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Protein kinase N1 promotes proliferation and invasion of liver cancer

  • Authors:
    • Xia Wang
    • Yansong Ge
    • Mingqi Shi
    • Hanhan Dai
    • Wei Liu
    • Peiyuan Wang
  • View Affiliations / Copyright

    Affiliations: Department of Pathology, Binzhou Medical University, Yantai, Shandong 264003, P.R. China, Department of Radiology, Yantai Affiliated Hospital of Binzhou Medical University, Yantai, Shandong 264100, P.R. China
    Copyright: © Wang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 651
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    Published online on: April 19, 2021
       https://doi.org/10.3892/etm.2021.10083
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Abstract

Protein kinase (PK) N1, also called PKC‑related protein 1, participates in the proliferation, invasion and metastasis of various malignant tumors. However, the role of PKN1 in liver cancer remains to be elucidated. The present study investigated the expression of PKN1 using immunohistochemistry in surgical specimens from 36 patients and analyzed the correlation with VEGF, microvascular density (MVD), cell proliferation index (Ki67) and clinicopathological parameters. PKN1 was highly expressed in hepatocellular carcinoma (HCC) and was positively correlated with histological grading of HCC, Ki67 expression and MVD. PKN1 expression in moderately and poorly differentiated HCC was significantly higher compared with highly differentiated HCC. Expression of PKN1 was positively correlated with Ki67 and MVD, and Ki67 expression was positively correlated with MVD. The effects of PKN1 on proliferation, invasion and apoptosis of liver cancer cells were detected in vitro. Cell viability, migration and invasion were reduced and the apoptosis rate was significantly improved when PKN1 expression was silenced in liver cancer cells. Thus, PKN1 serves an important role in the development and progression of liver cancer. Inhibition of PKN1 activity may provide a promising therapeutic target for liver cancer.
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1 

Xie L, Dai H, Li M, Yang W, Yu G, Wang X, Wang P, Liu W, Hu X and Zhao M: MARCH1 encourages tumour progression of hepatocellular carcinoma via regulation of PI3K-AKT-β-catenin pathways. J Cell Mol Med. 23:3386–3401. 2019.PubMed/NCBI View Article : Google Scholar

2 

Torre LA, Bray F, Siegel RL, Ferlay J, Lortet-Tieulent J and Jemal A: Global cancer statistics, 2012. CA Cancer J Clin. 65:87–108. 2015.PubMed/NCBI View Article : Google Scholar

3 

Bray F, Ferlay J, Soerjomataram I, Siegel RL, Torre LA and Jemal A: Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 68:394–424. 2018.PubMed/NCBI View Article : Google Scholar

4 

Syed YY: Ramucirumab: A review in hepatocellular carcinoma. Drugs. 80:315–322. 2020.PubMed/NCBI View Article : Google Scholar

5 

Cui H, Dai G and Guan J: Programmed cell death protein-1 (PD-1)-targeted immunotherapy for advanced hepatocellular carcinoma in real world. Onco Targets Ther. 13:143–149. 2020.PubMed/NCBI View Article : Google Scholar

6 

Kirstein MM and Wirth TC: Multimodal treatment of hepatocellular carcinoma. Internist (Berl). 61:164–169. 2020.PubMed/NCBI View Article : Google Scholar : (In German).

7 

Metzger E, Yin N, Wissmann M, Kunowska N, Fischer K, Friedrichs N, Patnaik D, Higgins JM, Potier N, Scheidtmann KH, et al: Phosphorylation of histone H3 at threonine 11 establishes a novel chromatin mark for transcriptional regulation. Nat Cell Biol. 10:53–60. 2008.PubMed/NCBI View Article : Google Scholar

8 

Jilg CA, Ketscher A, Metzger E, Hummel B, Willmann D, Rüsseler V, Drendel V, Imhof A, Jung M, Franz H, et al: PRK1/PKN1 controls migration and metastasis of androgen-independent prostate cancer cells. Oncotarget. 5:12646–12664. 2014.PubMed/NCBI View Article : Google Scholar

9 

Mukai H: The structure and function of PKN, a protein kinase having a catalytic domain homologous to that of PKC. J Biochem. 133:17–27. 2003.PubMed/NCBI View Article : Google Scholar

