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Expression of STAT3 and vasculogenic mimicry in gallbladder carcinoma promotes invasion and metastasis

  • Authors:
    • Hongbing Zhou
    • Yin Yuan
    • Haixin Qian
  • View Affiliations / Copyright

    Affiliations: Department of General Surgery, The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu 215006, P.R. China, Department of Hepatobiliary Surgery, The Fifth Affiliated Hospital of The Medical School of Nantong University, Taizhou, Jiangsu 225300, P.R. China, Department of General Surgery, The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu 215006, P.R. China
    Copyright: © Zhou et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 738
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    Published online on: May 9, 2021
       https://doi.org/10.3892/etm.2021.10170
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Abstract

Surgical treatment of gallbladder carcinoma remains challenging, while targeted therapy has been demonstrated to have potential. In the present study, the effect of signal transducer and activator of transcription 3 (STAT3) expression and vasculogenic mimicry (VM) on the occurrence and development of gallbladder carcinoma was evaluated. A total of 72 patients with gallbladder carcinoma and 10 patients with chronic cholecystitis were examined. Immunohistochemical staining was performed to determine the positive expression rates of STAT3. Periodic acid Schiff CD34 double staining was performed to detect VM in the gallbladder carcinoma group. STAT3 expression and VM in gallbladder carcinoma tissues was compared among patients with different clinical characteristics. In postoperative patients with gallbladder cancer, the relationship of the postoperative recurrence time with STAT3 expression and VM was assessed. STAT3 expression in gallbladder carcinoma tissue was significantly higher than that in cholecystitis tissue (P<0.05). STAT3 expression levels and VM were positively correlated in gallbladder carcinoma tissue. STAT3 protein expression in gallbladder carcinoma tissues differed significantly among patients with different degrees of differentiation and clinical stages (P<0.05). Among the 51 patients who completed the 3‑year follow‑up, the mean time to relapse was 17.353 and 35.647 months in those with high and low STAT3 expression, respectively, with significant differences (P<0.05). The VM structure was detected in 47 cases (92.15%) and not detected in four cases (7.84%), which exhibited no immediate recurrence after surgery, and the difference in the mean postoperative recurrence time was significant (22.38 vs. 36.00 months, respectively; P<0.05). In gallbladder carcinoma tissues, a lower degree of differentiation, higher malignancy degree and higher clinical stage were associated with higher expression of STAT3 and VM. Thus, STAT3 may promote VM formation in the process of tumor occurrence, development and metastasis. Therefore, STAT3 as a regulatory target, may inhibit the proliferation and invasion of tumor cells and block the development of VM, thereby representing a suitable target for antitumor angiogenesis therapy.
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1 

Hundal R and Shaffer EA: Galltesticles Cancer: Epidemiology and outcome. Clin Epidemiol. 6:99–109. 2014.

2 

Chen W, Zheng R, Baade PD, Zhang S, Zeng H, Bray F, Jemal A, Yu XQ and He J: Cancer statistics in China, 2015. CA Cancer J Clin. 66:115–132. 2016.PubMed/NCBI View Article : Google Scholar

3 

Liu S, Wang X and Liu Y: Advances in comprehensive treatment of gallbladder cancer. Surgery Concepts & Practice. 21:365–368. 2016.

4 

Folkman J: Tumor angiogenesis: Therapeutic implications. N Engl J Med. 285:1182–1186. 1971.PubMed/NCBI View Article : Google Scholar

5 

Niu G, Wright KL, Huang M, Song L, Haura E, Turkson J, Zhang S, Wang T, Sinibaldi D, Coppola D, et al: Constitutive Stat3 activity up-regulates VEGF expression and tumor angiogenesis. Oncogene. 21:2000–2008. 2002.PubMed/NCBI View Article : Google Scholar

6 

Lee SE, Jang JY, Lim CS, Kang MJ and Kim SW: Systematic review on the surgical treatment for T1 gallbladder cancer. World J Gastroenterol. 17:174–180. 2011.PubMed/NCBI View Article : Google Scholar

7 

Isambert M, Leux C, Métairie S and Paineau J: Incidentally-discovered gallbladder cancer: When, why and which reoperation. J Visc Surg. 148:e77–e84. 2011.PubMed/NCBI View Article : Google Scholar

