|
1
|
Fan B, Wei Z, Yao X, Shi G, Cheng X, Zhou
X, Zhou H, Ning G, Kong X and Feng S: Microenvironment imbalance of
spinal cord injury. Cell Transplant. 27:853–866. 2018.PubMed/NCBI View Article : Google Scholar
|
|
2
|
McDonald JW and Sadowsky C: Spinal-Cord
injury. Lancet. 359:417–425. 2002.PubMed/NCBI View Article : Google Scholar
|
|
3
|
Dominguez E, Rivat C, Pommier B, Mauborgne
A and Pohl M: JAK/STAT3 pathway is activated in spinal cord
microglia after peripheral nerve injury and contributes to
neuropathic pain development in rat. J Neurochem. 107:50–60.
2008.PubMed/NCBI View Article : Google Scholar
|
|
4
|
Shibata N, Kakita A, Takahashi H, Ihara Y,
Nobukuni K, Fujimura H, Sakoda S, Sasaki S, Iwata M, Morikawa S, et
al: Activation of signal transducer and activator of
transcription-3 in the spinal cord of sporadic amyotrophic lateral
sclerosis patients. Neurodegener Dis. 6:118–126. 2009.PubMed/NCBI View Article : Google Scholar
|
|
5
|
LeComte MD, Shimada IS, Sherwin C and
Spees JL: Notch1-STAT3-ETBR signaling axis controls reactive
astrocyte proliferation after brain injury. Proc Natl Acad Sci USA.
112:8726–8731. 2015.PubMed/NCBI View Article : Google Scholar
|
|
6
|
Okada S, Nakamura M, Katoh H, Miyao T,
Shimazaki T, Ishii K, Yamane J, Yoshimura A, Iwamoto Y, Toyama Y
and Okano H: Conditional ablation of stat3 or socs3 discloses a
dual role for reactive astrocytes after spinal cord injury. Nat
Med. 12:829–834. 2006.PubMed/NCBI View
Article : Google Scholar
|
|
7
|
Tsuda M, Kohro Y, Yano T, Tsujikawa T,
Kitano J, Tozaki-Saitoh H, Koyanagi S, Ohdo S, Ji RR, Salter MW and
Inoue K: JAK-STAT3 pathway regulates spinal astrocyte proliferation
and neuropathic pain maintenance in rats. Brain. 134:1127–1139.
2011.PubMed/NCBI View Article : Google Scholar
|
|
8
|
Park KW, Lin CY, Benveniste EN and Lee YS:
Mitochondrial STAT3 is negatively regulated by SOCS3 and
upregulated after spinal cord injury. Exp Neurol. 284:98–105.
2016.PubMed/NCBI View Article : Google Scholar
|
|
9
|
Gu F, Hata R, Ma YJ, Tanaka J, Mitsuda N,
Kumon Y, Hanakawa Y, Hashimoto K, Nakajima K and Sakanaka M:
Suppression of stat3 promotes neurogenesis in cultured neural stem
cells. J Neurosci Res. 81:163–171. 2005.PubMed/NCBI View Article : Google Scholar
|
|
10
|
Cao F, Hata R, Zhu P, Nakashiro Ki and
Sakanaka M: Conditional deletion of stat3 promotes neurogenesis and
inhibits astrogliogenesis in neural stem cells. Biochem Biophys Res
Commun. 394:843–847. 2010.PubMed/NCBI View Article : Google Scholar
|
|
11
|
Gong Z, Xia K, Xu A, Yu C, Wang C, Zhu J,
Huang X, Chen Q, Li F and Liang C: Stem cell transplantation: A
promising therapy for spinal cord injury. Curr Stem Cell Res Ther.
15:321–331. 2019.PubMed/NCBI View Article : Google Scholar
|
|
12
|
Assinck P, Duncan GJ, Hilton BJ, Plemel JR
and Tetzlaff W: Cell transplantation therapy for spinal cord
injury. Nat Neurosci. 20:637–647. 2017.PubMed/NCBI View
Article : Google Scholar
|
|
13
|
Muheremu AJ, Peng J and Ao Q: Stem cell
based therapies for spinal cord injury. Tissue Cell. 48:328–333.
2016.PubMed/NCBI View Article : Google Scholar
|
|
14
|
Natarajan R, Singal V, Benes R, Gao J,
Chan H, Chen H, Yu Y, Zhou J and Wu P: STAT3 modulation to enhance
motor neuron differentiation in human neural stem cells. PLoS One.
