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Article Open Access

Metformin attenuates diabetic renal injury via the AMPK‑autophagy axis

Retraction in: /10.3892/etm.2025.12957
  • Authors:
    • Tingli Sun
    • Jizhang Liu
    • Changying Xie
    • Jun Yang
    • Lijie Zhao
    • Jingbo Yang
  • View Affiliations / Copyright

    Affiliations: Department of Nephrology, General Hospital of Daqing Oil Field, Daqing, Heilongjiang 163001, P.R. China, Department of Geriatrics, General Hospital of Daqing Oil Field, Daqing, Heilongjiang 163001, P.R. China
    Copyright: © Sun et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 578
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    Published online on: March 31, 2021
       https://doi.org/10.3892/etm.2021.10010
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Abstract

Diabetic nephropathy (DN) is a clinical condition characterized by kidney damage that is observed in patients with diabetes. DN is the main cause of end‑stage renal disease (ESRD), which is the final stage of chronic kidney disease. Increasing evidence suggests that metformin, a characteristic oral hypoglycemic drug used for treating diabetes, exerts beneficial effects on various medical conditions and diseases, including cancer, cardiovascular diseases and thyroid‑related disorders. However, the impact of metformin on DN remains unknown. The present study investigated whether metformin could attenuate the inflammatory response, fibrosis and increased oxidative stress observed during DN in diabetic/dyslipidemic (db/db) mice. The kidneys of the mice (12‑16 weeks) were isolated for immunohistochemistry and western blotting. The results demonstrated that metformin significantly reduced the oxidative damage and fibrosis in the kidneys of db/db mice. Furthermore, metformin treatment significantly inhibited the generation of inflammatory cytokines, including TNF‑α and IL‑1β in db/db mice. These effects were induced by the activation of the AMP‑activated protein kinase (AMPK) pathway, which was mediated by increased phosphorylation of AMPK and mammalian target of rapamycin (mTOR), resulting in autophagy and the simultaneous decrease in reactive oxygen species production, cell apoptosis and inflammatory response. These findings suggested that metformin may reduce DN damage via regulation of the AMPK‑mTOR‑autophagy axis and indicated that metformin may be considered as a potential target in the treatment of DN.
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1 

da Silva EG, Borges Dos Anjos LR, Mendes de Lima R, Alves TB, Pedrino GR, Helena da Silva Cruz A, da Silva Santos R, Freiria-Oliveira AH and da Silva Reis AA: Clinical data and risk factors for diabetic nephropathy in Brazilian central population. Data Brief. 21:1315–1320. 2018.PubMed/NCBI View Article : Google Scholar

2 

Chai Z, Wu T, Dai A, Huynh P, Koentgen F, Krippner G, Ren S and Cooper ME: Targeting the CDA1/CDA1BP1 Axis Retards Renal Fibrosis in Experimental Diabetic Nephropathy. Diabetes. 68:395–408. 2019.PubMed/NCBI View Article : Google Scholar

3 

Du N, Xu Z, Gao M, Liu P, Sun B and Cao X: Combination of Ginsenoside Rg1 and Astragaloside IV reduces oxidative stress and inhibits TGF-β1/Smads signaling cascade on renal fibrosis in rats with diabetic nephropathy. Drug Des Devel Ther. 12:3517–3524. 2018.PubMed/NCBI View Article : Google Scholar

4 

Qiu DD, Liu J, Shi JS, An Y, Ge YC, Zhou ML and Jiang S: Renoprotection provided by dipeptidyl peptidase-4 inhibitors in combination with angiotensin receptor blockers in patients with type 2 diabetic nephropathy. Chin Med J (Engl). 131:2658–2665. 2018.PubMed/NCBI View Article : Google Scholar

5 

Chen F, Zhu X, Sun Z and Ma Y: Astilbin inhibits high glucose-induced inflammation and extracellular matrix accumulation by suppressing the TLR4/MyD88/NF-κB pathway in rat glomerular mesangial cells. Front Pharmacol. 9(1187)2018.PubMed/NCBI View Article : Google Scholar

6 

Rovira-Llopis S, Escribano-Lopez I, Diaz-Morales N, Iannantuoni F, Lopez-Domenech S, Andújar I, Jover A, Pantoja J, Pallardo LM, Bañuls C, et al: Downregulation of miR-31 in diabetic nephropathy and its relationship with inflammation. Cell Physiol Biochem. 50:1005–1014. 2018.PubMed/NCBI View Article : Google Scholar

