Expression and significance of S‑100β, CysC and NF‑κB in patients with acute cerebral infarction

Li,Zaili; Xin,Zaie

doi:10.3892/etm.2020.9580

Expression and significance of S‑100β, CysC and NF‑κB in patients with acute cerebral infarction

Authors:
- Zaili Li
- Zaie Xin
View Affiliations

Affiliations: Department of Neurology, Xuzhou Central Hospital, Xuzhou, Jiangsu 221009, P.R. China
Published online on: December 16, 2020 https://doi.org/10.3892/etm.2020.9580
Article Number: 149

Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )

Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )

Cited By (CrossRef): 0 citations Loading Articles...

Abstract

The present study aimed to explore the expression and significance of S100 protein β (S100β), cystatin C (CysC), and nuclear factor kappa B (NF‑κB) in patients with acute cerebral infarction (ACI). ACI patients (n=120) were selected as the experimental group at Xuzhou Central Hospital from August 2016 to August 2018. Ninety healthy subjects who underwent a physical examination at Xuzhou Central Hospital during the same period were selected as the control group. The expression levels of S‑100β, CysC and NF‑κB were compared between the two groups. Serum S‑100β, CysC and NF‑κB levels were compared between ACI patients with different degree of nervous functional defects, different infarct size and different prognosis. ROC curve analysis was used for the diagnosis of ACI by serum S‑100β, CysC and NF‑κB levels. Serum S‑100β, CysC and NF‑κB levels in the experimental group were higher than those in the control group (P<0.05). The levels of serum S‑100β, CysC and NF‑κB in patients with different neurological deficits were significantly different. The levels of serum S‑100β, CysC and NF‑κB in the severe and medium type infarction group were significantly higher than those in the mild type infarction group (both P<0.05). The levels of serum S‑100β, CysC and NF‑κB in the severe type infarction group were higher than those in the medium type infarction group (P<0.05). There were significant differences in serum S‑100β, CysC and NF‑κB levels in patients with different infarct sizes. The levels of serum S‑100β, CysC and NF‑κB in patients with large and medium size infarction were higher than those in the small size infarction group (both P<0.05). The levels of serum S‑100β, CysC and NF‑κB in patients with large size infarction were higher than those in patients with medium size infarction (P<0.05). Serum S‑100β, CysC and NF‑κB levels in patients of the worsening group were significantly higher than those in patients of the non‑worsening group. The levels of S‑100β, CysC, NF‑κB in ACI patients were significantly higher than those in healthy subjects. Increased levels of S‑100β, CysC and NF‑κB can be used as ideal indexes for diagnosing cerebral infarction and studying the condition.

