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Effects of Xiaochaihu decoction on the expression of cytochrome P450s in rats

  • Authors:
    • Hongfang Li
    • Yunyan Tang
    • Weipeng Wei
    • Chengchen Yin
    • Fushan Tang
  • View Affiliations / Copyright

    Affiliations: Department of Clinical Pharmacy, Key Laboratory of Basic Pharmacology of Guizhou Province and School of Pharmacy, Zunyi Medical University, Zunyi, Guizhou 563000, P.R. China
    Copyright: © Li et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 588
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    Published online on: April 2, 2021
       https://doi.org/10.3892/etm.2021.10020
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Abstract

Xiaochaihu decoction is one of the most important traditional Chinese medicines that is widely used with other drugs in clinical practice, and may cause drug‑drug interactions. However, there is not sufficient experimental evidence for the effects of Xiaochaihu decoction on cytochrome P450s (CYPs). The aim of the present study was to investigate the effects of Xiaochaihu decoction on the mRNA and protein levels of hepatic CYPs. Eighty normal male Sprague‑Dawley (SD) rats were randomly divided into two groups based on body weight and duration of drug administration (3 and 6 days). Each group was further divided into subgroups: Control group (2 ml 5‰ CMC‑Na); hepatic enzyme inducer group (50 mg/kg/day rifampicin); and experimental groups (Xiaochaihu decoction: Low dose, 1.7 g/kg/day; medium dose, 3.4 g/kg/day; high dose, 6.8 g/kg/day). The effects of Xiaochaihu decoction on Cyp1a2, Cyp3a1, Cyp2d6, and Cyp1b1 mRNA and protein expression in rats were evaluated using reverse transcription quantitative reverse transcription polymerase chain reaction and western blot analysis. After 3 days, medium dose of Xiaochaihu decoction inhibited the mRNA and protein expression of Cyp1a2, Cyp3a1 and Cyp1b1. In addition, after 6 days, Xiaochaihu decoction induced Cyp3a1 mRNA expression at low and medium doses; Cyp2d6 mRNA expression at low and high doses; and Cyp2d6 protein expression at high doses. Nonetheless, the gene and protein expression of Cyp1b1 was not affected at any dose. The findings of the present study may provide insights into potential drug‑drug interactions associated with Xiaochaihu decoction.
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1 

Nishimura N, Uemura T, Iwamoto K and Naora K: Change in tolbutamide permeability in rat jejunum and Caco-2 cells by Sho-saiko-to (Xiao Chai Hu Tang), a Chinese traditional medicine. J Pharm Pharmacol. 62:651–657. 2010.PubMed/NCBI View Article : Google Scholar

2 

Li JX, Cao Y, Zhang YW and Yang L: Analysis of disease spectrum of Xiaochaihu decoction. J China Pres Drug. 16:102–103. 2018.(In Chinese).

3 

Chinese Pharmacopoeia Commission: Pharmacopoeia of the People's Republic of China: One. Beijing: China Medical Science Press, 2015: 574-576.

4 

Liu CG and Du DH: Effects of Xiaochaihu decoction combined with Lansoprazole on reflux esophagitis. Contemp Med. 21:157–158. 2015.

5 

Li WJ: Evaluation of the efficacy of Xiaochaihu decoction in the treatment of angina pectoris. Res Integr Tradit Chin West Med. 8:41–42. 2016.(In Chinese).

6 

Lin JB, Zhang YG and Lin PJ: To analyze the clinical effect of Xiaochaihu decoction combined with entecavir on chronic hepatitis B. Guide China Med. 15:204–205. 2016.(In Chinese).

7 

Palleria C, Di Paolo A, Giofrè C, Caglioti C, Leuzzi G, Siniscalchi A, De Sarro G and Gallelli L: Pharmacokinetic drug-drug interaction and their implication in clinical management. J Res Med Sci. 18:601–610. 2018.

8 

Nishimura N, Uemura T, Iwamoto K and Naora K: Effects of Sho-saiko-to on the pharmacokinetics and pharmacodynamics of tolbutamide in rats. J Pharm Pharmacol. 50:231–236. 1998.PubMed/NCBI View Article : Google Scholar

9 

Ohnishi N, Okada K, Yoshioka M, Kuroda K, Nagasawa K, Takara K and Yokoyama T: Studies on interactions between traditional herbal and western medicines. V. Effects of Sho-saiko-to (Xiao-Cai-Hu-Tang) on the pharmacokinetics of carbamazepine in rats. Biol Pharm Bull. 25:1461–1466. 2002.PubMed/NCBI View Article : Google Scholar

10 

Zhou Y, Chu XM, Ling SS, Cai WM and Wang QW: Effects of oral administration of Xiaochaih granule on whole blood cyclosporin A concentration in kidney transplantation patients. Chin J Hosp Pharm. 19:713–714. 1999.(In Chinese).

