Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Experimental and Therapeutic Medicine
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-0981 Online ISSN: 1792-1015
Journal Cover
February-2021 Volume 21 Issue 2

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
February-2021 Volume 21 Issue 2

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML

  • Supplementary Files
    • Supplementary_Data1.xlsx
    • Supplemenatry_Data2.xls
Article Open Access

Identification of miR-4793-3p as a potential biomarker for bacterial infection in patients with hepatitis B virus-related liver cirrhosis: A pilot study

  • Authors:
    • Shenglong Lin
    • Minghua Lin
    • Huaxi Ma
    • Xiangmei Wang
    • Dongqing Zhang
    • Wenjun Wu
    • Jiahuang Lin
    • Haibing Gao
  • View Affiliations / Copyright

    Affiliations: Department of Severe Hepatopathy, Mengchao Hepatobiliary Hospital of Fujian Medical University, Fuzhou, Fujian 350002, P.R. China
    Copyright: © Lin et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 120
    |
    Published online on: December 3, 2020
       https://doi.org/10.3892/etm.2020.9552
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Hepatitis B virus-related liver cirrhosis (HBV-LC) is susceptible to bacterial infections, which could lead to adverse prognosis in patients. MicroRNAs (miRs/miRNAs) are easily detected in peripheral blood and are involved in multiple liver diseases. The present pilot study aimed to investigate differentially expressed (DE) miRNAs in the serum of patients with HBV-LC and bacterial infection, and to identify potential biomarkers. The first batch of clinical samples was collected, including four patients with HBV-LC and infection, four patients with HBV-LC without infection, four patients with chronic hepatitis B (CHB) and four healthy controls. miRNA expression was analyzed by Affymetrix GeneChip miRNA 4.0 Array. A total of 385 DE miRNAs (upregulated, 160; downregulated, 225) were detected in patients with HBV-LC and infection compared with patients with HBV-LC without infection. miR-4793-3p was significantly upregulated in patients with HBV-LC and infection compared with its levels in the other three groups: HBV-LC without infection [log-transformed fold change (logFC)=7.96; P=0.0458), CHB (logFC=34.53; P=0.0003) and healthy controls (logFC=3.34; P=0.0219)]. Reverse transcription-quantitative PCR (RT-qPCR) was performed to validate miR-4793-3p expression in another batch of clinical samples. RT-qPCR showed that miR-4793-3p was highly expressed in patients with HBV-LC and infection compared with its levels in patients with HBV-LC without infection (P<0.05). The non-parametric random forest regression model was built to access the diagnostic value of miR-4793-3p, and the receiver operating characteristic curve demonstrated that the area under the curve was 92.2%. Target gene analysis with bioinformatics tools and Gene Expression Omnibus data (GSE46955) showed that miR-4793-3p could participate in the TGF-β signaling pathway. Functional experiments revealed that overexpressed miR-4793-3p could impair TGF-β function by downregulating Gremlin-1. The present pilot study suggests that miR-4793-3p could be a feasible indicator for bacterial infection in patients with HBV-LC, and it would be valuable for further research.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

Figure 5

Figure 6

View References

1 

Guidelines WHO; Approved by the Guidelines Review Committee: In: Guidelines for the Prevention, Care and Treatment of Persons with Chronic Hepatitis B Infection. World Health Organization Copyright © World Health Organization 2015., Geneva2015.

2 

Lesmana LA, Leung NWY, Mahachai V, Phiet PH, Suh DJ, Yao G and Zhuang H: Hepatitis B: Overview of the burden of disease in the Asia-Pacific region. Liver Int. 26 (S2):3–10. 2006.

3 

Lin X, Robinson NJ, Thursz M, Rosenberg DM, Weild A, Pimenta JM and Hall AJ: Chronic hepatitis B virus infection in the Asia-Pacific region and Africa: Review of disease progression. J Gastroenterol Hepatol. 20:833–843. 2005.PubMed/NCBI View Article : Google Scholar

4 

Guan R and Lui HF: Treatment of hepatitis B in decompensated liver cirrhosis. Int J Hepatol. 2011(918017)2011.urihttps://doi.org/10.4061/2011/918017simplehttps://doi.org/10.4061/2011/918017.

