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cRGDyK‑modified procaine liposome inhibits the proliferation and motility of glioma cells via the ERK/p38MAPK pathway

  • Authors:
    • Dedong Li
    • Jie Gao
    • Chenyi Yang
    • Bo Li
    • Jian Sun
    • Mingdong Yu
    • Ying Wang
    • Haiyun Wang
    • Yuechun Lu
  • View Affiliations / Copyright

    Affiliations: Department of Anesthesiology, Second Hospital of Tianjin Medical University, Tianjin 300211, P.R. China, Department of Anesthesiology, Tianjin Haihe Hospital, Tianjin 300350, P.R. China, Department of Anesthesiology, Tianjin Third Central Hospital, Tianjin 300052, P.R. China
    Copyright: © Li et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 859
    |
    Published online on: June 9, 2021
       https://doi.org/10.3892/etm.2021.10291
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Abstract

Glioma is a common type of primary tumor in the central nervous system. Glioma has been increasing in incidence yearly and is a serious threat to human life and health. The aim of the present study was to prepare liposomes for enhanced penetration of the blood‑brain barrier and targeting of glioma. A procaine‑loaded liposome modified with the cyclic pentapeptide cRGDyK (Pro/cRGDyK‑L) was designed and developed. The particle size, ζ potential, encapsulation efficiency, release profile, stability and hemolysis of Pro/cRGDyK‑L were characterized in vitro. The targeting and antitumor effects of Pro/cRGDyK‑L were also investigated in vitro and in vivo. The results suggested that the cRGDyK peptide significantly facilitated the ability of liposomes to transfer procaine across the BBB and improved the cellular uptake of procaine by C6 glioma cells. The results further demonstrated that Pro/cRGDyK‑L strongly suppressed cell motility, stimulated apoptosis and induced cell cycle arrest. The findings further confirmed that Pro/cRGDyK‑L exhibited superior antitumor effects by targeting the ERK/p38MAPK pathway and thereby suppressed tumor growth in mice. In conclusion, the present study indicated the potential of Pro/cRGDyK‑L as a means to provide improved therapeutic effects on glioma through the ERK/p38MAPK pathway.
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1 

Comba A, Dunn PJ, Kish PE, Kadiyala P, Kahana A, Castro MG and Lowenstein PR: Laser Capture Microdissection of Glioma Subregions for Spatial and Molecular Characterization of Intratumoral Heterogeneity, Oncostreams, and Invasion. J Vis Exp 158: 10.3791/60939, 2020.

2 

Zhang G, Ju H, Huang P, Yue P, Wan F and Dou C: Advances in gene therapy and viral therapy for glioma. J Clin Neurosurg. 18:237–240. 2021.PubMed/NCBI View Article : Google Scholar

3 

Lawrie TA, Gillespie D, Dowswell T, Evans J, Erridge S, Vale L, Kernohan A and Grant R: Long-term neurocognitive and other side effects of radiotherapy, with or without chemotherapy, for glioma. Cochrane Database Syst Rev. 8(CD013047)2019.PubMed/NCBI View Article : Google Scholar

4 

Eulitz J, Troost EGC, Raschke F, Schulz E, Lutz B, Dutz A, Löck S, Wohlfahrt P, Enghardt W, Karpowitz C, et al: Predicting late magnetic resonance image changes in glioma patients after proton therapy. Acta Oncol. 58:1536–1539. 2019.PubMed/NCBI View Article : Google Scholar

5 

Yang Z, Du Y, Sun Q, Peng Y, Wang R, Zhou Y, Wang Y, Zhang C and Qi X: Albumin-Based Nanotheranostic Probe with Hypoxia Alleviating Potentiates Synchronous Multimodal Imaging and Phototherapy for Glioma. ACS Nano. 14:6191–6212. 2020.PubMed/NCBI View Article : Google Scholar

6 

Patel D, Wairkar S and Yergeri MC: Current Developments in Targeted Drug Delivery Systems for Glioma. Curr Pharm Des. 26:3973–3984. 2020.PubMed/NCBI View Article : Google Scholar

7 

Ran D, Zhou J, Chai Z, Li J, Xie C, Mao J, Lu L, Zhang Y, Wu S, Zhan C, et al: All-stage precisional glioma targeted therapy enabled by a well-designed D-peptide. Theranostics. 10:4073–4087. 2020.PubMed/NCBI View Article : Google Scholar

