Open Access

Role of mono‑ADP‑ribosylation histone modification (Review)

  • Authors:
    • Jing-Jing Zha
    • Yi Tang
    • Ya-Lan Wang
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  • Published online on: March 31, 2021     https://doi.org/10.3892/etm.2021.10009
  • Article Number: 577
  • Copyright: © Zha et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

The current knowledge regarding ADP‑ribosylation modifications of histones, particularly mono‑ADP‑ribosylation modifications, is limited. However, recent studies have identified an increasing number of mono‑ADP‑ribosyltransferases and the role of mono‑ADP‑ribosylation has become a hot research topic. In particular, histones that are substrates of several mono‑ADP‑ribosyltransferases and mono‑ADP‑ribosylated histones were indicated to be involved in numerous physiological or pathological processes. Compared to poly‑ADP‑ribosylation histone modification, the use of mono‑ADP‑ribosylation histone modification is restricted by the limited methods for research into its function in physiological or pathological processes. The aim of the present review was to discuss the details regarding mono‑ADP‑ribosylation modification of histones and the currently known functions thereof, such as cell physiological and pathological processes, including tumorigenesis.
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June-2021
Volume 21 Issue 6

Print ISSN: 1792-0981
Online ISSN:1792-1015

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Spandidos Publications style
Zha J, Tang Y and Wang Y: Role of mono‑ADP‑ribosylation histone modification (Review). Exp Ther Med 21: 577, 2021
APA
Zha, J., Tang, Y., & Wang, Y. (2021). Role of mono‑ADP‑ribosylation histone modification (Review). Experimental and Therapeutic Medicine, 21, 577. https://doi.org/10.3892/etm.2021.10009
MLA
Zha, J., Tang, Y., Wang, Y."Role of mono‑ADP‑ribosylation histone modification (Review)". Experimental and Therapeutic Medicine 21.6 (2021): 577.
Chicago
Zha, J., Tang, Y., Wang, Y."Role of mono‑ADP‑ribosylation histone modification (Review)". Experimental and Therapeutic Medicine 21, no. 6 (2021): 577. https://doi.org/10.3892/etm.2021.10009