Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Experimental and Therapeutic Medicine
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-0981 Online ISSN: 1792-1015
Journal Cover
June-2021 Volume 21 Issue 6

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
June-2021 Volume 21 Issue 6

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article Open Access

Transforming growth factor‑β1‑induced podocyte injury is associated with increased microRNA‑155 expression, enhanced inflammatory responses and MAPK pathway activation

  • Authors:
    • Xintong Zheng
    • Qiuhong Zhong
    • Xu Lin
    • Xianjun Gu
    • Xiaoyan Ling
    • Zhao Liang
    • Qing Qin
    • Xiuri Du
  • View Affiliations / Copyright

    Affiliations: Department of Nephrology, The Affiliated Hospital of Youjiang Medical University for Nationalities, Baise, Guangxi 533000, P.R. China, Department of Ultrasound, The Affiliated Hospital of Youjiang Medical University for Nationalities, Baise, Guangxi 533000, P.R. China
    Copyright: © Zheng et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 620
    |
    Published online on: April 14, 2021
       https://doi.org/10.3892/etm.2021.10052
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

MicroRNA‑155 (miR‑155) is associated with various diseases. However, the potential role of miR‑155 in early glomerular disease (EGD) remains elusive. In the present study, the clinical significance of urinary miR‑155 expression was explored in patients with EGD using receiver operating characteristic curve analysis. Conditionally immortalized mouse podocytes were cultured in vitro and treated with transforming growth factor‑β1 (TGF‑β1) at different concentrations and durations. The gene expression levels of mRNAs and miR‑155 were detected using reverse transcription‑quantitative PCR. Synaptopodin, CD2‑associated protein (CD2AP), p38, and extracellular signal‑regulated kinase (Erk) 1/2 expressions were detected using western blotting. Cell supernatants were collected for assaying tumor necrosis factor (TNF)‑α and interleukin (IL)‑6 concentrations using enzyme‑linked immunosorbent assay. The Pearson correlation analysis was used to analyze the correlation between miR‑155 levels and TNF‑α or IL‑6. It was found that miR‑155 levels in urine have high sensitivity and specificity in the diagnosis of EGD. Time‑ and dose‑dependent TGF‑β1 treatments downregulated synaptopodin and CD2AP expression levels, and activated the p38 and Erk 1/2 pathway. However, these effects were attenuated by p38 and Erk 1/2 phosphorylation inhibitors. Additionally, TNF‑α and IL‑6 secretions were elevated, and their concentrations were positively correlated with the expression of miR‑155 during podocyte injury. Thus, the present study indicated that miR‑155 is a potential biomarker for the diagnosis of EGD, and its expression is associated with the release of pro‑inflammatory cytokines and activation of mitogen‑activated protein kinase (MAPK) pathway in TGF‑β1‑induced podocyte injury. The present study suggests that the TGF‑β1/miR‑155/MAPK axis is a novel target in the mechanism of EGD.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

Figure 5

Figure 6

Figure 7

View References

1 

Zhou L and Liu Y: Wnt/β-catenin signalling and podocyte dysfunction in proteinuric kidney disease. Nat Rev Nephrol. 11:535–545. 2015.PubMed/NCBI View Article : Google Scholar

2 

D'Agati VD, Chagnac A, de Vries AP, Levi M, Porrini E, Herman-Edelstein M and Praga M: Obesity-related glomerulopathy: Clinical and pathologic characteristics and pathogenesis. Nat Rev Nephrol. 12:453–471. 2016.PubMed/NCBI View Article : Google Scholar

3 

Yaddanapudi S, Altintas MM, Kistler AD, Fernandez I, Möller CC, Wei C, Peev V, Flesche JB, Forst AL, Li J, et al: CD2AP in mouse and human podocytes controls a proteolytic program that regulates cytoskeletal structure and cellular survival. J Clin Invest. 121:3965–3980. 2011.PubMed/NCBI View Article : Google Scholar

4 

Perico L, Conti S, Benigni A and Remuzzi G: Podocyte-actin dynamics in health and disease. Nat Rev Nephrol. 12:692–710. 2016.PubMed/NCBI View Article : Google Scholar