8 

Wang D, Yang T, Liu J, Liu Y, Xing N, He J, Yang J and Ai Y: Propofol Inhibits the Migration and Invasion of Glioma Cells by Blocking the PI3K/AKT Pathway Through miR-206/ROCK1 Axis. OncoTargets Ther. 13:361–370. 2020.PubMed/NCBI View Article : Google Scholar

9 

Li C, Xia M, Wang H, Li W, Peng J and Jiang H: Propofol facilitates migration and invasion of oral squamous cell carcinoma cells by upregulating SNAI1 expression. Life Sci. 241(117143)2020.PubMed/NCBI View Article : Google Scholar

10 

Chang YC, Liu CL, Chen MJ, Hsu YW, Chen SN, Lin CH, Chen CM, Yang FM and Hu MC: Local anesthetics induce apoptosis in human breast tumor cells. Anesth Analg. 118:116–124. 2014.PubMed/NCBI View Article : Google Scholar

11 

Arita K, Utsumi T, Kato A, Kanno T, Kobuchi H, Inoue B, Akiyama J and Utsumi K: Mechanism of dibucaine-induced apoptosis in promyelocytic leukemia cells (HL-60). Biochem Pharmacol. 60:905–915. 2000.PubMed/NCBI View Article : Google Scholar

12 

Zhou H, Xu M, Luo G and Zhang Y: Effects of procaine on human nasopharyngeal carcinoma cell strain CNE-2Z. Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 21:1118–1121. 2007.PubMed/NCBI(In Chinese).

13 

Peifer C, Kinkel K, Abadleh M, Schollmeyer D and Laufer S: From five- to six-membered rings: 3,4-diarylquinolinone as lead for novel p38MAP kinase inhibitors. J Med Chem. 50:1213–1221. 2007.PubMed/NCBI View Article : Google Scholar

14 

Yang J, Zhang JN, Chen WL, Wang GS, Mao Q, Li SQ, Xiong WH, Lin YY, Ge JW, Li XX, et al: Effects of AQP5 gene silencing on proliferation, migration and apoptosis of human glioma cells through regulating EGFR/ERK/ p38 MAPK signaling pathway. Oncotarget. 8:38444–38455. 2017.PubMed/NCBI View Article : Google Scholar

15 

Rasheduzzaman M, Yin H and Park SY: Cardiac glycoside sensitized hepatocellular carcinoma cells to TRAIL via ROS generation, p38MAPK, mitochondrial transition, and autophagy mediation. Mol Carcinog. 58:2040–2051. 2019.PubMed/NCBI View Article : Google Scholar

16 

Zhao Y, Qu B, Wu X, Li X, Liu Q, Jin X, Guo L, Hai L and Wu Y: Design, synthesis and biological evaluation of brain targeting l-ascorbic acid prodrugs of ibuprofen with ‘lock-in’ function. Eur J Med Chem. 82:314–323. 2014.PubMed/NCBI View Article : Google Scholar

17 

Singh I, Swami R, Jeengar MK, Khan W and Sistla R: p-Aminophenyl-α-D-mannopyranoside engineered lipidic nanoparticles for effective delivery of docetaxel to brain. Chem Phys Lipids. 188:1–9. 2015.PubMed/NCBI View Article : Google Scholar

18 

Qiu L, Hu Q, Cheng L, Li L, Tian C, Chen W, Chen Q, Hu W, Xu L, Yang J, et al: cRGDyK modified pH responsive nanoparticles for specific intracellular delivery of doxorubicin. Acta Biomater. 30:285–298. 2016.PubMed/NCBI View Article : Google Scholar

19 

Yuan ZQ, Li JZ, Liu Y, Chen WL, Yang SD, Zhang CG, Zhu WJ, Zhou XF, Liu C and Zhang XN: Systemic delivery of micelles loading with paclitaxel using N-succinyl-palmitoyl-chitosan decorated with cRGDyK peptide to inhibit non-small-cell lung cancer. Int J Pharm. 492:141–151. 2015.PubMed/NCBI View Article : Google Scholar