7 

Moreno JA, Gomez-Guerrero C, Mas S, Sanz AB, Lorenzo O, Ruiz-Ortega M, Opazo L, Mezzano S and Egido J: Targeting inflammation in diabetic nephropathy: A tale of hope. Expert Opin Investig Drugs. 27:917–930. 2018.PubMed/NCBI View Article : Google Scholar

8 

Li J, Dong R, Yu J, Yi S, Da J, Yu F and Zha Y: Inhibitor of IGF1 receptor alleviates the inflammation process in the diabetic kidney mouse model without activating SOCS2. Drug Des Devel Ther. 12:2887–2896. 2018.PubMed/NCBI View Article : Google Scholar

9 

Eriguchi M, Bernstein EA, Veiras LC, Khan Z, Cao DY, Fuchs S, McDonough AA, Toblli JE, Gonzalez-Villalobos RA, Bernstein KE, et al: The absence of the ACE N-domain decreases renal inflammation and facilitates sodium excretion during diabetic kidney disease. J Am Soc Nephrol. 29:2546–2561. 2018.PubMed/NCBI View Article : Google Scholar

10 

Li J, Li N, Yan S, Liu M, Sun B, Lu Y and Shao Y: Ursolic acid alleviates inflammation and against diabetes induced nephropathy through TLR4 mediated inflammatory pathway. Mol Med Rep. 18:4675–4681. 2018.PubMed/NCBI View Article : Google Scholar

11 

Gurley SB, Ghosh S, Johnson SA, Azushima K, Sakban RB, George SE, Maeda M, Meyer TW and Coffman TM: Inflammation and Immunity Pathways Regulate Genetic Susceptibility to Diabetic Nephropathy. Diabetes. 67:2096–2106. 2018.PubMed/NCBI View Article : Google Scholar

12 

Olatunji OJ, Chen H and Zhou Y: Lycium chinense leaves extract ameliorates diabetic nephropathy by suppressing hyperglycemia mediated renal oxidative stress and inflammation. Biomed Pharmacother. 102:1145–1151. 2018.PubMed/NCBI View Article : Google Scholar

13 

Zhang X, Guo K, Feng X, Zhao X, Huang Z and Niu JJBB: FGF23C-tail improves diabetic nephropathy by attenuating renal fibrosis and inflammation. BMC Biotechnol. 18(33)2018.PubMed/NCBI View Article : Google Scholar

14 

Chen X and Fang M: Oxidative stress mediated mitochondrial damage plays roles in pathogenesis of diabetic nephropathy rat. Eur Rev Med Pharmacol Sci. 22:5248–5254. 2018.PubMed/NCBI View Article : Google Scholar

15 

Zhang B, Zhang X, Zhang C, Shen Q, Sun G and Sun X: Notoginsenoside R1 protects db/db mice against diabetic nephropathy via upregulation of Nrf2-mediated HO-1 expression. Molecules. 24(24)2019.PubMed/NCBI View Article : Google Scholar

16 

Liu CH, Hua N, Fu X, Pan YL, Li B and Li XD: Metformin regulates atrial SK2 and SK3 expression through inhibiting the PKC/ERK signaling pathway in type 2 diabetic rats. BMC Cardiovasc Disord. 18(236)2018.PubMed/NCBI View Article : Google Scholar

17 

Ashamalla M, Youssef I, Yacoub M, Jayarangaiah A, Gupta N, Ray J, Iqbal S, Miller R, Singh J and McFarlane SI: Obesity, Diabetes and Gastrointestinal Malignancy: The role of Metformin and other Anti-diabetic Therapy. Glob J Obes Diabetes Metab Syndr. 5:008–14. 2018.PubMed/NCBI View Article : Google Scholar

18 

Liu Y, Hu X, Shan X, Chen K and Tang H: Rosiglitazone metformin adduct inhibits hepatocellular carcinoma proliferation via activation of AMPK/p21 pathway. Cancer Cell Int. 19(13)2019.PubMed/NCBI View Article : Google Scholar

19 

Donnan K and Segar L: SGLT2 inhibitors and metformin: Dual antihyperglycemic therapy and the risk of metabolic acidosis in type 2 diabetes. Eur J Pharmacol. 846:23–29. 2019.PubMed/NCBI View Article : Google Scholar

20 

Abdellatif M, Sedej S, Carmona-Gutierrez D, Madeo F and Kroemer G: Autophagy in Cardiovascular Aging. Circ Res. 123:803–824. 2018.PubMed/NCBI View Article : Google Scholar

