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Article Open Access

Predictive value of PAPP‑A for ectopic pregnancy and analysis of related factors

  • Authors:
    • Xiaoyun Zhang
    • Chunxia Wang
  • View Affiliations / Copyright

    Affiliations: Department of Obstetrics, Affiliated Hospital of Jining Medical University, Jining, Shandong 272000, P.R. China
    Copyright: © Zhang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 801
    |
    Published online on: May 26, 2021
       https://doi.org/10.3892/etm.2021.10233
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Abstract

The present study was designed to analyze the expression of pregnancy‑associated plasma protein‑A (PAPP‑A) in the serum of patients with ectopic pregnancy (EP) and related factors inducing this condition. Seventy‑five patients with EP admitted to the Affiliated Hospital of Jining Medical University from January 2018 to February 2019 were selected as the research group, and another 59 healthy pregnant women of the corresponding age, gravidity and gestational week were enrolled in the control group. ELISA was employed to detect the serum expression levels of PAPP‑A and inflammatory factors such as interleukin‑8 (IL‑8) and tumor necrosis factor‑α (TNF‑α). ROC was adopted to evaluate the diagnostic value of serum PAPP‑A in patients with EP, and Pearson correlation coefficient was applied to analyze the correlation of PAPP‑A with inflammatory factors IL‑8 and TNF‑α. Serum PAPP‑A expression was significantly lower in EP patients than those in the control group. The area under the curve (AUC) of serum PAPP‑A in diagnosing EP patients was 0.812, and the PAPP‑A value in the control group was significantly higher than that of the research group at 7‑8 weeks and ≥9 weeks. With regard to the expression of inflammatory factors, the research group presented markedly higher IL‑8 and TNF‑α levels than the control group. PAPP‑A was negatively related to inflammatory factors IL‑8 and TNF‑α in the research group. In addition, it was revealed that patients with a history of genital surgery, salpingotomy, pelvic infection, EP or low PAPP‑A expression were at high risk of EP. In conclusion, PAPP‑A was revealed to be lowly expressed in the serum of EP patients, and to negatively be correlated with inflammatory factors IL‑8 and TNF‑α, which may serve as a useful marker for the diagnosis and prognosis of EP.
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1 

Perkins KM, Boulet SL, Kissin DM and Jamieson DJ: National ART Surveillance (NASS) Group. Risk of ectopic pregnancy associated with assisted reproductive technology in the United States, 2001-2011. Obstet Gynecol. 125:70–78. 2015.PubMed/NCBI View Article : Google Scholar

2 

Bronson R: Ectopic pregnancy-still a challenge. Fertil Steril. 110:1265–1266. 2018.PubMed/NCBI View Article : Google Scholar

3 

Refaat B, Dalton E and Ledger WL: Ectopic pregnancy secondary to in vitro fertilisation-embryo transfer: Pathogenic mechanisms and management strategies. Reprod Biol Endocrinol. 13(30)2015.PubMed/NCBI View Article : Google Scholar

4 

Ashshi AM, Batwa SA, Kutbi SY, Malibary FA, Batwa M and Refaat B: Prevalence of 7 sexually transmitted organisms by multiplex real-time PCR in Fallopian tube specimens collected from Saudi women with and without ectopic pregnancy. BMC Infect Dis. 15(569)2015.PubMed/NCBI View Article : Google Scholar

5 

Li C, Zhao WH, Zhu Q, Cao SJ, Ping H, Xi X, Qin GJ, Yan MX, Zhang D, Qiu J and Zhang J: Risk factors for ectopic pregnancy: A multi-center case-control study. BMC Pregnancy Childbirth. 15(187)2015.PubMed/NCBI View Article : Google Scholar

6 

Lagana AS, Vitale SG, De Dominici R, Padula F, Rapisarda AM, Biondi A, Cianci S, Valenti G, Capriglione S, Frangez HB and Sturlese E: Fertility outcome after laparoscopic salpingostomy or salpingectomy for tubal ectopic pregnancy A 12-years retrospective cohort study. Ann Ital Chir. 87:461–465. 2016.PubMed/NCBI

7 

Hsu JY, Chen L, Gumer AR, Tergas AI, Hou JY, Burke WM, Ananth CV, Hershman DL and Wright JD: Disparities in the management of ectopic pregnancy. Am J Obstet Gynecol. 217:49.e1–49.e10. 2017.PubMed/NCBI View Article : Google Scholar

8 

Chanana C, Gupta N, Bansal I, Hooda K, Sharma P, Gupta M, Gandhi D and Kumar Y: Different sonographic faces of ectopic pregnancy. J Clin Imaging Sci. 7(6)2017.PubMed/NCBI View Article : Google Scholar

9 

Bøtkjær JA, Noer PR, Oxvig C and Yding Andersen C: A common variant of the pregnancy-associated plasma protein-A (PAPPA) gene encodes a protein with reduced proteolytic activity towards IGF-binding proteins. Sci Rep. 9(13231)2019.PubMed/NCBI View Article : Google Scholar

