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Histone demethylase KDM2A: Biological functions and clinical values (Review)

  • Authors:
    • Lisheng Liu
    • Jiangnan Liu
    • Qinghai Lin
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    Affiliations: Key Laboratory of Animal Resistance Research, College of Life Science, Shandong Normal University, Jinan, Shandong 250014, P.R. China, Department of Cell and Molecular Biology, Karolinska Institutet, Stockholm, SE-171 77, Sweden, Department of Clinical Laboratory, Shandong Cancer Hospital and Institute, Shandong First Medical University and Shandong Academy of Medical Sciences, Jinan, Shandong 250117, P.R. China
  • Article Number: 723
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    Published online on: May 4, 2021
       https://doi.org/10.3892/etm.2021.10155
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Abstract

Histone lysine demethylation modification is a critical epigenetic modification. Lysine demethylase 2A (KDM2A), a Jumonji C domain‑containing demethylase, demethylates the dimethylated H3 lysine 36 (H3K36) residue and exerts little or no activity on monomethylated and trimethylated H3K36 residues. KDM2A expression is regulated by several factors, such as microRNAs, and the phosphorylation of KDM2A also plays a vital role in its function. KDM2A mainly recognizes the unmethylated region of CpG islands and subsequently demethylates histone H3K36 residues. In addition, KDM2A recognizes and binds to phosphorylated proteins, and promotes their ubiquitination and degradation. KDM2A plays an important role in chromosome remodeling and gene transcription, and is involved in cell proliferation and differentiation, cell metabolism, heterochromosomal homeostasis and gene stability. Notably, KDM2A is crucial for tumorigenesis and progression. In the present review, the documented biological functions of KDM2A in physiological and pathological processes are comprehensively summarized.
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Copy and paste a formatted citation
Spandidos Publications style
Liu L, Liu J and Lin Q: Histone demethylase KDM2A: Biological functions and clinical values (Review). Exp Ther Med 22: 723, 2021.
APA
Liu, L., Liu, J., & Lin, Q. (2021). Histone demethylase KDM2A: Biological functions and clinical values (Review). Experimental and Therapeutic Medicine, 22, 723. https://doi.org/10.3892/etm.2021.10155
MLA
Liu, L., Liu, J., Lin, Q."Histone demethylase KDM2A: Biological functions and clinical values (Review)". Experimental and Therapeutic Medicine 22.1 (2021): 723.
Chicago
Liu, L., Liu, J., Lin, Q."Histone demethylase KDM2A: Biological functions and clinical values (Review)". Experimental and Therapeutic Medicine 22, no. 1 (2021): 723. https://doi.org/10.3892/etm.2021.10155
Copy and paste a formatted citation
x
Spandidos Publications style
Liu L, Liu J and Lin Q: Histone demethylase KDM2A: Biological functions and clinical values (Review). Exp Ther Med 22: 723, 2021.
APA
Liu, L., Liu, J., & Lin, Q. (2021). Histone demethylase KDM2A: Biological functions and clinical values (Review). Experimental and Therapeutic Medicine, 22, 723. https://doi.org/10.3892/etm.2021.10155
MLA
Liu, L., Liu, J., Lin, Q."Histone demethylase KDM2A: Biological functions and clinical values (Review)". Experimental and Therapeutic Medicine 22.1 (2021): 723.
Chicago
Liu, L., Liu, J., Lin, Q."Histone demethylase KDM2A: Biological functions and clinical values (Review)". Experimental and Therapeutic Medicine 22, no. 1 (2021): 723. https://doi.org/10.3892/etm.2021.10155
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