Open Access

Fetal cardiac evaluation in HIV‑positive women under HAART therapy in a Romanian hospital

  • Authors:
    • Alexandra Ursache
    • Alexandra Maria Tibeica
    • Alexandru Luca
    • Mircea Onofriescu
    • Daniela Roxana Matasariu
    • Dragos Nemescu
  • View Affiliations

  • Published online on: April 14, 2021     https://doi.org/10.3892/etm.2021.10038
  • Article Number: 606
  • Copyright: © Ursache et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Human immunodeficiency virus (HIV) is an RNA (ribonucleic acid) virus that causes acquired immunodeficiency syndrome (AIDS). This disease has a major socioeconomical impact. The aim of the present study was to assess the fetal heart structure and function in HIV‑positive pregnant women on highly active antiretroviral therapy (HAART). This is a prospective study conducted between January, 2018 and December, 2019. The hearts of fetuses from 14 HIV‑positive pregnant women on HAART were assessed. Statistically significant sex‑related cardiac changes in HIV‑exposed uninfected fetuses of pregnant women on HAART were found. A narrow aorta was detected in female fetuses and a smaller left ventricular transverse diameter in male fetuses. Overall, the myocardial performance index remained unaltered. The impact of antiretroviral therapy on fetal heart seems to be sex‑related. Accurate and complete information about the risks and benefits of antiretroviral treatment and management strategies to improve fetal outcomes may also ensure better compliance of the mothers to this treatment.
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June-2021
Volume 21 Issue 6

Print ISSN: 1792-0981
Online ISSN:1792-1015

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Spandidos Publications style
Ursache A, Tibeica AM, Luca A, Onofriescu M, Matasariu DR and Nemescu D: Fetal cardiac evaluation in HIV‑positive women under HAART therapy in a Romanian hospital. Exp Ther Med 21: 606, 2021.
APA
Ursache, A., Tibeica, A.M., Luca, A., Onofriescu, M., Matasariu, D.R., & Nemescu, D. (2021). Fetal cardiac evaluation in HIV‑positive women under HAART therapy in a Romanian hospital. Experimental and Therapeutic Medicine, 21, 606. https://doi.org/10.3892/etm.2021.10038
MLA
Ursache, A., Tibeica, A. M., Luca, A., Onofriescu, M., Matasariu, D. R., Nemescu, D."Fetal cardiac evaluation in HIV‑positive women under HAART therapy in a Romanian hospital". Experimental and Therapeutic Medicine 21.6 (2021): 606.
Chicago
Ursache, A., Tibeica, A. M., Luca, A., Onofriescu, M., Matasariu, D. R., Nemescu, D."Fetal cardiac evaluation in HIV‑positive women under HAART therapy in a Romanian hospital". Experimental and Therapeutic Medicine 21, no. 6 (2021): 606. https://doi.org/10.3892/etm.2021.10038