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Diclofenac impairs the proliferation and glucose metabolism of triple‑negative breast cancer cells by targeting the c‑Myc pathway

  • Authors:
    • Lihui Yang
    • Jiachen Li
    • Yongzhuo Li
    • Yongli Zhou
    • Ziqian Wang
    • Dahao Zhang
    • Jinlu Liu
    • Xiaodong Zhang
  • View Affiliations / Copyright

    Affiliations: Department of Nursing, Guangxi Medical University Nursing College, Nanning, Guangxi 530021, P.R. China, Department of Clinical Medicine, Guangxi Medical University The First Clinical Medical College, Nanning, Guangxi 530021, P.R. China, Department of Medicine Guangxi University Medical College, Nanning, Guangxi 530004, P.R. China, Department of Gastrointestinal and Gland Surgery, The First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi 530021, P.R. China
    Copyright: © Yang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 584
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    Published online on: April 2, 2021
       https://doi.org/10.3892/etm.2021.10016
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Abstract

Triple‑negative breast cancer (TNBC) cells obtain energy mainly through aerobic glycolysis, and their glycolytic rate is significantly higher compared with that of non‑TNBC cells. Glucose transporter 1 (GLUT1) is a transmembrane transporter necessary for the entry of glucose into tumor cells, hexokinase (HK) is a key enzyme in the glycolytic pathway, and both are targets of the transcription factor c‑Myc. c‑Myc can promote aerobic glycolysis by upregulating GLUT1 expression and enhancing HK activity. c‑Myc and GLUT1 are highly expressed in TNBC. The non‑steroidal anti‑inflammatory drug diclofenac can inhibit glycolysis in melanoma cells and thereby promote apoptosis by downregulating c‑Myc and GLUT1. To explore the effect of diclofenac on the energy metabolism of TNBC cells and determine the underlying mechanism, a comparative study in two TNBC cell lines (MDA‑MB‑231 and HCC1937) and one non‑TNBC cell line (MCF‑7) was conducted. Cell proliferation was detected by Cell Counting Kit‑8 (CCK‑8) and flow cytometric assays; GLUT1 and c‑Myc expression was measured by western blotting. Diclofenac significantly inhibited cell proliferation, downregulated GLUT1 and c‑Myc expression, and decreased HK activity in TNBC cells compared with non‑TNBC cells. In conclusion, the studies suggested that diclofenac inhibited cell glycolysis and suppressed TNBC cell growth by decreasing GLUT1 protein expression and HK activity through the c‑Myc pathway.
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1 

Foulkes WD, Smith IE and Reis-Filho JS: Triple-negative breast cancer. N Engl J Med. 363:1938–1948. 2010.PubMed/NCBI View Article : Google Scholar

2 

Shen L, O'Shea JM, Kaadige MR, Cunha S, Wilde BR, Cohen AL, Welm AL and Ayer DE: Metabolic reprogramming in triple-negative breast cancer through Myc suppression of TXNIP. Proc Natl Acad Sci USA. 112:5425–5430. 2015.PubMed/NCBI View Article : Google Scholar

3 

Luo C, Wang Y, Wei C, Chen Y and Ji Z: The anti-migration and anti-invasion effects of Bruceine D in human triple-negative breast cancer MDA-MB-231 cells. Exp Ther Med. 19:273–279. 2020.PubMed/NCBI View Article : Google Scholar

4 

Yin L, Qi XW, Liu XZ, Yang ZY, Cai RL, Cui HJ, Chen L and Yu SC: Icaritin enhances the efficacy of cetuximab against triple-negative breast cancer cells. Oncol Lett. 19:3950–3958. 2020.PubMed/NCBI View Article : Google Scholar

5 

Li C, Li X, Li G, Sun L, Zhang W, Jiang J and Ge Q: Identification of a prognosis-associated signature associated with energy metabolism in triple-negative breast cancer. Oncol Rep. 44:819–837. 2020.PubMed/NCBI View Article : Google Scholar

6 

Warburg O: On the origin of cancer cells. Science. 123:309–314. 1956.PubMed/NCBI View Article : Google Scholar

7 

Long JP, Li XN and Zhang F: Targeting metabolism in breast cancer: How far we can go? World J Clin Oncol. 7:122–130. 2016.PubMed/NCBI View Article : Google Scholar

8 

Deng D and Yan N: GLUT, SGLT, and SWEET: Structural and mechanistic investigations of the glucose transporters. Protein Sci. 25:546–558. 2016.PubMed/NCBI View Article : Google Scholar