9(e100405)2014.PubMed/NCBI View Article : Google Scholar
|
|
15
|
White CW III, Fan X, Maynard JC, Wheatley
EG, Bieri G, Couthouis J, Burlingame AL and Villeda SA: Age-Related
loss of neural stem cell O-GlcNAc promotes a glial fate switch
through STAT3 activation. Proc Natl Acad Sci USA. 117:22214–22224.
2020.PubMed/NCBI View Article : Google Scholar
|
|
16
|
Lizee G, Aerts JL, Gonzales MI, Chinnasamy
N, Morgan RA and Topalian SL: Real-Time quantitative reverse
transcriptase-polymerase chain reaction as a method for determining
lentiviral vector titers and measuring transgene expression. Hum
Gene Ther. 14:497–507. 2003.PubMed/NCBI View Article : Google Scholar
|
|
17
|
Chen N, Cen JS, Wang J, Qin G, Long L,
Wang L, Wei F, Xiang Q, Deng DY and Wan Y: Targeted inhibition of
leucine-rich repeat and immunoglobulin domain-containing protein 1
in transplanted neural stem cells promotes neuronal differentiation
and functional recovery in rats subjected to spinal cord injury.
Crit Care Med. 44:e146–e157. 2016.PubMed/NCBI View Article : Google Scholar
|
|
18
|
Livak KJ and Schmittgen TD: Analysis of
relative gene expression data using real-time quantitative PCR and
the 2(-Delta Delta C(T)) method. Methods. 25:402–408.
2001.PubMed/NCBI View Article : Google Scholar
|
|
19
|
Bloomsmith MA, Perlman JE, Hutchinson E
and Sharpless M: Behavioral management programs to promote
laboratory animal welfare, In: Management of Animal Care and Use
Programs in Research, Education, and Testing. 2nd edition.
Weichbrod RH, Thompson GAH and Norton JN (eds). CRC Press/Taylor
& Francis, Boca Raton, FL, pp63-82, 2018.
|
|
20
|
Peng Z, Li X, Fu M, Zhu K, Long L, Zhao X,
Chen Q, Deng DY and Wan Y: Inhibition of notch1 signaling promotes
neuronal differentiation and improves functional recovery in spinal
cord injury through suppressing the activation of ras homolog
family member A. J Neurochem. 150:709–722. 2019.PubMed/NCBI View Article : Google Scholar
|
|
21
|
Basso DM, Beattie MS and Bresnahan JC: A
sensitive and reliable locomotor rating scale for open field
testing in rats. J Neurotrauma. 12:1–21. 1995.PubMed/NCBI View Article : Google Scholar
|
|
22
|
Zhao X, Peng Z, Long L, Chen N, Zheng H,
Deng DY and Wan Y: Lentiviral vector delivery of short hairpin RNA
to NgR1 promotes nerve regeneration and locomotor recovery in
injured rat spinal cord. Sci Rep. 8(5447)2018.PubMed/NCBI View Article : Google Scholar
|
|
23
|
Cheng X, Yeung PK, Zhong K, Zilundu PL,
Zhou L and Chung SK: Astrocytic endothelin-1 overexpression
promotes neural progenitor cells proliferation and differentiation
into astrocytes via the Jak2/Stat3 pathway after stroke. J
Neuroinflammation. 16(227)2019.PubMed/NCBI View Article : Google Scholar
|
|
24
|
Dai J, Xu LJ, Han GD, Sun HL, Zhu GT,
Jiang HT, Yu GY and Tang XM: MicroRNA-125b promotes the
regeneration and repair of spinal cord injury through regulation of
JAK/STAT pathway. Eur Rev Med Pharmacol Sci. 22:582–589.
2018.PubMed/NCBI View Article : Google Scholar
|
|
25
|
Lee DY: Roles of mTOR signaling in brain
development. Exp Neurobiol. 24:177–185. 2015.PubMed/NCBI View Article : Google Scholar
|
|
26
|
Pfyffer D, Huber E, Sutter R, Curt A and
Freund P: Tissue bridges predict recovery after traumatic and
ischemic thoracic spinal cord injury. Neurology. 93:e1550–e1560.
2019.PubMed/NCBI View Article : Google Scholar
|
|
27
|
Zhang T, Liu C and Chi L: Suppression of
miR-10a-5p in bone marrow mesenchymal stem cells enhances the
therapeutic effect on spinal cord injury via BDNF. Neurosci.
