Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Experimental and Therapeutic Medicine
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-0981 Online ISSN: 1792-1015
Journal Cover
July-2021 Volume 22 Issue 1

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
July-2021 Volume 22 Issue 1

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article Open Access

Abnormal expression of miR‑135a in patients with depression and its possible involvement in the pathogenesis of the condition

  • Authors:
    • Yinxia Ding
    • Ming Zhong
    • Bingjie Qiu
    • Chuanpeng Liu
    • Jinfeng Wang
    • Jie Liang
  • View Affiliations / Copyright

    Affiliations: Department of Psychiatry, Binzhou Youfu Hospital, Binzhou, Shandong 256600, P.R. China, Department of Psychiatry, Binzhou People's Hospital, Binzhou, Shandong 256600, P.R. China, Binzhou Family Planning Association, Binzhou, Shandong 256600, P.R. China, Ministry of Public Infrastructure, Zhaoqing Medical College, Zhaoqing, Guangdong 526020, P.R. China
    Copyright: © Ding et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 726
    |
    Published online on: May 4, 2021
       https://doi.org/10.3892/etm.2021.10158
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

At present, due to the increasing pressures on society and the stress of everyday living, the number of individuals suffering from depression has increased. Therefore, the treatment of depression has also received increasing attention. MicroRNA (miRNA/miR)‑135a is a well‑studied miRNA. It has been reported that miR‑135a is significantly downregulated in patients with depression and may be a potential marker for the diagnosis of the condition. However, the specific mechanisms of action of miR‑135a in patients with depression remain unclear. In the present study, it was found that miR‑135a was downregulated in patients with depression, and in a mouse model of depression. The effects of miR‑135a on depression‑related symptoms in mice were then explored. In the mice with chronic unpredictable mild stress (CUMS) that were treated with miR‑135a for 3 weeks, a significantly reduced level of weight gain was observed in comparison with the control group. In addition, treatment with miR‑135a mimic significantly increased sucrose preference in the sucrose preference test in the mice, and reduced the immobility time in the forced swimming test and tail suspension test. Treatment with miR‑135a mimic also inhibited CUMS‑induced hippocampal cell apoptosis. Furthermore, treatment with miR‑135a mimic and fluoxetine significantly reduced the CUMS‑induced increase in the expression levels of inflammatory factors (IL‑1β, IL‑6 and TNF‑α) in the hippocampus of the mice. Subsequently, reverse transcription‑quantitative polymerase chain reaction and western blot analysis revealed that treatment with miR‑135a mimic significantly inhibited the expression of Toll‑like receptor 4 in the mouse hippocampus. In conclusion, the findings of the present study indicate that miR‑135a may be a novel potential target for the treatment of depression.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

Figure 5

View References

1 

Bortolato B, Carvalho AF, Soczynska JK, Perini GI and McIntyre RS: The involvement of TNF-α in cognitive dysfunction associated with major depressive disorder: An opportunity for domain specific treatments. Curr Neuropharmacol. 13:558–576. 2015.PubMed/NCBI View Article : Google Scholar

2 

Belmaker RH and Agam G: Major depressive disorder. N Engl J Med. 358:55–68. 2008.PubMed/NCBI View Article : Google Scholar

3 

Prokofieva M, Koukia E and Dikeos D: Mental health nursing in Greece: Nursing diagnoses and interventions in major depression. Issues Ment Health Nurs. 37:556–562. 2016.PubMed/NCBI View Article : Google Scholar

4 

Chuang YH and Kuo LM: Nurses' confidence in providing and managing care for older persons with depressive symptoms or depression in long-term care facilities: A national survey. Int J Ment Health Nurs. 27:1767–1775. 2018.PubMed/NCBI View Article : Google Scholar

5 

Xie X, Shi Y and Zhang J: Structural network connectivity impairment and depressive symptoms in cerebral small vessel disease. J Affect Disord. 220:8–14. 2017.PubMed/NCBI View Article : Google Scholar

6 

Suzuki H, Matsumoto Y, Ota H, Sugimura K, Takahashi J, Ito K, Miyata S, Furukawa K, Arai H, Fukumoto Y, et al: Hippocampal blood flow abnormality associated with depressive symptoms and cognitive impairment in patients with chronic heart failure. Circ J. 80:1773–1780. 2016.PubMed/NCBI View Article : Google Scholar

7 

Nabavi SM, Daglia M, Braidy N and Nabavi SF: Natural products, micronutrients, and nutraceuticals for the treatment of depression: A short review. Nutr Neurosci. 20:180–194. 2017.PubMed/NCBI View Article : Google Scholar

8 

Weil-Malherbe H: The biochemistry of affective disorders. In: Handbook of Neurochemistry. Springer, Boston, MA, pp371-416, 1972.

