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Inflammatory signals induce MUC16 expression in ovarian cancer cells via NF‑κB activation

  • Authors:
    • Jie Liu
    • Li Li
    • Ning Luo
    • Qi Liu
    • Li Liu
    • Dandan Chen
    • Zhongping Cheng
    • Xiaowei Xi
  • View Affiliations / Copyright

    Affiliations: Department of Obstetrics and Gynecology, Shanghai General Hospital of Nanjing Medical University, Shanghai 200080, P.R. China, Department of Obstetrics and Gynecology, Shanghai Tenth People's Hospital, Clinical College of Nanjing Medical University, Shanghai 200072, P.R. China
    Copyright: © Liu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 163
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    Published online on: December 21, 2020
       https://doi.org/10.3892/etm.2020.9594
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Abstract

Cancer antigen 125 (CA125), encoded by the mucin 16 cell surface associated (MUC16) gene, has been widely used as a biomarker for ovarian cancer (OC) screening. However, it has yet to be elucidated as to why its levels increase with tumor progression as well as with certain other non‑malignant conditions. Based on our knowledge of the inflammatory microenvironment (IME) in OC, HEY cells were treated with several inflammation‑associated factors as well as their antagonists, and it was observed that inflammation‑associated factors upregulated MUC16 gene expression. Considering the role of nuclear factor (NF)‑κB in the inflammatory signaling network and our previous research on OC, chromatin immunoprecipitation was performed, and it was observed that activated NF‑κB bound to the MUC16 gene promoter and enhanced its expression, thereby elevating secreted CA125 levels. These findings demonstrated that IME and MUC16 gene expression were associated in OC, partly elucidating the role of IME in tumor progression, explaining the elevated serum CA125 levels in some non‑malignant conditions, and confirming IME as a potential target for OC therapy.
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Copy and paste a formatted citation
Spandidos Publications style
Liu J, Li L, Luo N, Liu Q, Liu L, Chen D, Cheng Z and Xi X: Inflammatory signals induce MUC16 expression in ovarian cancer cells via NF‑κB activation. Exp Ther Med 21: 163, 2021.
APA
Liu, J., Li, L., Luo, N., Liu, Q., Liu, L., Chen, D. ... Xi, X. (2021). Inflammatory signals induce MUC16 expression in ovarian cancer cells via NF‑κB activation. Experimental and Therapeutic Medicine, 21, 163. https://doi.org/10.3892/etm.2020.9594
MLA
Liu, J., Li, L., Luo, N., Liu, Q., Liu, L., Chen, D., Cheng, Z., Xi, X."Inflammatory signals induce MUC16 expression in ovarian cancer cells via NF‑κB activation". Experimental and Therapeutic Medicine 21.2 (2021): 163.
Chicago
Liu, J., Li, L., Luo, N., Liu, Q., Liu, L., Chen, D., Cheng, Z., Xi, X."Inflammatory signals induce MUC16 expression in ovarian cancer cells via NF‑κB activation". Experimental and Therapeutic Medicine 21, no. 2 (2021): 163. https://doi.org/10.3892/etm.2020.9594
Copy and paste a formatted citation
x
Spandidos Publications style
Liu J, Li L, Luo N, Liu Q, Liu L, Chen D, Cheng Z and Xi X: Inflammatory signals induce MUC16 expression in ovarian cancer cells via NF‑κB activation. Exp Ther Med 21: 163, 2021.
APA
Liu, J., Li, L., Luo, N., Liu, Q., Liu, L., Chen, D. ... Xi, X. (2021). Inflammatory signals induce MUC16 expression in ovarian cancer cells via NF‑κB activation. Experimental and Therapeutic Medicine, 21, 163. https://doi.org/10.3892/etm.2020.9594
MLA
Liu, J., Li, L., Luo, N., Liu, Q., Liu, L., Chen, D., Cheng, Z., Xi, X."Inflammatory signals induce MUC16 expression in ovarian cancer cells via NF‑κB activation". Experimental and Therapeutic Medicine 21.2 (2021): 163.
Chicago
Liu, J., Li, L., Luo, N., Liu, Q., Liu, L., Chen, D., Cheng, Z., Xi, X."Inflammatory signals induce MUC16 expression in ovarian cancer cells via NF‑κB activation". Experimental and Therapeutic Medicine 21, no. 2 (2021): 163. https://doi.org/10.3892/etm.2020.9594
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