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Dynamics of APRI and FIB‑4 in HCV cirrhotic patients who achieved SVR after DAA therapy

  • Authors:
    • Anca Leuştean
    • Cristina Popescu
    • Luciana Nichita
    • Cătălin Tilişcan
    • Victoria Aramă
  • View Affiliations / Copyright

    Affiliations: Department of Infectious Diseases, Faculty of Medicine, ‘Carol Davila’ University of Medicine and Pharmacy, 020021 Bucharest, Romania, Department of Pathology, Faculty of Dental Medicine, ‘Carol Davila’ University of Medicine and Pharmacy, 020021 Bucharest, Romania, Third Clinical Department, ‘Prof. Dr. Matei Balş’ National Institute for Infectious Diseases, 021105 Bucharest, Romania
    Copyright: © Leuştean et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 99
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    Published online on: November 26, 2020
       https://doi.org/10.3892/etm.2020.9531
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Abstract

There are limited data available on the regression of fibrosis in hepatitis C virus (HCV) patients who have achieved sustained virologic response (SVR) after interferon‑free treatments. Moreover, a perfect method for assessing liver fibrosis and its dynamics has not been established yet. The main objective of this study was to evaluate the dynamics of aspartate aminotransferase to platelet ratio index (APRI) and Fibrosis‑4 (FIB‑4) scores in patients with HCV who registered SVR. We performed ROC curve analysis to evaluate the diagnostic performance of APRI and FIB‑4 scores in determining the presence of cirrhosis in comparison to FibroTest. In total 251 patients were enrolled: 164 cirrhotic and 83 non‑cirrhotic patients, and they were evaluated at baseline, at 6 and at 12 months post‑end of treatment (EOT). In the cirrhotic group, at baseline, there was a weak but statistically significant correlation between APRI and FibroTest (τ=0.173, P=0.001), as well as between FIB‑4 and FibroTest (τ=0.265, P<0.001). At the 6-month follow‑up, APRI no longer correlated with FibroTest (τ=0.144, P=0.057), while FIB‑4 was correlated (τ=0.256, P=0.001). The same pattern was shown at 12 months post‑EOT. Between baseline and the 6-month evaluation, there was a significant decrease in APRI (P<0.001) and FIB‑4 (P<0.001) scores, but for the next follow‑up period, there was no reduction. In the non‑cirrhotic group, APRI and FIB‑4 did not correlate with the FibroTest value at any of the evaluation times. There was a significant difference between baseline and the 6-month visit for APRI (P=0.01) and for FIB‑4 (P=0.014). The areas under the receiver operating characteristics curve (AUROCs) for the presence of cirrhosis compared with FibroTest for APRI and FIB‑4 were 0.682 [95% confidence interval (CI), 0.613‑0.752] and 0.693 (95% CI 0.625‑0.76). Both APRI and FIB‑4 prove to be easy, quick and inexpensive tools for screening HCV cirrhosis, with moderate diagnostic accuracy and FIB‑4 can be useful for monitoring patients post‑EOT.
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1 

Popescu C, Stratan L, Catană R, Leuștean A, Dragomirescu C, Badea A, Murariu C, Năstase R, Molagic V, Aramă V, et al: The efficacy of Ombitasvir-paritaprevir/ritonavir, dasabuvir and ribavirin in patients with genotype 1 HCV compensated cirrhosis. The 12th Edition of the Scientific Days of the National Institute for Infectious Diseases “Prof. Dr. Matei Bals” and the 12th National Infectious Diseases Conference. BMC Infectious Diseases. 16:31–76. 2016.10.1186/s12879-016-1877-4.

2 

Aramă V, Leuştean A, Catană R, Stratan L, Nastase RM, Molagic V, Radulescu M, Munteanu DI, Tiliscan C, Orfanu A, et al: The efficacy of OBV/PTV/r + DSV and RBV in a Romanian cohort with genotype 1 HCV compensated cirrhosis. Poster presentation at the 26th Annual Conference of APASL, Shanghai, China. Hepatol Int. 11 (Suppl 1)(S1028 (PP1765))2017.

