Association between IL‑33 and other inflammatory factors in patients with rheumatoid arthritis and in fibroblast‑like synoviocytes in vitro

  • Authors:
    • Jing Wu
    • Qiang Li
    • Jiaxin Deng
    • Jin-Jun Zhao
    • Qing-Hong Yu
  • View Affiliations

  • Published online on: December 18, 2020     https://doi.org/10.3892/etm.2020.9592
  • Article Number: 161
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Abstract

IL‑33 is a member of the IL‑1 family of cytokines whose role remains controversial in rheumatoid arthritis (RA). The present study was performed to evaluate the correlation of IL‑33 with other cytokines and chemokines in serum and the synovia, and to explore the nature of the association. The concentration of IL‑33 in samples from 96 patients with RA was analyzed. The response of fibroblast‑like synoviocytes (FLSs) to treatment with different concentrations of IL‑33 was assessed in vitro. IL‑33 was indicated to exhibit an association with multiple cytokines and chemokines in synovial fluid with an inverted‑U‑shaped trend, including IL‑6, IL‑1β, IL‑8, MIG and IP‑10, but not in the serum. Furthermore, in vitro experiments confirmed that IL‑33 also exerted a U‑type dose‑dependent regulatory effect on FLS function. In addition, the data‑points do not exactly follow the U‑shaped curve fit in most cases, therefore, the applicability of this mathematical model in clinical practice is limited.
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February-2021
Volume 21 Issue 2

Print ISSN: 1792-0981
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Spandidos Publications style
Wu J, Li Q, Deng J, Zhao J and Yu Q: Association between IL‑33 and other inflammatory factors in patients with rheumatoid arthritis and in fibroblast‑like synoviocytes <em>in vitro</em>. Exp Ther Med 21: 161, 2021
APA
Wu, J., Li, Q., Deng, J., Zhao, J., & Yu, Q. (2021). Association between IL‑33 and other inflammatory factors in patients with rheumatoid arthritis and in fibroblast‑like synoviocytes <em>in vitro</em>. Experimental and Therapeutic Medicine, 21, 161. https://doi.org/10.3892/etm.2020.9592
MLA
Wu, J., Li, Q., Deng, J., Zhao, J., Yu, Q."Association between IL‑33 and other inflammatory factors in patients with rheumatoid arthritis and in fibroblast‑like synoviocytes <em>in vitro</em>". Experimental and Therapeutic Medicine 21.2 (2021): 161.
Chicago
Wu, J., Li, Q., Deng, J., Zhao, J., Yu, Q."Association between IL‑33 and other inflammatory factors in patients with rheumatoid arthritis and in fibroblast‑like synoviocytes <em>in vitro</em>". Experimental and Therapeutic Medicine 21, no. 2 (2021): 161. https://doi.org/10.3892/etm.2020.9592