View Figures

View References

1	Sun Y, He W and Geng L: Neuroprotective mechanism of HIF-1α overexpression in the early stage of acute cerebral infarction in rats. Exp Ther Med. 12:391–395. 2016.PubMed/NCBI View Article : Google Scholar
2	Shen HJ, He HY and Dai MX: Observation on the therapeutic effect of aspirin in combined with ozagrel sodium in the treatment of acute cerebral infarction. J Hainan Med Univ. 23:141–144. 2017.(In Chinese).
3	Qing-Qing R, Wei-Dong Q and Neurology DO: The role of Th17 in stroke in patients with acute atherosclerotic cerebral infarction. Chin J Stroke, 2017.
4	Podolecki T, Pudlo R, Mazurek M, Koziel M, Jedrzejczyk-Patej E, Boidol J, Przybylska K, Sokal A, Kowalski O, Kowalczyk J, et al: The incidence, clinical significance, and treatment effects of depression in cardiac resynchronization therapy recipients. Cardiology. 138:115–121. 2017.PubMed/NCBI View Article : Google Scholar
5	Wang Y and Zhou ZF: Correlation analysis of carotid intima media thickness and function in patients with H-type hypertension and acute cerebral infarction. J Hainan Med Univ: 23, 2017.
6	He X, Li DR, Cui C and Wen LJ: Clinical significance of serum MCP-1 and VE-cadherin levels in patients with acute cerebral infarction. Eur Rev Med Pharmacol Sci. 21:804–808. 2017.PubMed/NCBI
7	Wang A, Wang J, Zhang F, Han J, Sun D and Li M: Correlation between earlyimaging and curative effect of Ⅳ rt-PA thrombolytic therapy inacute ischemic stroke patients. Chinese Journal of Geriatric Heart Brain and Vessel Diseases. 1054–1056. 2013.
8	Sun PZ, Wang Y, Mandeville E, Chan ST, Lo EH and Ji X: Validation of fast diffusion kurtosis MRI for imaging acute ischemia in a rodent model of stroke. NMR Biomed. 27:1413–1418. 2014.PubMed/NCBI View Article : Google Scholar
9	Takahashi H, Kimura T, Yuki N and Yoshioka A: A case of stroke-like migraine attacks after radiation therapy (SMART) syndrome followed by cerebral infarction. Intern Med. 57:1921–1924. 2018.PubMed/NCBI View Article : Google Scholar
10	Hao MM, Capoccia E, Cirillo C, Boesmans W and Vanden Berghe P: Arundic acid prevents developmental upregulation of S100B expression and inhibits enteric glial development. Front Cell Neurosci. 11(42)2017.PubMed/NCBI View Article : Google Scholar
11	Sidoryk-Wegrzynowicz M, Gerber YN, Ries M, Sastre M, Tolkovsky AM and Spillantini MG: Astrocytes in mouse models oftauopathies acquire early deficits and lose neurosupportivefunctions. Acta Neuropathol Commun. 5(89)2017.PubMed/NCBI View Article : Google Scholar
12	Esposito G, Cirillo C, Sarnelli G, De Filippis D, D'Armiento FP, Rocco A, Nardone G, Petruzzelli R, Grosso M, Izzo P, et al: Enteric glial-derived S100B proteinstimulates nitric oxide production in celiac disease. Gastroenterology. 133:918–925. 2007.PubMed/NCBI View Article : Google Scholar
13	Zhao L, Han D and Feng J: Department of Neurology, the Affiliated Shengjing Hospital of China Medical University. Correlation of serum neuron specific enolase levels with severity and prognosis of acute cerebral infarction. Chin J Practical Internal Med. 34:484–487. 2014.(In Chinese).
14	Zi M and Xu Y: Involvement of cystatin C in immunity and apoptosis. Immunol Lett. 196:80–90. 2018.PubMed/NCBI View Article : Google Scholar
15	Ye Q, Tian GP, Cheng HP, Zhang X, Ou X, Yu XH, Tan RQ, Yang FY, Gong D, Huang C, et al: MicroRNA-134 promotes the development of atherosclerosis via the ANGPTL4/LPL pathway in apolipoprotein E knockout mice. J Atheroscler Thromb. 25:244–253. 2017.PubMed/NCBI View Article : Google Scholar
16	Meng QT, Chen R, Chen C, Su K, Li W, Tang LH, Liu HM, Xue R, Sun Q, Leng Y, et al: Transcription factors Nrf2 and NF-κB contribute to inflammation and apoptosis induced by intestinal ischemia-reperfusion in mice. Int J Mol Med. 40:1731–1740. 2017.PubMed/NCBI View Article : Google Scholar
17	Chen X, Wu S, Chen C, Xie B, Fang Z, Hu W, Chen J, Fu H and He H: Omega-3 polyunsaturated fatty acid supplementation attenuates microglial-induced inflammation by inhibiting the HMGB1/TLR4/NF-κB pathway following experimental traumatic brain injury. J Neuroinflammation. 14(143)2017.PubMed/NCBI View Article : Google Scholar