10 

Dong LQ, Landa LR, Wick MJ, Zhu L, Mukai H, Ono Y and Liu F: Phosphorylation of protein kinase N by phosphoinositide-dependent protein kinase-1 mediates insulin signals to the actin cytoskeleton. Proc Natl Acad Sci USA. 97:5089–5094. 2000.PubMed/NCBI View Article : Google Scholar

11 

Yasui T, Sakakibara-Yada K, Nishimura T, Morita K, Tada S, Mosialos G, Kieff E and Kikutani H: Protein kinase N1, a cell inhibitor of Akt kinase, has a central role in quality control of germinal center formation. Proc Natl Acad Sci USA. 109:21022–21027. 2012.PubMed/NCBI View Article : Google Scholar

12 

Lachmann S, Jevons A, De Rycker M, Casamassima A, Radtke S, Collazos A and Parker PJ: Regulatory domain selectivity in the cell-type specific PKN-dependence of cell migration. PLoS One. 6(e21732)2011.PubMed/NCBI View Article : Google Scholar

13 

Cuny GD: Kinase inhibitors as potential therapeutics for acute and chronic neurodegenerative conditions. Curr Pharm Des. 15:3919–3939. 2009.PubMed/NCBI View Article : Google Scholar

14 

Galgano MT, Conaway M, Spencer AM, Paschal BM and Frierson HF Jr: PRK1 distribution in normal tissues and carcinomas: Overexpression and activation in ovarian serous carcinoma. Hum Pathol. 40:1434–1440. 2009.PubMed/NCBI View Article : Google Scholar

15 

Attarha S, Saini RK, Andersson S, Mints M and Souchelnytskyi S: PKN1 modulates TGFβ and EGF signaling in HEC-1-A endometrial cancer cell line. Onco Targets Ther. 7:1397–1408. 2014.PubMed/NCBI View Article : Google Scholar

16 

Zeng R, Wang Z, Li X, Chen Y, Yang S and Dong J: Cyclin-dependent kinase 1-mediated phosphorylation of protein kinase N1 promotes anchorage-independent growth and migration. Cell Signal. 69(109546)2020.PubMed/NCBI View Article : Google Scholar

17 

Deaton RA, Su C, Valencia TG and Grant SR: Transforming growth factor-beta1-induced expression of smooth muscle marker genes involves activation of PKN and p38 MAPK. J Biol Chem. 280:31172–31181. 2005.PubMed/NCBI View Article : Google Scholar

18 

Yang CS, Melhuish TA, Spencer A, Ni L, Hao Y, Jividen K, Harris TE, Snow C, Frierson HF, Wotton D and Paschal BM: The protein kinase C super-family member PKN is regulated by mTOR and influences differentiation during prostate cancer progression. Prostate. 77:1452–1467. 2017.PubMed/NCBI View Article : Google Scholar

19 

James RG, Bosch KA, Kulikauskas RM, Yang PT, Robin NC, Toroni RA, Biechele TL, Berndt JD, von Haller PD, Eng JK, et al: Protein kinase PKN1 represses Wnt/β-catenin signaling in human melanoma cells. J Biol Chem. 288:34658–34670. 2013.PubMed/NCBI View Article : Google Scholar

20 

Park BV, Gaba RC, Huang YH, Chen YF, Guzman G and Lokken RP: Histology of hepatocellular carcinoma: Association with clinical features, radiological findings, and locoregional therapy outcomes. J Clin Imaging Sci. 9(52)2019.PubMed/NCBI View Article : Google Scholar

21 

Zhou L, Rui JA, Zhou WX, Wang SB, Chen SG and Qu Q: Edmondson-Steiner grade: A crucial predictor of recurrence and survival in hepatocellular carcinoma without microvascular invasion. Pathol Res Pract. 213:824–830. 2017.PubMed/NCBI View Article : Google Scholar

22 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods. 25:402–408. 2001.PubMed/NCBI View Article : Google Scholar

23 

Faivre S, Rimassa L and Finn RS: Molecular therapies for HCC: Looking outside the box. J Hepatol. 72:342–352. 2020.PubMed/NCBI View Article : Google Scholar

24 

Jonas S, Bechstein WO, Steinmüller T, Herrmann M, Radke C, Berg T, Settmacher U and Neuhaus P: Vascular invasion and histopathologic grading determine outcome after liver transplantation for hepatocellular carcinoma in cirrhosis. Hepatology. 33:1080–1086. 2001.PubMed/NCBI View Article : Google Scholar