5 

Tian X and Ishibe S: Targeting the podocyte cytoskeleton: From pathogenesis to therapy in proteinuric kidney disease. Nephrol Dial Transplant. 31:1577–1583. 2016.PubMed/NCBI View Article : Google Scholar

6 

Mundel P, Heid HW, Mundel TM, Krüger M, Reiser J and Kriz W: Synaptopodin: An actin-associated protein in telencephalic dendrites and renal podocytes. J Cell Biol. 139:193–204. 1997.PubMed/NCBI View Article : Google Scholar

7 

Asanuma K, Kim K, Oh J, Giardino L, Chabanis S, Faul C, Reiser J and Mundel P: Synaptopodin regulates the actin-bundling activity of alpha-actinin in an isoform-specific manner. J Clin Invest. 115:1188–1198. 2005.PubMed/NCBI View Article : Google Scholar

8 

Shih NY, Li J, Karpitskii V, Nguyen A, Dustin ML, Kanagawa O, Miner JH and Shaw AS: Congenital nephrotic syndrome in mice lacking CD2-associated protein. Science. 286:312–315. 1999.PubMed/NCBI View Article : Google Scholar

9 

Huang G, Lv J, Li T, Huai G, Li X, Xiang S, Wang L, Qin Z, Pang J, Zou B, et al: Notoginsenoside R1 ameliorates podocyte injury in rats with diabetic nephropathy by activating the PI3K/Akt signaling pathway. Int J Mol Med. 38:1179–1189. 2016.PubMed/NCBI View Article : Google Scholar

10 

Koga K, Yokoi H, Mori K, Kasahara M, Kuwabara T, Imamaki H, Ishii A, Mori KP, Kato Y, Ohno S, et al: MicroRNA-26a inhibits TGF-β-induced extracellular matrix protein expression in podocytes by targeting CTGF and is downregulated in diabetic nephropathy. Diabetologia. 58:2169–2180. 2015.PubMed/NCBI View Article : Google Scholar

11 

Li Z and Rana TM: Therapeutic targeting of microRNAs: Current status and future challenges. Nat Rev Drug Discov. 13:622–638. 2014.PubMed/NCBI View Article : Google Scholar

12 

Hausser J and Zavolan M: Identification and consequences of miRNA-target interactions - beyond repression of gene expression. Nat Rev Genet. 15:599–612. 2014.PubMed/NCBI View Article : Google Scholar

13 

Mashima R: Physiological roles of miR-155. Immunology. 145:323–333. 2015.PubMed/NCBI View Article : Google Scholar

14 

Lin X, You Y, Wang J, Qin Y, Huang P and Yang F: MicroRNA-155 deficiency promotes nephrin acetylation and attenuates renal damage in hyperglycemia-induced nephropathy. Inflammation. 38:546–554. 2015.PubMed/NCBI View Article : Google Scholar

15 

Chen XW, Liu WT, Wang YX, Chen WJ, Li HY, Chen YH, Du XY, Peng FF, Zhou WD, Xu ZZ, et al: Cyclopropanyldehydrocostunolide LJ attenuates high glucose-induced podocyte injury by suppressing RANKL/RANK-mediated NF-κB and MAPK signaling pathways. J Diabetes Complications. 30:760–769. 2016.PubMed/NCBI View Article : Google Scholar

16 

Chuang PY and He JC: Signaling in regulation of podocyte phenotypes. Nephron, Physiol. 111:9–15. 2009.PubMed/NCBI View Article : Google Scholar

17 

Kaminska B: MAPK signalling pathways as molecular targets for anti-inflammatory therapy - from molecular mechanisms to therapeutic benefits. Biochim Biophys Acta. 1754:253–262. 2005.PubMed/NCBI View Article : Google Scholar

18 

Kim Y, Lim HJ, Jang HJ, Lee S, Jung K, Lee SW, Lee SJ and Rho MC: Portulaca oleracea extracts and their active compounds ameliorate inflammatory bowel diseases in vitro and in vivo by modulating TNF-α, IL-6 and IL-1β signalling. Food Res Int. 106:335–343. 2018.PubMed/NCBI View Article : Google Scholar

