Open Access

Antiproliferative and antibacterial potential of tetrahexylammonium bromide‑based ionic liquids

  • Authors:
    • Roxana Popescu
    • Marioara Nicoleta Filimon
    • Daliborca Cristina Vlad
    • Doina Verdes
    • Aurica Moatar
    • Georgiana Moise
    • Kristine Guran
    • Ion Valeriu Caraba
    • Liliana Petculescu Ciochina
    • Iulia Pinzaru
    • Cristina Adriana Dehelean
    • Gabi Dumitrescu
  • View Affiliations

  • Published online on: April 23, 2021     https://doi.org/10.3892/etm.2021.10104
  • Article Number: 672
  • Copyright: © Popescu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Ionic liquids (ILs) exhibit cytotoxic effects on prokaryotic and eukaryotic cells. In this study, the antibacterial and antiproliferative activities of tetrahexylammonium bromide‑based ILs were investigated. In order to evaluate the therapeutic potential of these ionic liquids, firstly microbiological assay using both Gram‑positive and Gram‑negative bacteria were conducted by employing Disk‑Diffusion and 2,3,5‑triphenyltetrazolium chlorine (TTC) methods to assess the antimicrobial effects. Likewise, the antitumor effects on 2D and 3D cell culture systems were assessed using the human colon cancer Caco‑2 cell line and cytotoxic activity was assessed using 3‑(4,5‑dimethylthiazol‑2‑yl)‑2,5‑diphenyltetrazolium bromide (MTT) and Alamar blue assays. Results obtained showed that [CH3(CH2)5]4N(Br) possesses an antibacterial potential, particularly in the case of two bacteria, S. aureus (Gram+) and H. influenzae (Gram). Preliminary screening of antiproliferative activity showed moderate activity, except for the concentration of 10 mM. Furthermore, regarding the effect of [CH3(CH2)5]4N(Br) on tumor cell aggregation, positive outcomes were noted. [CH3(CH2)5]4N(Br) presents promising and under‑explored potential to improve antibacterial or anticancer therapies.
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July-2021
Volume 22 Issue 1

Print ISSN: 1792-0981
Online ISSN:1792-1015

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Spandidos Publications style
Popescu R, Filimon MN, Vlad DC, Verdes D, Moatar A, Moise G, Guran K, Caraba IV, Ciochina LP, Pinzaru I, Pinzaru I, et al: Antiproliferative and antibacterial potential of tetrahexylammonium bromide‑based ionic liquids. Exp Ther Med 22: 672, 2021
APA
Popescu, R., Filimon, M.N., Vlad, D.C., Verdes, D., Moatar, A., Moise, G. ... Dumitrescu, G. (2021). Antiproliferative and antibacterial potential of tetrahexylammonium bromide‑based ionic liquids. Experimental and Therapeutic Medicine, 22, 672. https://doi.org/10.3892/etm.2021.10104
MLA
Popescu, R., Filimon, M. N., Vlad, D. C., Verdes, D., Moatar, A., Moise, G., Guran, K., Caraba, I. V., Ciochina, L. P., Pinzaru, I., Dehelean, C. A., Dumitrescu, G."Antiproliferative and antibacterial potential of tetrahexylammonium bromide‑based ionic liquids". Experimental and Therapeutic Medicine 22.1 (2021): 672.
Chicago
Popescu, R., Filimon, M. N., Vlad, D. C., Verdes, D., Moatar, A., Moise, G., Guran, K., Caraba, I. V., Ciochina, L. P., Pinzaru, I., Dehelean, C. A., Dumitrescu, G."Antiproliferative and antibacterial potential of tetrahexylammonium bromide‑based ionic liquids". Experimental and Therapeutic Medicine 22, no. 1 (2021): 672. https://doi.org/10.3892/etm.2021.10104