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MicroRNA‑140‑5p regulates the proliferation, apoptosis and inflammation of RA FLSs by repressing STAT3

  • Authors:
    • Jiehua Zhu
    • Jianglin Wang
    • Jialin Huang
    • Wensheng Du
    • Yingzhong He
    • Hongfei Pan
    • Junmin Luo
  • View Affiliations / Copyright

    Affiliations: Department of Laboratory Medicine, The Affiliated Hospital of Zunyi Medical University, Zunyi, Guizhou 563000, P.R. China, School of Laboratory Medicine, Zunyi Medical University, Zunyi, Guizhou 563000, P.R. China, Department of Immunology, Zunyi Medical University, Zunyi, Guizhou 563000, P.R. China
    Copyright: © Zhu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 171
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    Published online on: December 27, 2020
       https://doi.org/10.3892/etm.2020.9602
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Abstract

Ectopic expression of microRNA (miRNA) in rheumatoid arthritis (RA) fibroblast‑like synoviocyte (RA FLS) is associated with the development of rheumatoid arthritis. The present study aimed to evaluate the effects of miRNA‑140‑5p (miR‑140) on the properties of RA FLSs. It was found that miR‑140 expression was decreased in 33 RA patients and extracted RA FLS samples, when compared to the corresponding healthy controls. Abnormally increased miR‑140 expression in RA FLSs attenuated cell proliferation and increased cell apoptosis. Additionally, reduced pro‑inflammatory cytokine production was observed in RA FLSs transfected with a miR‑140 precursor. Furthermore, the 3'‑UTR of the signal transducer and activator of transcription (STAT) 3 gene was identified as a target of miR‑140. Notably, restoration of STAT3 expression rescued the regulatory effect of miR‑140 on the proliferation, apoptosis and inflammatory cytokine production of RA FLSs. Therefore, the current findings indicated that miR‑140 is a crucial modulator of both proliferation and apoptosis, shedding light on the etiology behind RA FLS viability, which is modulated by an interplay between miR‑140 and STAT3 in the context of RA.
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1 

Meier FM, Frerix M, Hermann W and Muller-Ladner U: Current immunotherapy in rheumatoid arthritis. Immunotherapy. 5:955–974. 2013.PubMed/NCBI View Article : Google Scholar

2 

Boissier MC, Semerano L, Challal S, Saidenberg-Kermanac'h N and Falgarone G: Rheumatoid arthritis: From autoimmunity to synovitis and joint destruction. J Autoimmun. 39:222–228. 2012.PubMed/NCBI View Article : Google Scholar

3 

Tobon GJ, Youinou P and Saraux A: The environment, geo-epidemiology, and autoimmune disease: Rheumatoid arthritis. J Autoimmun. 35:10–14. 2010.PubMed/NCBI View Article : Google Scholar

4 

Rockel JS and Kapoor M: Autophagy: Controlling cell fate in rheumatic diseases. Nat Rev Rheumatol. 13(193)2017.PubMed/NCBI View Article : Google Scholar

5 

Bartok B, Hammaker D and Firestein GS: Phosphoinositide 3-kinase delta regulates migration and invasion of synoviocytes in rheumatoid arthritis. J Immunol. 192:2063–2070. 2014.PubMed/NCBI View Article : Google Scholar

6 

Qin B, Yang M, Fu H, Ma N, Wei T, Tang Q, Hu Z, Liang Y, Yang Z and Zhong R: Body mass index and the risk of rheumatoid arthritis: A systematic review and dose-response meta-analysis. Arthritis Res Ther. 17(86)2015.PubMed/NCBI View Article : Google Scholar

7 

Qin B, Liang Y, Yang Z and Zhong R: Response to: ‘Body mass index and the risk of rheumatoid arthritis: A systematic review and dose-response meta-analysis’-authors' reply. Arthritis Res Ther. 17(217)2015.PubMed/NCBI View Article : Google Scholar

8 

Lee RC, Feinbaum RL and Ambros V: The C. Elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14. Cell. 75:843–854. 1993.PubMed/NCBI View Article : Google Scholar

9 

Kozomara A and Griffiths-Jones S: miRBase: Integrating microRNA annotation and deep-sequencing data. Nucleic Acids Res. 39:D152–D157. 2011.PubMed/NCBI View Article : Google Scholar

