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Pharmacological inhibition of EZH2 by GSK126 decreases atherosclerosis by modulating foam cell formation and monocyte adhesion in apolipoprotein E‑deficient mice

  • Authors:
    • Xianjing Wei
    • Ying Zhang
    • Lianna Xie
    • Kaijun Wang
    • Xiaoqing Wang
  • View Affiliations / Copyright

    Affiliations: Department of Cardiology, Affiliated Zhongshan Hospital of Dalian University, Dalian, Liaoning 116023, P.R. China
    Copyright: © Wei et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 841
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    Published online on: June 6, 2021
       https://doi.org/10.3892/etm.2021.10273
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Abstract

Histone modifications play an important role in the occurrence and development of athero­sclerosis in human and atherosclerosis‑prone mice. Histone methylation in macrophages, monocytes and endothelial cells markedly influence the progression of atherosclerosis. However, it remains unclear whether treatment with a histone methyltransferase enhancer of zeste homolog 2 (EZH2) inhibitor may suppress atherosclerosis. The present study aimed to determine the effects of the EZH2 inhibitor, GSK126, on the suppression and regression of atherosclerosis in apolipoprotein E‑deficient mouse models. In vitro, it was found that pharmacological inhibition of EZH2 by GSK126 markedly reduced lipid transportation and monocyte adhesion during atherogenesis, predominantly through increasing the expression levels of ATP‑binding cassette transporter A1 and suppressing vascular cell adhesion molecule 1 in human THP‑1 cells. In vivo, it was found that atherosclerotic plaques in GSK126‑treated mice were significantly decreased when comparing with the vehicle‑treated animals. These results indicated that the GSK126 has the ability to attenuate the progression of atherosclerosis by reducing macrophage foam cell formation and monocyte adhesion in cell and mouse models. In conclusion, the present study provided new insights into the molecular mechanism behind the action of GSK126 and suggested its therapeutic potential for the treatment of atherosclerosis.
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Copy and paste a formatted citation
Spandidos Publications style
Wei X, Zhang Y, Xie L, Wang K and Wang X: Pharmacological inhibition of EZH2 by GSK126 decreases atherosclerosis by modulating foam cell formation and monocyte adhesion in apolipoprotein E‑deficient mice. Exp Ther Med 22: 841, 2021.
APA
Wei, X., Zhang, Y., Xie, L., Wang, K., & Wang, X. (2021). Pharmacological inhibition of EZH2 by GSK126 decreases atherosclerosis by modulating foam cell formation and monocyte adhesion in apolipoprotein E‑deficient mice. Experimental and Therapeutic Medicine, 22, 841. https://doi.org/10.3892/etm.2021.10273
MLA
Wei, X., Zhang, Y., Xie, L., Wang, K., Wang, X."Pharmacological inhibition of EZH2 by GSK126 decreases atherosclerosis by modulating foam cell formation and monocyte adhesion in apolipoprotein E‑deficient mice". Experimental and Therapeutic Medicine 22.2 (2021): 841.
Chicago
Wei, X., Zhang, Y., Xie, L., Wang, K., Wang, X."Pharmacological inhibition of EZH2 by GSK126 decreases atherosclerosis by modulating foam cell formation and monocyte adhesion in apolipoprotein E‑deficient mice". Experimental and Therapeutic Medicine 22, no. 2 (2021): 841. https://doi.org/10.3892/etm.2021.10273
Copy and paste a formatted citation
x
Spandidos Publications style
Wei X, Zhang Y, Xie L, Wang K and Wang X: Pharmacological inhibition of EZH2 by GSK126 decreases atherosclerosis by modulating foam cell formation and monocyte adhesion in apolipoprotein E‑deficient mice. Exp Ther Med 22: 841, 2021.
APA
Wei, X., Zhang, Y., Xie, L., Wang, K., & Wang, X. (2021). Pharmacological inhibition of EZH2 by GSK126 decreases atherosclerosis by modulating foam cell formation and monocyte adhesion in apolipoprotein E‑deficient mice. Experimental and Therapeutic Medicine, 22, 841. https://doi.org/10.3892/etm.2021.10273
MLA
Wei, X., Zhang, Y., Xie, L., Wang, K., Wang, X."Pharmacological inhibition of EZH2 by GSK126 decreases atherosclerosis by modulating foam cell formation and monocyte adhesion in apolipoprotein E‑deficient mice". Experimental and Therapeutic Medicine 22.2 (2021): 841.
Chicago
Wei, X., Zhang, Y., Xie, L., Wang, K., Wang, X."Pharmacological inhibition of EZH2 by GSK126 decreases atherosclerosis by modulating foam cell formation and monocyte adhesion in apolipoprotein E‑deficient mice". Experimental and Therapeutic Medicine 22, no. 2 (2021): 841. https://doi.org/10.3892/etm.2021.10273
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