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Effect of the interference with DRP1 expression on the biological characteristics of glioma stem cells

  • Authors:
    • Linna Zhang
    • Huimei Cao
    • Hong Tao
    • Jijuan Yang
    • Wei Gong
    • Qikuan Hu
  • View Affiliations / Copyright

    Affiliations: Department of Physiology, Ningxia Medical University, Yinchuan, Ningxia Hui Autonomous Region 750004, P.R. China, Department of Orthopedics, Ningxia People's Hospital, Yinchuan, Ningxia Hui Autonomous Region 750004, P.R. China
    Copyright: © Zhang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 696
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    Published online on: May 2, 2021
       https://doi.org/10.3892/etm.2021.10128
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Abstract

In the present study, a model of glioma stem cells (GSCs) was established and combined with molecular targeting drugs in order to observe its inhibitory effect on the proliferation and biological characteristics of GSCs, with the aim of providing a potential target for the treatment of glioma. On the basis of a relatively classical induction strategy with neuron induction medium, a large number of GSC‑like cells in good condition and globular growth were amplified in vitro, which had the potential to differentiate into neurons, oligodendrocytes and astrocytes/glioma cells. It was observed that the interference with dynamin‑related protein 1 expression using Mdivi‑1, a mitochondrial mitotic inhibitor, at the optimal concentration, decreased the expression level of stem cell‑associated genes, inhibited proliferation and promoted apoptosis in GSCs. The present study provided an experimental basis for a novel strategy of cancer treatment with tumor stem cells as the target.
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Copy and paste a formatted citation
Spandidos Publications style
Zhang L, Cao H, Tao H, Yang J, Gong W and Hu Q: Effect of the interference with DRP1 expression on the biological characteristics of glioma stem cells. Exp Ther Med 22: 696, 2021.
APA
Zhang, L., Cao, H., Tao, H., Yang, J., Gong, W., & Hu, Q. (2021). Effect of the interference with DRP1 expression on the biological characteristics of glioma stem cells. Experimental and Therapeutic Medicine, 22, 696. https://doi.org/10.3892/etm.2021.10128
MLA
Zhang, L., Cao, H., Tao, H., Yang, J., Gong, W., Hu, Q."Effect of the interference with DRP1 expression on the biological characteristics of glioma stem cells". Experimental and Therapeutic Medicine 22.1 (2021): 696.
Chicago
Zhang, L., Cao, H., Tao, H., Yang, J., Gong, W., Hu, Q."Effect of the interference with DRP1 expression on the biological characteristics of glioma stem cells". Experimental and Therapeutic Medicine 22, no. 1 (2021): 696. https://doi.org/10.3892/etm.2021.10128
Copy and paste a formatted citation
x
Spandidos Publications style
Zhang L, Cao H, Tao H, Yang J, Gong W and Hu Q: Effect of the interference with DRP1 expression on the biological characteristics of glioma stem cells. Exp Ther Med 22: 696, 2021.
APA
Zhang, L., Cao, H., Tao, H., Yang, J., Gong, W., & Hu, Q. (2021). Effect of the interference with DRP1 expression on the biological characteristics of glioma stem cells. Experimental and Therapeutic Medicine, 22, 696. https://doi.org/10.3892/etm.2021.10128
MLA
Zhang, L., Cao, H., Tao, H., Yang, J., Gong, W., Hu, Q."Effect of the interference with DRP1 expression on the biological characteristics of glioma stem cells". Experimental and Therapeutic Medicine 22.1 (2021): 696.
Chicago
Zhang, L., Cao, H., Tao, H., Yang, J., Gong, W., Hu, Q."Effect of the interference with DRP1 expression on the biological characteristics of glioma stem cells". Experimental and Therapeutic Medicine 22, no. 1 (2021): 696. https://doi.org/10.3892/etm.2021.10128
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