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circSKIL promotes the ossification of cervical posterior longitudinal ligament by activating the JNK/STAT3 pathway

  • Authors:
    • Naikun Sun
    • Yunbang Liang
    • Baoshan Hu
    • Jinyi Feng
    • Guangxun Lin
    • Xin Chen
    • Gang Rui
  • View Affiliations / Copyright

    Affiliations: Department of Clinical Medicine, Fujian Medical University, Fuzhou, Fujian 350122, P.R. China, Department of Orthopedic Surgery, The First Affiliated Hospital of Xiamen University, Xiamen, Fujian 361005, P.R. China
    Copyright: © Sun et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 761
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    Published online on: May 13, 2021
       https://doi.org/10.3892/etm.2021.10193
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Abstract

Ossification of the posterior longitudinal ligament (OPLL) is a hyperostotic spinal condition that involves genetic factors as well as non‑genetic factors, and its underlying molecular mechanism is largely unknown. Recently, circular RNAs (circRNAs) have been attracting the attention of researchers since they have important regulatory roles in many diseases, including bone metabolism disorders. The present study aimed to investigate the role of circRNA SKI‑like proto‑oncogene (circSKIL) in OPLL disease progression. First, primary posterior longitudinal ligament cells from patients with cervical spondylotic myelopathy (CSM) without OPLL (control group) and CSM patients with OPLL (OPLL group) were isolated, and the expression levels of circSKIL in ligament cells was found to be significantly increased in the OPLL group compared with control. This result was also confirmed in OPLL tissues. Next, circSKIL was overexpressed in control ligament cells, and the proliferation, mineralization, and osteogenic differentiation of ligament cells were found to be significantly enhanced; the phosphorylation levels of both JNK and STAT3 were upregulated. By contrast, the knockdown of circSKIL in OPLL ligament cells inhibited proliferation, mineralization, and osteogenic differentiation and inactivated the JNK/STAT3 pathway. Therefore, circSKIL may have a significant role in osteogenic differentiation and could serve as a potential target to prevent OPLL progression.
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1 

Ramos-Remus C, Russell AS, Gomez-Vargas A, Hernandez-Chavez A, Maksymowych WP, Gamez-Nava JI, Gonzalez-Lopez L, Garcia-Hernandez A, Meono-Morales E, Burgos-Vargas R and Suarez-Almazor ME: Ossification of the posterior longitudinal ligament in three geographically and genetically different populations of ankylosing spondylitis and other spondyloarthropathies. Ann Rheum Dis. 57:429–433. 1998.PubMed/NCBI View Article : Google Scholar

2 

Xu N, Yu M, Liu X, Sun C, Chen Z and Liu Z: A systematic review of complications in thoracic spine surgery for ossification of the posterior longitudinal ligament. Eur Spine J. 26:1803–1809. 2017.PubMed/NCBI View Article : Google Scholar

3 

Guo Q, Ni B and Yang J, Zhu Z and Yang J: Simultaneous ossification of the posterior longitudinal ligament and ossification of the ligamentum flavum causing upper thoracic myelopathy in DISH: Case report and literature review. Eur Spine J. 20 (Suppl 2):S195–S201. 2011.PubMed/NCBI View Article : Google Scholar

4 

Nam DC, Lee HJ, Lee CJ and Hwang SC: Molecular pathophysiology of ossification of the posterior longitudinal ligament (OPLL). Biomol Ther (Seoul). 27:342–348. 2019.PubMed/NCBI View Article : Google Scholar

5 

Yu F, Cui Y, Zhou X, Zhang X and Han J: Osteogenic differentiation of human ligament fibroblasts induced by conditioned medium of osteoclast-like cells. Biosci Trends. 5:46–51. 2011.PubMed/NCBI View Article : Google Scholar

6 

Wang Y, Niu H, Liu Y, Yang H, Zhang M and Wang L: Promoting effect of long non-coding RNA SNHG1 on osteogenic differentiation of fibroblastic cells from the posterior longitudinal ligament by the microRNA-320b/IFNGR1 network. Cell Cycle. 19:2836–2850. 2020.PubMed/NCBI View Article : Google Scholar