21 

Li DD, Guo JF, Huang JJ, Wang LL, Deng R, Liu JN, Feng GK, Xiao DJ, Deng SZ, Zhang XS and Zhu XF: Rhabdastrellic acid-A induced autophagy-associated cell death through blocking Akt pathway in human cancer cells. PLoS One. 5(e12176)2010.PubMed/NCBI View Article : Google Scholar

22 

DiTacchio KA, Heinemann SF and Dziewczapolski G: Metformin treatment alters memory function in a mouse model of Alzheimer's disease. J Alzheimers Dis. 44:43–48. 2015.PubMed/NCBI View Article : Google Scholar

23 

Arnoux I, Willam M, Griesche N, Krummeich J, Watari H, Offermann N, Weber S, Narayan Dey P, Chen C, Monteiro O, et al: Metformin reverses early cortical network dysfunction and behavior changes in Huntington's disease. eLife. 7(7)2018.PubMed/NCBI View Article : Google Scholar

24 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method. Methods. 25:402–408. 2001.PubMed/NCBI View Article : Google Scholar

25 

Huang S, Xu Y, Ge X, Xu B, Peng W, Jiang X, Shen L and Xia L: Long noncoding RNA NEAT1 accelerates the proliferation and fibrosis in diabetic nephropathy through activating Akt/mTOR signaling pathway. J Cell Physiol, 2018.

26 

Kim H, Dusabimana T, Kim SR, Je J, Jeong K, Kang MC, Cho KM, Kim HJ and Park SW: Supplementation of abelmoschus manihot ameliorates diabetic nephropathy and hepatic steatosis by activating autophagy in mice. Nutrients. 10(10)2018.PubMed/NCBI View Article : Google Scholar

27 

Liu L, Yang L, Chang B, Zhang J, Guo Y and Yang X: The protective effects of rapamycin on cell autophagy in the renal tissues of rats with diabetic nephropathy via mTOR-S6K1-LC3II signaling pathway. Ren Fail. 40:492–497. 2018.PubMed/NCBI View Article : Google Scholar

28 

Hu ZB, Ma KL, Zhang Y, Wang GH, Liu L, Lu J, Chen PP, Lu CC and Liu BC: Inflammation-activated CXCL16 pathway contributes to tubulointerstitial injury in mouse diabetic nephropathy. Acta Pharmacol Sin. 39:1022–1033. 2018.PubMed/NCBI View Article : Google Scholar

29 

Cebeci E, Cakan C, Gursu M, Uzun S, Karadag S, Koldas M, Calhan T, Helvaci SA and Ozturk S: The main determinants of serum resistin level in type 2 diabetic patients are renal function and inflammation not presence of microvascular complication, Obesity and Insulin Resistance. Exp Clin Endocrinol Diabetes. 127:189–194. 2019.PubMed/NCBI View Article : Google Scholar

30 

Heidari A, Hamidi G, Soleimani A, Aghadavod E and Asemi Z: Effects of coenzyme Q10 supplementation on gene expressions related to insulin, lipid, and inflammation pathways in patients with diabetic nephropathy. Iran J Kidney Dis. 12:14–21. 2018.PubMed/NCBI

31 

Aroune D, Libdiri F, Leboucher S, Maouche B, Marco S and El-Aoufi S: Changes in the NFκB and E-cadherin expression are associated to diabetic nephropathy inPsammomys obesus. Saudi J Biol Sci. 24:843–850. 2017.PubMed/NCBI View Article : Google Scholar

32 

Jain SK, Croad JL, Velusamy T, Rains JL and Bull R: Chromium dinicocysteinate supplementation can lower blood glucose, CRP, MCP-1, ICAM-1, creatinine, apparently mediated by elevated blood vitamin C and adiponectin and inhibition of NFkappaB, Akt, and Glut-2 in livers of zucker diabetic fatty rats. Mol Nutr Food Res. 54:1371–1380. 2010.PubMed/NCBI View Article : Google Scholar

33 

Liu X, Zhang Y, Shi M, Wang Y, Zhang F, Yan R, Liu L, Xiao Y and Guo B: Notch1 regulates PTEN expression to exacerbate renal tubulointerstitial fibrosis in diabetic nephropathy by inhibiting autophagy via interactions with Hes1. Biochem Biophys Res Commun. 497:1110–1116. 2018.PubMed/NCBI View Article : Google Scholar