5 

Peng CY, Chien RN and Liaw YF: Hepatitis B virus-related decompensated liver cirrhosis: Benefits of antiviral therapy. J Hepatol. 57:442–450. 2012.PubMed/NCBI View Article : Google Scholar

6 

Bajaj JS, O'Leary JG, Wong F, Reddy KR and Kamath PS: Bacterial infections in end-stage liver disease: Current challenges and future directions. Gut. 61:1219–1225. 2012.PubMed/NCBI View Article : Google Scholar

7 

Jalan R, Fernandez J, Wiest R, Schnabl B, Moreau R, Angeli P, Stadlbauer V, Gustot T, Bernardi M, Canton R, et al: Bacterial infections in cirrhosis: A position statement based on the EASL Special Conference 2013. J Hepatol. 60:1310–1324. 2014.PubMed/NCBI View Article : Google Scholar

8 

Arvaniti V, D'Amico G, Fede G, Manousou P, Tsochatzis E, Pleguezuelo M and Burroughs AK: Infections in patients with cirrhosis increase mortality four-fold and should be used in determining prognosis. Gastroenterology. 139:1246–1256, e1245. 2010.PubMed/NCBI View Article : Google Scholar

9 

Dueck A, Ziegler C, Eichner A, Berezikov E and Meister G: microRNAs associated with the different human Argonaute proteins. Nucleic Acids Res. 40:9850–9862. 2012.PubMed/NCBI View Article : Google Scholar

10 

Loosen SH, Schueller F, Trautwein C, Roy S and Roderburg C: Role of circulating microRNAs in liver diseases. World J Hepatol. 9:586–594. 2017.PubMed/NCBI View Article : Google Scholar

11 

Starkey Lewis PJ, Dear J, Platt V, Simpson KJ, Craig DG, Antoine DJ, French NS, Dhaun N, Webb DJ, Costello EM, et al: Circulating microRNAs as potential markers of human drug-induced liver injury. Hepatology. 54:1767–1776. 2011.PubMed/NCBI View Article : Google Scholar

12 

DiStefano JK and Gerhard GS: Circulating microRNAs in nonalcoholic fatty liver disease. Expert Rev Gastroenterol Hepatol. 10:161–163. 2016.PubMed/NCBI View Article : Google Scholar

13 

Migita K, Komori A, Kozuru H, Jiuchi Y, Nakamura M, Yasunami M, Furukawa H, Abiru S, Yamasaki K, Nagaoka S, et al: Circulating microRNA profiles in patients with type-1 autoimmune hepatitis. PLoS One. 10(e0136908)2015.PubMed/NCBI View Article : Google Scholar

14 

Das K, Garnica O and Dhandayuthapani S: Modulation of Host miRNAs by intracellular bacterial pathogens. Front Cell Infect Microbiol. 6(79)2016.PubMed/NCBI View Article : Google Scholar

15 

Zhou X, Li X and Wu M: miRNAs reshape immunity and inflammatory responses in bacterial infection. Signal Transduct Target Ther. 3(14)2018.PubMed/NCBI View Article : Google Scholar

16 

Ma C, Li Y, Li M, Deng G, Wu X, Zeng J, Hao X, Wang X, Liu J, Cho WC, et al: microRNA-124 negatively regulates TLR signaling in alveolar macrophages in response to mycobacterial infection. Mol Immunol. 62:150–158. 2014.PubMed/NCBI View Article : Google Scholar

17 

Schulte LN, Eulalio A, Mollenkopf HJ, Reinhardt R and Vogel J: Analysis of the host microRNA response to Salmonella uncovers the control of major cytokines by the let-7 family. EMBO J. 30:1977–1989. 2011.PubMed/NCBI View Article : Google Scholar