19 

Han R, Zhang F, Wan C, Liu L, Zhong Q and Ding W: Effect of perfluorooctane sulphonate-induced Kupffer cell activation on hepatocyte proliferation through the NF-κB/TNF-α/IL-6-dependent pathway. Chemosphere. 200:283–294. 2018.PubMed/NCBI View Article : Google Scholar

20 

Yoshimura A, Wakabayashi Y and Mori T: Cellular and molecular basis for the regulation of inflammation by TGF-beta. J Biochem. 147:781–792. 2010.PubMed/NCBI View Article : Google Scholar

21 

Chapnick DA, Warner L, Bernet J, Rao T and Liu X: Partners in crime: The TGFβ and MAPK pathways in cancer progression. Cell Biosci. 1(42)2011.PubMed/NCBI View Article : Google Scholar

22 

Huang H, You Y, Lin X, Tang C, Gu X, Huang M, Qin Y, Tan J and Huang F: Inhibition of TRPC6 signal pathway alleviates podocyte injury induced by TGF-β1. Cell Physiol Biochem. 41:163–172. 2017.PubMed/NCBI View Article : Google Scholar

23 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods. 25:402–408. 2001.PubMed/NCBI View Article : Google Scholar

24 

Koshikawa M, Mukoyama M, Mori K, Suganami T, Sawai K, Yoshioka T, Nagae T, Yokoi H, Kawachi H, Shimizu F, et al: Role of p38 mitogen-activated protein kinase activation in podocyte injury and proteinuria in experimental nephrotic syndrome. J Am Soc Nephrol. 16:2690–2701. 2005.PubMed/NCBI View Article : Google Scholar

25 

Wickman L, Afshinnia F, Wang SQ, Yang Y, Wang F, Chowdhury M, Graham D, Hawkins J, Nishizono R, Tanzer M, et al: Urine podocyte mRNAs, proteinuria, and progression in human glomerular diseases. J Am Soc Nephrol. 24:2081–2095. 2013.PubMed/NCBI View Article : Google Scholar

26 

Toyoda M, Najafian B, Kim Y, Caramori ML and Mauer M: Podocyte detachment and reduced glomerular capillary endothelial fenestration in human type 1 diabetic nephropathy. Diabetes. 56:2155–2160. 2007.PubMed/NCBI View Article : Google Scholar

27 

Masum MA, Ichii O, Elewa YH, Nakamura T, Otani Y, Hosotani M and Kon Y: Modified scanning electron microscopy reveals pathological crosstalk between endothelial cells and podocytes in a murine model of membranoproliferative glomerulonephritis. Sci Rep. 8(10276)2018.PubMed/NCBI View Article : Google Scholar

28 

Mallipattu SK and He JC: Podocyte as a direct target for treatment of glomerular disease? Am J Physiol Renal Physiol. 311:F46–F51. 2016.PubMed/NCBI View Article : Google Scholar

29 

Verheijden KA, Sonneveld R, Bakker-van Bebber M, Wetzels JF, van der Vlag J and Nijenhuis T: The calcium-dependent protease calpain-1 links TRPC6 activity to podocyte injury. J Am Soc Nephrol. 29:2099–2109. 2018.PubMed/NCBI View Article : Google Scholar

30 

Qiao J, Liu Y, Jiang Z, Yang Y, Liu W and Han B: Preparation and renoprotective effects of carboxymethyl chitosan oligosaccharide on adriamycin nephropathy. Carbohydr Polym. 201:347–356. 2018.PubMed/NCBI View Article : Google Scholar

31 

Dos Santos M, Poletti PT, Favero G, Stacchiotti A, Bonomini F, Montanari CC, Bona SR, Marroni NP, Rezzani R and Veronese FV: Protective effects of quercetin treatment in a pristane-induced mouse model of lupus nephritis. Autoimmunity. 51:69–80. 2018.PubMed/NCBI View Article : Google Scholar