34 

Zhang Y, Zhao S, Wu D, Liu X, Shi M, Wang Y, Zhang F, Ding J, Xiao Y and Guo B: MicroRNA-22 promotes renal tubulointerstitial fibrosis by targeting PTEN and suppressing autophagy in diabetic nephropathy. J Diabetes Res. 2018(4728645)2018.PubMed/NCBI View Article : Google Scholar

35 

Wang X, Gao L, Lin H, Song J, Wang J, Yin Y, Zhao J, Xu X, Li Z and Li L: Mangiferin prevents diabetic nephropathy progression and protects podocyte function via autophagy in diabetic rat glomeruli. Eur J Pharmacol. 824:170–178. 2018.PubMed/NCBI View Article : Google Scholar

36 

Feng Y, Chen S, Xu J, Zhu Q, Ye X, Ding D, Yao W and Lu Y: Dysregulation of lncRNAs GM5524 and GM15645 involved in high glucose induced podocyte apoptosis and autophagy in diabetic nephropathy. Mol Med Rep. 18:3657–3664. 2018.PubMed/NCBI View Article : Google Scholar

37 

Pontrelli P, Oranger A, Barozzino M, Divella C, Conserva F, Fiore MG, Rossi R, Papale M, Castellano G, Simone S, et al: Deregulation of autophagy under hyperglycemic conditions is dependent on increased lysine 63 ubiquitination: A candidate mechanism in the progression of diabetic nephropathy. J Mol Med (Berl). 96:645–659. 2018.PubMed/NCBI View Article : Google Scholar

38 

Hou S, Zhang T, Li Y, Guo F and Jin X: Glycyrrhizic acid prevents diabetic nephropathy by activating AMPK/SIRT1/PGC-1α signaling in db/db Mice. J Diabetes Res. 2017(2865912)2017.PubMed/NCBI View Article : Google Scholar

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Copy and paste a formatted citation
Spandidos Publications style
Sun T, Liu J, Xie C, Yang J, Zhao L and Yang J: Metformin attenuates diabetic renal injury via the AMPK‑autophagy axis Retraction in /10.3892/etm.2025.12957. Exp Ther Med 21: 578, 2021.
APA
Sun, T., Liu, J., Xie, C., Yang, J., Zhao, L., & Yang, J. (2021). Metformin attenuates diabetic renal injury via the AMPK‑autophagy axis Retraction in /10.3892/etm.2025.12957. Experimental and Therapeutic Medicine, 21, 578. https://doi.org/10.3892/etm.2021.10010
MLA
Sun, T., Liu, J., Xie, C., Yang, J., Zhao, L., Yang, J."Metformin attenuates diabetic renal injury via the AMPK‑autophagy axis Retraction in /10.3892/etm.2025.12957". Experimental and Therapeutic Medicine 21.6 (2021): 578.
Chicago
Sun, T., Liu, J., Xie, C., Yang, J., Zhao, L., Yang, J."Metformin attenuates diabetic renal injury via the AMPK‑autophagy axis Retraction in /10.3892/etm.2025.12957". Experimental and Therapeutic Medicine 21, no. 6 (2021): 578. https://doi.org/10.3892/etm.2021.10010
Copy and paste a formatted citation
x
Spandidos Publications style
Sun T, Liu J, Xie C, Yang J, Zhao L and Yang J: Metformin attenuates diabetic renal injury via the AMPK‑autophagy axis Retraction in /10.3892/etm.2025.12957. Exp Ther Med 21: 578, 2021.
APA
Sun, T., Liu, J., Xie, C., Yang, J., Zhao, L., & Yang, J. (2021). Metformin attenuates diabetic renal injury via the AMPK‑autophagy axis Retraction in /10.3892/etm.2025.12957. Experimental and Therapeutic Medicine, 21, 578. https://doi.org/10.3892/etm.2021.10010
MLA
Sun, T., Liu, J., Xie, C., Yang, J., Zhao, L., Yang, J."Metformin attenuates diabetic renal injury via the AMPK‑autophagy axis Retraction in /10.3892/etm.2025.12957". Experimental and Therapeutic Medicine 21.6 (2021): 578.
Chicago
Sun, T., Liu, J., Xie, C., Yang, J., Zhao, L., Yang, J."Metformin attenuates diabetic renal injury via the AMPK‑autophagy axis Retraction in /10.3892/etm.2025.12957". Experimental and Therapeutic Medicine 21, no. 6 (2021): 578. https://doi.org/10.3892/etm.2021.10010
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