that used cetrimide mouth rinse that highlighted the best improvements of parameter values, whereas the control and coating‑using group did not obtain statistically significant improvements. Cetrimide oral rinse was demonstrated to be an efficient adjunct method in achieving better oral hygiene and improved periodontal parameters in chemotherapy patients. The present study offers an alternative to the commonly used compounds that may present unwanted side effects in patients during chemotherapy, it promotes the importance of good oral hygiene in the prevention of chemotherapy‑induced oral adverse effects and improves the quality of life of the patient.

View Figures

View References

1	Oun R, Moussa YE and Wheate NJ: The side effects of platinum-based chemotherapy drugs: A review for chemists. Dalton Trans. 47:6645–6653. 2018.PubMed/NCBI View Article : Google Scholar
2	American Cancer Society: After diagnosis: A guide for patients and families, 2012.
3	Napeñas JJ, Brennan MT, Bahrani-Mougeot FK, Fox PC and Lockhart PB: Relationship between mucositis and changes in oral microflora during cancer chemotherapy. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 103:48–59. 2007.PubMed/NCBI View Article : Google Scholar
4	Poulopoulos A, Papadopoulos P and Andreadis D: Chemotherapy: Oral side effects and dental interventions -a review of the literature. Stomatological Dis Sci. 1:35–49. 2017.
5	Luchian I, Nanu S, Martu I, Martu A, Nichitean G, Kappennerg-Nitescu DC, Gurău G, Stefanescu V, Pasarin L, Tatarciuc M and Solomon SM: The influence of the composite resin material on the clinical working time in fiberglass reinforced periodontal splints. Mater Plast. 57:316–320. 2020.
6	Teodorescu AC, Martu I, Teslaru S, Kappenberg-Nitescu DC, Goriuc A, Luchian I, Martu MA, Solomon SM and Mârțu S: Assessment of salivary levels of RANKL and OPG in aggressive versus chronic periodontitis. J Immunol Res. 2019(6195258)2019.PubMed/NCBI View Article : Google Scholar
7	Zhou C, Ren S, Zhou S, Zhang L, Su C, Zhang Z, Deng Q and Zhang J: Predictive effects of ERCC1 and XRCC3 SNP on efficacy of platinum-based chemotherapy in advanced NSCLC patients. Jpn J Clin Oncol. 40:954–960. 2010.PubMed/NCBI View Article : Google Scholar
8	Park SY, Lee JG, Kim J, Byun GE, Bae MK, Lee CY, Kim DJ and Chung KY: Efficacy of platinum-based adjuvant chemotherapy in T2aN0 stage IB non-small cell lung cancer. J Cardiothorac Surg. 8(151)2013.PubMed/NCBI View Article : Google Scholar
9	Chambers MS, Toth BB, Martin JW, Fleming TJ and Lemon JC: Oral and dental management of the cancer patient: Prevention and treatment of complications. Support Care Cancer. 3:168–175. 1995.PubMed/NCBI View Article : Google Scholar
10	Jensen SB, Mouridsen HT, Bergmann OJ, Reibel J, Brünner N and Nauntofte B: Oral mucosal lesions, microbial changes, and taste disturbances induced by adjuvant chemotherapy in breast cancer patients. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 106:217–226. 2008.PubMed/NCBI View Article : Google Scholar
11	DePaola LG, Overholser CD, Meiller TF, Minah GE and Niehaus C: Chemotherapeutic inhibition of supragingival dental plaque and gingivitis development. J Clin Periodontol. 16:311–315. 1989.PubMed/NCBI View Article : Google Scholar
12	Engebretsen KA, Hald M, Johansen JD and Thyssen JP: Allergic contact dermatitis caused by an antiseptic containing cetrimide. Contact Dermatitis. 72:60–61. 2015.PubMed/NCBI View Article : Google Scholar