10 

Filkova M, Jungel A, Gay RE and Gay S: MicroRNAs in rheumatoid arthritis: Potential role in diagnosis and therapy. BioDrugs. 26:131–141. 2012.PubMed/NCBI View Article : Google Scholar

11 

Li S, Jin Z and Lu X: MicroRNA-192 suppresses cell proliferation and induces apoptosis in human rheumatoid arthritis fibroblast-like synoviocytes by downregulating caveolin 1. Mol Cell Biochem. 432:123–130. 2017.PubMed/NCBI View Article : Google Scholar

12 

Kurowska-Stolarska M, Alivernini S, Melchor EG, Elmesmari A, Tolusso B, Tange C, Petricca L, Gilchrist DS, Di Sante G, Keijzer C, et al: MicroRNA-34a dependent regulation of AXL controls the activation of dendritic cells in inflammatory arthritis. Nat Commun. 8(15877)2017.PubMed/NCBI View Article : Google Scholar

13 

Gao W, McCormick J, Connolly M, Balogh E, Veale D and Fearon U: Hypoxia and STAT3 signalling interactions regulate pro-inflammatory pathways in rheumatoid arthritis. Ann Rheum Dis. 74:1275–1283. 2015.PubMed/NCBI View Article : Google Scholar

14 

Isomaki P, Junttila I, Vidqvist KL, Korpela M and Silvennoinen O: The activity of JAK-STAT pathways in rheumatoid arthritis: constitutive activation of STAT3 correlates with interleukin 6 levels. Rheumatology (Oxford). 54:1103–1113. 2015.PubMed/NCBI View Article : Google Scholar

15 

Nowell MA, Richards PJ, Fielding CA, Ognjanovic S, Topley N, Williams AS, Bryant-Greenwood G and Jones SA: Regulation of pre-B cell colony-enhancing factor by STAT-3-dependent interleukin-6 tranes-signaling: Implications in the pathogenesis of rheumatoid arthritis. Arthritis Rheum. 54:2084–2095. 2006.PubMed/NCBI View Article : Google Scholar

16 

Turkson J and Jove R: STAT proteins: Novel molecular targets for cancer drug discovery. Oncogene. 19:6613–6626. 2000.PubMed/NCBI View Article : Google Scholar

17 

Turkson J, Bowman T, Garcia R, Caldenhoven E, De Groot RP and Jove R: Stat3 activation by src induces specific gene regulation and is required for cell transformation. Mol Cell Biol. 18:2545–2552. 1998.PubMed/NCBI View Article : Google Scholar

18 

Chen Z and Han ZC: STAT3: A critical transcription activator in angiogenesis. Med Res Rev. 28:185–200. 2008.PubMed/NCBI View Article : Google Scholar

19 

Devarajan E and Huang S: STAT3 as a central regulator of tumor metastases. Curr Mol Med. 9:626–633. 2009.PubMed/NCBI View Article : Google Scholar

20 

Starr R, Willson TA, Viney EM, Murray LJ, Rayner JR, Jenkins BJ, Gonda TJ, Alexander WS, Metcalf D, Nicola NA and Hilton DJ: A family of cytokine-inducible inhibitors of signalling. Nature. 387:917–921. 1997.PubMed/NCBI View Article : Google Scholar

21 

Endo TA, Masuhara M, Yokouchi M, Suzuki R, Sakamoto H, Mitsui K, Matsumoto A, Tanimura S, Ohtsubo M, Misawa H, et al: A new protein containing an SH2 domain that inhibits JAK kinases. Nature. 387:921–924. 1997.PubMed/NCBI View Article : Google Scholar

22 

Coombs JH, Bloom BJ, Breedveld FC, Fletcher MP, Gruben D, Kremer JM, Burgos-Vargas R, Wilkinson B, Zerbini CA and Zwillich SH: Improved pain, physical functioning and health status in patients with rheumatoid arthritis treated with CP-690,550, an orally active Janus kinase (JAK) inhibitor: Results from a randomised, double-blind, placebo-controlled trial. Ann Rheum Dis. 69:413–416. 2010.PubMed/NCBI View Article : Google Scholar

23 

Tanaka Y, Suzuki M, Nakamura H, Toyoizumi S and Zwillich SH: Tofacitinib Study Investigators. Phase II study of tofacitinib (CP-690,550) combined with methotrexate in patients with rheumatoid arthritis and an inadequate response to methotrexate. Arthritis Care Res (Hoboken). 63:1150–1158. 2011.PubMed/NCBI View Article : Google Scholar