25 

Zhou L, Rui JA, Wang SB, Chen SG and Qu Q: Clinicopathological predictors of poor survival and recurrence after curative resection in hepatocellular carcinoma without portal vein tumor thrombosis. Pathol Oncol Res. 21:131–138. 2015.PubMed/NCBI View Article : Google Scholar

26 

Zhang W, Kim R, Quintini C, Hashimoto K, Fujiki M, Diago T, Eghtesad B, Miller C, Fung J, Tan A, et al: Prognostic role of plasma vascular endothelial growth factor in patients with hepatocellular carcinoma undergoing liver transplantation. Liver Transpl. 21:101–111. 2015.PubMed/NCBI View Article : Google Scholar

27 

Raoul JL and Edeline J: Systemic treatment of hepatocellular carcinoma: Standard of care in China and elsewhere. Lancet Oncol. 21:479–481. 2020.PubMed/NCBI View Article : Google Scholar

28 

Tong X, Wang Q, Wu D, Bao L, Yin T and Chen H: MEK inhibition by cobimetinib suppresses hepatocellular carcinoma and angiogenesis in vitro and in vivo. Biochem Biophys Res Commun. 523:147–152. 2020.PubMed/NCBI View Article : Google Scholar

29 

Berretta M, Cobellis G, Franco R, Panarese I, Rinaldi B, Nasti G, Di Francia R and Rinaldi L: Features of microvessel density (MVD) and angiogenesis inhibitors in therapeutic approach of hepatocellular carcinoma (HCC). Eur Rev Med Pharmacol Sci. 23:10139–10150. 2019.PubMed/NCBI View Article : Google Scholar

30 

Mukai H, Muramatsu A, Mashud R, Kubouchi K, Tsujimoto S, Hongu T, Kanaho Y, Tsubaki M, Nishida S, Shioi G, et al: PKN3 is the major regulator of angiogenesis and tumor metastasis in mice. Sci Rep. 6(18979)2016.PubMed/NCBI View Article : Google Scholar

31 

Santel A, Aleku M, Röder N, Möpert K, Durieux B, Janke O, Keil O, Endruschat J, Dames S, Lange C, et al: Atu027 prevents pulmonary metastasis in experimental and spontaneous mouse metastasis models. Clin Cancer Res. 16:5469–5480. 2010.PubMed/NCBI View Article : Google Scholar

32 

Stroescu C, Dragnea A, Ivanov B, Pechianu C, Herlea V, Sgarbura O, Popescu A and Popescu I: Expression of p53, Bcl-2, VEGF, Ki67 and PCNA and prognostic significance in hepatocellular carcinoma. J Gastrointestin Liver Dis. 17:411–417. 2008.PubMed/NCBI

33 

Xie L, Li M, Liu D, Wang X, Wang P, Dai H, Yang W, Liu W, Hu X and Zhao M: Secalonic Acid-F, a novel mycotoxin, represses the progression of hepatocellular carcinoma via MARCH1 regulation of the PI3K/AKT/β-catenin signaling pathway. Molecules. 24(393)2019.PubMed/NCBI View Article : Google Scholar

34 

Turner EC, Kavanagh DJ, Mulvaney EP, McLean C, Wikström K, Reid HM and Kinsella BT: Identification of an interaction between the TPand TP isoforms of the human thromboxane A2 receptor with protein kinase C-related kinase (PRK) 1. Implications for prostate cancer. J Biol Chem. 286:15440–15457. 2011.PubMed/NCBI View Article : Google Scholar

35 

Owen D, Lowe PN, Nietlispach D, Brosnan CE, Chirgadze DY, Parker PJ, Blundell TL and Mott HR: Molecular dissection of the interaction between the small G proteins Rac1 and RhoA and protein kinase C-related kinase 1 (PRK1). J Biol Chem. 278:50578–50587. 2003.PubMed/NCBI View Article : Google Scholar

36 

Modha R, Campbell LJ, Nietlispach D, Buhecha HR, Owen D and Mott HR: The Rac1 polybasic region is required for interaction with its effector PRK1. J Biol Chem. 283:1492–1500. 2008.PubMed/NCBI View Article : Google Scholar