8 

Cavallaro A, Piccolo G, Panebianco V, Lo Menzo E, Berretta M, Zanghì A, Di Vita M and Cappellani A: Incidental gallbladder cancer during laparoscopic cholecystectomy: Managing an unexpected finding. World J Gastroenterol. 18:4019–4027. 2012.PubMed/NCBI View Article : Google Scholar

9 

Horiguchi A, Miyakawa S, Ishihara S, Miyazaki M, Ohtsuka M, Shimizu H, Sano K, Miura F, Ohta T, Kayahara M, et al: Gallbladder bed resection or hepatectomy of segments 4a and 5 for pT2 gallbladder carcinoma: Analysis of Japanese registration cases by the study group for biliary surgery of the Japanese Society of Hepato-Biliary-Pancreatic Surgery. J Hepatobiliary Pancreat Sci. 20:518–524. 2013.PubMed/NCBI View Article : Google Scholar

10 

Fathi N, Rashidi G, Khodadadi A, Shahi S and Sharifi S: STAT3 and apoptosis challenges in cancer. Int J Biol Macromol. 117:993–1001. 2018.PubMed/NCBI View Article : Google Scholar

11 

Kitamura H, Ohno Y, Toyoshima Y, Ohtake J, Homma S, Kawamura H, Takahashi N and Taketomi A: Interleukin-6/STAT3 signaling as a promising target to improve the efficacy of cancer immunotherapy. Cancer Sci. 108:1947–1952. 2017.PubMed/NCBI View Article : Google Scholar

12 

Nagakura S, Shirai Y, Yokoyama N and Hatakeyama K: Clinical significance of lymph node micrometastasis in gallbladder carcinoma. Surgery. 129:704–713. 2001.PubMed/NCBI View Article : Google Scholar

13 

Wang H, Zhan M, Liu Q and Wang J: Glycochenodeoxycholate promotes the metastasis of gallbladder cancer cells by inducing epithelial to mesenchymal transition via activation of SOCS3/JAK2/STAT3 signaling pathway. J Cell Physiol. 235:1615–1623. 2020.PubMed/NCBI View Article : Google Scholar

14 

Fernandez-Cortes M, Delgado-Bellido D and Oliver FJ: Vasculogenic mimicry: Become an endothelial cell ‘but not so much’. Front Oncol. 9:803–809. 2019.PubMed/NCBI View Article : Google Scholar

15 

Kim SH, Lee HS, Kang BJ, Song BJ, Kim HB, Lee H, Jin MS and Lee A: Dynamic contrast-enhanced MRI perfusion parameters as imaging biomarkers of angiogenesis. PLoS One. 11(E0168632)2016.PubMed/NCBI View Article : Google Scholar

16 

Dutta S, Going JJ, Crumley AB, Mohammed Z, Orange C, Edwards J, Fullarton GM, Horgan PG and McMillan DC: The relationship between tumour necrosis, tumour proliferation, local and systemic inflammation, microvessel density and survival in patients undergoing potentially curative resection of oesophageal adenocarcinoma. Brit J Cancer. 106:702–710. 2012.PubMed/NCBI View Article : Google Scholar

17 

Lazcano-Ponce EC, Miquel JF, Muñoz N, Herrero R, Ferrecio C, Wistuba II, Alonso de Ruiz P, Aristi Urista G and Nervi F: Epidemiology and molecular pathology of gallbladder cancer. CA Cancer J Clin. 51:349–364. 2001.PubMed/NCBI View Article : Google Scholar

18 

Lesina M, Kurkowski MU, Ludes K, Rose-John S, Treiber M, Klöppel G, Yoshimura A, Reindl W, Sipos B, Akira S, et al: Stat3/Socs3 activation by IL-6 transsignaling promotes progression of pancreatic intraepithelial neoplasia and development of pancreatic cancer. Cancer Cell. 19:456–69. 201l.PubMed/NCBI View Article : Google Scholar

19 

Edge S, Byrd DR, Compton CC, Fritz AG, Greene F and Trotti A (eds): AJCC Cancer Staging Manual. 7th edition, Springer, New York, 2010. https://www.springer.com/us/book/9780387884424.