24 

Dong W, Yao C, Teng X, Chai J, Yang X and Li B: miR-140-3p suppressed cell growth and invasion by downregulating the expression of ATP8A1 in non-small cell lung cancer. Tumour Biol. 37:2973–2985. 2016.PubMed/NCBI View Article : Google Scholar

25 

Wang Z, Hu J, Pan Y, Shan Y, Jiang L, Qi X and Jia L: miR-140-5p/miR-149 affects chondrocyte proliferation, apoptosis, and autophagy by targeting FUT1 in osteoarthritis. Inflammation. 41:959–971. 2018.PubMed/NCBI View Article : Google Scholar

26 

Flamini V, Jiang WG and Cui Y: Therapeutic role of miR-140-5p for the treatment of non-small cell lung cancer. Anticancer Res. 37:4319–4327. 2017.PubMed/NCBI View Article : Google Scholar

27 

Li W and He F: Monocyte to macrophage differentiation-associated (MMD) targeted by miR-140-5p regulates tumor growth in non-small cell lung cancer. Biochem Biophys Res Commun. 450:844–850. 2014.PubMed/NCBI View Article : Google Scholar

28 

Xie WB, Liang LH, Wu KG, Wang LX, He X, Song C, Wang YQ and Li YH: miR-140 expression regulates cell proliferation and targets PD-L1 in NSCLC. Cell Physiol Biochem. 46:654–663. 2018.PubMed/NCBI View Article : Google Scholar

29 

Yuan Y, Shen Y, Xue L and Fan H: miR-140 suppresses tumor growth and metastasis of non-small cell lung cancer by targeting insulin-like growth factor 1 receptor. PLoS One. 8(e73604)2013.PubMed/NCBI View Article : Google Scholar

30 

Song B, Wang Y, Xi Y, Kudo K, Bruheim S, Botchkina GI, Gavin E, Wan Y, Formentini A, Kornmann M, et al: Mechanism of chemoresistance mediated by miR-140 in human osteosarcoma and colon cancer cells. Oncogene. 28:4065–4074. 2009.PubMed/NCBI View Article : Google Scholar

31 

Wei R, Cao G, Deng Z, Su J and Cai L: miR-140-5p attenuates chemotherapeutic drug-induced cell death by regulating autophagy through inositol 1,4,5-trisphosphate kinase 2 (IP3k2) in human osteosarcoma cells. Biosci Rep. 36(e00392)2016.PubMed/NCBI View Article : Google Scholar

32 

Xiao Q, Huang L, Zhang Z, Chen X, Luo J, Zhang Z, Chen S, Shu Y, Han Z and Cao K: Overexpression of miR-140 inhibits proliferation of osteosarcoma cells via suppression of histone deacetylase 4. Oncol Res. 25:267–275. 2017.PubMed/NCBI View Article : Google Scholar

33 

Li H, Guan SB, Lu Y and Wang F: miR-140-5p inhibits synovial fibroblasts proliferation and inflammatory cytokines secretion through targeting TLR4. Biomed Pharmacother. 96:208–214. 2017.PubMed/NCBI View Article : Google Scholar

34 

Liu X, Wang S, Yuan A, Yuan X and Liu B: MicroRNA-140 represses glioma growth and metastasis by directly targeting ADAM9. Oncol Rep. 36:2329–2338. 2016.PubMed/NCBI View Article : Google Scholar

35 

Rothman AM, Arnold ND, Pickworth JA, Iremonger J, Ciuclan L, Allen RM, Guth-Gundel S, Southwood M, Morrell NW, Thomas M, et al: MicroRNA-140-5p and SMURF1 regulate pulmonary arterial hypertension. J Clin Invest. 126:2495–2508. 2016.PubMed/NCBI View Article : Google Scholar

36 

Zhang R, Ma J and Yao J: Molecular mechanisms of the cartilage-specific microRNA-140 in osteoarthritis. Inflamm Res. 62:871–877. 2013.PubMed/NCBI View Article : Google Scholar

37 

Aggarwal R, Rider LG, Ruperto N, Bayat N, Erman B, Feldman BM, Oddis CV, Amato AA, Chinoy H, Cooper RG, et al: 2016 American college of rheumatology/european league against rheumatism criteria for minimal, moderate, and major clinical response in adult dermatomyositis and polymyositis: An international myositis assessment and clinical studies group/paediatric rheumatology international trials organisation collaborative initiative. Ann Rheum Dis. 76:792–801. 2017.PubMed/NCBI View Article : Google Scholar