3 

Poordad F, Hezode C, Trinh S1028R, Kowdley KV, Zeuzem S, Agarwal K, Shiffman ML, Wedemeyer H, Berg T, Yoshida EM, et al: ABT-450/r-ombitasvir and dasabuvir with ribavirin for hepatitis C with cirrhosis. N Engl J Med. 370:1973–1982. 2014.PubMed/NCBI View Article : Google Scholar

4 

Poynard T, Imbert-Bismut F, Munteanu M, Messous D, Myers RP, Thabut D, Ratziu V, Mercadier A, Benhamou Y and Hainque B: Overview of the diagnostic value of biochemical markers of liver fibrosis (FibroTest, HCV FibroSure) and necrosis (ActiTest) in patients with chronic hepatitis C. Comp Hepatol. 3(8)2004.PubMed/NCBI View Article : Google Scholar

5 

Cadranel JF, Rufat P and Degos F: Practices of liver biopsy in France: Results of a prospective nationwide survey. For the group of epidemiology of the French Association for the study of the liver (AFEF). Hepatology. 32:477–481. 2000.PubMed/NCBI View Article : Google Scholar

6 

Regev A, Berho M, Jeffers LJ, Milikowski C, Molina EG, Pyrsopoulos NT, Feng ZZ, Reddy KR and Schiff ER: Sampling error and intraobserver variation in liver biopsy in patients with chronic HCV infection. Am J Gastroenterol. 97:2614–2618. 2002.PubMed/NCBI View Article : Google Scholar

7 

Bedossa P, Dargère D and Paradis V: Sampling variability of liver fibrosis in chronic hepatitis C. Hepatology. 38:1449–1457. 2003.PubMed/NCBI View Article : Google Scholar

8 

Ferraioli G, Tinelli C, Dal Bello B, Zicchetti M, Lissandrin R, Filice G, Filice C, Above E, Barbarini G, Brunetti E, et al: Performance of liver stiffness measurements by transient elastography in chronic hepatitis. World J Gastroenterol. 19:49–56. 2013.PubMed/NCBI View Article : Google Scholar

9 

Poynard T, Munteanu M, Imbert-Bismut F, Charlotte F, Thabut D, Le Calvez S, Messous D, Thibault V, Benhamou Y, Moussalli J and Ratziu V: Prospective analysis of discordant results between biochemical markers and biopsy in patients with chronic hepatitis C. Clin Chem. 50:1344–1355. 2004.PubMed/NCBI View Article : Google Scholar

10 

Wai CT, Greenson JK, Fontana RJ, Kalbfleisch JD, Marrero JA, Conjeevaram HS and Lok AS: A simple noninvasive index can predict both significant fibrosis and cirrhosis in patients with chronic hepatitis C. Hepatology. 38:518–526. 2003.PubMed/NCBI View Article : Google Scholar

11 

Sterling RK, Lissen E, Clumeck N, Sola R, Correa MC, Montaner J, S Sulkowski M, Torriani FJ, Dieterich DT, Thomas DL, et al: Development of a simple noninvasive index to predict significant fibrosis patients with HIV/HCV coinfection. Hepatology. 43:1317–1325. 2006.PubMed/NCBI View Article : Google Scholar

12 

Zubair I and Wajid B: Comparison of APRI, FIB-4 and fibro test in prediction of fibrosis and cirrhosis in patients with hepatitis C. 2018 15th International Bhurban Conference on Applied Sciences and Technology (IBCAST), Islamabad, pp222-227, 2018.

13 

Chou R and Wasson N: Blood tests to diagnose fibrosis or cirrhosis in patients with chronic hepatitis C virus infection: A systematic review. Ann Intern Med. 158:807–820. 2013.PubMed/NCBI View Article : Google Scholar

14 

Vallet-Pichard A, Mallet V, Nalpas B, Verkarre V, Nalpas A, Dhalluin-Venier V, Fontaine H and Pol S: FIB-4: An inexpensive and accurate marker of fibrosis in HCV infection. Comparison with liver biopsy and fibrotest. Hepatology. 46:32–36. 2007.PubMed/NCBI View Article : Google Scholar

15 

Poynard T, Ngo Y, Perazzo H, Munteanu M, Lebray P, Moussalli J, Thabut D, Benhamou Y and Ratziu V: Prognostic value of liver fibrosis biomarkers: A meta-analysis. Gastroenterol Hepatol. 7:445–454. 2011.PubMed/NCBI