9 

Godoy A, Ulloa V, Rodríguez F, Reinicke K, Yañez AJ, García Mde L, Medina RA, Carrasco M, Barberis S, Castro T, et al: Differential subcellular distribution of glucose transporters GLUT1-6 and GLUT9 in human cancer: Ultrastructural localization of GLUT1 and GLUT5 in breast tumor tissues. J Cell Physiol. 207:614–627. 2006.PubMed/NCBI View Article : Google Scholar

10 

Rogers S, Docherty SE, Slavin JL, Henderson MA and Best JD: Differential expression of GLUT12 in breast cancer and normal breast tissue. Cancer Lett. 193:225–233. 2003.PubMed/NCBI View Article : Google Scholar

11 

Garrido P, Morán J, Alonso A, González S and González C: 17β-estradiol activates glucose uptake via GLUT4 translocation and PI3K/Akt signaling pathway in MCF-7 cells. Endocrinology. 154:1979–1989. 2013.PubMed/NCBI View Article : Google Scholar

12 

Krzeslak A, Wojcik-Krowiranda K, Forma E, Jozwiak P, Romanowicz H, Bienkiewicz A and Brys M: Expression of GLUT1 and GLUT3 glucose transporters in endometrial and breast cancers. Pathol Oncol Res. 18:721–728. 2012.PubMed/NCBI View Article : Google Scholar

13 

Choi J, Jung WH and Koo JS: Metabolism-related proteins are differentially expressed according to the molecular subtype of invasive breast cancer defined by surrogate immunohistochemistry. Pathobiology. 80:41–52. 2013.PubMed/NCBI View Article : Google Scholar

14 

Hsieh AL, Walton ZE, Altman BJ, Stine ZE and Dang CV: MYC and metabolism on the path to cancer. Semin Cell Dev Biol. 43:11–21. 2015.PubMed/NCBI View Article : Google Scholar

15 

Palaskas N, Larson SM, Schultz N, Komisopoulou E, Wong J, Rohle D, Campos C, Yannuzzi N, Osborne JR, Linkov I, et al: 18F-fluorodeoxy-glucose positron emission tomography marks MYC-overexpressing human basal-like breast cancers. Cancer Res. 71:5164–5174. 2011.PubMed/NCBI View Article : Google Scholar

16 

Gottfried E, Lang SA, Renner K, Bosserhoff A, Gronwald W, Rehli M, Einhell S, Gedig I, Singer K, Seilbeck A, et al: New aspects of an old drug-diclofenac targets MYC and glucose metabolism in tumor cells. PLoS One. 8(e66987)2013.PubMed/NCBI View Article : Google Scholar

17 

Penny HL, Sieow JL, Adriani G, Yeap WH, See Chi Ee P, San Luis B, Lee B, Lee T, Mak SY, Ho YS, et al: Warburg metabolism in tumor-conditioned macrophages promotes metastasis in human pancreatic ductal adenocarcinoma. Oncoimmunology. 5(e1191731)2016.PubMed/NCBI View Article : Google Scholar

18 

Guo X, Zhang X, Wang T, Xian S and Lu Y: 3-Bromopyruvate and sodium citrate induce apoptosis in human gastric cancer cell line MGC-803 by inhibiting glycolysis and promoting mitochondria-regulated apoptosis pathway. Biochem Biophys Res Commun. 475:37–43. 2016.PubMed/NCBI View Article : Google Scholar

19 

Johnson J, Rychahou P, Sviripa VM, Weiss HL, Liu C, Watt DS and Evers BM: Induction of AMPK activation by N,N'-diarylurea FND-4b decreases growth and increases apoptosis in triple negative and estrogen-receptor positive breast cancers. PLoS One. 14(e0209392)2019.PubMed/NCBI View Article : Google Scholar

20 

Pelicano H, Zhang W, Liu J, Hammoudi N, Dai J, Xu RH, Pusztai L and Huang P: Mitochondrial dysfunction in some triple-negative breast cancer cell lines: Role of mTOR pathway and therapeutic potential. Breast Cancer Res. 16(434)2014.PubMed/NCBI View Article : Google Scholar

21 

Butt JH, Barthel JS, Hosokawa MC and Moore RA: NSAIDs: A clinical approach to the problems of gastrointestinal side-effects. Aliment Pharmacol Ther. 2 (Suppl 1):S121–S129. 1988.PubMed/NCBI View Article : Google Scholar

