Open Access

Fatty acids and their role in type‑2 diabetes (Review)

  • Authors:
    • Shilpa S. Shetty
    • Suchetha Kumari
  • View Affiliations

  • Published online on: May 2, 2021     https://doi.org/10.3892/etm.2021.10138
  • Article Number: 706
  • Copyright: © Shetty et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Age, lifestyle and diet are major risk factors for the onset of type 2 diabetes mellitus (T2DM). Insulin resistance (IR) and β‑cell dysfunction underlie the pathophysiology of T2DM. Diabetic populations are also prone to lipid and lipoprotein abnormalities as an indirect effect of IR on key metabolic enzymes. However, recent studies suggested that lipid changes may not only be a consequence of impaired glucose metabolism but also a causative factor. Fatty acids (FAs) influence translocation of glucose transporters and insulin receptor binding and signalling, in addition to cell membrane fluidity and permeability. It is thus suggested that FAs may have an essential role in the development of IR and T2DM. Specific combinations of FAs within phospholipids and triglycerides were indicated to exhibit the strongest associations with the risk of T2DM. The aim of the present review was to investigate the role of FAs in the pathogenesis of T2DM, as it has yet to be fully elucidated.
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July-2021
Volume 22 Issue 1

Print ISSN: 1792-0981
Online ISSN:1792-1015

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Spandidos Publications style
Shetty SS and Shetty SS: Fatty acids and their role in type‑2 diabetes (Review). Exp Ther Med 22: 706, 2021
APA
Shetty, S.S., & Shetty, S.S. (2021). Fatty acids and their role in type‑2 diabetes (Review). Experimental and Therapeutic Medicine, 22, 706. https://doi.org/10.3892/etm.2021.10138
MLA
Shetty, S. S., Kumari, S."Fatty acids and their role in type‑2 diabetes (Review)". Experimental and Therapeutic Medicine 22.1 (2021): 706.
Chicago
Shetty, S. S., Kumari, S."Fatty acids and their role in type‑2 diabetes (Review)". Experimental and Therapeutic Medicine 22, no. 1 (2021): 706. https://doi.org/10.3892/etm.2021.10138