Fetal cardiac evaluation in HIV‑positive women under HAART therapy in a Romanian hospital

Ursache,Alexandra; Tibeica,Alexandra Maria; Luca,Alexandru; Onofriescu,Mircea; Matasariu,Daniela Roxana; Nemescu,Dragos

doi:10.3892/etm.2021.10038

June-2021 Volume 21 Issue 6

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June-2021 Volume 21 Issue 6

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Fetal cardiac evaluation in HIV‑positive women under HAART therapy in a Romanian hospital

Authors:
- Alexandra Ursache
- Alexandra Maria Tibeica
- Alexandru Luca
- Mircea Onofriescu
- Daniela Roxana Matasariu
- Dragos Nemescu
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Affiliations: Department of Obstetrics and Gynecology, ‘Grigore T. Popa’ University of Medicine and Pharmacy, 700115 Iasi, Romania, Department of Obstetrics ‘Cuza Voda’ Obstetrics and Gynecology Clinical Hospital, 700038 Iasi, Romania

Copyright: © Ursache et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
Article Number: 606
|
Published online on: April 14, 2021

https://doi.org/10.3892/etm.2021.10038
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Abstract

Human immunodeficiency virus (HIV) is an RNA (ribonucleic acid) virus that causes acquired immunodeficiency syndrome (AIDS). This disease has a major socioeconomical impact. The aim of the present study was to assess the fetal heart structure and function in HIV‑positive pregnant women on highly active antiretroviral therapy (HAART). This is a prospective study conducted between January, 2018 and December, 2019. The hearts of fetuses from 14 HIV‑positive pregnant women on HAART were assessed. Statistically significant sex‑related cardiac changes in HIV‑exposed uninfected fetuses of pregnant women on HAART were found. A narrow aorta was detected in female fetuses and a smaller left ventricular transverse diameter in male fetuses. Overall, the myocardial performance index remained unaltered. The impact of antiretroviral therapy on fetal heart seems to be sex‑related. Accurate and complete information about the risks and benefits of antiretroviral treatment and management strategies to improve fetal outcomes may also ensure better compliance of the mothers to this treatment.

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Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Fetal cardiac evaluation in HIV‑positive women under HAART therapy in a Romanian hospital

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