18 

Lutz P, M Haimid M, Pohlmann A, Lehmann J, Jansen C, Schierwagen R, Klein S, Strassburg CP, Spengler U and Trebicka J: MicroRNA-155 is upregulated in ascites in patients with spontaneous bacterial peritonitis. Sci Rep. 7(40556)2017.PubMed/NCBI View Article : Google Scholar

19 

Sarin SK, Kumar M, Lau GK, Abbas Z, Chan HL, Chen CJ, Chen DS, Chen HL, Chen PJ, Chien RN, et al: Asian-Pacific clinical practice guidelines on the management of hepatitis B: A 2015 update. Hepatol Int. 10:1–98. 2016.PubMed/NCBI View Article : Google Scholar

20 

Shiha G, Sarin SK, Ibrahim AE, Omata M, Kumar A, Lesmana LA, Leung N, Tozun N, Hamid S, Jafri W, et al: Jury of the APASL Consensus Development Meeting 29 January 2008 on Liver Fibrosis With Without Hepatitis B or C: Liver fibrosis: Consensus recommendations of the Asian Pacific Association for the Study of the Liver (APASL). Hepatol Int. 3:323–333. 2009.PubMed/NCBI View Article : Google Scholar

21 

Bolstad BM, Irizarry RA, Åstrand M and Speed TP: A comparison of normalization methods for high density oligonucleotide array data based on variance and bias. Bioinformatics. 19:185–193. 2003.PubMed/NCBI View Article : Google Scholar

22 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method. Methods. 25:402–408. 2001.PubMed/NCBI View Article : Google Scholar

23 

Agarwal V, Bell GW, Nam JW and Bartel DP: Predicting effective microRNA target sites in mammalian mRNAs. eLife 42015.

24 

Liu W and Wang X: Prediction of functional microRNA targets by integrative modeling of microRNA binding and target expression data. 20: 18, 2019.

25 

Yu G, Wang LG, Han Y and He QY: clusterProfiler: An R package for comparing biological themes among gene clusters. OMICS. 16:284–287. 2012.PubMed/NCBI View Article : Google Scholar

26 

Shalova IN, Lim JY, Chittezhath M, Zinkernagel AS, Beasley F, Hernández-Jiménez E, Toledano V, Cubillos-Zapata C, Rapisarda A, Chen J, et al: Human monocytes undergo functional re-programming during sepsis mediated by hypoxia-inducible factor-1α. Immunity. 42:484–498. 2015.PubMed/NCBI View Article : Google Scholar

27 

Atri C, Guerfali FZ and Laouini D: Role of human macrophage polarization in inflammation during infectious diseases. Int J Mol Sci. 19(1801)2018.PubMed/NCBI View Article : Google Scholar

28 

Zhang F, Wang H, Wang X, Jiang G, Liu H, Zhang G, Wang H, Fang R, Bu X, Cai S, et al: TGF-β induces M2-like macrophage polarization via SNAIL-mediated suppression of a pro-inflammatory phenotype. Oncotarget. 7:52294–52306. 2016.PubMed/NCBI View Article : Google Scholar

29 

Song X, Xie S, Lu K and Wang C: Mesenchymal stem cells alleviate experimental asthma by inducing polarization of alveolar macrophages. Inflammation. 38:485–492. 2015.PubMed/NCBI View Article : Google Scholar

30 

Saha B, Kodys K, Szabo G and Hepatitis C: Hepatitis C virus-induced monocyte differentiation into polarized M2 macrophages promotes stellate cell activation via TGF-β. Cell Mol Gastroenterol Hepatol. 2:302–316.e8. 2016.PubMed/NCBI View Article : Google Scholar

