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Article

Toxicity of Melastoma dodecandrum Lour. and its effects on lipopolysaccharide‑induced inflammation and oxidative stress

  • Authors:
    • Gang Huang
    • Yuli Ge
    • Zhihong Gui
    • Meixiao Zhu
    • Jin Liu
    • Huafu Wang
  • View Affiliations / Copyright

    Affiliations: Department of Traditional Chinese Medicine, Lishui People's Hospital, Lishui, Zhejiang 323000, P.R. China, Department of Infection, Lishui People's Hospital, Lishui, Zhejiang 323000, P.R. China, Department of Nephrology, Lishui People's Hospital, Lishui, Zhejiang 323000, P.R. China, Department of Pharmacy, Lishui People's Hospital, Lishui, Zhejiang 323000, P.R. China, Department of Scientific Research Office, Lishui People's Hospital, Lishui, Zhejiang 323000, P.R. China, Department of Clinical Pharmacology, Lishui People's Hospital, Lishui, Zhejiang 323000, P.R. China
  • Article Number: 807
    |
    Published online on: May 27, 2021
       https://doi.org/10.3892/etm.2021.10239
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Abstract

Melastoma dodecandrum Lour. (MDL) is component used in traditional Chinese medicine that is widely distributed throughout southern China. MDL has been long utilized in clinical treatment for various conditions, such as inflammation. However, the toxicity and underlying anti‑inflammatory mechanism of MDL remain to be elucidated. In the present study, Sprague‑Dawley rats received intragastric administration of MDL for 2 months, and the toxicity of MDL was investigated. The rats were treated with lipopolysaccharide (LPS) for 8 h to determine the potential anti‑inflammatory mechanism of MDL. The results demonstrated that MDL alone did not affect the expression levels of factors associated with inflammation (IL‑1β, IL‑6 and TNF‑α) and oxidative stress [malondialdehyde (MDA), superoxide dismutase (SOD) and nitric oxide (NO)] in the rat serum and exerted no effects on rat liver and kidneys. By contrast, MDL attenuated LPS‑induced inflammation and oxidative stress by regulating specific cytokines, such as IL‑1β, IL‑6, TNF‑α, MDA, SOD and NO in the rat serum and alleviated LPS‑induced liver and kidney damage. Additionally, compared with the LPS group, MDL inhibited CD4+ T cell differentiation into Th1 and Th17 cells and enhanced CD4+ T cell differentiation into Th2 and Treg cells. MDL also suppressed reactive oxygen species (ROS) production and mitochondrial apoptosis by modulating mitochondrial apoptosis‑related proteins in spleen CD4+ T cells. In conclusion, the results of the present study demonstrated the non‑toxic nature of MDL and revealed that it alleviated LPS‑induced inflammation and oxidative stress by regulating differentiation and ROS production in CD4+ T cells.
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Copy and paste a formatted citation
Spandidos Publications style
Huang G, Ge Y, Gui Z, Zhu M, Liu J and Wang H: Toxicity of <em>Melastoma dodecandrum</em> Lour. and its effects on lipopolysaccharide‑induced inflammation and oxidative stress. Exp Ther Med 22: 807, 2021.
APA
Huang, G., Ge, Y., Gui, Z., Zhu, M., Liu, J., & Wang, H. (2021). Toxicity of <em>Melastoma dodecandrum</em> Lour. and its effects on lipopolysaccharide‑induced inflammation and oxidative stress. Experimental and Therapeutic Medicine, 22, 807. https://doi.org/10.3892/etm.2021.10239
MLA
Huang, G., Ge, Y., Gui, Z., Zhu, M., Liu, J., Wang, H."Toxicity of <em>Melastoma dodecandrum</em> Lour. and its effects on lipopolysaccharide‑induced inflammation and oxidative stress". Experimental and Therapeutic Medicine 22.2 (2021): 807.
Chicago
Huang, G., Ge, Y., Gui, Z., Zhu, M., Liu, J., Wang, H."Toxicity of <em>Melastoma dodecandrum</em> Lour. and its effects on lipopolysaccharide‑induced inflammation and oxidative stress". Experimental and Therapeutic Medicine 22, no. 2 (2021): 807. https://doi.org/10.3892/etm.2021.10239
Copy and paste a formatted citation
x
Spandidos Publications style
Huang G, Ge Y, Gui Z, Zhu M, Liu J and Wang H: Toxicity of <em>Melastoma dodecandrum</em> Lour. and its effects on lipopolysaccharide‑induced inflammation and oxidative stress. Exp Ther Med 22: 807, 2021.
APA
Huang, G., Ge, Y., Gui, Z., Zhu, M., Liu, J., & Wang, H. (2021). Toxicity of <em>Melastoma dodecandrum</em> Lour. and its effects on lipopolysaccharide‑induced inflammation and oxidative stress. Experimental and Therapeutic Medicine, 22, 807. https://doi.org/10.3892/etm.2021.10239
MLA
Huang, G., Ge, Y., Gui, Z., Zhu, M., Liu, J., Wang, H."Toxicity of <em>Melastoma dodecandrum</em> Lour. and its effects on lipopolysaccharide‑induced inflammation and oxidative stress". Experimental and Therapeutic Medicine 22.2 (2021): 807.
Chicago
Huang, G., Ge, Y., Gui, Z., Zhu, M., Liu, J., Wang, H."Toxicity of <em>Melastoma dodecandrum</em> Lour. and its effects on lipopolysaccharide‑induced inflammation and oxidative stress". Experimental and Therapeutic Medicine 22, no. 2 (2021): 807. https://doi.org/10.3892/etm.2021.10239
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