20 

Maniotis AJ, Folberg R, Hess A, Seftor EA, Gardner LM, Pe'er J, Trent JM, Meltzer PS and Hendrix MJ: Vascular channel formation by human melanoma cells in vivo and in vitro: Vasculogenic mimicry. Am J Pathol. 155:739–752. 1999.PubMed/NCBI View Article : Google Scholar

21 

Okayasu I and Hara A: Cyclooxygenase-2 and inducible nitric oxide synthase expression in human astrocytic gliomas: Correlation with angiogenesis and prognostic significance. Acta Neuropathol. 108:43–48. 2004.PubMed/NCBI View Article : Google Scholar

22 

Li C, Chen J and Qin G: Partial Youden index and its inferences. J Biopharm Stat. 29:385–399. 2019.PubMed/NCBI View Article : Google Scholar

23 

Lee SE, Jang JY, Lim CS, Kang MJ and Kim SW: Systematic review on the surgical treatment for T1 gallbladder cancer. World J Gastroenterol. 17:174–180. 2011.PubMed/NCBI View Article : Google Scholar

24 

Fratto ME, Santini D, Vincenzi B, Silvestris N, Azzariti A, Tommasi S, Zoccoli A, Galluzzo S, Maiello E, Colucci G and Tonini G: Targeting EGFR in bilio-pancreatic and liver carcinoma. Front Biosci (Schol Ed). 3:16–22. 2011.PubMed/NCBI View Article : Google Scholar

25 

Chen Y, Jiang L, She F, Tang N, Wang X, Li X, Han S and Zhu J: Vascular endothelial growth factor-C, promotes the growth and invasion of gallbladder cancer via an autocrine mechanism. Mol Cell Biochem. 345:77–89. 2010.PubMed/NCBI View Article : Google Scholar

26 

Lirdprapamongkol K, Sakurai H, Abdelhamed S, Yokoyama S, Athikomkulchai S, Viriyaroj A, Awale S, Ruchirawat S, Svasti J and Saiki I: Chrysin overcomes TRAIL resistance of cancer cells through Mcl-1 downregulation by inhibiting STAT3 phosphorylation. Int J Oncol. 43:329–337. 2013.PubMed/NCBI View Article : Google Scholar

27 

Wu YS, Chung I, Wong WF, Masamune A, Sim MS and Looi CY: Paracrine IL-6 signaling mediates the effects of pancreatic stellate cells on epithelial-mesenchymal transition via Stat3/Nrf2 pathway in pancreatic cancer cells. Biochim Biophys Acta Gen Subj. 1861:296–306. 2017.PubMed/NCBI View Article : Google Scholar

28 

O'Sullivan T, Saddawi-Konefka R, Vermi W, Koebel CM, Arthur C, White JM, Uppaluri R, Andrews DM, Ngiow SF, Teng MW, et al: Cancer immunoediting by the innate immune system in the absence of adaptive immunity. J Exp Med. 209:1869–1882. 2012.PubMed/NCBI View Article : Google Scholar

29 

Zhang Y, Guo S, Fang J, Peng B, Zhang Y and Cao T: Tanshinone IIA inhibits cell proliferation and tumor growth by downregulating STAT3 in human gastric cancer. Exp Ther Med. 16:2931–2937. 2018.PubMed/NCBI View Article : Google Scholar

30 

Ke F, Wang Z, Song X, Ma Q, Hu Y, Jiang L, Zhang Y, Liu Y, Zhang Y and Gong W: Cryptotanshinone induces cell cycle arrest and apoptosis through the JAK2/STAT3 and PI3K/Akt/NFκB pathways in cholangiocarcinoma cells. Drug Des Devel Ther. 11:1753–1766. 2017.PubMed/NCBI View Article : Google Scholar

31 

Ruiz P and Günthert U: The cellular basis of metastasis. World J Urol. 14:141–150. 1996.PubMed/NCBI View Article : Google Scholar

32 

Sohn EJ, Jung DB, Lee H, Han I, Lee J, Lee H and Kim SH: CNOT2 promotes proliferation and angiogenesis via VEGF signaling in MDA-MB-231 breast cancer cells. Cancer Lett. 412:88–98. 2018.PubMed/NCBI View Article : Google Scholar