9 

Lee S, Jeong J, Kwak Y and Park SK: Depression research: Where are we now? Mol Brain. 3:8–0. 2010.PubMed/NCBI View Article : Google Scholar

10 

Ebmeier KP, Donaghey C and Steele JD: Recent developments and current controversies in depression. Lancet. 367:153–167. 2006.PubMed/NCBI View Article : Google Scholar

11 

Leistedt SJ and Linkowski P: Brain, networks, depression, and more. Eur Neuropsychopharmacol. 23:55–62. 2013.PubMed/NCBI View Article : Google Scholar

12 

Kessler RC: The costs of depression. Psychiatr Clin North Am. 35:1–14. 2012.PubMed/NCBI View Article : Google Scholar

13 

Ota KT and Duman RS: Environmental and pharmacological modulations of cellular plasticity: Role in the pathophysiology and treatment of depression. Neurobiol Dis. 57:28–37. 2013.PubMed/NCBI View Article : Google Scholar

14 

Bartel DP: MicroRNAs: Genomics, biogenesis, mechanism, and function. Cell. 116:281–297. 2004.PubMed/NCBI View Article : Google Scholar

15 

Calin GA, Sevignani C, Dumitru CD, Hyslop T, Noch E, Yendamuri S, Shimizu M, Rattan S, Bullrich F, Negrini M, et al: Human microRNA genes are frequently located at fragile sites and genomic regions involved in cancers. Proc Natl Acad Sci USA. 101:2999–3004. 2004.PubMed/NCBI View Article : Google Scholar

16 

Krol J, Loedige I and Filipowicz W: The widespread regulation of microRNA biogenesis, function and decay. Nat Rev Genet. 11:597–610. 2010.PubMed/NCBI View Article : Google Scholar

17 

Mendell J and Olson E: . MicroRNAs in stress signaling and human disease. Cell. 148:1172–1187. 2012.PubMed/NCBI View Article : Google Scholar

18 

Maes OC, Chertkow HM, Wang E and Schipper HM: MicroRNA: Implications for Alzheimer disease and other human CNS disorders. Curr Genomics. 10:154–168. 2009.PubMed/NCBI View Article : Google Scholar

19 

Kocerha J, Kauppinen S and Wahlestedt C: MicroRNAs in CNS disorders. Neuromolecular Med. 11:162–172. 2009.PubMed/NCBI View Article : Google Scholar

20 

Zeng YB, Liang XH, Zhang GX, Jiang N, Zhang T, Huang JY, Zhang L and Zeng XC: miRNA-135a promotes hepatocellular carcinoma cell migration and invasion by targeting forkhead box O1. Cancer Cell Int. 16(63)2016.PubMed/NCBI View Article : Google Scholar

21 

Yao S, Tian C, Ding Y, Ye Q, Gao Y, Yang N and Li Q: Down-regulation of Krüppel-like factor-4 by microRNA-135a-5p promotes proliferation and metastasis in hepatocellular carcinoma by transforming growth factor-β1. Oncotarget. 7:42566–42578. 2016.PubMed/NCBI View Article : Google Scholar

22 

Ren JW, Li ZJ and Tu C: miR-135 post-transcriptionally regulates FOXO1 expression and promotes cell proliferation in human malignant melanoma cells. Int J Clin Exp Pathol. 8:6356–6366. 2015.PubMed/NCBI

23 

Xu B, Lu X, Zhao Y, Liu C, Huang X, Chen S, Zhu W, Zhang L and Chen M: MicroRNA-135a induces prostate cancer cell apoptosis via inhibition of STAT6. Oncol Lett. 17:1889–1895. 2019.PubMed/NCBI View Article : Google Scholar

24 

Gheysarzadeh A, Sadeghifard N, Afraidooni L, Pooyan F, Mofid MR, Valadbeigi H, Bakhtiari H and Keikhavani S: Serum-based microRNA biomarkers for major depression: miR-16, miR-135a, and miR-1202. J Res Med Sci. 23(69)2018.PubMed/NCBI View Article : Google Scholar

25 

Deng XY, Li HY, Chen JJ, Li RP, Qu R, Fu Q and Ma SP: Thymol produces an antidepressant-like effect in a chronic unpredictable mild stress model of depression in mice. Behav Brain Res. 291:12–19. 2015.PubMed/NCBI View Article : Google Scholar