7 

Dong J, Xu X, Zhang Q, Yuan Z and Tan B: Dkk1 acts as a negative regulator in the osteogenic differentiation of the posterior longitudinal ligament cells. Cell Biol Int. 44:2450–2458. 2020.PubMed/NCBI View Article : Google Scholar

8 

Zhang H, Xu C, Liu Y and Yuan W: MicroRNA-563 promotes the osteogenic differentiation of posterior longitudinal ligament cells by inhibiting SMURF1. Zhonghua Wai Ke Za Zhi. 55:203–207. 2017.PubMed/NCBI View Article : Google Scholar : (In Chinese).

9 

Santosh B, Varshney A and Yadava PK: Non-coding RNAs: Biological functions and applications. Cell Biochem Funct. 33:14–22. 2015.PubMed/NCBI View Article : Google Scholar

10 

Xie L, Huang W, Fang Z, Ding F, Zou F, Ma X, Tao J, Guo J, Xia X, Wang H, et al: CircERCC2 ameliorated intervertebral disc degeneration by regulating mitophagy and apoptosis through miR-182-5p/SIRT1 axis. Cell Death Dis. 10(751)2019.PubMed/NCBI View Article : Google Scholar

11 

Patil S, Dang K, Zhao X, Gao Y and Qian A: Role of LncRNAs and CircRNAs in bone metabolism and osteoporosis. Front Genet. 11(584118)2020.PubMed/NCBI View Article : Google Scholar

12 

Qian DY, Yan GB, Bai B, Chen Y, Zhang SJ, Yao YC and Xia H: Differential circRNA expression profiles during the BMP2-induced osteogenic differentiation of MC3T3-E1 cells. Biomed Pharmacother. 90:492–499. 2017.PubMed/NCBI View Article : Google Scholar

13 

Chen G, Wang Q, Yang Q, Li Z, Du Z, Ren M, Zhao H, Song Y and Zhang G: Circular RNAs hsa_circ_0032462, hsa_circ_0028173, hsa_circ_0005909 are predicted to promote CADM1 expression by functioning as miRNAs sponge in human osteosarcoma. PLoS One. 13(e0202896)2018.PubMed/NCBI View Article : Google Scholar

14 

Zhang M, Jia L and Zheng Y: circRNA expression profiles in human bone marrow stem cells undergoing osteoblast differentiation. Stem Cell Rev Rep. 15:126–138. 2019.PubMed/NCBI View Article : Google Scholar

15 

Gu X, Li M, Jin Y, Liu D and Wei F: Identification and integrated analysis of differentially expressed lncRNAs and circRNAs reveal the potential ceRNA networks during PDLSC osteogenic differentiation. BMC Genet. 18(100)2017.PubMed/NCBI View Article : Google Scholar

16 

Fehlings MG, Tetreault LA, Riew KD, Middleton JW, Aarabi B, Arnold PM, Brodke DS, Burns AS, Carette S, Chen R, et al: A clinical practice guideline for the management of patients with degenerative cervical myelopathy: Recommendations for patients with mild, moderate, and severe disease and nonmyelopathic patients with evidence of cord compression. Global Spine J. 7 (Suppl 3):70S–83S. 2017.PubMed/NCBI View Article : Google Scholar

17 

Tetreault L, Nakashima H, Kato S, Kryshtalskyj M, Nagoshi N, Nouri A, Singh A and Fehlings MG: A systematic review of classification systems for cervical ossification of the posterior longitudinal ligament. Global Spine J. 9:85–103. 2019.PubMed/NCBI View Article : Google Scholar

18 

Li Y, Wang Y, Li Y, Luo W, Jiang J, Zhao J and Liu C: Controllable synthesis of biomimetic hydroxyapatite nanorods with high osteogenic bioactivity. ACS Biomater Sci Eng. 6:320–328. 2020.PubMed/NCBI View Article : Google Scholar

19 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods. 25:402–408. 2001.PubMed/NCBI View Article : Google Scholar