38 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods. 25:402–408. 2001.PubMed/NCBI View Article : Google Scholar

39 

Agarwal V, Bell GW, Nam JW and Bartel DP: Predicting effective microRNA target sites in mammalian mRNAs. Elife. 12(4)2015.PubMed/NCBI View Article : Google Scholar

40 

Friedman RC, Farh KK, Burge CB and Bartel DP: Most mammalian mRNAs are conserved targets of microRNAs. Genome Res. 19:92–105. 2009.PubMed/NCBI View Article : Google Scholar

41 

Lan H, Chen W, He G and Yang S: miR-140-5p inhibits ovarian cancer growth partially by repression of PDGFRA. Biomed Pharmacother. 75:117–122. 2015.PubMed/NCBI View Article : Google Scholar

42 

Alsaleh G, Francois A, Philippe L, Gong YZ, Bahram S, Cetin S, Pfeffer S, Gottenberg JE, Wachsmann D, Georgel P and Sibilia J: miR-30a-3p negatively regulates BAFF synthesis in systemic sclerosis and rheumatoid arthritis fibroblasts. PLoS One. 9(e111266)2014.PubMed/NCBI View Article : Google Scholar

43 

Alivernini S, Kurowska-Stolarska M, Tolusso B, Benvenuto R, Elmesmari A, Canestri S, Petricca L, Mangoni A, Fedele AL, Di Mario C, et al: MicroRNA-155 influences B-cell function through PU.1 in rheumatoid arthritis. Nat Commun. 7(12970)2016.PubMed/NCBI View Article : Google Scholar

44 

Chen SY: MicroRNA-223: A double-edged sword in rheumatoid arthritis. Rheumatol Int. 34:285–286. 2014.PubMed/NCBI View Article : Google Scholar

45 

Shi DL, Shi GR, Xie J, Du XZ and Yang H: MicroRNA-27a inhibits cell migration and invasion of fibroblast-like synoviocytes by targeting follistatin-like protein 1 in rheumatoid arthritis. Mol Cells. 39:611–618. 2016.PubMed/NCBI View Article : Google Scholar

46 

Chen Y, Xian PF, Yang L and Wang SX: MicroRNA-21 promotes proliferation of fibroblast-like synoviocytes through mediation of NF-κB nuclear translocation in a rat model of collagen-induced rheumatoid arthritis. Biomed Res Int. 2016(9279078)2016.PubMed/NCBI View Article : Google Scholar

47 

Zhang F and Wu Z: Significantly altered expression of miR-511-3p and its target AKT3 has negative prognostic value in human prostate cancer. Biochimie. 140:66–72. 2017.PubMed/NCBI View Article : Google Scholar

48 

Pais H, Nicolas FE, Soond SM, Swingler TE, Clark IM, Chantry A, Moulton V and Dalmay T: Analyzing mRNA expression identifies Smad3 as a microRNA-140 target regulated only at protein level. RNA. 16:489–494. 2010.PubMed/NCBI View Article : Google Scholar

49 

Sun J, Shi R, Zhao S, Li X, Lu S, Bu H, Ma X and Su C: E2F8, a direct target of miR-144, promotes papillary thyroid cancer progression via regulating cell cycle. J Exp Clin Cancer Res. 36(40)2017.PubMed/NCBI View Article : Google Scholar

50 

Masuda M, Suzui M, Yasumatu R, Nakashima T, Kuratomi Y, Azuma K, Tomita K, Komiyama S and Weinstein IB: Constitutive activation of signal transducers and activators of transcription 3 correlates with cyclin D1 overexpression and may provide a novel prognostic marker in head and neck squamous cell carcinoma. Cancer Res. 62:3351–3355. 2002.PubMed/NCBI

51 

Kim BH, Yi EH and Ye SK: Signal transducer and activator of transcription 3 as a therapeutic target for cancer and the tumor microenvironment. Arch Pharm Res. 39:1085–1099. 2016.PubMed/NCBI View Article : Google Scholar

52 

Cafferkey C and Chau I: Novel STAT 3 inhibitors for treating gastric cancer. Expert Opin Investig Drugs. 25:1023–1031. 2016.PubMed/NCBI View Article : Google Scholar

53 

Bosch-Barrera J, Queralt B and Menendez JA: Targeting STAT3 with silibinin to improve cancer therapeutics. Cancer Treat Rev. 58:61–69. 2017.PubMed/NCBI View Article : Google Scholar