32 

Ishikawa M, Kobayashi N, Sugiyama F, Onoda S and Ishimitsu T: Renoprotective effect of vasopressin v2 receptor antagonist tolvaptan in Dahl rats with end-stage heart failure. Int Heart J. 54:98–106. 2013.PubMed/NCBI View Article : Google Scholar

33 

Tu Y, Sun W, Wan YG, Che XY, Pu HP, Yin XJ, Chen HL, Meng XJ, Huang YR and Shi XM: Huangkui capsule, an extract from Abelmoschus manihot (L.) medic, ameliorates adriamycin-induced renal inflammation and glomerular injury via inhibiting p38MAPK signaling pathway activity in rats. J Ethnopharmacol. 147:311–320. 2013.PubMed/NCBI View Article : Google Scholar

34 

Saikumar J, Hoffmann D, Kim TM, Gonzalez VR, Zhang Q, Goering PL, Brown RP, Bijol V, Park PJ, Waikar SS, et al: Expression, circulation, and excretion profile of microRNA-21, -155, and -18a following acute kidney injury. Toxicol Sci. 129:256–267. 2012.PubMed/NCBI View Article : Google Scholar

35 

Beltrami C, Simpson K, Jesky M, Wonnacott A, Carrington C, Holmans P, Newbury L, Jenkins R, Ashdown T, Dayan C, et al: Association of elevated urinary miR-126, miR-155, and miR-29b with diabetic kidney disease. Am J Pathol. 188:1982–1992. 2018.PubMed/NCBI View Article : Google Scholar

36 

Yang X, Zhang J and Ding Y: Association of microRNA-155, interleukin 17A, and proteinuria in preeclampsia. Medicine (Baltimore). 96(e6509)2017.PubMed/NCBI View Article : Google Scholar

37 

Neilsen PM, Noll JE, Mattiske S, Bracken CP, Gregory PA, Schulz RB, Lim SP, Kumar R, Suetani RJ, Goodall GJ, et al: Mutant p53 drives invasion in breast tumors through up-regulation of miR-155. Oncogene. 32:2992–3000. 2013.PubMed/NCBI View Article : Google Scholar

38 

Yao J, Du X, Chen S, Shao Y, Deng K, Jiang M, Liu J, Shen Z, Chen X and Feng G: Rv2346c enhances mycobacterial survival within macrophages by inhibiting TNF-α and IL-6 production via the p38/miRNA/NF-κB pathway. Emerg Microbes Infect. 7(158)2018.PubMed/NCBI View Article : Google Scholar

39 

Park M, Choi S, Kim S, Kim J, Lee DK, Park W, Kim T, Jung J, Hwang JY, Won MH, et al: NF-κB-responsive miR-155 induces functional impairment of vascular smooth muscle cells by downregulating soluble guanylyl cyclase. Exp Mol Med. 51:1–12. 2019.PubMed/NCBI View Article : Google Scholar

40 

Peng W, Zhao N, Liu Q, Nie C, Qing C, Shao Q, Liu F, Qian K and Ding C: MicroRNA-155 reduces inflammatory response induced by lipopolysaccharide in alveolar macrophages. Zhonghua Wei Zhong Bing Ji Jiu Yi Xue. 30:1061–1065. 2018.PubMed/NCBI View Article : Google Scholar : (In Chinese).

41 

Mann M, Mehta A, Zhao JL, Lee K, Marinov GK, Garcia-Flores Y, Lu LF, Rudensky AY and Baltimore D: An NF-kappaB-microRNA regulatory network tunes macrophage inflammatory responses. Nat Commun. 8(851)2017.PubMed/NCBI View Article : Google Scholar

42 

Joyce CE and Novina CD: miR-155 in acute myeloid leukemia: Not merely a prognostic marker? J Clin Oncol. 31:2219–2221. 2013.PubMed/NCBI View Article : Google Scholar

43 

Chakraborty C, Sharma AR, Patra BC, Bhattacharya M, Sharma G and Lee SS: MicroRNAs mediated regulation of MAPK signaling pathways in chronic myeloid leukemia. Oncotarget. 7:42683–42697. 2016.PubMed/NCBI View Article : Google Scholar