11 

Khojasteh SC, Driscoll JP, Jackson KD, Miller GP, Mitra K, Rietjens IMCM and Zhang D: Novel advances in cytochrome p450 research. Drug Discov Today. 16:793–799. 2011.PubMed/NCBI View Article : Google Scholar

12 

Pillai VC, Strom SC, Caritis SN and Venkataramanan R: A sensitive and specific Cyp cocktail assay for the simultaneous assessment of human cytochrome p450 activities in primary cultures of human hepatocytes using LC-MS/MS. J Pharm Biomed Anal. 74:126–132. 2013.PubMed/NCBI View Article : Google Scholar

13 

Zanger UM and Schwab M: Cytochrome p450 enzymes in drug metabolism: Regulation of gene expression, enzyme activities, and impact of genetic variation. Pharmacol Ther. 138:103–141. 2013.PubMed/NCBI View Article : Google Scholar

14 

Zanger UM, Turpeinen M, Klein K and Schwab M: Functional pharmacogenetics/genomics of human cytochromes p450 involved in drug biotransformation. Anal Bioanal Chem. 392:1093–1108. 2008.PubMed/NCBI View Article : Google Scholar

15 

Xiu LL, Yu X, Liu DN, Wang SR, Liu HY, Chen SH and Chen F: Effects of different species of sargassum and radix Glycyrrhizae in Haizao Yuhu decoction on cytochrome P450 in goiter rats. China J Trad Chin Med Pharm. 32:2020–2025. 2017.(In Chinese).

16 

Cai H, Zhuang YS, Liu X and Cai BC: Orthogonal optimization of extraction technology of Xiaochaihu decoction. J Chin Med Mater. 35:2036–2039. 2012.(In Chinese).

17 

Li J, Xie M and Gan Y: Effect of Xiaochaihu decoction and different herbal formulation of component on inhibiting H22 liver cancer in mice and enhancing immune function. Zhongguo Zhong Yao Za Zhi. 33:1039–1044. 2008.PubMed/NCBI(In Chinese).

18 

Wu FR, Ning LJ and Zhou R: Protective effect of Xiaochaihu decoction chemical hepatic fibrosis in mice. Chin J Clin Pharm Ther. 25:481–488. 2020.(In Chinese).

19 

Lan X, Tang FS, Chen ZG, Zhang Y, Wang W and Zhou XM: Determination of baicalin in Xiaochaihu decoction by HPLC. J Zunyi Med Univ. 38:435–438. 2015.(In Chinese).

20 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C (T)) method. Methods. 25:402–408. 2001.PubMed/NCBI View Article : Google Scholar

21 

Zhao F, Tao W, Shang Z, Zhang W, Ruan J, Zhang C, Zhou L, Aiello H, Lai H and Qu R: Facilitating granule cell survival and maturation in dentate gyrus with Baicalin for antidepressant therapeutics. Front Pharmacol. 11(556845)2020.PubMed/NCBI View Article : Google Scholar

22 

Yang F, Feng C, Yao Y, Qin A, Shao H and Qian K: Antiviral effect of baicalin on Marek's disease virus in CEF cells. BMC Vet Res. 16(371)2020.PubMed/NCBI View Article : Google Scholar

23 

Li F, Wang WQ and You PJ: Advances in extraction technology of flavonoids from radix astragali. Mod Chin Med. 12:5–9. 2010.(In Chinese).

24 

Niemi M, Backman JT, Fromm MF, Neuvonen PJ and Kivistö KT: Pharmacokinetic interactions with rifampicin: Clinical relevance. Clin Pharmacokinet. 42:819–850. 2003.PubMed/NCBI View Article : Google Scholar

25 

Huang SM, Temple R, Throckmorton DC and Lesko LJ: Drug interaction studies: Study design, data analysis, and implications for dosing and labeling. Clin Pharmacol Ther. 81:298–304. 2007.PubMed/NCBI View Article : Google Scholar

26 

Mo CK, Xie YR, Chen YL, Huang M and He F: The effect of Ginkgolide A on the expression of CYP450mRNA by application of human primary hepatocyte. Pharm Today. 29:79–82. 2019.(In Chinese).