33 

Chen Z and Han ZC: STAT3: A critical transcription activator in angiogenesis. Med Res Rev. 28:185–200. 2008.PubMed/NCBI View Article : Google Scholar

34 

Okazaki H, Tokumaru S, Hanakawa Y, Shiraishi K, Shirakata Y, Dai X, Yang L, Tohyama M, Hashimoto K and Sayama K: Nuclear translocation of phosphorylated STAT3 regulates VEGF-A-induced lymphatic endothelial cell migration and tube formation. Biochem Biophys Res Commun. 412:441–445. 2011.PubMed/NCBI View Article : Google Scholar

35 

Wang Y, Shen Y, Wang S, Shen Q and Zhou X: The role of STAT3 in leading the crosstalk between human cancers and the immune system. Cancer Lett. 415:117–128. 2018.PubMed/NCBI View Article : Google Scholar

36 

Bao W, Wang HH, Tian FJ, He XY, Qiu MT, Wang JY, Zhang HJ, Wang LH and Wan XP: A TrkB-STAT3-miR-204-5p regulatory circuitry controls proliferation and invasion of endometrial carcinoma cells. Mol Cancer. 12(155)2013.PubMed/NCBI View Article : Google Scholar

37 

Kruczyk M, Przanowski P, Dabrowski M, Swiatek-Machado K, Mieczkowski J, Wallerman O, Ronowicz A, Piotrowski A, Wadelius C, Kaminska B and Komorowski J: Integration of genome-wide of Stat3 binding and epigenetic modification mapping with transcriptome reveals novel Stat3 target genes in glioma cells. Biochim Biophys Acta. 1839:1341–1350. 2014.PubMed/NCBI View Article : Google Scholar

38 

Cheng GZ, Zhang WZ, Sun M, Wang Q, Coppola D, Mansour M, Xu LM, Costanzo C, Cheng JQ and Wang LH: Twist is transcriptionally induced by activation of STAT3 and mediates STAT3 oncogenic function. J Biol Chem. 283:14665–14673. 2008.PubMed/NCBI View Article : Google Scholar

39 

Cao C, Zhao G, Yu W, Xie X, Wang W, Yang R, Lv X and Liu D: Activation of STAT3 stimulates AHSP expression in K562 cells. Sci China Life Sci. 57:488–494. 2014.PubMed/NCBI View Article : Google Scholar

40 

Enyu L, Na W, Chuanzong Z, Ben W, Xiaojuan W, Yan W, Zequn L, Jianguo H, Jiayong W, Benjia L, et al: The clinical significance and underlying correlation of pStat-3 and integrin αvβ6 expression in gallbladder cancer. Oncotarget. 8:19467–19477. 2017.PubMed/NCBI View Article : Google Scholar

41 

Sun B, Zhang D, Zhao N and Zhao X: Epithelial-to-endothelial transition and cancer stem cells: Two cornerstones of vasculogenic mimicry in malignant tumors. Oncotarget. 8:30502–30510. 2017.PubMed/NCBI View Article : Google Scholar

42 

Vartanian A, Karshieva S, Dombrovsky V and Belyavsky A: Melanoma educates mesenchymal stromal cells towards vasculogenic mimicry. Oncol Lett. 11:4264–4268. 2016.PubMed/NCBI View Article : Google Scholar

43 

Pereira JA, Bilhim T, Rio Tinto H, Fernandes L, Martins Pisco J and Goyri-O'Neill J: Radiologic anatomy of arteriogenic erectile dysfunction: A systematized approach. Acta Med Port. 26:219–225. 2013.PubMed/NCBI

44 

Bissell MJ: Tumor plasticity allows vasculogenic mimicry, a novel form of angiogenic switch. A rose by anyother name? Am J Pathol. 155:675–679. 1999.PubMed/NCBI View Article : Google Scholar

45 

Wang HF, Wang SS, Zheng M, Dai LL, Wang K, Gao XL, Cao MX, Yu XH, Pang X, Zhang M, et al: Hypoxia promotes vasculogenic mimicry formation by vascular endothelial growth factor A mediating epithelial-mesenchymal transition in salivary adenoid cystic carcinoma. Cell Prolif. 52(e12600)2019.PubMed/NCBI View Article : Google Scholar