44 

Wang RM, Wang ZB, Wang Y, Liu WY, Li Y, Tong LC, Zhang S, Su DF, Cao YB, Li L, et al: Swiprosin-1 promotes mitochondria-dependent apoptosis of glomerular podocytes via P38 MAPK pathway in early-stage diabetic nephropathy. Cell Physiol Biochem. 45:899–916. 2018.PubMed/NCBI View Article : Google Scholar

45 

Zhu Y: PRMT1 mediates podocyte injury and glomerular fibrosis through phosphorylation of ERK pathway. Biochem Biophys Res Commun. 495:828–838. 2018.PubMed/NCBI View Article : Google Scholar

46 

Fogo AB and Kon V: The glomerulus - a view from the inside - the endothelial cell. Int J Biochem Cell Biol. 42:1388–1397. 2010.PubMed/NCBI View Article : Google Scholar

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Zheng X, Zhong Q, Lin X, Gu X, Ling X, Liang Z, Qin Q and Du X: Transforming growth factor‑β1‑induced podocyte injury is associated with increased microRNA‑155 expression, enhanced inflammatory responses and MAPK pathway activation. Exp Ther Med 21: 620, 2021.
APA
Zheng, X., Zhong, Q., Lin, X., Gu, X., Ling, X., Liang, Z. ... Du, X. (2021). Transforming growth factor‑β1‑induced podocyte injury is associated with increased microRNA‑155 expression, enhanced inflammatory responses and MAPK pathway activation. Experimental and Therapeutic Medicine, 21, 620. https://doi.org/10.3892/etm.2021.10052
MLA
Zheng, X., Zhong, Q., Lin, X., Gu, X., Ling, X., Liang, Z., Qin, Q., Du, X."Transforming growth factor‑β1‑induced podocyte injury is associated with increased microRNA‑155 expression, enhanced inflammatory responses and MAPK pathway activation". Experimental and Therapeutic Medicine 21.6 (2021): 620.
Chicago
Zheng, X., Zhong, Q., Lin, X., Gu, X., Ling, X., Liang, Z., Qin, Q., Du, X."Transforming growth factor‑β1‑induced podocyte injury is associated with increased microRNA‑155 expression, enhanced inflammatory responses and MAPK pathway activation". Experimental and Therapeutic Medicine 21, no. 6 (2021): 620. https://doi.org/10.3892/etm.2021.10052
Copy and paste a formatted citation
x
Spandidos Publications style
Zheng X, Zhong Q, Lin X, Gu X, Ling X, Liang Z, Qin Q and Du X: Transforming growth factor‑β1‑induced podocyte injury is associated with increased microRNA‑155 expression, enhanced inflammatory responses and MAPK pathway activation. Exp Ther Med 21: 620, 2021.
APA
Zheng, X., Zhong, Q., Lin, X., Gu, X., Ling, X., Liang, Z. ... Du, X. (2021). Transforming growth factor‑β1‑induced podocyte injury is associated with increased microRNA‑155 expression, enhanced inflammatory responses and MAPK pathway activation. Experimental and Therapeutic Medicine, 21, 620. https://doi.org/10.3892/etm.2021.10052
MLA
Zheng, X., Zhong, Q., Lin, X., Gu, X., Ling, X., Liang, Z., Qin, Q., Du, X."Transforming growth factor‑β1‑induced podocyte injury is associated with increased microRNA‑155 expression, enhanced inflammatory responses and MAPK pathway activation". Experimental and Therapeutic Medicine 21.6 (2021): 620.
Chicago
Zheng, X., Zhong, Q., Lin, X., Gu, X., Ling, X., Liang, Z., Qin, Q., Du, X."Transforming growth factor‑β1‑induced podocyte injury is associated with increased microRNA‑155 expression, enhanced inflammatory responses and MAPK pathway activation". Experimental and Therapeutic Medicine 21, no. 6 (2021): 620. https://doi.org/10.3892/etm.2021.10052
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team