|
1
|
McCloskey SC, Patel BD, Hinchliffe SJ,
Reid ED, Wareham NJ and Lomas DA: Siblings of patients with severe
chronic obstructive pulmonary disease have significant risk of
airflow obstruction. Am J Respir Crit Care Med. 164:1419–1424.
2001.PubMed/NCBI View Article : Google Scholar
|
|
2
|
Bames PJ, Burney PG, Silverman EK, Celli
BR, Vestbo J, Wedzicha JA and Wouters EFM: Chronic obstructive
pulmonary disease. Nat Rev Dis Primers. 1(15076)2015.PubMed/NCBI View Article : Google Scholar
|
|
3
|
Briscoe J and Therond PP: The mechanisms
of Hedgehog signalling and its roles in development and disease.
Nat Rev Mol Cell Biol. 14:416–429. 2013.PubMed/NCBI View
Article : Google Scholar
|
|
4
|
Kasper M, Regl G, Frischauf AM and Aberger
F: GLI1 transcription factors: Mediators of oncogenic Hedgehog
signaling. Eur J Cancer. 42:437–445. 2006.PubMed/NCBI View Article : Google Scholar
|
|
5
|
Lemjabbar-Alaoui H, Dasari V, Sidhu SS,
Mengistab A, Finkbeiner W, Gallup M and Basbaum C: Wnt and Hedgehog
are critical mediators of cigarette smoke-induced lung cancer. PLoS
One. 1(e93)2006.PubMed/NCBI View Article : Google Scholar
|
|
6
|
Kugler MC, Loomis CA, Zhao Z, Cushman JC,
Liu L and Munger JS: Sonic Hedgehog signaling regulates
myofibroblast function during alveolar septum formation in murine
postnatal lung. Am J Respir Cell Mol Biol. 57:280–293.
2017.PubMed/NCBI View Article : Google Scholar
|
|
7
|
Lao T, Jiang Z, Yun J, Qiu W, Guo F, Huang
C, Mancini JD, Gupta K, Laucho-Contreras ME, Naing ZZC, et al: Hhip
haploin sufficiency sensitizes mice to age-related emphysema. Proc
Natl Acad Sci USA. 113:E4681–E4687. 2016.PubMed/NCBI View Article : Google Scholar
|
|
8
|
Lao T, Glass K, Qiu W, Polverino F, Gupta
K, Morrow J, Dominic Mancini J, Vuong L, Perrella MA, Hersh CP, et
al: Haploinsufficiency of Hedgehog interacting protein causes
increased emphysema induced by cigarette smoke through network
rewiring. Genome Med. 7(12)2015.PubMed/NCBI View Article : Google Scholar
|
|
9
|
Guo Y, Shi GC, Wan HY and Zhou M: Hedgehog
signaling regulates the expression levels of inflammatory mediators
in cigarette-induced airway inflammation. Mol Med Rep.
17:8557–8563. 2018.PubMed/NCBI View Article : Google Scholar
|
|
10
|
Wu F, He ZQ, Ding R, Huang ZG, Jiang QX,
Cui HM, Lin Y, Huang SB, Dai XL, Zhang JY, et al: Danhong promotes
angiogenesis in diabetic mice after critical limb ischemia by
activation of CSE-H2S-VEGF axis. Evid Based Complement Alternat
Med. 2015(276263)2015.PubMed/NCBI View Article : Google Scholar
|
|
11
|
D'hulst AI, Vermaelen KY, Brusselle GG,
Joos GF and Pauwels RA: Time course of cigarette smoke-induced
pulmonary inflammation in mice. Eur Respir J. 26:204–213.
2005.PubMed/NCBI View Article : Google Scholar
|
|
12
|
Chen X, Jin YT, Hou XM, Liu FQ and Wang
YL: Sonic Hedgehog signaling: Evidence for its protective role
protective role in endotoxin induced acute lung injury in mouse
model. PLoS One. 10(e0140886)2015.PubMed/NCBI View Article : Google Scholar
|
|
13
|
Livak KJ and Schmittgen TD: Analysis of
relative gene expression data using real-time quantitative PCR and
the 2(-Delta Delta C(T)) method. Methods. 25:402–408.
