Open Access

Protective effects of halophyte complex extract against UVB‑induced damage in human keratinocytes and the skin of hairless mice

  • Authors:
    • Jae Young Shin
    • Ji Hyeon Park
    • Denis Nchang Che
    • Hyun Ju Kang
    • Byoung Ok Cho
    • Yi Teak Lim
    • Seon Il Jang
  • View Affiliations

  • Published online on: April 25, 2021     https://doi.org/10.3892/etm.2021.10114
  • Article Number: 682
  • Copyright: © Shin et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Limonium tetragonum, Triglochin maritimum, Artemisia scoparia and red ginseng have been used as folk remedies for treating a variety of diseases. In the current study, the protective effects of halophyte and red ginseng against ultraviolet (UV)‑induced skin damage were investigated. Halophyte red ginseng complex extract (HRCE) was prepared and its effects on UV‑B irradiated human keratinocytes and mouse skin were studied through ELISA, Western blotting immunofluorescence and histological staining. HRCE inhibited peroxide‑induced damage in human keratinocytes. HRCE also inhibited UVB‑induced collagen and elastin degradation in human keratinocytes and mouse skin. In addition, HRCE inhibited mast cell infiltration in the skin of mice irradiated with UVB light. This effect was likely due to HRCE inhibiting the activation of MAPK and NF‑κB. By protecting the skin from UVB‑induced skin damage, HRCE has the potential to be used in the treatment and prevention of UV‑induced skin damage and photoaging.
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July-2021
Volume 22 Issue 1

Print ISSN: 1792-0981
Online ISSN:1792-1015

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Spandidos Publications style
Shin JY, Park JH, Che DN, Kang HJ, Cho BO, Lim YT and Jang SI: Protective effects of halophyte complex extract against UVB‑induced damage in human keratinocytes and the skin of hairless mice. Exp Ther Med 22: 682, 2021.
APA
Shin, J.Y., Park, J.H., Che, D.N., Kang, H.J., Cho, B.O., Lim, Y.T., & Jang, S.I. (2021). Protective effects of halophyte complex extract against UVB‑induced damage in human keratinocytes and the skin of hairless mice. Experimental and Therapeutic Medicine, 22, 682. https://doi.org/10.3892/etm.2021.10114
MLA
Shin, J. Y., Park, J. H., Che, D. N., Kang, H. J., Cho, B. O., Lim, Y. T., Jang, S. I."Protective effects of halophyte complex extract against UVB‑induced damage in human keratinocytes and the skin of hairless mice". Experimental and Therapeutic Medicine 22.1 (2021): 682.
Chicago
Shin, J. Y., Park, J. H., Che, D. N., Kang, H. J., Cho, B. O., Lim, Y. T., Jang, S. I."Protective effects of halophyte complex extract against UVB‑induced damage in human keratinocytes and the skin of hairless mice". Experimental and Therapeutic Medicine 22, no. 1 (2021): 682. https://doi.org/10.3892/etm.2021.10114