Toxicity of the acetyl‑para‑aminophenol group of medicines to intact intervertebral disc tissue cells

Karaarslan,Numan; Yilmaz,Ibrahi̇m; Yasar Sirin,Duygu

doi:10.3892/etm.2020.9578

Toxicity of the acetyl‑para‑aminophenol group of medicines to intact intervertebral disc tissue cells

Authors:
- Numan Karaarslan
- Ibrahi̇m Yilmaz
- Duygu Yasar Sirin
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Affiliations: Department of Neurosurgery, School of Medicine, Namik Kemal University, Tekirdag 59100, Turkey, Department of Medical Pharmacology, School of Medicine, Istanbul Medipol University, Istanbul 34810, Turkey, Department of Molecular Biology and Genetics, Faculty of Arts and Sciences, Namik Kemal University, Tekirdag 59100, Turkey
Published online on: December 16, 2020 https://doi.org/10.3892/etm.2020.9578
Article Number: 147
Copyright: © Karaarslan et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

The present study aimed to investigate the effects of paracetamol, an analgesic and antipyretic that is used in emergency departments and neurosurgery departments for postoperative pain management on intervertebral disc tissue. Paracetamol‑treated human primary cell cultures and untreated cell cultures were compared using molecular analyses. Cell proliferation and gene expression were statistically analyzed. Cell proliferation was suppressed on days 10 (P=0.05) and 20 (P<0.05) in the paracetamol‑treated groups. Gene expression of chondroadherin, matrix metalloproteinase (MMP)‑7, MMP‑13 and MMP‑19 was higher in the paracetamol‑treated samples while gene expression of Cartilage Oligomeric Matrix Protein and interleukin‑1β was lower (P<0.05). Paracetamol, which appears innocuous compared with many analgesics, may increase the expression of MMPs, which serve a significant role in catabolic reactions and suppress the proliferation of intact intervertebral disc tissue cells.

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