22 

Grosser T, Ricciotti E and FitzGerald GA: The cardiovascular pharmacology of nonsteroidal anti-inflammatory drugs. Trends Pharmacol Sci. 38:733–748. 2017.PubMed/NCBI View Article : Google Scholar

23 

Barron CC, Bilan PJ, Tsakiridis T and Tsiani E: Facilitative glucose transporters: Implications for cancer detection, prognosis and treatment. Metabolism. 65:124–139. 2016.PubMed/NCBI View Article : Google Scholar

24 

Zhou YX, Zhou KM, Liu Q, Wang H, Wang W, Shi Y and Ma YQ: The effect of Glut1 and c-myc on prognosis in esophageal squamous cell carcinoma of Kazakh and Han patients. Future Oncol. 14:1801–1815. 2018.PubMed/NCBI View Article : Google Scholar

25 

Carvalho KC, Cunha IW, Rocha RM, Ayala FR, Cajaíba MM, Begnami MD, Vilela RS, Paiva GR, Andrade RG and Soares FA: GLUT1 expression in malignant tumors and its use as an immunodiagnostic marker. Clinics (Sao Paulo). 66:965–972. 2011.PubMed/NCBI View Article : Google Scholar

26 

Vander Heiden MG, Cantley LC and Thompson CB: Understanding the Warburg effect: The metabolic requirements of cell proliferation. Science. 324:1029–1033. 2009.PubMed/NCBI View Article : Google Scholar

27 

Geng C, Li J, Ding F, Wu G, Yang Q, Sun Y, Zhang Z, Dong T and Tian X: Curcumin suppresses 4-hydroxytamoxifen resistance in breast cancer cells by targeting SLUG/Hexokinase 2 pathway. Biochem Biophys Res Commun. 473:147–153. 2016.PubMed/NCBI View Article : Google Scholar

28 

Chauhan A, Paul R, Debnath M, Bessi I, Mandal S, Schwalbe H and Dash J: Synthesis of fluorescent binaphthyl amines that bind c-MYC G-quadruplex DNA and repress c-MYC expression. J Med Chem. 59:7275–7281. 2016.PubMed/NCBI View Article : Google Scholar

29 

Chen H, Liu H and Qing G: Targeting oncogenic Myc as a strategy for cancer treatment. Signal Transduct Target Ther. 3(5)2018.PubMed/NCBI View Article : Google Scholar

30 

Kfoury A, Armaro M, Collodet C, Sordet-Dessimoz J, Giner MP, Christen S, Moco S, Leleu M, de Leval L, Koch U, et al: AMPK promotes survival of c-Myc-positive melanoma cells by suppressing oxidative stress. EMBO J. 37(e97673)2018.PubMed/NCBI View Article : Google Scholar

31 

Jayasooriya RGPT, Dilshara MG, Karunarathne WAHM, Molagoda IMN, Choi YH and Kim GY: Camptothecin enhances c-Myc-mediated endoplasmic reticulum stress and leads to autophagy by activating Ca2+-mediated AMPK. Food Chem Toxicol. 121:648–656. 2018.PubMed/NCBI View Article : Google Scholar

32 

Duan Q, Li H, Gao C, Zhao H, Wu S, Wu H, Wang C, Shen Q and Yin T: High glucose promotes pancreatic cancer cells to escape from immune surveillance via AMPK-Bmi1-GATA2-MICA/B pathway. J Exp Clin Cancer Res. 38(192)2019.PubMed/NCBI View Article : Google Scholar

33 

Gutiérrez-Salmerón M, García-Martínez JM, Martínez-Useros J, Fernández-Aceñero MJ, Viollet B, Olivier S, Chauhan J, Lucena SR, De la Vieja A, Goding CR, et al: Paradoxical activation of AMPK by glucose drives selective EP300 activity in colorectal cancer. PLoS Biol. 18(e3000732)2020.PubMed/NCBI View Article : Google Scholar

34 

Li Y, Liang R, Sun M, Li Z, Sheng H, Wang J, Xu P, Liu S, Yang W, Lu B, et al: AMPK-dependent phosphorylation of HDAC8 triggers PGM1 expression to promote lung cancer cell survival under glucose starvation. Cancer Lett. 478:82–92. 2020.PubMed/NCBI View Article : Google Scholar

35 

Osthus RC, Shim H, Kim S, Li Q, Reddy R, Mukherjee M, Xu Y, Wonsey D, Lee LA and Dang CV: Deregulation of glucose transporter 1 and glycolytic gene expression by c-Myc. J Biol Chem. 275:21797–21800. 2000.PubMed/NCBI View Article : Google Scholar

