Open Access

Bioinformatics identification of hub genes and signaling pathways regulated by intravenous immunoglobulin treatment in acute Kawasaki disease

  • Authors:
    • Hongbiao Huang
    • Lei Xu
    • Yueyue Ding
    • Jie Qin
    • Chengcheng Huang
    • Xuan Li
    • Yunjia Tang
    • Guanghui Qian
    • Haitao Lv
  • View Affiliations

  • Published online on: May 19, 2021     https://doi.org/10.3892/etm.2021.10216
  • Article Number: 784
  • Copyright: © Huang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Kawasaki disease (KD) is an acute, self‑limiting form of vasculitis commonly encountered in infants and young children. Intravenous immunoglobulin (IVIG) is the primary drug used for the treatment of KD, which may significantly reduce the occurrence of coronary artery lesions. However, the specific molecular profile changes of KD caused by IVIG treatment have remained elusive and require further research. The present study was designed to identify key genes, pathways and immune cells affected by IVIG treatment using multiple bioinformatics analysis methods. The results suggested that myeloid cells and neutrophils were affected by IVIG treatment. Kyoto Encyclopedia of Genes and Genomes pathway analysis identified that hematopoietic cell lineages and osteoclast differentiation may have an important role in the mechanism of action of IVIG treatment. Immune cell analysis indicated that the levels of monocytes, M1 macrophages, neutrophils and platelets were markedly changed in patients with KD after vs. prior to IVIG treatment. The key upregulated genes, including ZW10 interacting kinetochore protein, GINS complex subunit 1 and microRNA‑30b‑3p in whole blood cells of patients with KD following treatment with IVIG indicated that these IVIG‑targeted molecules may have important roles in KD. In addition, these genes were further examined by literature review and indicated to be involved in cell proliferation, apoptosis and virus‑related immune response in patients with KD. Therefore, the present results may provide novel insight into the mechanisms of action of IVIG treatment for KD.
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July-2021
Volume 22 Issue 1

Print ISSN: 1792-0981
Online ISSN:1792-1015

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Spandidos Publications style
Huang H, Xu L, Ding Y, Qin J, Huang C, Li X, Tang Y, Qian G and Lv H: Bioinformatics identification of hub genes and signaling pathways regulated by intravenous immunoglobulin treatment in acute Kawasaki disease. Exp Ther Med 22: 784, 2021
APA
Huang, H., Xu, L., Ding, Y., Qin, J., Huang, C., Li, X. ... Lv, H. (2021). Bioinformatics identification of hub genes and signaling pathways regulated by intravenous immunoglobulin treatment in acute Kawasaki disease. Experimental and Therapeutic Medicine, 22, 784. https://doi.org/10.3892/etm.2021.10216
MLA
Huang, H., Xu, L., Ding, Y., Qin, J., Huang, C., Li, X., Tang, Y., Qian, G., Lv, H."Bioinformatics identification of hub genes and signaling pathways regulated by intravenous immunoglobulin treatment in acute Kawasaki disease". Experimental and Therapeutic Medicine 22.1 (2021): 784.
Chicago
Huang, H., Xu, L., Ding, Y., Qin, J., Huang, C., Li, X., Tang, Y., Qian, G., Lv, H."Bioinformatics identification of hub genes and signaling pathways regulated by intravenous immunoglobulin treatment in acute Kawasaki disease". Experimental and Therapeutic Medicine 22, no. 1 (2021): 784. https://doi.org/10.3892/etm.2021.10216