46 

Li S, Meng W, Guan Z, Guo Y and Han X: The hypoxia-related signaling pathways of vasculogenic mimicryin tumor treatment. Biomed Pharmacother. 80:127–135. 2016.PubMed/NCBI View Article : Google Scholar

47 

Liu K, Sun B, Zhao X, Wang X, Li Y, Qiu Z, Liu T, Gu Q, Dong X, Zhang Y, et al: Hypoxia promotes vasculogenic mimicry formation by the Twist1-Bmi1 connection in hepatocellular carcinoma. Int J Mol Med. 36:783–791. 2015.PubMed/NCBI View Article : Google Scholar

48 

Sun H, Zhang D, Yao Z, Lin X, Liu J, Gu Q, Dong X, Liu F, Wang Y, Yao N, et al: Anti-angiogenic treatment promotes triple-negative breast cancer invasion via vasculogenic mimicry. Cancer Biol Ther. 18:205–213. 2017.PubMed/NCBI View Article : Google Scholar

49 

Hendrix MJ, Seflor EA, Seflor RE, Chao JT, Chien DS and Chu YW: Tumor cell vascular mimicry: Novel targeting opportunity in melanoma. Pharmacol Ther. 159:83–92. 2016.PubMed/NCBI View Article : Google Scholar

50 

Huang B, Xiao E and Huang M: MEK/ERK pathway is positively involved in hypoxia-induced vasculogenic mimicry formation in hepatocellular carcinoma which is regulated negatively by protein kinase A. Med Oncol. 32(408)2015.PubMed/NCBI View Article : Google Scholar

51 

Vacca A, Ria R, Reale A and Ribatti D: Angiogenesis in multiple myeloma. Chem Immunol Allergy. 99:180–196. 2014.PubMed/NCBI View Article : Google Scholar

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Copy and paste a formatted citation
Spandidos Publications style
Zhou H, Yuan Y and Qian H: Expression of STAT3 and vasculogenic mimicry in gallbladder carcinoma promotes invasion and metastasis. Exp Ther Med 22: 738, 2021.
APA
Zhou, H., Yuan, Y., & Qian, H. (2021). Expression of STAT3 and vasculogenic mimicry in gallbladder carcinoma promotes invasion and metastasis. Experimental and Therapeutic Medicine, 22, 738. https://doi.org/10.3892/etm.2021.10170
MLA
Zhou, H., Yuan, Y., Qian, H."Expression of STAT3 and vasculogenic mimicry in gallbladder carcinoma promotes invasion and metastasis". Experimental and Therapeutic Medicine 22.1 (2021): 738.
Chicago
Zhou, H., Yuan, Y., Qian, H."Expression of STAT3 and vasculogenic mimicry in gallbladder carcinoma promotes invasion and metastasis". Experimental and Therapeutic Medicine 22, no. 1 (2021): 738. https://doi.org/10.3892/etm.2021.10170
Copy and paste a formatted citation
x
Spandidos Publications style
Zhou H, Yuan Y and Qian H: Expression of STAT3 and vasculogenic mimicry in gallbladder carcinoma promotes invasion and metastasis. Exp Ther Med 22: 738, 2021.
APA
Zhou, H., Yuan, Y., & Qian, H. (2021). Expression of STAT3 and vasculogenic mimicry in gallbladder carcinoma promotes invasion and metastasis. Experimental and Therapeutic Medicine, 22, 738. https://doi.org/10.3892/etm.2021.10170
MLA
Zhou, H., Yuan, Y., Qian, H."Expression of STAT3 and vasculogenic mimicry in gallbladder carcinoma promotes invasion and metastasis". Experimental and Therapeutic Medicine 22.1 (2021): 738.
Chicago
Zhou, H., Yuan, Y., Qian, H."Expression of STAT3 and vasculogenic mimicry in gallbladder carcinoma promotes invasion and metastasis". Experimental and Therapeutic Medicine 22, no. 1 (2021): 738. https://doi.org/10.3892/etm.2021.10170
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