27 

Li Q, Zhen YQ, Cao WL, Gao L, Wang YC, Zhang XJ and Niu LY: Effects of saikosaponins and total glucosides of paeony on CYP450 enzyme activity and liver function of rat liver microsomes. Chin Tradit Pat Med. 4:3025–3028. 2019.(In Chinese).

28 

He M, Huang RB and Liu Z: Effects of rifampicin on cytochrome P450 superfamily and related drugs. China Pharm. 17:1664–1666. 2006.(In Chinese).

29 

Rae JM, Johnson MD, Lippman ME and Flockhart DA: Rifampin is a selective, pleiotropic inducer of drug metabolism genes in human hepatocytes: Studies with cDNA and oligonucleotide expression arrays. J Pharmacol Exp Ther. 299:849–857. 2001.PubMed/NCBI

30 

Takeda K, Watanabe J, Inoue K and Kanamura S: Rifampicin suppresses hepatic cyp2e1 expression and minimizes DNA injury caused by carbon tetrachloride in perivenular hepatocytes of mice. Alcohol Clin Exp Res. 24 (Suppl 4):87S–92S. 2000.PubMed/NCBI

31 

Yue J, Peng RX, Yang J, Kong R and Liu J: CYP2E1 mediated isoniazid-induced hepatotoxicity in rats. Acta Pharmacol Sin. 25:699–704. 2004.PubMed/NCBI

32 

Wu S, Yang HL, Li H and Sun ZX: Prohibitive effect of processed polygonum multiflorum on CYP1A2 activities and mRNA expressions of rats. World Chin Med. 11:475–478-482. 2012.(In Chinese).

33 

Pragyan P, Kesharwani SS, Nandekar PP, Rathod V and Sangamwar AT: Predicting drug metabolism by CYP1A1, CYP1A2, and CYP1B1: Insights from MetaSite, molecular docking and quantum chemical calculations. Mol Divers. 18:865–878. 2014.PubMed/NCBI View Article : Google Scholar

34 

Zhou SF, Wang B, Yang LP and Liu JP: Structure, function, regulation and polymorphism and the clinical significance of human cytochrome P4501A2. Drug Metab Rev. 42:268–354. 2010.PubMed/NCBI View Article : Google Scholar

35 

Saruwatari J, Nakagawa K, Shindo J, Nachi S, Echizen H and Ishizaki T: The in-vivo effects of sho-saiko-to, a traditional Chinese herbal medicine, on two cytochrome P450 enzymes (1A2 and 3A) and xanthine oxidase in man. J Pharm Pharmacol. 55:1553–1559. 2003.PubMed/NCBI View Article : Google Scholar

36 

Wei LY, Zhang YJ, Wei BH, Ye J, Yang XY and Sun GX: Effects of Coptis chinensis Franch, Scutellaria baicalensis Georgi and their compatibility on five CYP450 subenzymes in rat liver microsomes. China J Chin Mater Med. 38:1426–1429. 2013.PubMed/NCBI(In Chinese).

37 

Yao YC, Ni J, Han J, Feng LJ and Yan L: Effects of Scutellaria extract on cytochrome P450 enzymes. Chin J Exp Tradit Med Formul. 18:202–205. 2012.(In Chinese).

38 

Tian S, He GR, Gao M, Sun JL, Wang FB and Gui GH: Drug interaction potential of oral baicalein on metabolic enzymes in rats. Chin J New Drug. 21:2230–2234+2301. 2012.(In Chinese).

39 

Huang K, Liu ZH and He Q: Inhibition of Baicalin on activity of cytochrome P450 enzyme in rat and human liver microsomes. Chin J Exp Tradit Med Formul. 22:20–23. 2016.(In Chinese).

40 

He YJ, Shi SY, Jin KT and Gao Y: The modulation effect of Glycyrrhiza in combination with Euphorbia pekinensis, Euphorbia kansui, and Daphne genkwa on the enzyme activity of CYP1A2 in rat livers. Chin Remed Clin. 7:278–280. 2016.(In Chinese).

41 

Xiao CR, Wang YG, Dai FG, Ma ZC, Tan HL and Gao Y: The effect of aconitum coadministration with lilac daphne on cytochrome P450 in rat liver. Chin J Exper Tradit Med Formul. 12:48–50. 2006.(In Chinese).