18	Kawano H, Inatomi Y, Hirano T and Yonehara T: Vertebral artery stump syndrome in acute ischemic stroke. J Neurol Sci. 324:74–79. 2013.PubMed/NCBI View Article : Google Scholar
19	Chu J, Shen X, Fan J and Chen C: Heat rate variability and dyssomnia and their correlations to neurological defects in cerebral infarction patients complicated by insomnia a concurrent on-randomized case-control study. Neural Regen Res. 3:66–70. 2008.
20	Finocchi C, Balestrino M, Malfatto L, Mancardi G, Serrati C and Gandolfo C: National Institutes of Health Stroke Scale in patients with primary intracerebral hemorrhage. Neurol Sci. 39:1751–1755. 2018.PubMed/NCBI View Article : Google Scholar
21	Wang XF, Li G, Fu QF, Yu XM, Zhang Z, Wang M, Xiao Y and Shen W: Effect of butylphthalide injection on volume of acute massive cerebral infarction and the matrix metalloproteinase-9. Chin J Stroke. 54–57. 2018.
22	Onatsu J, Vanninen R, Jäkälä P, Mustonen P, Pulkki K, Korhonen M, Hedman M, Zetterberg H, Blennow K, Höglund K, et al: Serum neurofilament light chain concentration correlates with infarct volume but not prognosis in acute ischemic stroke. J Stroke Cerebrovasc Dis. 28:2242–2249. 2019.PubMed/NCBI View Article : Google Scholar
23	Abe A, Sakamoto Y, Nishiyama Y, Suda S, Suzuki K, Aoki J and Kimura K: Decline in hemoglobin during hospitalization may be associated with poor outcome in acute stroke patients. J Stroke Cerebrovasc Dis. 27:1646–1652. 2018.PubMed/NCBI View Article : Google Scholar
24	Wang J, Zhang Y and Xu F: Function and mechanism of microRNA-210 in acute cerebral infarction. Exp Ther Med. 15:1263–1268. 2018.PubMed/NCBI View Article : Google Scholar
25	Xi YB: Correlation of serum MCP-1 and VE-cadherin levels with neural function and carotid atherosclerosis in patients with acute cerebral infarction. J Hainan Med Univ. 23:129–133. 2017.PubMed/NCBI
26	Wang XM, Zhang GY, Xu K, et al: Changes of serum neuron specific enolase, protein S-100 and myelin basic protein levels in patients with cerebral infarction. Zhongguo Wei Zhong Bing Ji Jiu Yi Xue. 17:572–573. 2005.PubMed/NCBI View Article : Google Scholar : (In Chinese).
27	Xu Z, Leng C, Yang B, Wang H, Sun J, Liu Z, Yang L, Ge W and Zhu J: Serum cystatin C is associated with large cerebral artery stenosis in acute ischemic stroke. Oncotarget. 8:67181–67188. 2017.PubMed/NCBI View Article : Google Scholar
28	Yang B, Zhu J, Miao Z, Zhou B, Ge W, Zhao H and Xu X: Cystatin C is an independent risk factor and therapeutic target for acute ischemic stroke. Neurotox Res. 28:1–7. 2015.PubMed/NCBI View Article : Google Scholar
29	Chan LP, Liu C, Chiang FY, Wang LF, Lee KW, Chen WT, Kuo PL and Liang CH: IL-8 promotes inflammatory mediators and stimulates activation of p38 MAPK/ERK-NF-κB pathway and reduction of JNK in HNSCC. Oncotarget. 8:56375–56388. 2017.PubMed/NCBI View Article : Google Scholar
30	Shi LH, Zhou Y, Guo MF, Liu JS, Li CX, Wang GF, Liu W and Tian L: Serum levels of S-100β correlate with the clinical status and severity of hypoxic-ischemic encephalopathy in neonates. Genet Mol Res. 14:14760–14771. 2015.PubMed/NCBI View Article : Google Scholar
31	Zhang J and Jiao Y: Effects of Maixuekang capsules combined with edaravone on serum MMP-9, S-100β protein levels and neurological functions in patients with hemorrhagic cerebral infarction. World J Integrated Tradit Western Med. 5:40–45. 2019.
32	Jiang Y and Lian YJ: Effects of Danhong injection on hemodynamics and the inflammation-related NF-κB signaling pathway in patients with acute cerebral infarction. Genet Mol Res. 14:16929–16937. 2015.PubMed/NCBI View Article : Google Scholar
33	Yang S, Cai J, Lu R, Wu J, Zhang M and Zhou X: Association between serum cystatin C level and total magnetic resonance imaging burden of cerebral small vessel disease in patients with acute lacunar stroke. J Stroke Cerebrovasc Dis. 26:186–191. 2017.PubMed/NCBI View Article : Google Scholar