20 

Miao J, Sun J, Shi J, Chen Y and Chen D: A novel anterior revision surgery for the treatment of cervical ossification of posterior longitudinal ligament: Case report and review of the literature. World Neurosurg. 113:212–216. 2018.PubMed/NCBI View Article : Google Scholar

21 

Franceschi RT, Ge C, Xiao G, Roca H and Jiang D: Transcriptional regulation of osteoblasts. Ann N Y Acad Sci. 1116:196–207. 2007.PubMed/NCBI View Article : Google Scholar

22 

Liu Y, Zhao Y, Chen Y, Shi G and Yuan W: RUNX2 polymorphisms associated with OPLL and OLF in the Han population. Clin Orthop Relat Res. 468:3333–3341. 2010.PubMed/NCBI View Article : Google Scholar

23 

Jafary F, Hanachi P and Gorjipour K: Osteoblast differentiation on collagen scaffold with immobilized alkaline phosphatase. Int J Organ Transplant Med. 8:195–202. 2017.PubMed/NCBI

24 

Wei QS, Huang L, Tan X, Chen ZQ, Chen SM and Deng WM: Serum osteopontin levels in relation to bone mineral density and bone turnover markers in postmenopausal women. Scand J Clin Lab Invest. 76:33–39. 2016.PubMed/NCBI View Article : Google Scholar

25 

Tsao YT, Huang YJ, Wu HH, Liu YA, Liu YS and Lee OK: Osteocalcin mediates biomineralization during osteogenic maturation in human mesenchymal stromal cells. Int J Mol Sci. 18(159)2017.PubMed/NCBI View Article : Google Scholar

26 

Asari T, Furukawa K, Tanaka S, Kudo H, Mizukami H, Ono A, Numasawa T, Kumagai G, Motomura S, Yagihashi S and Toh S: Mesenchymal stem cell isolation and characterization from human spinal ligaments. Biochem Biophys Res Commun. 417:1193–1199. 2012.PubMed/NCBI View Article : Google Scholar

27 

Ishihara K and Hirano T: Molecular basis of the cell specificity of cytokine action. Biochim Biophys Acta. 1592:281–296. 2002.PubMed/NCBI View Article : Google Scholar

28 

Lin J, Cai R, Sun B, Dong J, Zhao Y, Miao Q and Chen C: Gd@C82(OH)22 harnesses inflammatory regeneration for osteogenesis of mesenchymal stem cells through JNK/STAT3 signaling pathway. J Mater Chem B. 6:5802–5811. 2018.PubMed/NCBI View Article : Google Scholar

29 

Yu X, Wan Q, Cheng G, Cheng X, Zhang J, Pathak JL and Li Z: CoCl2, a mimic of hypoxia, enhances bone marrow mesenchymal stem cells migration and osteogenic differentiation via STAT3 signaling pathway. Cell Biol Int. 42:1321–1329. 2018.PubMed/NCBI View Article : Google Scholar

30 

Matsuguchi T, Chiba N, Bandow K, Kakimoto K, Masuda A and Ohnishi T: JNK activity is essential for Atf4 expression and late-stage osteoblast differentiation. J Bone Miner Res. 24:398–410. 2009.PubMed/NCBI View Article : Google Scholar

31 

Yang Q, Han Y, Liu P, Huang Y, Li X, Jia L, Zheng Y and Li W: Long noncoding RNA GAS5 promotes osteogenic differentiation of human periodontal ligament stem cells by regulating GDF5 and p38/JNK signaling pathway. Front Pharmacol. 11(701)2020.PubMed/NCBI View Article : Google Scholar

32 

Li X, Zheng Y, Zheng Y, Huang Y, Zhang Y, Jia L and Li W: Circular RNA CDR1as regulates osteoblastic differentiation of periodontal ligament stem cells via the miR-7/GDF5/SMAD and p38 MAPK signaling pathway. Stem Cell Res Ther. 9(232)2018.PubMed/NCBI View Article : Google Scholar

33 

Huang XQ, Cen X, Sun WT, Xia K, Yu LY, Liu J and Zhao ZH: CircPOMT1 and circMCM3AP inhibit osteogenic differentiation of human adipose-derived stem cells by targeting miR-6881-3p. Am J Transl Res. 11:4776–4788. 2019.PubMed/NCBI