42 

Nose M, Tamura M, Ryu N, Mizukami H and Ogihara Y: Sho-saiko-to and Saiko-keisi-to, the traditional Chinese and Japanese herbal medicines, altered hepatic drug-metabolizing enzymes in mice and rats when administered orally for a long time. J Pharm Pharmacol. 55:1419–1426. 2003.PubMed/NCBI View Article : Google Scholar

43 

Wang YH, Qi JF and Lin M: Effect of total saikosaponins on the intestinal first-pass effect and liver Cyp3a,Cyp2el. Chin J Clin Pharm Ther. 16:740–748. 2011.(In Chinese).

44 

Cheng Y, Huang Y, Tian Y, Xu L, Liu GQ and Zhang ZJ: Assessment of the effects of Radix Bupleuri and vinegar-baked Radix Bupleuri on cytochrome 450 activity by a six-drug cocktail approach. Chin J Nat Med. 11:302–308. 2013.PubMed/NCBI View Article : Google Scholar : (In Chinese).

45 

Ingelman-Sundberg M: Genetic polymorphisms of cytochrome P450 2D6 (CYP2D6): Clinical consequences, evolutionary aspects and functional diversity. Pharmacogenomics J. 5:6–13. 2005.PubMed/NCBI View Article : Google Scholar

46 

Kawakami M, Takenoshita-Nakaya S, Takeba Y, Nishimura Y, Oda M, Watanabe M, Ohta Y, Kobayashi S, Ohtsubo T, Kobayashi S, et al: Evaluation of CYP2D6 protein expression and activity in the small intestine to determine its metabolic capability in the Japanese population. Biol Pharm Bull. 40:1344–1351. 2017.PubMed/NCBI View Article : Google Scholar

47 

Zhou SF, Di YM, Chan E, Du YM, Chow VD, Xue CC, Lai X, Wang JC, Li CG, Tian M and Duan W: Clinical pharmacogenetics and potential application in personalized medicine. Curr Drug Metab. 9:738–784. 2008.PubMed/NCBI View Article : Google Scholar

48 

Dai GF, Luo R, Wang YG, Xia CY, Tan HL, Xiao CR, Zhao YH and Gao Y: Compatible effects of euphorbia and glycyrrhiza on CYP2E1 expression and activity in rat liver. J Third Mil Med Univ. 27:742–744. 2009.(In Chinese).

49 

Liu MC, Meng QQ, Cui JH and Li JS: Recent research progress on the CYP1B1 inhibitors. Prog Mod Biomed. 17:4190–4196. 2017.(In Chinese).

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Copy and paste a formatted citation
Spandidos Publications style
Li H, Tang Y, Wei W, Yin C and Tang F: Effects of Xiaochaihu decoction on the expression of cytochrome P450s in rats. Exp Ther Med 21: 588, 2021.
APA
Li, H., Tang, Y., Wei, W., Yin, C., & Tang, F. (2021). Effects of Xiaochaihu decoction on the expression of cytochrome P450s in rats. Experimental and Therapeutic Medicine, 21, 588. https://doi.org/10.3892/etm.2021.10020
MLA
Li, H., Tang, Y., Wei, W., Yin, C., Tang, F."Effects of Xiaochaihu decoction on the expression of cytochrome P450s in rats". Experimental and Therapeutic Medicine 21.6 (2021): 588.
Chicago
Li, H., Tang, Y., Wei, W., Yin, C., Tang, F."Effects of Xiaochaihu decoction on the expression of cytochrome P450s in rats". Experimental and Therapeutic Medicine 21, no. 6 (2021): 588. https://doi.org/10.3892/etm.2021.10020
Copy and paste a formatted citation
x
Spandidos Publications style
Li H, Tang Y, Wei W, Yin C and Tang F: Effects of Xiaochaihu decoction on the expression of cytochrome P450s in rats. Exp Ther Med 21: 588, 2021.
APA
Li, H., Tang, Y., Wei, W., Yin, C., & Tang, F. (2021). Effects of Xiaochaihu decoction on the expression of cytochrome P450s in rats. Experimental and Therapeutic Medicine, 21, 588. https://doi.org/10.3892/etm.2021.10020
MLA
Li, H., Tang, Y., Wei, W., Yin, C., Tang, F."Effects of Xiaochaihu decoction on the expression of cytochrome P450s in rats". Experimental and Therapeutic Medicine 21.6 (2021): 588.
Chicago
Li, H., Tang, Y., Wei, W., Yin, C., Tang, F."Effects of Xiaochaihu decoction on the expression of cytochrome P450s in rats". Experimental and Therapeutic Medicine 21, no. 6 (2021): 588. https://doi.org/10.3892/etm.2021.10020
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