13	Elzanfaly ES, Bassuoni YF, Essam HAM and Zaazaa HE: Ion selective membrane electrodes for determination of cetrimide in pure form and in pharmaceutical formulations. Anal Bioanal Electrochem. 7:401–414. 2015.
14	Dostie S, Alkadi LT, Owen G, Bi J, Shen Y, Haapasalo M and Larjava HS: Chemotherapeutic decontamination of dental implants colonized by mature multispecies oral biofilm. J Clin Periodontol. 44:403–409. 2017.PubMed/NCBI View Article : Google Scholar
15	Guerreiro-Tanomaru JM, Nascimento CA, Faria-Júnior NB, Graeff MS, Watanabe E and Tanomaru-Filho M: Antibiofilm activity of irrigating solutions associated with cetrimide. Confocal laser scanning microscopy. Int Endod J. 47:1058–1063. 2014.PubMed/NCBI View Article : Google Scholar
16	Ruiz-Linares M, Ferrer-Luque CM, Arias-Moliz T, de Castro P, Aguado B and Baca P: Antimicrobial activity of alexidine, chlorhexidine and cetrimide against Streptococcus mutans biofilm. Ann Clin Microbiol Antimicrob. 13(41)2014.PubMed/NCBI View Article : Google Scholar
17	Moisei M, Pasarin L, Solomon S, Oanta C, Tatarciuc D, Ursarescu I and Martu S: The role of antibiotherapy in the oral rehabilitation of the periodontal affected patient. Rom J Oral Rehabil. 7:107–112. 2015.
18	Vallance S, Jones B, Arabi Y and Keighley MR: Importance of adding neomycin to metronidazole for bowel preparation. J R Soc Med. 73:238–240. 1980.PubMed/NCBI
19	Espin-Basany E, Sanchez-Garcia JL, Lopez-Cano M, Lozoya-Trujillo R, Medarde-Ferrer M, Armadans-Gil L, Alemany-Vilches L and Armengol-Carrasco M: Prospective, randomised study on antibiotic prophylaxis in colorectal surgery. Is it really necessary to use oral antibiotics? Int J Colorectal Dis. 20:542–546. 2005.PubMed/NCBI View Article : Google Scholar
20	Rapone B, Nardi GM, DI Venere D, Pettini F, Grassi FR and Corsalini M: Oral hygiene in patients with oral cancer undergoing chemotherapy and/or radiotherapy after prosthesis rehabilitation: Protocol proposal. Oral Implantol (Rome). 9 (Suppl 1/2016 to N 4/2016):S90–S97. 2017.PubMed/NCBI View Article : Google Scholar
21	Bonesvoll P and Gjermo P: A comparison between chlorhexidine and some quaternary ammonium compounds with regard to retention, salivary concentration and plaque-inhibiting effect in the human mouth after mouth rinses. Arch Oral Biol. 23:289–294. 1978.PubMed/NCBI View Article : Google Scholar
22	Dodd MJ, Dibble S, Miaskowski C, Paul S, Cho M, MacPhail L, Greenspan D and Shiba G: A comparison of the affective state and quality of life of chemotherapy patients who do and do not develop chemotherapy-induced oral mucositis. J Pain Symptom Manage. 21:498–505. 2001.PubMed/NCBI View Article : Google Scholar
23	Nitescu DCK, Constantin M, Oanta C, Martu I, Volovat SR and Martu S: Evaluation of cumulative effects of chemotherapy and bevacizumab (Avastin^®) in oncological patients with periodontal disease. Rev Chim (Bucharest). 68:549–552. 2017.
24	Calenic B, Greabu M, Caruntu C, Nicolescu MI, Moraru L, Surdu-Bob CC, Badulescu M, Anghel A, Logofatu C and Boda D: Oral keratinocyte stem cells behavior on diamond like carbon films. Rom Biotechnol Lett. 21:11914–11922. 2016.
25	Boda D: Cellomics as integrative omics for cancer. Curr Proteomics. 10:237–245. 2013.
26	Neagu M, Constantin C, Tanase C and Boda D: Patented biomarker panels in early detection of cancer. Recent Pat Biomark. 1:10–24. 2011.