2001.PubMed/NCBI View Article : Google Scholar
|
|
14
|
Wang C, de Mochel NSR, Christenson SA,
Cassandras M, Moon R, Brumwell AN, Byrnes L, Li A, Yokosaki Y, Shan
P, et al: Expansion of Hedgehog disrupts mesenchymal identity and
induces emphysema phenotype. J Clin Invest. 128:4343–4358.
2018.PubMed/NCBI View
Article : Google Scholar
|
|
15
|
Solanas G and Benitah SA: Regenerating the
skin: A task for the heterogeneous stem cell pool and surrounding
niche. Nat Rev Mol Cell Biol. 14:737–748. 2013.PubMed/NCBI View
Article : Google Scholar
|
|
16
|
Varjosalo M and Taipale J: Hedgehog:
Functions and mechanisms. Genes Dev. 22:2454–2472. 2008.PubMed/NCBI View Article : Google Scholar
|
|
17
|
Onishi H, Morisaki T, Nakao F, Odate S,
Morisaki T and Katano M: Protein-bound polysaccharide decreases
invasiveness and proliferation in pancreatic cancer by inhibition
of Hedgehog signaling and HIF-1α pathways under hypoxia. Cancer
Lett. 335:289–298. 2013.PubMed/NCBI View Article : Google Scholar
|
|
18
|
Chuang PT, Kawcak T and McMahon AP:
Feedback control of mammalian Hedgehog signaling by the
Hedgehog-binding protein, Hip1, modulates Fgf signaling during
branching morphogenesis of the lung. Genes Dev. 17:342–347.
2003.PubMed/NCBI View Article : Google Scholar
|
|
19
|
Hancock DB, Eijgelsheim M, Wilk JB, Gharib
SA, Loehr LR, Marciante KD, Franceschini N, van Durme YMTA, Chen
TH, Barr RG, et al: Meta-analyses of genome-wide association
studies identify multiple loci associated with pulmonary function.
Nat Genet. 42:45–52. 2010.PubMed/NCBI View
Article : Google Scholar
|
|
20
|
Pillai SG, Ge DL, Zhu GH, Kong XY, Shianna
KV, Need AC, Feng S, Hersh CP, Bakke P, Gulsvik A, et al: A
genome-wide association study in chronic obstructive pulmonary
disease (COPD): Identification of two major susceptibility loci.
PLoS Genet. 5(e1000421)2009.PubMed/NCBI View Article : Google Scholar
|
|
21
|
Guo Y, Gong Y, Pan C, Qian Y, Shi G, Cheng
Q, Li QY, Ren L, Weng QL, Chen Y, et al: Association of genetic
polymorphisms with chronic obstructive pulmonary disease in the
chinese han population: A case-control study. BMC Med Genomics.
5(64)2012.PubMed/NCBI View Article : Google Scholar
|
|
22
|
Li R, Cai L, Ding J, Hu CM, Wu TN and Hu
XY: Inhibition of Hedgehog signal pathway by cyclopamine attenuates
inflammation and articular cartilage damage in rats with
adjuvant-induced arthritis. J Pharm Pharmacol. 67:963–971.
2015.PubMed/NCBI View Article : Google Scholar
|
|
23
|
El-Zaatari M, Kao JY, Tessier A, Bai L,
Hayes MM, Fontaine C, Eaton KA and Merchant JL: Gli1 deletion
prevents helicobacter-induced gastric metaplasia and expansion of
myeloid cell subsets. PLoS One. 8(e58935)2013.PubMed/NCBI View Article : Google Scholar
|
|
24
|
Wang CQ, Cassandras M and Peng T: The role
of Hedgehog signaling in adult lung regeneration and maintenance. J
Dev Biol. 7(14)2019.PubMed/NCBI View Article : Google Scholar
|
