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Preclinical study analysis of massive magnesium alloy graft for calcaneal fractures

  • Authors:
    • Şerban Dragosloveanu
    • Dragoş Corneliu Cotor
    • Christiana D.M. Dragosloveanu
    • Cătălin Stoian
    • Cristian Ioan Stoica
  • View Affiliations / Copyright

    Affiliations: Department of Orthopedics, ‘Carol Davila’ University of Medicine and Pharmacy, 050474 Bucharest, Romania, Department of Ophthalmology, ‘Carol Davila’ University of Medicine and Pharmacy, 050474 Bucharest, Romania
    Copyright: © Dragosloveanu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 731
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    Published online on: May 7, 2021
       https://doi.org/10.3892/etm.2021.10163
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Abstract

The highly comminuted calcaneal fractures represent a challenge for surgeons and require bone grafts for a good clinical outcome. Postoperative results are generally associated with increased morbidity and long periods of inactivity. The biomedical community promotes the use of artificial materials for grafts in order to achieve improved results. In an era when cosmetic concerns as well as the satisfaction of patients are mandatory and the use of autologous bone grafts is not without complications, an artificial replacement appears to be a favorable option. Synthetic bone grafts are known to fail under stress shield or are associated with systemic side effects. The purpose of the present study was to investigate and determine an already commercially available magnesium (Mg) alloy whose design is most suitable for long‑term use. The mechanical properties of Mg1Ca and MgYREZr compared with normal cortical and cancellous bone were assessed. Another discussed aspect was the influence of the alloy in the graft fixation. The results revealed that Mg1Ca and MgYREZr alloys had a low tensile strength of 75 and 250 MPa, respectively. For this reason, it was surmised that MgYREZr alloy could be an optimal choice with favorable corrosion resistance. Since calcaneal fractures are prone to skin necrosis and septic complications, the need for antibacterial procedures and antibiotic prophylaxis is highlighted. Thus, an in vivo attempt was also made to identify the relationship between Mg alloy products and bacterial load. However, the most important feature of the present study was the creation of a 3D model grafting, with an anti‑sliding design, which can be potentially used with the preferred Mg alloy in this type of fractures. In conclusion, artificial materials are the future in medicine, replacing the body‑limiting capabilities of grafts. They are safe and incur less comorbidities. This method could pave the way for reducing patient discomfort and increasing patient satisfaction. Although further testing is required, this research represents a great starting point for calcaneal fractures.
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Copy and paste a formatted citation
Spandidos Publications style
Dragosloveanu Ş, Cotor DC, Dragosloveanu CD, Stoian C and Stoica CI: Preclinical study analysis of massive magnesium alloy graft for calcaneal fractures. Exp Ther Med 22: 731, 2021.
APA
Dragosloveanu, Ş., Cotor, D.C., Dragosloveanu, C.D., Stoian, C., & Stoica, C.I. (2021). Preclinical study analysis of massive magnesium alloy graft for calcaneal fractures. Experimental and Therapeutic Medicine, 22, 731. https://doi.org/10.3892/etm.2021.10163
MLA
Dragosloveanu, Ş., Cotor, D. C., Dragosloveanu, C. D., Stoian, C., Stoica, C. I."Preclinical study analysis of massive magnesium alloy graft for calcaneal fractures". Experimental and Therapeutic Medicine 22.1 (2021): 731.
Chicago
Dragosloveanu, Ş., Cotor, D. C., Dragosloveanu, C. D., Stoian, C., Stoica, C. I."Preclinical study analysis of massive magnesium alloy graft for calcaneal fractures". Experimental and Therapeutic Medicine 22, no. 1 (2021): 731. https://doi.org/10.3892/etm.2021.10163
Copy and paste a formatted citation
x
Spandidos Publications style
Dragosloveanu Ş, Cotor DC, Dragosloveanu CD, Stoian C and Stoica CI: Preclinical study analysis of massive magnesium alloy graft for calcaneal fractures. Exp Ther Med 22: 731, 2021.
APA
Dragosloveanu, Ş., Cotor, D.C., Dragosloveanu, C.D., Stoian, C., & Stoica, C.I. (2021). Preclinical study analysis of massive magnesium alloy graft for calcaneal fractures. Experimental and Therapeutic Medicine, 22, 731. https://doi.org/10.3892/etm.2021.10163
MLA
Dragosloveanu, Ş., Cotor, D. C., Dragosloveanu, C. D., Stoian, C., Stoica, C. I."Preclinical study analysis of massive magnesium alloy graft for calcaneal fractures". Experimental and Therapeutic Medicine 22.1 (2021): 731.
Chicago
Dragosloveanu, Ş., Cotor, D. C., Dragosloveanu, C. D., Stoian, C., Stoica, C. I."Preclinical study analysis of massive magnesium alloy graft for calcaneal fractures". Experimental and Therapeutic Medicine 22, no. 1 (2021): 731. https://doi.org/10.3892/etm.2021.10163
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