26 

Chen YP, Wang C and Xu JP: Chronic unpredictable mild stress induced depression-like behaviours and glutamate-glutamine cycling dysfunctions in both blood and brain of mice. Pharm Biol. 57:280–286. 2019.PubMed/NCBI View Article : Google Scholar

27 

Duan CM, Zhang JR, Wan TF, Wang Y, Chen HS and Liu L: SRT2104 attenuates chronic unpredictable mild stress-induced depressive-like behaviors and imbalance between microglial M1 and M2 phenotypes in the mice. Behav Brain Res. 378(112296)2020.PubMed/NCBI View Article : Google Scholar

28 

Lian N, Niu Q, Lei Y, Li X, Li Y and Song X: miR-221 is involved in depression by regulating Wnt2/CREB/BDNF axis in hippocampal neurons. Cell Cycle. 17:2745–2755. 2018.PubMed/NCBI View Article : Google Scholar

29 

Iñiguez SD, Riggs LM, Nieto SJ, Dayrit G, Zamora NN, Shawhan KL, Cruz B and Warren BL: Social defeat stress induces a depression-like phenotype in adolescent male c57BL/6 mice. Stress. 17:247–255. 2014.PubMed/NCBI View Article : Google Scholar

30 

Steru L, Chermat R, Thierry B and Simon P: The tail suspension test: A new method for screening antidepressants in mice. Psychopharmacology (Berl). 85:367–370. 1985.PubMed/NCBI View Article : Google Scholar

31 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method. Methods. 25:402–408. 2001.PubMed/NCBI View Article : Google Scholar

32 

Xie B, Lu C, Chen C, Zhou J and Deng Z: miR-135a alleviates silica-induced pulmonary fibrosis by targeting NF-κB/Inflammatory signaling pathway. Mediators Inflamm. 2020(1231243)2020.PubMed/NCBI View Article : Google Scholar

33 

Ferrúa CP, Giorgi R, da Rosa LC, do Amaral CC, Ghisleni GC, Pinheiro RT and Nedel F: MicroRNAs expressed in depression and their associated pathways: A systematic review and a bioinformatics analysis. J Chem Neuroanat. 100(101650)2019.PubMed/NCBI View Article : Google Scholar

34 

Allen L and Dwivedi Y: MicroRNA mediators of early life stress vulnerability to depression and suicidal behavior. Mol Psychiatry. 25:308–320. 2020.PubMed/NCBI View Article : Google Scholar

35 

Lou D, Wang J and Wang X: miR-124 ameliorates depressive-like behavior by targeting STAT3 to regulate microglial activation. Mol Cell Probes. 48(101470)2019.PubMed/NCBI View Article : Google Scholar

36 

Xu B, Tao T, Wang Y, Fang F, Huang Y, Chen S, Zhu W and Chen M: hsa-miR-135a-1 inhibits prostate cancer cell growth and migration by targeting EGFR. Tumour Biol. 37:14141–14151. 2016.PubMed/NCBI View Article : Google Scholar

37 

Shi H, Ji Y, Zhang D, Liu Y and Fang P: miR-135a inhibits migration and invasion and regulates EMT-related marker genes by targeting KLF8 in lung cancer cells. Biochem Biophys Res Commun. 465:125–130. 2015.PubMed/NCBI View Article : Google Scholar

38 

Yan LH, Chen ZN, Li-Li Chen J, Wei WE, Mo XW, Qin YZ, Lin Y and Chen JS: miR-135a promotes gastric cancer progression and resistance to oxaliplatin. Oncotarget. 7:70699–70714. 2016.PubMed/NCBI View Article : Google Scholar

39 

Zhou W, Li X, Liu F, Xiao Z, He M, Shen S and Liu S: miR-135a promotes growth and invasion of colorectal cancer via metastasis suppressor 1 in vitro. Acta Biochim Biophys Sin (Shanghai). 44:838–846. 2012.PubMed/NCBI View Article : Google Scholar

40 

Shi HZ, Wang DN, Xu F, Teng JH and Wang YL: miR-135a inhibits glioma cell proliferation and invasion by directly targeting FOXO1. Eur Rev Med Pharmacol Sci. 22:4215–4223. 2018.PubMed/NCBI View Article : Google Scholar

41 

Henn FA and Vollmayr B: Stress models of depression: Forming genetically vulnerable strains. Neurosci Biobehav Rev. 29:799–804. 2005.PubMed/NCBI View Article : Google Scholar

