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Helicobacter pylori causes delayed gastric emptying by decreasing interstitial cells of Cajal

  • Authors:
    • Bin Liu
    • Jun Dong
    • Shasha Wang
    • Haining Yu
    • Zhongchao  Li
    • Pengfei Sun
    • Lei Zhao
  • View Affiliations / Copyright

    Affiliations: School of Medicine, Shandong University, Jinan, Shandong 250012, P.R. China, Department of General Surgery, Changqing District People's Hospital, Jinan, Shandong 250300, P.R. China, Department of Hepatobiliary Surgery, Shandong Cancer Hospital, Shandong University, Jinan, Shandong 250117, P.R. China
    Copyright: © Liu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 663
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    Published online on: April 22, 2021
       https://doi.org/10.3892/etm.2021.10095
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Abstract

Helicobacter pylori (HP) infection is one of the most frequent bacterial infections in humans and is associated with the pathogenesis of gastric motility disorders such as delayed gastric emptying (DGE). Although HP infection is considered to delay gastric emptying, there has been little research on the underlying mechanism. Gastric motility involves interactions among gastrointestinal hormones, smooth muscle, enteric and extrinsic autonomic nerves and interstitial cells of Cajal (ICCs), and ICCs play an important role in gastrointestinal motility. Mutation or loss of stem cell factor (SCF) expression is known to reduce the number of ICCs or alter the integrity of the ICC network, contributing to gastrointestinal dysmotility. The aim of the present study was to investigate whether a reduction in ICCs contributes to the DGE caused by HP. A mouse model of HP infection was established and gastric emptying was compared between HP‑infected and uninfected mice using the bead method. In addition, ICC counts and SCF expression levels in gastric tissue were evaluated using immunohistochemistry and western blotting, respectively. The results revealed that gastric emptying was significantly slower, the number of ICCs in gastric tissue was significantly reduced and the protein level of SCF in gastric tissue was significantly decreased in HP‑infected mice compared with uninfected mice. Therefore, it may be concluded that HP reduced the number of ICCs by decreasing the expression of SCF protein in gastric tissue, thereby causing DGE.
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Copy and paste a formatted citation
Spandidos Publications style
Liu B, Dong J, Wang S, Yu H, Li Z, Sun P and Zhao L: <em>Helicobacter pylori</em> causes delayed gastric emptying by decreasing interstitial cells of Cajal. Exp Ther Med 22: 663, 2021.
APA
Liu, B., Dong, J., Wang, S., Yu, H., Li, Z., Sun, P., & Zhao, L. (2021). <em>Helicobacter pylori</em> causes delayed gastric emptying by decreasing interstitial cells of Cajal. Experimental and Therapeutic Medicine, 22, 663. https://doi.org/10.3892/etm.2021.10095
MLA
Liu, B., Dong, J., Wang, S., Yu, H., Li, Z., Sun, P., Zhao, L."<em>Helicobacter pylori</em> causes delayed gastric emptying by decreasing interstitial cells of Cajal". Experimental and Therapeutic Medicine 22.1 (2021): 663.
Chicago
Liu, B., Dong, J., Wang, S., Yu, H., Li, Z., Sun, P., Zhao, L."<em>Helicobacter pylori</em> causes delayed gastric emptying by decreasing interstitial cells of Cajal". Experimental and Therapeutic Medicine 22, no. 1 (2021): 663. https://doi.org/10.3892/etm.2021.10095
Copy and paste a formatted citation
x
Spandidos Publications style
Liu B, Dong J, Wang S, Yu H, Li Z, Sun P and Zhao L: <em>Helicobacter pylori</em> causes delayed gastric emptying by decreasing interstitial cells of Cajal. Exp Ther Med 22: 663, 2021.
APA
Liu, B., Dong, J., Wang, S., Yu, H., Li, Z., Sun, P., & Zhao, L. (2021). <em>Helicobacter pylori</em> causes delayed gastric emptying by decreasing interstitial cells of Cajal. Experimental and Therapeutic Medicine, 22, 663. https://doi.org/10.3892/etm.2021.10095
MLA
Liu, B., Dong, J., Wang, S., Yu, H., Li, Z., Sun, P., Zhao, L."<em>Helicobacter pylori</em> causes delayed gastric emptying by decreasing interstitial cells of Cajal". Experimental and Therapeutic Medicine 22.1 (2021): 663.
Chicago
Liu, B., Dong, J., Wang, S., Yu, H., Li, Z., Sun, P., Zhao, L."<em>Helicobacter pylori</em> causes delayed gastric emptying by decreasing interstitial cells of Cajal". Experimental and Therapeutic Medicine 22, no. 1 (2021): 663. https://doi.org/10.3892/etm.2021.10095
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