714(134562)2020.PubMed/NCBI View Article : Google Scholar
|
|
28
|
Qian D, Li L, Rong Y, Liu W, Wang Q, Zhou
Z, Gu C, Huang Y, Zhao X, Chen J, et al: Blocking notch signal
pathway suppresses the activation of neurotoxic A1 astrocytes after
spinal cord injury. Cell Cycle. 18:3010–3029. 2019.PubMed/NCBI View Article : Google Scholar
|
|
29
|
Mothe AJ and Tator CH: Review of
transplantation of neural stem/progenitor cells for spinal cord
injury. Int J Dev Neurosci. 31:701–713. 2013.PubMed/NCBI View Article : Google Scholar
|
|
30
|
Namiki J and Tator CH: Cell proliferation
and nestin expression in the ependyma of the adult rat spinal cord
after injury. J Neuropathol Exp Neurol. 58:489–498. 1999.PubMed/NCBI View Article : Google Scholar
|
|
31
|
Decker T and Kovarik P: Transcription
factor activity of STAT proteins: Structural requirements and
regulation by phosphorylation and interacting proteins. Cell Mol
Life Sci. 55:1535–1546. 1999.PubMed/NCBI View Article : Google Scholar
|
|
32
|
Herrmann JE, Imura T, Song B, Qi J, Ao Y,
Nguyen TK, Korsak RA, Takeda K, Akira S and Sofroniew MV: STAT3 is
a critical regulator of astrogliosis and scar formation after
spinal cord injury. J Neurosci. 28:7231–7243. 2008.PubMed/NCBI View Article : Google Scholar
|
|
33
|
Ohta S, Misawa A, Fukaya R, Inoue S,
Kanemura Y, Okano H, Kawakami Y and Toda M: Macrophage migration
inhibitory factor (MIF) promotes cell survival and proliferation of
neural stem/progenitor cells. J Cell Sci. 125:3210–3220.
2012.PubMed/NCBI View Article : Google Scholar
|
|
34
|
Kong X, Gong Z, Zhang L, Sun X, Ou Z, Xu
B, Huang J, Long D, He X, Lin X, et al: JAK2/STAT3 signaling
mediates IL-6-inhibited neurogenesis of neural stem cells through
DNA demethylation/methylation. Brain Behav Immun. 79:159–173.
2019.PubMed/NCBI View Article : Google Scholar
|
|
35
|
Cheng PY, Lin YP, Chen YL, Lee YC, Tai CC,
Wang YT, Chen YJ, Kao CF and Yu J: Interplay between SIN3A and
STAT3 mediates chromatin conformational changes and GFAP expression
during cellular differentiation. PLoS One. 6(e22018)2011.PubMed/NCBI View Article : Google Scholar
|
|
36
|
Takizawa T, Nakashima K, Namihira M,
Ochiai W, Uemura A, Yanagisawa M, Fujita N, Nakao M and Taga T: DNA
methylation is a critical cell-intrinsic determinant of astrocyte
differentiation in the fetal brain. Dev Cell. 1:749–758.
2001.PubMed/NCBI View Article : Google Scholar
|
|
37
|
LiCausi F and Hartman NW: Role of mTOR
complexes in neurogenesis. Int J Mol Sci. 19(1544)2018.PubMed/NCBI View Article : Google Scholar
|
|
38
|
Russell RC, Fang C and Guan KL: An
emerging role for TOR signaling in mammalian tissue and stem cell
physiology. Development. 138:3343–3356. 2011.PubMed/NCBI View Article : Google Scholar
|
|
39
|
Lee JE, Lim MS, Park JH, Park CH and Koh
HC: S6K promotes dopaminergic neuronal differentiation through
PI3K/Akt/mTOR-dependent signaling pathways in human neural stem
cells. Mol Neurobiol. 53:3771–3782. 2016.PubMed/NCBI View Article : Google Scholar
|
|
40
|
Wang B, Xiao Z, Chen B, Han J, Gao Y,
Zhang J, Zhao W, Wang X and Dai J: Nogo-66 promotes the
differentiation of neural progenitors into astroglial lineage cells
through mTOR-STAT3 pathway. PLoS One. 3(e1856)2008.PubMed/NCBI View Article : Google Scholar
|
|
41
|
Easley CA IV, Ben-Yehudah A, Redinger CJ,
Oliver SL, Varum ST, Eisinger VM, Carlisle DL, Donovan PJ and
Schatten GP: mTOR-Mediated activation of p70 S6K induces
differentiation of pluripotent human embryonic stem cells. Cell
Reprogram. 12:263–273. 2010.PubMed/NCBI View Article : Google Scholar
|
|
42
|
Rajan P, Panchision DM, Newell LF and
McKay RD: BMPs signal alternately through a SMAD or FRAP-STAT
pathway to regulate fate choice in CNS stem cells. J Cell Biol.