31 

ischer P, Grigoras C, Bugariu A, Nicoara-Farcau O, Stefanescu H, Benea A, Hadade A, Margarit S, Sparchez Z, Tantau M, Ionescu D and Procopet B: Are presepsin and resistin better markers for bacterial infection in patients with decompensated liver cirrhosis? Dig Liver Dis. 51:1685–1691. 2019.PubMed/NCBI View Article : Google Scholar

32 

Johnston CJ, Smyth DJ, Dresser DW and Maizels RM: TGF-β in tolerance, development and regulation of immunity. Cell Immunol. 299:14–22. 2016.PubMed/NCBI View Article : Google Scholar

33 

Marcoe JP, Lim JR, Schaubert KL, Fodil-Cornu N, Matka M, McCubbrey AL, Farr AR, Vidal SM and Laouar Y: TGF-β is responsible for NK cell immaturity during ontogeny and increased susceptibility to infection during mouse infancy. Nat Immunol. 13:843–850. 2012.PubMed/NCBI View Article : Google Scholar

34 

Meadows SK, Eriksson M, Barber A and Sentman CL: Human NK cell IFN-gamma production is regulated by endogenous TGF-beta. Int Immunopharmacol. 6:1020–1028. 2006.PubMed/NCBI View Article : Google Scholar

35 

Dong C: TH17 cells in development: An updated view of their molecular identity and genetic programming. Nat Rev Immunol. 8:337–348. 2008.PubMed/NCBI View Article : Google Scholar

36 

Lee YS, Park JS, Jung SM, Kim SD, Kim JH, Lee JY, Jung KC, Mamura M, Lee S, Kim SJ, et al: Inhibition of lethal inflammatory responses through the targeting of membrane-associated Toll-like receptor 4 signaling complexes with a Smad6-derived peptide. EMBO Mol Med. 7:577–592. 2015.PubMed/NCBI View Article : Google Scholar

37 

Park BS and Lee JO: Recognition of lipopolysaccharide pattern by TLR4 complexes. Exp Mol Med. 45(e66)2013.PubMed/NCBI View Article : Google Scholar

38 

Choi KC, Lee YS, Lim S, Choi HK, Lee CH, Lee EK, Hong S, Kim IH, Kim SJ and Park SH: Smad6 negatively regulates interleukin 1-receptor-Toll-like receptor signaling through direct interaction with the adaptor Pellino-1. Nat Immunol. 7:1057–1065. 2006.PubMed/NCBI View Article : Google Scholar

39 

Ng PC, Chan KY, Leung KT, Tam YH, Ma TP, Lam HS, Cheung HM, Lee KH, To KF and Li K: Comparative MiRNA Expressional profiles and molecular networks in human small bowel tissues of necrotizing enterocolitis and spontaneous intestinal perforation. PLoS One. 10(e0135737)2015.PubMed/NCBI View Article : Google Scholar

40 

Staloch D, Gao X, Liu K, Xu M, Feng X, Aronson JF, Falzon M, Greeley GH, Rastellini C, Chao C, et al: Gremlin is a key pro-fibrogenic factor in chronic pancreatitis. J Mol Med (Berl). 93:1085–1093. 2015.PubMed/NCBI View Article : Google Scholar

41 

Miao H, Wang N, Shi LX, Wang Z and Song WB: Overexpression of mircoRNA-137 inhibits cervical cancer cell invasion, migration and epithelial-mesenchymal transition by suppressing the TGF-β/smad pathway via binding to GREM1. Cancer Cell Int. 19(147)2019.PubMed/NCBI View Article : Google Scholar

42 

Mori T, Takahashi K, Naito M, Kodama T, Hakamata H, Sakai M, Miyazaki A, Horiuchi S and Ando M: Endocytic pathway of scavenger receptors via trans-Golgi system in bovine alveolar macrophages. Lab Invest. 71:409–416. 1994.PubMed/NCBI

43 

Xu Z, Xu L, Li W, Jin X, Song X, Chen X, Zhu J, Zhou S, Li Y, Zhang W, et al: Innate scavenger receptor-A regulates adaptive T helper cell responses to pathogen infection. Nat Commun. 8(16035)2017.PubMed/NCBI View Article : Google Scholar