34 

Huang J, Zhao L, Xing L and Chen D: MicroRNA-204 regulates Runx2 protein expression and mesenchymal progenitor cell differentiation. Stem Cells. 28:357–364. 2010.PubMed/NCBI View Article : Google Scholar

35 

Xu C, Zhang H, Gu W, Wu H, Chen Y, Zhou W, Sun B, Shen X, Zhang Z, Wang Y, et al: The microRNA-10a/ID3/RUNX2 axis modulates the development of ossification of posterior longitudinal ligament. Sci Rep. 8(9225)2018.PubMed/NCBI View Article : Google Scholar

36 

Yuan X, Guo Y, Chen D, Luo Y, Chen D, Miao J and Chen Y: Long non-coding RNA MALAT1 functions as miR-1 sponge to regulate Connexin 43-mediated ossification of the posterior longitudinal ligament. Bone. 127:305–314. 2019.PubMed/NCBI View Article : Google Scholar

37 

Liao X, Tang D, Yang H, Chen Y, Chen D, Jia L, Yang L and Chen X: Long non-coding RNA XIST may influence cervical ossification of the posterior longitudinal ligament through regulation of miR-17-5P/AHNAK/BMP2 signaling pathway. Calcif Tissue Int. 105:670–680. 2019.PubMed/NCBI View Article : Google Scholar

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Copy and paste a formatted citation
Spandidos Publications style
Sun N, Liang Y, Hu B, Feng J, Lin G, Chen X and Rui G: circSKIL promotes the ossification of cervical posterior longitudinal ligament by activating the JNK/STAT3 pathway. Exp Ther Med 22: 761, 2021.
APA
Sun, N., Liang, Y., Hu, B., Feng, J., Lin, G., Chen, X., & Rui, G. (2021). circSKIL promotes the ossification of cervical posterior longitudinal ligament by activating the JNK/STAT3 pathway. Experimental and Therapeutic Medicine, 22, 761. https://doi.org/10.3892/etm.2021.10193
MLA
Sun, N., Liang, Y., Hu, B., Feng, J., Lin, G., Chen, X., Rui, G."circSKIL promotes the ossification of cervical posterior longitudinal ligament by activating the JNK/STAT3 pathway". Experimental and Therapeutic Medicine 22.1 (2021): 761.
Chicago
Sun, N., Liang, Y., Hu, B., Feng, J., Lin, G., Chen, X., Rui, G."circSKIL promotes the ossification of cervical posterior longitudinal ligament by activating the JNK/STAT3 pathway". Experimental and Therapeutic Medicine 22, no. 1 (2021): 761. https://doi.org/10.3892/etm.2021.10193
Copy and paste a formatted citation
x
Spandidos Publications style
Sun N, Liang Y, Hu B, Feng J, Lin G, Chen X and Rui G: circSKIL promotes the ossification of cervical posterior longitudinal ligament by activating the JNK/STAT3 pathway. Exp Ther Med 22: 761, 2021.
APA
Sun, N., Liang, Y., Hu, B., Feng, J., Lin, G., Chen, X., & Rui, G. (2021). circSKIL promotes the ossification of cervical posterior longitudinal ligament by activating the JNK/STAT3 pathway. Experimental and Therapeutic Medicine, 22, 761. https://doi.org/10.3892/etm.2021.10193
MLA
Sun, N., Liang, Y., Hu, B., Feng, J., Lin, G., Chen, X., Rui, G."circSKIL promotes the ossification of cervical posterior longitudinal ligament by activating the JNK/STAT3 pathway". Experimental and Therapeutic Medicine 22.1 (2021): 761.
Chicago
Sun, N., Liang, Y., Hu, B., Feng, J., Lin, G., Chen, X., Rui, G."circSKIL promotes the ossification of cervical posterior longitudinal ligament by activating the JNK/STAT3 pathway". Experimental and Therapeutic Medicine 22, no. 1 (2021): 761. https://doi.org/10.3892/etm.2021.10193
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