161:911–921. 2003.PubMed/NCBI View Article : Google Scholar
|
|
43
|
Wanner IB, Anderson MA, Song B, Levine J,
Fernandez A, Gray-Thompson Z, Ao Y and Sofroniew MV: Glial scar
borders are formed by newly proliferated, elongated astrocytes that
interact to corral inflammatory and fibrotic cells via
STAT3-dependent mechanisms after spinal cord injury. J Neurosci.
33:12870–12886. 2013.PubMed/NCBI View Article : Google Scholar
|
|
44
|
Kim C, Kim HJ, Lee H, Lee H, Lee SJ, Lee
ST, Yang SR and Chung CK: Mesenchymal stem cell transplantation
promotes functional recovery through MMP2/STAT3 related
astrogliosis after spinal cord injury. Int J Stem Cells.
12:331–339. 2019.PubMed/NCBI View Article : Google Scholar
|
|
45
|
Hackett AR, Lee DH, Dawood A, Rodriguez M,
Funk L, Tsoulfas P and Lee JK: STAT3 and SOCS3 regulate NG2 cell
proliferation and differentiation after contusive spinal cord
injury. Neurobiol Dis. 89:10–22. 2016.PubMed/NCBI View Article : Google Scholar
|
|
46
|
Hosseini SM, Sani M, Haider KH, Dorvash M,
Ziaee SM, Karimi A and Namavar MR: Concomitant use of mesenchymal
stem cells and neural stem cells for treatment of spinal cord
injury: A combo cell therapy approach. Neurosci Lett. 668:138–146.
2018.PubMed/NCBI View Article : Google Scholar
|
|
47
|
Lopez-Serrano C, Torres-Espín A, Hernández
J, Alvarez-Palomo AB, Requena J, Gasull X, Edel MJ and Navarro X:
Effects of the post-spinal cord injury microenvironment on the
differentiation capacity of human neural stem cells derived from
induced pluripotent stem cells. Cell Transplant. 25:1833–1852.
2016.PubMed/NCBI View Article : Google Scholar
|
|
48
|
Squair JW, West CR, Popok D, Assinck P,
Liu J, Tetzlaff W and Krassioukov AV: High thoracic contusion model
for the investigation of cardiovascular function after spinal cord
injury. J Neurotrauma. 34:671–684. 2017.PubMed/NCBI View Article : Google Scholar
|
|
49
|
Wu WD, Wang LH, Wei NX, Kong DH, Shao G,
Zhang SR and Du YS: MicroRNA-15a inhibits inflammatory response and
apoptosis after spinal cord injury via targeting STAT3. Eur Rev Med
Pharmacol Sci. 23:9189–9198. 2019.PubMed/NCBI View Article : Google Scholar
|
|
50
|
van Gorp S, Leerink M, Kakinohana O,
Platoshyn O, Santucci C, Galik J, Joosten EA, Hruska-Plochan M,
Goldberg D, Marsala S, et al: Amelioration of motor/sensory
dysfunction and spasticity in a rat model of acute lumbar spinal
cord injury by human neural stem cell transplantation. Stem Cell
Res Ther. 4(57)2013.PubMed/NCBI View Article : Google Scholar
|
|
51
|
Zhao XM, He XY, Liu J, Xu Y, Xu FF, Tan
YX, Zhang ZB and Wang TH: Neural stem cell transplantation improves
locomotor function in spinal cord transection rats associated with
nerve regeneration and IGF-1 R expression. Cell Transplant.
28:1197–1211. 2019.PubMed/NCBI View Article : Google Scholar
|
|
52
|
Winkler T, Sharma HS, Gordh T, Badgaiyan
RD, Stålberg E and Westman J: Topical application of dynorphin A
(1-17) antiserum attenuates trauma induced alterations in spinal
cord evoked potentials, microvascular permeability disturbances,
edema formation and cell injury: An experimental study in the rat
using electrophysiological and morphological approaches. Amino
Acids. 23:273–281. 2002.PubMed/NCBI View Article : Google Scholar
|
|
53
|
Ramadan WS, Abdel-Hamid GA, Al-Karim S and
Abbas AT: Histological, immunohistochemical and ultrastructural
study of secondary compressed spinal cord injury in a rat model.
Folia Histochem Cytobiol. 55:11–20. 2017.PubMed/NCBI View Article : Google Scholar
|
|
54
|
Pereira IM, Marote A, Salgado AJ and Silva
NA: Filling the gap: Neural stem cells as a promising therapy for
spinal cord injury. Pharmaceuticals (Basel). 29(65)2019.PubMed/NCBI View Article : Google Scholar
|
|
55
|
Trounson A and McDonald C: Stem cell
therapies in clinical trials: Progress and challenges. Cell Stem
Cell. 17:11–22. 2015.PubMed/NCBI View Article : Google Scholar
|