42 

Wan YQ, Feng JG, Li M, Wang MZ, Liu L, Liu X, Duan XX, Zhang CX and Wang XB: Prefrontal cortex miR-29b-3p plays a key role in the antidepressant-like effect of ketamine in rats. Exp Mol Med. 50:1–14. 2018.PubMed/NCBI View Article : Google Scholar

43 

Dey A and Hankey Giblin PA: Insights into macrophage heterogeneity and cytokineinduced neuroinflammation in major depressive disorder. Pharmaceuticals (Basel). 11(E64)2018.PubMed/NCBI View Article : Google Scholar

44 

Iwata M, Ota KT and Duman RS: The inflammasome: Pathways linking psychological stress, depression, and systemic illnesses. Brain Behav Immun. 31:105–114. 2013.PubMed/NCBI View Article : Google Scholar

45 

Rush G, O'Donovan A, Nagle L, Conway C, McCrohan A, O'Farrelly C, Lucey JV and Malone KM: Alteration of immune markers in a group of melancholic depressed patients and their response to electroconvulsive therapy. J Affect Disord. 205:60–68. 2016.PubMed/NCBI View Article : Google Scholar

46 

Shen Z, Xu Y, Jiang X, Wang Z, Guo Y, Pan W and Hou J: Avicularin relieves depressive-like behaviors induced by chronic unpredictable mild stress in mice. Med Sci Monit. 24:1643–3750. 2018.PubMed/NCBI View Article : Google Scholar

47 

Du XJ and Lu JM: miR-135a represses oxidative stress and vascular inflammatory events via targeting toll-like receptor 4 in atherogenesis. J Cell Biochem. 119:6154–6161. 2018.PubMed/NCBI View Article : Google Scholar

48 

den Dekker WK, Cheng C, Pasterkamp G and Duckers HJ: Toll like receptor 4 in atherosclerosis and plaque destabilization. Atherosclerosis. 209:314–320. 2010.PubMed/NCBI View Article : Google Scholar

49 

Yang L and Gao C: miR-590 inhibits endothelial cell apoptosis by inactivating the TLR4/NF-κB pathway in atherosclerosis. Yonsei Med J. 60:298–307. 2019.PubMed/NCBI View Article : Google Scholar

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Ding Y, Zhong M, Qiu B, Liu C, Wang J and Liang J: Abnormal expression of miR‑135a in patients with depression and its possible involvement in the pathogenesis of the condition. Exp Ther Med 22: 726, 2021.
APA
Ding, Y., Zhong, M., Qiu, B., Liu, C., Wang, J., & Liang, J. (2021). Abnormal expression of miR‑135a in patients with depression and its possible involvement in the pathogenesis of the condition. Experimental and Therapeutic Medicine, 22, 726. https://doi.org/10.3892/etm.2021.10158
MLA
Ding, Y., Zhong, M., Qiu, B., Liu, C., Wang, J., Liang, J."Abnormal expression of miR‑135a in patients with depression and its possible involvement in the pathogenesis of the condition". Experimental and Therapeutic Medicine 22.1 (2021): 726.
Chicago
Ding, Y., Zhong, M., Qiu, B., Liu, C., Wang, J., Liang, J."Abnormal expression of miR‑135a in patients with depression and its possible involvement in the pathogenesis of the condition". Experimental and Therapeutic Medicine 22, no. 1 (2021): 726. https://doi.org/10.3892/etm.2021.10158
Copy and paste a formatted citation
x
Spandidos Publications style
Ding Y, Zhong M, Qiu B, Liu C, Wang J and Liang J: Abnormal expression of miR‑135a in patients with depression and its possible involvement in the pathogenesis of the condition. Exp Ther Med 22: 726, 2021.
APA
Ding, Y., Zhong, M., Qiu, B., Liu, C., Wang, J., & Liang, J. (2021). Abnormal expression of miR‑135a in patients with depression and its possible involvement in the pathogenesis of the condition. Experimental and Therapeutic Medicine, 22, 726. https://doi.org/10.3892/etm.2021.10158
MLA
Ding, Y., Zhong, M., Qiu, B., Liu, C., Wang, J., Liang, J."Abnormal expression of miR‑135a in patients with depression and its possible involvement in the pathogenesis of the condition". Experimental and Therapeutic Medicine 22.1 (2021): 726.
Chicago
Ding, Y., Zhong, M., Qiu, B., Liu, C., Wang, J., Liang, J."Abnormal expression of miR‑135a in patients with depression and its possible involvement in the pathogenesis of the condition". Experimental and Therapeutic Medicine 22, no. 1 (2021): 726. https://doi.org/10.3892/etm.2021.10158
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team