10 

Bale LK, Chakraborty S and Conover CA: Inducible reduction in pregnancy-associated plasma protein-A gene expression inhibits established atherosclerotic plaque progression in mice. Endocrinology. 155:1184–1187. 2014.PubMed/NCBI View Article : Google Scholar

11 

Smith YE, Toomey S, Napoletano S, Kirwan G, Schadow C, Chubb AJ, Mikkelsen JH, Oxvig C and Harmey JH: Recombinant PAPP-A resistant insulin-like growth factor binding protein 4 (dBP4) inhibits angiogenesis and metastasis in a murine model of breast cancer. BMC Cancer. 18(1016)2018.PubMed/NCBI View Article : Google Scholar

12 

Prithviraj P, Anaka M, McKeown SJ, Permezel M, Walkiewicz M, Cebon J, Behren A and Jayachandran A: Pregnancy associated plasma protein-A links pregnancy and melanoma progression by promoting cellular migration and invasion. Oncotarget. 6:15953–15965. 2015.PubMed/NCBI View Article : Google Scholar

13 

Sert A, Leung K, Waring ME, Rojas-Rodriguez R, Corvera S and Moore Simas TA: Association between first trimester pregnancy associated plasma protein-A (PAPP-A) and gestational diabetes mellitus development. 2016.

14 

Peeva G, Oakley L, Von Rège I, Nicolaides K and Oteng-Ntim E: Does first trimester serum pregnancy-associated plasma protein A differ in pregnant women with sickle cell disease? Prenat Diagn. 39:921–924. 2019.PubMed/NCBI View Article : Google Scholar

15 

Antsaklis P, Fasoulakis Z, Theodora M, Diakosavvas M and Kontomanolis EN: Association of low maternal pregnancy-associated plasma protein A with adverse perinatal outcome. Cureus. 11(e4912)2019.PubMed/NCBI View Article : Google Scholar

16 

Papastefanou I, Wright D, Syngelaki A, Lolos M, Anampousi K and Nicolaides KH: Competing-risks model for prediction of small-for-gestational-age neonate from maternal characteristics and serum pregnancy-associated plasma protein-A at 11-13 weeks' gestation. Ultrasound Obstet Gynecol. 56:541–548. 2020.PubMed/NCBI View Article : Google Scholar

17 

Xin H, Liu W and Li P: Diagnostic value of detection of serum β-HCG and CT-IgG combined with transvaginal ultrasonography in early tubal pregnancy. Exp Ther Med. 16:277–281. 2018.PubMed/NCBI View Article : Google Scholar

18 

Hoffmann S, Abele H and Bachmann C: Spontaneous bilateral tubal ectopic pregnancy: Incidental finding during laparoscopy-brief report and review of literature. Geburtshilfe Frauenheilkd. 76:413–416. 2016.PubMed/NCBI View Article : Google Scholar

19 

Hornbeck PV: Enzyme-linked immunosorbent assays. Curr Protoc Immunol. 110:2.1.1–2.1.23. 2015.PubMed/NCBI View Article : Google Scholar

20 

Browne JL, Klipstein-Grobusch K, Koster MP, Ramamoorthy D, Antwi E, Belmouden I, Franx A, Grobbee DE and Schielen PC: Pregnancy associated plasma protein-a and placental growth factor in a sub-Saharan African population: A nested cross-sectional study. PLoS One. 11(e0159592)2016.PubMed/NCBI View Article : Google Scholar

21 

Sowter M: Finding an ectopic pregnancy. Imaging. 17:2015.

22 

Perlman BE, Guerrero K, Karsalia R and Heller DS: Reproductive outcomes following a ruptured ectopic pregnancy. Eur J Contracept Reprod Health Care. 25:206–208. 2020.PubMed/NCBI View Article : Google Scholar

23 

Murano T, Shaker L and Marco CA: Evaluation and management of ectopic pregnancy in the emergency department. Emergency Med Rep. 40:2019.

24 

Batson RJ, Mills BB, Nagy Z and Roudebush W: Pregnancy-associated plasma protein A (PAPP-A): A biomarker for the aid in risk stratification of nonviable pregnancy. Fertil Steril. 104(e351)2015.

25 

Kaijomaa M, Rahkonen L, Ulander VM, Hämäläinen E, Alfthan H, Markkanen H, Heinonen S and Stefanovic V: Low maternal pregnancy-associated plasma protein A during the first trimester of pregnancy and pregnancy outcomes. Int J Gynaecol Obstet. 136:76–82. 2017.PubMed/NCBI View Article : Google Scholar

26 

Melero Bermejo I, Jaffee EM, Davar D, Cardarelli J, Williams D, Phillips P, Phillips P, Carleton M, Zhou M, De Henau O, et al: Phase 1b/2 study of nivolumab in combination with an anti-IL-8 monoclonal antibody, BMS-986253, in a biomarker-enriched population of patients with advanced cancer. J Clin Oncol. 36 (Suppl 15)(TPS3109)2018.