16 

Bachofner JA, Valli PV, Kröger A, Bergamin I, Künzler P, Baserga A, Braun D, Seifert B, Moncsek A, Fehr J, et al: Direct antiviral agent treatment of chronic hepatitis C results in rapid regression of transient elastography and fibrosis markers fibrosis-4 score and aspartate aminotransferase-platelet ratio index. Liver Int. 37:369–376. 2017.PubMed/NCBI View Article : Google Scholar

17 

Tamaki N, Kurosaki M, Tanaka K, Suzuki Y, Hoshioka Y, Kato T, Yasui Y, Hosokawa T, Ueda K, Tsuchiya K, et al: Noninvasive estimation of fibrosis progression overtime using the FIB-4 index in chronic hepatitis C. J Viral Hepat. 20:72–76. 2013.PubMed/NCBI View Article : Google Scholar

18 

Houot M, Ngo Y, Munteanu M, Marque S and Poynard T: Systematic review with meta-analysis: Direct comparisons of biomarkers for the diagnosis of fibrosis in chronic hepatitis C and B. Aliment Pharmacol Ther. 43:16–29. 2016.PubMed/NCBI View Article : Google Scholar

19 

Cepeda JA, Solomon SS, Srikrishnan AK, Nandagopal P, Balakrishnan P, Kumar MS, Thomas DL, Sulkowski MS and Mehta SH: Serum fibrosis markers for the diagnosis of liver disease among people with chronic hepatitis C in Chennai, India. Open Forum Infect Dis. 3(ofw156)2016.PubMed/NCBI View Article : Google Scholar

20 

Amorim TG, Staub GJ, Lazzarotto C, Silva AP, Manes J, Ferronato Mda G, Shiozawa MB, Narciso-Schiavon JL, Dantas-Correa EB and Schiavon Lde L: Validation and comparison of simple noninvasive models for the prediction of liver fibrosis in chronic hepatitis C. Ann Hepatol. 11:855–861. 2012.PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Leuştean A, Popescu C, Nichita L, Tilişcan C and Aramă V: Dynamics of APRI and FIB‑4 in HCV cirrhotic patients who achieved SVR after DAA therapy. Exp Ther Med 21: 99, 2021.
APA
Leuştean, A., Popescu, C., Nichita, L., Tilişcan, C., & Aramă, V. (2021). Dynamics of APRI and FIB‑4 in HCV cirrhotic patients who achieved SVR after DAA therapy. Experimental and Therapeutic Medicine, 21, 99. https://doi.org/10.3892/etm.2020.9531
MLA
Leuştean, A., Popescu, C., Nichita, L., Tilişcan, C., Aramă, V."Dynamics of APRI and FIB‑4 in HCV cirrhotic patients who achieved SVR after DAA therapy". Experimental and Therapeutic Medicine 21.1 (2021): 99.
Chicago
Leuştean, A., Popescu, C., Nichita, L., Tilişcan, C., Aramă, V."Dynamics of APRI and FIB‑4 in HCV cirrhotic patients who achieved SVR after DAA therapy". Experimental and Therapeutic Medicine 21, no. 1 (2021): 99. https://doi.org/10.3892/etm.2020.9531
Copy and paste a formatted citation
x
Spandidos Publications style
Leuştean A, Popescu C, Nichita L, Tilişcan C and Aramă V: Dynamics of APRI and FIB‑4 in HCV cirrhotic patients who achieved SVR after DAA therapy. Exp Ther Med 21: 99, 2021.
APA
Leuştean, A., Popescu, C., Nichita, L., Tilişcan, C., & Aramă, V. (2021). Dynamics of APRI and FIB‑4 in HCV cirrhotic patients who achieved SVR after DAA therapy. Experimental and Therapeutic Medicine, 21, 99. https://doi.org/10.3892/etm.2020.9531
MLA
Leuştean, A., Popescu, C., Nichita, L., Tilişcan, C., Aramă, V."Dynamics of APRI and FIB‑4 in HCV cirrhotic patients who achieved SVR after DAA therapy". Experimental and Therapeutic Medicine 21.1 (2021): 99.
Chicago
Leuştean, A., Popescu, C., Nichita, L., Tilişcan, C., Aramă, V."Dynamics of APRI and FIB‑4 in HCV cirrhotic patients who achieved SVR after DAA therapy". Experimental and Therapeutic Medicine 21, no. 1 (2021): 99. https://doi.org/10.3892/etm.2020.9531
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