54 

Xiong H, Zhang ZG, Tian XQ, Sun DF, Liang QC, Zhang YJ, Lu R, Chen YX and Fang JY: Inhibition of JAK1, 2/STAT3 signaling induces apoptosis, cell cycle arrest, and reduces tumor cell invasion in colorectal cancer cells. Neoplasia. 10:287–297. 2008.PubMed/NCBI View Article : Google Scholar

55 

Liu Y, Li PK, Li C and Lin J: Inhibition of STAT3 signaling blocks the anti-apoptotic activity of IL-6 in human liver cancer cells. J Biol Chem. 285:27429–27439. 2010.PubMed/NCBI View Article : Google Scholar

56 

Aoki Y, Feldman GM and Tosato G: Inhibition of STAT3 signaling induces apoptosis and decreases survivin expression in primary effusion lymphoma. Blood. 101:1535–1542. 2003.PubMed/NCBI View Article : Google Scholar

57 

Meng Q, Du X, Wang H, Gu H, Zhan J and Zhou Z: Astragalus polysaccharides inhibits cell growth and pro-inflammatory response in IL-1β-stimulated fibroblast-like synoviocytes by enhancement of autophagy via PI3K/AKT/mTOR inhibition. Apoptosis. 22:1138–1146. 2017.PubMed/NCBI View Article : Google Scholar

58 

Li J, Li Y, Jiao J, Wang J, Li Y, Qin D and Li P: Mitofusin 1 is negatively regulated by microRNA 140 in cardiomyocyte apoptosis. Mol Cell Biol. 34:1788–1799. 2014.PubMed/NCBI View Article : Google Scholar

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Copy and paste a formatted citation
Spandidos Publications style
Zhu J, Wang J, Huang J, Du W, He Y, Pan H and Luo J: MicroRNA‑140‑5p regulates the proliferation, apoptosis and inflammation of RA FLSs by repressing STAT3. Exp Ther Med 21: 171, 2021.
APA
Zhu, J., Wang, J., Huang, J., Du, W., He, Y., Pan, H., & Luo, J. (2021). MicroRNA‑140‑5p regulates the proliferation, apoptosis and inflammation of RA FLSs by repressing STAT3. Experimental and Therapeutic Medicine, 21, 171. https://doi.org/10.3892/etm.2020.9602
MLA
Zhu, J., Wang, J., Huang, J., Du, W., He, Y., Pan, H., Luo, J."MicroRNA‑140‑5p regulates the proliferation, apoptosis and inflammation of RA FLSs by repressing STAT3". Experimental and Therapeutic Medicine 21.2 (2021): 171.
Chicago
Zhu, J., Wang, J., Huang, J., Du, W., He, Y., Pan, H., Luo, J."MicroRNA‑140‑5p regulates the proliferation, apoptosis and inflammation of RA FLSs by repressing STAT3". Experimental and Therapeutic Medicine 21, no. 2 (2021): 171. https://doi.org/10.3892/etm.2020.9602
Copy and paste a formatted citation
x
Spandidos Publications style
Zhu J, Wang J, Huang J, Du W, He Y, Pan H and Luo J: MicroRNA‑140‑5p regulates the proliferation, apoptosis and inflammation of RA FLSs by repressing STAT3. Exp Ther Med 21: 171, 2021.
APA
Zhu, J., Wang, J., Huang, J., Du, W., He, Y., Pan, H., & Luo, J. (2021). MicroRNA‑140‑5p regulates the proliferation, apoptosis and inflammation of RA FLSs by repressing STAT3. Experimental and Therapeutic Medicine, 21, 171. https://doi.org/10.3892/etm.2020.9602
MLA
Zhu, J., Wang, J., Huang, J., Du, W., He, Y., Pan, H., Luo, J."MicroRNA‑140‑5p regulates the proliferation, apoptosis and inflammation of RA FLSs by repressing STAT3". Experimental and Therapeutic Medicine 21.2 (2021): 171.
Chicago
Zhu, J., Wang, J., Huang, J., Du, W., He, Y., Pan, H., Luo, J."MicroRNA‑140‑5p regulates the proliferation, apoptosis and inflammation of RA FLSs by repressing STAT3". Experimental and Therapeutic Medicine 21, no. 2 (2021): 171. https://doi.org/10.3892/etm.2020.9602
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