27 

Shao R, Feng Y, Zou S, Li X, Cui P and Billig H: Quantitative analysis of hormones and inflammatory cytokines in Chlamydia trachomatis-infected women with tubal ectopic pregnancy and early intrauterine pregnancy. Data Brief. 6:135–142. 2015.PubMed/NCBI View Article : Google Scholar

28 

Ma L, Li Z, Xi S, Guo Q, Zhao P, Li W, Ai J and Chen X: Tubal ectopic pregnancy occurrence is associated with high expressions of prokineticin receptors and aberrant secretion of inflammatory cytokines. Am J Transl Res. 12:5741–5751. 2020.PubMed/NCBI

29 

Jiang PR, Cao Z, Qiu ZL, Pan JW, Zhang N and Wu YF: Plasma levels of TNF-α and MMP-9 in patients with silicosis. Eur Rev Med Pharmacol Sci. 19:1716–1720. 2015.PubMed/NCBI

30 

Zaka M, Abbasi BH and Durdagi S: Novel tumor necrosis factor-α (TNF-α) inhibitors from small molecule library screening for their therapeutic activity profiles against rheumatoid arthritis using target-driven approaches and binary QSAR models. J Biomol Struct Dyn. 37:2464–2476. 2019.PubMed/NCBI View Article : Google Scholar

31 

Cha HH, Hwang JR, Kim HY, Choi SJ, Oh SY and Roh CR: Autophagy induced by tumor necrosis factor α mediates intrinsic apoptosis in trophoblastic cells. Reprod Sci. 21:612–622. 2014.PubMed/NCBI View Article : Google Scholar

32 

Li HH, Xu XH, Tong J, Zhang KY, Zhang C and Chen ZJ: Association of TNF-α genetic polymorphisms with recurrent pregnancy loss risk: A systematic review and meta-analysis. Reprod Biol Endocrinol. 14(6)2016.PubMed/NCBI View Article : Google Scholar

33 

Soriano D, Hugol D, Quang NT and Darai E: Serum concentrations of interleukin-2R (IL-2R), IL-6, IL-8, and tumor necrosis factor alpha in patients with ectopic pregnancy. Fertil Steril. 79:975–980. 2003.PubMed/NCBI View Article : Google Scholar

34 

Tang SL, Zhao ZW, Liu SM, Wang G, Yu XH, Zou J, Wang SQ, Dai XY, Fu MG, Zheng XL, et al: Pregnancy-associated plasma protein-A accelerates atherosclerosis by regulating reverse cholesterol transport and inflammation. Circ J. 83:515–523. 2019.PubMed/NCBI View Article : Google Scholar

35 

Zhang D, Shi W, Li C, Yuan JJ, Xia W, Xue RH, Sun J and Zhang J: Risk factors for recurrent ectopic pregnancy: A case-control study. BJOG. 123 (Suppl 3):S82–S89. 2016.PubMed/NCBI View Article : Google Scholar

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Copy and paste a formatted citation
Spandidos Publications style
Zhang X and Wang C: Predictive value of PAPP‑A for ectopic pregnancy and analysis of related factors. Exp Ther Med 22: 801, 2021.
APA
Zhang, X., & Wang, C. (2021). Predictive value of PAPP‑A for ectopic pregnancy and analysis of related factors. Experimental and Therapeutic Medicine, 22, 801. https://doi.org/10.3892/etm.2021.10233
MLA
Zhang, X., Wang, C."Predictive value of PAPP‑A for ectopic pregnancy and analysis of related factors". Experimental and Therapeutic Medicine 22.2 (2021): 801.
Chicago
Zhang, X., Wang, C."Predictive value of PAPP‑A for ectopic pregnancy and analysis of related factors". Experimental and Therapeutic Medicine 22, no. 2 (2021): 801. https://doi.org/10.3892/etm.2021.10233
Copy and paste a formatted citation
x
Spandidos Publications style
Zhang X and Wang C: Predictive value of PAPP‑A for ectopic pregnancy and analysis of related factors. Exp Ther Med 22: 801, 2021.
APA
Zhang, X., & Wang, C. (2021). Predictive value of PAPP‑A for ectopic pregnancy and analysis of related factors. Experimental and Therapeutic Medicine, 22, 801. https://doi.org/10.3892/etm.2021.10233
MLA
Zhang, X., Wang, C."Predictive value of PAPP‑A for ectopic pregnancy and analysis of related factors". Experimental and Therapeutic Medicine 22.2 (2021): 801.
Chicago
Zhang, X., Wang, C."Predictive value of PAPP‑A for ectopic pregnancy and analysis of related factors". Experimental and Therapeutic Medicine 22, no. 2 (2021): 801. https://doi.org/10.3892/etm.2021.10233
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