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Antiproliferative and antibacterial potential of tetrahexylammonium bromide‑based ionic liquids

  • Authors:
    • Roxana Popescu
    • Marioara Nicoleta Filimon
    • Daliborca Cristina Vlad
    • Doina Verdes
    • Aurica Moatar
    • Georgiana Moise
    • Kristine Guran
    • Ion Valeriu Caraba
    • Liliana Petculescu Ciochina
    • Iulia Pinzaru
    • Cristina Adriana Dehelean
    • Gabi Dumitrescu
  • View Affiliations / Copyright

    Affiliations: Faculty of Medicine, ‘Victor Babes’ University of Medicine and Pharmacy of Timisoara, 300041 Timisoara, Romania, ANAPATMOL Research Center, ‘Victor Babes’ University of Medicine and Pharmacy of Timisoara, 300041 Timisoara, Romania, Faculty of Bioengineering of Animal Resources, ‘Regele Mihai I al României’ Banat University of Agricultural Sciences and Veterinary Medicine, 300645 Timisoara, Romania, Faculty of Pharmacy, ‘Victor Babes’ University of Medicine and Pharmacy of Timisoara, 300041 Timisoara, Romania
    Copyright: © Popescu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 672
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    Published online on: April 23, 2021
       https://doi.org/10.3892/etm.2021.10104
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Abstract

Ionic liquids (ILs) exhibit cytotoxic effects on prokaryotic and eukaryotic cells. In this study, the antibacterial and antiproliferative activities of tetrahexylammonium bromide‑based ILs were investigated. In order to evaluate the therapeutic potential of these ionic liquids, firstly microbiological assay using both Gram‑positive and Gram‑negative bacteria were conducted by employing Disk‑Diffusion and 2,3,5‑triphenyltetrazolium chlorine (TTC) methods to assess the antimicrobial effects. Likewise, the antitumor effects on 2D and 3D cell culture systems were assessed using the human colon cancer Caco‑2 cell line and cytotoxic activity was assessed using 3‑(4,5‑dimethylthiazol‑2‑yl)‑2,5‑diphenyltetrazolium bromide (MTT) and Alamar blue assays. Results obtained showed that [CH3(CH2)5]4N(Br) possesses an antibacterial potential, particularly in the case of two bacteria, S. aureus (Gram+) and H. influenzae (Gram‑). Preliminary screening of antiproliferative activity showed moderate activity, except for the concentration of 10 mM. Furthermore, regarding the effect of [CH3(CH2)5]4N(Br) on tumor cell aggregation, positive outcomes were noted. [CH3(CH2)5]4N(Br) presents promising and under‑explored potential to improve antibacterial or anticancer therapies.
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Copy and paste a formatted citation
Spandidos Publications style
Popescu R, Filimon MN, Vlad DC, Verdes D, Moatar A, Moise G, Guran K, Caraba IV, Ciochina LP, Pinzaru I, Pinzaru I, et al: Antiproliferative and antibacterial potential of tetrahexylammonium bromide‑based ionic liquids. Exp Ther Med 22: 672, 2021.
APA
Popescu, R., Filimon, M.N., Vlad, D.C., Verdes, D., Moatar, A., Moise, G. ... Dumitrescu, G. (2021). Antiproliferative and antibacterial potential of tetrahexylammonium bromide‑based ionic liquids. Experimental and Therapeutic Medicine, 22, 672. https://doi.org/10.3892/etm.2021.10104
MLA
Popescu, R., Filimon, M. N., Vlad, D. C., Verdes, D., Moatar, A., Moise, G., Guran, K., Caraba, I. V., Ciochina, L. P., Pinzaru, I., Dehelean, C. A., Dumitrescu, G."Antiproliferative and antibacterial potential of tetrahexylammonium bromide‑based ionic liquids". Experimental and Therapeutic Medicine 22.1 (2021): 672.
Chicago
Popescu, R., Filimon, M. N., Vlad, D. C., Verdes, D., Moatar, A., Moise, G., Guran, K., Caraba, I. V., Ciochina, L. P., Pinzaru, I., Dehelean, C. A., Dumitrescu, G."Antiproliferative and antibacterial potential of tetrahexylammonium bromide‑based ionic liquids". Experimental and Therapeutic Medicine 22, no. 1 (2021): 672. https://doi.org/10.3892/etm.2021.10104
Copy and paste a formatted citation
x
Spandidos Publications style
Popescu R, Filimon MN, Vlad DC, Verdes D, Moatar A, Moise G, Guran K, Caraba IV, Ciochina LP, Pinzaru I, Pinzaru I, et al: Antiproliferative and antibacterial potential of tetrahexylammonium bromide‑based ionic liquids. Exp Ther Med 22: 672, 2021.
APA
Popescu, R., Filimon, M.N., Vlad, D.C., Verdes, D., Moatar, A., Moise, G. ... Dumitrescu, G. (2021). Antiproliferative and antibacterial potential of tetrahexylammonium bromide‑based ionic liquids. Experimental and Therapeutic Medicine, 22, 672. https://doi.org/10.3892/etm.2021.10104
MLA
Popescu, R., Filimon, M. N., Vlad, D. C., Verdes, D., Moatar, A., Moise, G., Guran, K., Caraba, I. V., Ciochina, L. P., Pinzaru, I., Dehelean, C. A., Dumitrescu, G."Antiproliferative and antibacterial potential of tetrahexylammonium bromide‑based ionic liquids". Experimental and Therapeutic Medicine 22.1 (2021): 672.
Chicago
Popescu, R., Filimon, M. N., Vlad, D. C., Verdes, D., Moatar, A., Moise, G., Guran, K., Caraba, I. V., Ciochina, L. P., Pinzaru, I., Dehelean, C. A., Dumitrescu, G."Antiproliferative and antibacterial potential of tetrahexylammonium bromide‑based ionic liquids". Experimental and Therapeutic Medicine 22, no. 1 (2021): 672. https://doi.org/10.3892/etm.2021.10104
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