37 

Takahashi M, Mukai H, Toshimori M, Miyamoto M and Ono Y: Proteolytic activation of PKN by caspase·3 or related protease during apoptosis. Proc Natl Acad Sci USA. 95:11566–11571. 1998.PubMed/NCBI View Article : Google Scholar

38 

Ueyama T, Ren Y, Sakai N, Takahashi M, Ono Y, Kondoh T, Tamaki N and Saito N: Generation of a constitutively active fragment of PKN in microglia/macrophages after middle cerebral artery occlusion in rats. J Neurochem. 79:903–913. 2001.PubMed/NCBI View Article : Google Scholar

39 

Cryns VL, Byun Y, Rana A, Mellor H, Lustig KD, Ghanem L, Parker PJ, Kirschner MW and Yuan J: Specific proteolysis of the kinase protein kinase C-related kinase 2 by caspase·3 during apoptosis. Identification by a novel, small pool expression cloning strategy. J Biol Chem. 272:29449–29453. 1997.PubMed/NCBI View Article : Google Scholar

40 

Koh H, Lee KH, Kim D, Kim S, Kim JW and Chung J: Inhibition of Akt and its anti-apoptotic activities by tumor necrosis factor-induced protein kinase C-related kinase 2 (PRK2) cleavage. J Biol Chem. 275:34451–34458. 2000.PubMed/NCBI View Article : Google Scholar

41 

Aittomäki S and Pesu M: Therapeutic targeting of the Jak/STAT pathway. Basic Clin Pharmacol Toxicol. 114:18–23. 2014.PubMed/NCBI View Article : Google Scholar

42 

Ostrovskyi D, Rumpf T, Eib J, Lumbroso A, Slynko I, Klaeger S, Heinzlmeir S, Forster M, Gehringer M, Pfaffenrot E, et al: Tofacitinib and analogs as inhibitors of the histone kinase PRK1 (PKN1). Future Med Chem. 8:1537–1551. 2016.PubMed/NCBI View Article : Google Scholar

43 

Hosseini A, Gharibi T, Marofi F, Javadian M, Babaloo Z and Baradaran B: Janus kinase inhibitors: A therapeutic strategy for cancer and autoimmune diseases. J Cell Physiol. 235:5903–5924. 2020.PubMed/NCBI View Article : Google Scholar

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Copy and paste a formatted citation
Spandidos Publications style
Wang X, Ge Y, Shi M, Dai H, Liu W and Wang P: Protein kinase N1 promotes proliferation and invasion of liver cancer. Exp Ther Med 21: 651, 2021.
APA
Wang, X., Ge, Y., Shi, M., Dai, H., Liu, W., & Wang, P. (2021). Protein kinase N1 promotes proliferation and invasion of liver cancer. Experimental and Therapeutic Medicine, 21, 651. https://doi.org/10.3892/etm.2021.10083
MLA
Wang, X., Ge, Y., Shi, M., Dai, H., Liu, W., Wang, P."Protein kinase N1 promotes proliferation and invasion of liver cancer". Experimental and Therapeutic Medicine 21.6 (2021): 651.
Chicago
Wang, X., Ge, Y., Shi, M., Dai, H., Liu, W., Wang, P."Protein kinase N1 promotes proliferation and invasion of liver cancer". Experimental and Therapeutic Medicine 21, no. 6 (2021): 651. https://doi.org/10.3892/etm.2021.10083
Copy and paste a formatted citation
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Spandidos Publications style
Wang X, Ge Y, Shi M, Dai H, Liu W and Wang P: Protein kinase N1 promotes proliferation and invasion of liver cancer. Exp Ther Med 21: 651, 2021.
APA
Wang, X., Ge, Y., Shi, M., Dai, H., Liu, W., & Wang, P. (2021). Protein kinase N1 promotes proliferation and invasion of liver cancer. Experimental and Therapeutic Medicine, 21, 651. https://doi.org/10.3892/etm.2021.10083
MLA
Wang, X., Ge, Y., Shi, M., Dai, H., Liu, W., Wang, P."Protein kinase N1 promotes proliferation and invasion of liver cancer". Experimental and Therapeutic Medicine 21.6 (2021): 651.
Chicago
Wang, X., Ge, Y., Shi, M., Dai, H., Liu, W., Wang, P."Protein kinase N1 promotes proliferation and invasion of liver cancer". Experimental and Therapeutic Medicine 21, no. 6 (2021): 651. https://doi.org/10.3892/etm.2021.10083
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