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Anti‑inflammatory activities of Gardenia jasminoides extracts in retinal pigment epithelial cells and zebrafish embryos

  • Authors:
    • Jianrong Chen
    • Gabriel Mbuta Tchivelekete
    • Xinzhi Zhou
    • Weizhuo Tang
    • Fang Liu
    • Minzhuo Liu
    • Chenxi Zhao
    • Xinhua Shu
    • Zhihong Zeng
  • View Affiliations / Copyright

    Affiliations: College of Biological and Environmental Engineering, Changsha University, Changsha, Hunan 410022, P.R. China, Department of Biological and Biomedical Sciences, Glasgow Caledonian University, Glasgow, G4 0BA, UK
    Copyright: © Chen et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 700
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    Published online on: May 2, 2021
       https://doi.org/10.3892/etm.2021.10132
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Abstract

Age‑related macular degeneration (AMD) is the most common cause of visual impairment in developed countries. Inflammation serves a critical role in the pathogenesis of AMD. Gardenia jasminoides is found in several regions of China and is traditionally used as an organic yellow dye but has also been widely used as a therapeutic agent in numerous diseases, including inflammation, depression, hepatic and vascular disorders, which may reflect the variability of functional compounds that are present in Gardenia jasminoides extracts (GJE). To investigate the therapeutic potential of GJE for AMD, ARPE‑19 cells were treated with lipopolysaccharide (LPS) or LPS plus GJE. GJE significantly decreased LPS‑induced expression of proinflammatory cytokines, including IL‑1β, IL‑6 and TNF‑α. In the in vivo study, GJE inhibited CuSO4‑induced migration of primitive macrophages to the lateral line in zebrafish embryos. GJE also attenuated expression of cytokines (IL‑1β, IL‑6 and TNF‑α), NFKB activating protein (nkap) and TLR4 in ARPE‑19 cells. The results of the present study demonstrated the anti‑inflammatory potential of GJE in vitro and in vivo, and suggested GJE as a therapeutic candidate for AMD.
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Copy and paste a formatted citation
Spandidos Publications style
Chen J, Tchivelekete GM, Zhou X, Tang W, Liu F, Liu M, Zhao C, Shu X and Zeng Z: Anti‑inflammatory activities of <em>Gardenia jasminoides</em> extracts in retinal pigment epithelial cells and zebrafish embryos. Exp Ther Med 22: 700, 2021.
APA
Chen, J., Tchivelekete, G.M., Zhou, X., Tang, W., Liu, F., Liu, M. ... Zeng, Z. (2021). Anti‑inflammatory activities of <em>Gardenia jasminoides</em> extracts in retinal pigment epithelial cells and zebrafish embryos. Experimental and Therapeutic Medicine, 22, 700. https://doi.org/10.3892/etm.2021.10132
MLA
Chen, J., Tchivelekete, G. M., Zhou, X., Tang, W., Liu, F., Liu, M., Zhao, C., Shu, X., Zeng, Z."Anti‑inflammatory activities of <em>Gardenia jasminoides</em> extracts in retinal pigment epithelial cells and zebrafish embryos". Experimental and Therapeutic Medicine 22.1 (2021): 700.
Chicago
Chen, J., Tchivelekete, G. M., Zhou, X., Tang, W., Liu, F., Liu, M., Zhao, C., Shu, X., Zeng, Z."Anti‑inflammatory activities of <em>Gardenia jasminoides</em> extracts in retinal pigment epithelial cells and zebrafish embryos". Experimental and Therapeutic Medicine 22, no. 1 (2021): 700. https://doi.org/10.3892/etm.2021.10132
Copy and paste a formatted citation
x
Spandidos Publications style
Chen J, Tchivelekete GM, Zhou X, Tang W, Liu F, Liu M, Zhao C, Shu X and Zeng Z: Anti‑inflammatory activities of <em>Gardenia jasminoides</em> extracts in retinal pigment epithelial cells and zebrafish embryos. Exp Ther Med 22: 700, 2021.
APA
Chen, J., Tchivelekete, G.M., Zhou, X., Tang, W., Liu, F., Liu, M. ... Zeng, Z. (2021). Anti‑inflammatory activities of <em>Gardenia jasminoides</em> extracts in retinal pigment epithelial cells and zebrafish embryos. Experimental and Therapeutic Medicine, 22, 700. https://doi.org/10.3892/etm.2021.10132
MLA
Chen, J., Tchivelekete, G. M., Zhou, X., Tang, W., Liu, F., Liu, M., Zhao, C., Shu, X., Zeng, Z."Anti‑inflammatory activities of <em>Gardenia jasminoides</em> extracts in retinal pigment epithelial cells and zebrafish embryos". Experimental and Therapeutic Medicine 22.1 (2021): 700.
Chicago
Chen, J., Tchivelekete, G. M., Zhou, X., Tang, W., Liu, F., Liu, M., Zhao, C., Shu, X., Zeng, Z."Anti‑inflammatory activities of <em>Gardenia jasminoides</em> extracts in retinal pigment epithelial cells and zebrafish embryos". Experimental and Therapeutic Medicine 22, no. 1 (2021): 700. https://doi.org/10.3892/etm.2021.10132
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