44 

Thomas CA, Li Y, Kodama T, Suzuki H, Silverstein SC and El Khoury J: Protection from lethal gram-positive infection by macrophage scavenger receptor-dependent phagocytosis. J Exp Med. 191:147–156. 2000.PubMed/NCBI View Article : Google Scholar

45 

Arredouani MS, Yang Z, Imrich A, Ning Y, Qin G and Kobzik L: The macrophage scavenger receptor SR-AI/II and lung defense against pneumococci and particles. Am J Respir Cell Mol Biol. 35:474–478. 2006.PubMed/NCBI View Article : Google Scholar

46 

Wang J, Nikrad MP, Travanty EA, Zhou B, Phang T, Gao B, Alford T, Ito Y, Nahreini P, Hartshorn K, et al: Innate immune response of human alveolar macrophages during influenza A infection. PLoS One. 7(e29879)2012.PubMed/NCBI View Article : Google Scholar

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Lin S, Lin M, Ma H, Wang X, Zhang D, Wu W, Lin J and Gao H: Identification of miR-4793-3p as a potential biomarker for bacterial infection in patients with hepatitis B virus-related liver cirrhosis: A pilot study. Exp Ther Med 21: 120, 2021.
APA
Lin, S., Lin, M., Ma, H., Wang, X., Zhang, D., Wu, W. ... Gao, H. (2021). Identification of miR-4793-3p as a potential biomarker for bacterial infection in patients with hepatitis B virus-related liver cirrhosis: A pilot study. Experimental and Therapeutic Medicine, 21, 120. https://doi.org/10.3892/etm.2020.9552
MLA
Lin, S., Lin, M., Ma, H., Wang, X., Zhang, D., Wu, W., Lin, J., Gao, H."Identification of miR-4793-3p as a potential biomarker for bacterial infection in patients with hepatitis B virus-related liver cirrhosis: A pilot study". Experimental and Therapeutic Medicine 21.2 (2021): 120.
Chicago
Lin, S., Lin, M., Ma, H., Wang, X., Zhang, D., Wu, W., Lin, J., Gao, H."Identification of miR-4793-3p as a potential biomarker for bacterial infection in patients with hepatitis B virus-related liver cirrhosis: A pilot study". Experimental and Therapeutic Medicine 21, no. 2 (2021): 120. https://doi.org/10.3892/etm.2020.9552
Copy and paste a formatted citation
x
Spandidos Publications style
Lin S, Lin M, Ma H, Wang X, Zhang D, Wu W, Lin J and Gao H: Identification of miR-4793-3p as a potential biomarker for bacterial infection in patients with hepatitis B virus-related liver cirrhosis: A pilot study. Exp Ther Med 21: 120, 2021.
APA
Lin, S., Lin, M., Ma, H., Wang, X., Zhang, D., Wu, W. ... Gao, H. (2021). Identification of miR-4793-3p as a potential biomarker for bacterial infection in patients with hepatitis B virus-related liver cirrhosis: A pilot study. Experimental and Therapeutic Medicine, 21, 120. https://doi.org/10.3892/etm.2020.9552
MLA
Lin, S., Lin, M., Ma, H., Wang, X., Zhang, D., Wu, W., Lin, J., Gao, H."Identification of miR-4793-3p as a potential biomarker for bacterial infection in patients with hepatitis B virus-related liver cirrhosis: A pilot study". Experimental and Therapeutic Medicine 21.2 (2021): 120.
Chicago
Lin, S., Lin, M., Ma, H., Wang, X., Zhang, D., Wu, W., Lin, J., Gao, H."Identification of miR-4793-3p as a potential biomarker for bacterial infection in patients with hepatitis B virus-related liver cirrhosis: A pilot study". Experimental and Therapeutic Medicine 21, no. 2 (2021): 120. https://doi.org/10.3892/etm.2020.9552
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team