36 

O'Connell BC, Cheung AF, Simkevich CP, Tam W, Ren X, Mateyak MK and Sedivy JM: A large scale genetic analysis of c-Myc-regulated gene expression patterns. J Biol Chem. 278:12563–12573. 2003.PubMed/NCBI View Article : Google Scholar

37 

Dang CV, O'Donnell KA, Zeller KI, Nguyen T, Osthus RC and Li F: The c-Myc target gene network. Semin Cancer Biol. 16:253–264. 2006.PubMed/NCBI View Article : Google Scholar

38 

Liu Y, Xiang F, Huang Y, Shi L, Hu C, Yang Y, Wang D, He N, Tao K, Wu K and Wang G: Interleukin-22 promotes aerobic glycolysis associated with tumor progression via targeting hexokinase-2 in human colon cancer cells. Oncotarget. 8:25372–25383. 2017.PubMed/NCBI View Article : Google Scholar

39 

Koepsell H: The Na+-D-glucose cotransporters SGLT1 and SGLT2 are targets for the treatment of diabetes and cancer. Pharmacol Ther. 170:148–165. 2017.PubMed/NCBI View Article : Google Scholar

40 

Komatsu S, Nomiyama T, Numata T, Kawanami T, Hamaguchi Y, Iwaya C, Horikawa T, Fujimura-Tanaka Y, Hamanoue N, Motonaga R, et al: SGLT2 inhibitor ipragliflozin attenuates breast cancer cell proliferation. Endocr J. 67:99–106. 2020.PubMed/NCBI View Article : Google Scholar

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Copy and paste a formatted citation
Spandidos Publications style
Yang L, Li J, Li Y, Zhou Y, Wang Z, Zhang D, Liu J and Zhang X: Diclofenac impairs the proliferation and glucose metabolism of triple‑negative breast cancer cells by targeting the c‑Myc pathway. Exp Ther Med 21: 584, 2021.
APA
Yang, L., Li, J., Li, Y., Zhou, Y., Wang, Z., Zhang, D. ... Zhang, X. (2021). Diclofenac impairs the proliferation and glucose metabolism of triple‑negative breast cancer cells by targeting the c‑Myc pathway. Experimental and Therapeutic Medicine, 21, 584. https://doi.org/10.3892/etm.2021.10016
MLA
Yang, L., Li, J., Li, Y., Zhou, Y., Wang, Z., Zhang, D., Liu, J., Zhang, X."Diclofenac impairs the proliferation and glucose metabolism of triple‑negative breast cancer cells by targeting the c‑Myc pathway". Experimental and Therapeutic Medicine 21.6 (2021): 584.
Chicago
Yang, L., Li, J., Li, Y., Zhou, Y., Wang, Z., Zhang, D., Liu, J., Zhang, X."Diclofenac impairs the proliferation and glucose metabolism of triple‑negative breast cancer cells by targeting the c‑Myc pathway". Experimental and Therapeutic Medicine 21, no. 6 (2021): 584. https://doi.org/10.3892/etm.2021.10016
Copy and paste a formatted citation
x
Spandidos Publications style
Yang L, Li J, Li Y, Zhou Y, Wang Z, Zhang D, Liu J and Zhang X: Diclofenac impairs the proliferation and glucose metabolism of triple‑negative breast cancer cells by targeting the c‑Myc pathway. Exp Ther Med 21: 584, 2021.
APA
Yang, L., Li, J., Li, Y., Zhou, Y., Wang, Z., Zhang, D. ... Zhang, X. (2021). Diclofenac impairs the proliferation and glucose metabolism of triple‑negative breast cancer cells by targeting the c‑Myc pathway. Experimental and Therapeutic Medicine, 21, 584. https://doi.org/10.3892/etm.2021.10016
MLA
Yang, L., Li, J., Li, Y., Zhou, Y., Wang, Z., Zhang, D., Liu, J., Zhang, X."Diclofenac impairs the proliferation and glucose metabolism of triple‑negative breast cancer cells by targeting the c‑Myc pathway". Experimental and Therapeutic Medicine 21.6 (2021): 584.
Chicago
Yang, L., Li, J., Li, Y., Zhou, Y., Wang, Z., Zhang, D., Liu, J., Zhang, X."Diclofenac impairs the proliferation and glucose metabolism of triple‑negative breast cancer cells by targeting the c‑Myc pathway". Experimental and Therapeutic Medicine 21, no. 6 (2021): 584. https://doi.org/10.3892/etm.2021.10016
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