Histone demethylase KDM2A: Biological functions and clinical values (Review)

  • Authors:
    • Lisheng Liu
    • Jiangnan Liu
    • Qinghai Lin
  • View Affiliations

  • Published online on: May 4, 2021     https://doi.org/10.3892/etm.2021.10155
  • Article Number: 723
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Abstract

Histone lysine demethylation modification is a critical epigenetic modification. Lysine demethylase 2A (KDM2A), a Jumonji C domain‑containing demethylase, demethylates the dimethylated H3 lysine 36 (H3K36) residue and exerts little or no activity on monomethylated and trimethylated H3K36 residues. KDM2A expression is regulated by several factors, such as microRNAs, and the phosphorylation of KDM2A also plays a vital role in its function. KDM2A mainly recognizes the unmethylated region of CpG islands and subsequently demethylates histone H3K36 residues. In addition, KDM2A recognizes and binds to phosphorylated proteins, and promotes their ubiquitination and degradation. KDM2A plays an important role in chromosome remodeling and gene transcription, and is involved in cell proliferation and differentiation, cell metabolism, heterochromosomal homeostasis and gene stability. Notably, KDM2A is crucial for tumorigenesis and progression. In the present review, the documented biological functions of KDM2A in physiological and pathological processes are comprehensively summarized.
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July-2021
Volume 22 Issue 1

Print ISSN: 1792-0981
Online ISSN:1792-1015

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Spandidos Publications style
Liu L, Liu J and Lin Q: Histone demethylase KDM2A: Biological functions and clinical values (Review). Exp Ther Med 22: 723, 2021
APA
Liu, L., Liu, J., & Lin, Q. (2021). Histone demethylase KDM2A: Biological functions and clinical values (Review). Experimental and Therapeutic Medicine, 22, 723. https://doi.org/10.3892/etm.2021.10155
MLA
Liu, L., Liu, J., Lin, Q."Histone demethylase KDM2A: Biological functions and clinical values (Review)". Experimental and Therapeutic Medicine 22.1 (2021): 723.
Chicago
Liu, L., Liu, J., Lin, Q."Histone demethylase KDM2A: Biological functions and clinical values (Review)". Experimental and Therapeutic Medicine 22, no. 1 (2021): 723. https://doi.org/10.3892/etm.2021.10155