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Silencing miRNA‑1297 suppresses the invasion and migration of prostate cancer cells via targeting modulation of PTEN and blocking of the AKT/ERK pathway

  • Authors:
    • Lei Wang
    • Jing Gao
    • Yu Zhang
    • Shaosan Kang
  • View Affiliations / Copyright

    Affiliations: Department of Urology, North China University of Science and Technology Affiliated Hospital, Tangshan, Hebei 063000, P.R. China, Department of Obstetrics and Gynecology, Tangshan Hongci Hospital, Tangshan, Hebei 063000, P.R. China, Department of Intensive Care Units, Tangshan People's Hospital, Tangshan, Hebei 063000, P.R. China
    Copyright: © Wang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 768
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    Published online on: May 17, 2021
       https://doi.org/10.3892/etm.2021.10200
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Abstract

Phosphatase and tensin homolog (PTEN) loss is a major contributing factor of prostate cancer (PC). miRNA‑1297 was reported to serve role in various cancer types; however, the potential roles of miRNA‑1297 in PC had not been investigated. In the present study, tumor and adjacent tissues were collected from patients with PC. The gene expression level of miRNA‑1297 was measured via polymerase chain reaction. Results indicated that the miRNA‑1297 was overexpressed in tumor tissues from PC patients and in PC cell lines. miRNA‑1297 also contributed toward the progression of PC. PTEN was confirmed as the direct target of miRNA‑1297 and bound with miRNA‑1297 via four binding sites. The miRNA‑1297 level was negatively associated with the PTEN level. Silencing miRNA‑1297 or overexpression of PTEN significantly inhibited the cell migration and invasion. In addition, the AKT/ERK pathway was also inhibited following silencing of miRNA‑1297 or overexpression of PTEN. Taken together, the results indicated that silencing miRNA‑1297 exerted inhibitory effects on the invasion and migration of PC cells via modulating PTEN and blocking of the AKT/ERK pathway. The results of the present study provided a novel strategy for treatment of prostate cancer cells.
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Spandidos Publications style
Wang L, Gao J, Zhang Y and Kang S: Silencing miRNA‑1297 suppresses the invasion and migration of prostate cancer cells via targeting modulation of PTEN and blocking of the AKT/ERK pathway. Exp Ther Med 22: 768, 2021.
APA
Wang, L., Gao, J., Zhang, Y., & Kang, S. (2021). Silencing miRNA‑1297 suppresses the invasion and migration of prostate cancer cells via targeting modulation of PTEN and blocking of the AKT/ERK pathway. Experimental and Therapeutic Medicine, 22, 768. https://doi.org/10.3892/etm.2021.10200
MLA
Wang, L., Gao, J., Zhang, Y., Kang, S."Silencing miRNA‑1297 suppresses the invasion and migration of prostate cancer cells via targeting modulation of PTEN and blocking of the AKT/ERK pathway". Experimental and Therapeutic Medicine 22.1 (2021): 768.
Chicago
Wang, L., Gao, J., Zhang, Y., Kang, S."Silencing miRNA‑1297 suppresses the invasion and migration of prostate cancer cells via targeting modulation of PTEN and blocking of the AKT/ERK pathway". Experimental and Therapeutic Medicine 22, no. 1 (2021): 768. https://doi.org/10.3892/etm.2021.10200
Copy and paste a formatted citation
x
Spandidos Publications style
Wang L, Gao J, Zhang Y and Kang S: Silencing miRNA‑1297 suppresses the invasion and migration of prostate cancer cells via targeting modulation of PTEN and blocking of the AKT/ERK pathway. Exp Ther Med 22: 768, 2021.
APA
Wang, L., Gao, J., Zhang, Y., & Kang, S. (2021). Silencing miRNA‑1297 suppresses the invasion and migration of prostate cancer cells via targeting modulation of PTEN and blocking of the AKT/ERK pathway. Experimental and Therapeutic Medicine, 22, 768. https://doi.org/10.3892/etm.2021.10200
MLA
Wang, L., Gao, J., Zhang, Y., Kang, S."Silencing miRNA‑1297 suppresses the invasion and migration of prostate cancer cells via targeting modulation of PTEN and blocking of the AKT/ERK pathway". Experimental and Therapeutic Medicine 22.1 (2021): 768.
Chicago
Wang, L., Gao, J., Zhang, Y., Kang, S."Silencing miRNA‑1297 suppresses the invasion and migration of prostate cancer cells via targeting modulation of PTEN and blocking of the AKT/ERK pathway". Experimental and Therapeutic Medicine 22, no. 1 (2021): 768. https://doi.org/10.3892/etm.2021.10200
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