20 

Zhao Z, Zhao Y, Xie C, Chen C, Lin D, Wang S, Lin D, Cui X, Guo Z and Zhou J: Dual-active targeting liposomes drug delivery system for bone metastatic breast cancer: Synthesis and biological evaluation. Chem Phys Lipids. 223(104785)2019.PubMed/NCBI View Article : Google Scholar

21 

Qiu Y, Yu Q, Liu Y, Tang J, Wang X, Lu Z, Xu Z and He Q: Dual Receptor Targeting Cell Penetrating Peptide Modified Liposome for Glioma and Breast Cancer Postoperative Recurrence Therapy. Pharm Res. 35(130)2018.PubMed/NCBI View Article : Google Scholar

22 

Yang Y, Zhao Z, Xie C and Zhao Y: Dual-targeting liposome modified by glutamic hexapeptide and folic acid for bone metastatic breast cancer. Chem Phys Lipids. 228(104882)2020.PubMed/NCBI View Article : Google Scholar

23 

Belhadj Z, Ying M, Cao X, Hu X, Zhan C, Wei X, Gao J, Wang X, Yan Z and Lu W: Design of Y-shaped targeting material for liposome-based multifunctional glioblastoma-targeted drug delivery. J Control Release. 255:132–141. 2017.PubMed/NCBI View Article : Google Scholar

24 

Zhao Z, Chen C, Xie C and Zhao Y: Design, synthesis and evaluation of liposomes modified with dendritic aspartic acid for bone-specific targeting. Chem Phys Lipids. 226(104832)2020.PubMed/NCBI View Article : Google Scholar

25 

Yue H, Xie K, Ji X, Xu B, Wang C and Shi P: Vascularized neural constructs for ex-vivo reconstitution of blood-brain barrier function. Biomaterials. 245(119980)2020.PubMed/NCBI View Article : Google Scholar

26 

Radünz M, Hackbart HCDS, Bona NP, Pedra NS, Hoffmann JF, Stefanello FM and Da Rosa Zavareze E: Glucosinolates and phenolic compounds rich broccoli extract: Encapsulation by electrospraying and antitumor activity against glial tumor cells. Colloids Surf B Biointerfaces. 192(111020)2020.PubMed/NCBI View Article : Google Scholar

27 

Delgado-López PD and Martín-Alonso J: Prophylactic anticonvulsant therapy in high-grade glioma: A systematic review and meta-analysis of longitudinal studies. Neurocirugia (Astur : Engl Ed). 31:268–278. 2020.PubMed/NCBI View Article : Google Scholar : (In English, Spanish).

28 

Lübtow MM, Oerter S, Quader S, Jeanclos E, Cubukova A, Krafft M, Haider MS, Schulte C, Meier L, Rist M, et al: In Vitro Blood-Brain Barrier Permeability and Cytotoxicity of an Atorvastatin-Loaded Nanoformulation Against Glioblastoma in 2D and 3D Models. Mol Pharm. 17:1835–1847. 2020.PubMed/NCBI View Article : Google Scholar

29 

Zhao X, Qi T, Yang M, Zhang W, Kong C, Hao M, Wang Y, Zhang H, Yang B, Yang J, et al: Synthesis of dual functional procaine-derived carbon dots for bioimaging and anticancer therapy. Nanomedicine (Lond). 15:677–689. 2020.PubMed/NCBI View Article : Google Scholar

30 

Dunaway SB, Maxwell CL, Tantalo LC, Sahi SK and Marra CM: Neurosyphilis Treatment Outcomes After Intravenous Penicillin G Versus Intramuscular Procaine Penicillin Plus Oral Probenecid. Clin Infect Dis. 71:267–273. 2020.PubMed/NCBI View Article : Google Scholar

31 

Li YC, Wang Y, Li DD, Zhang Y, Zhao TC and Li CF: Procaine is a specific DNA methylation inhibitor with anti-tumor effect for human gastric cancer. J Cell Biochem. 119:2440–2449. 2018.PubMed/NCBI View Article : Google Scholar

32 

Li C, Gao S, Li X, Li C and Ma L: Procaine Inhibits the Proliferation and Migration of Colon Cancer Cells Through Inactivation of the ERK/MAPK/FAK Pathways by Regulation of RhoA. Oncol Res. 26:209–217. 2018.PubMed/NCBI View Article : Google Scholar

33 

Ying B, Huang H, Li H, Song M, Wu S and Ying H: Procaine Inhibits Proliferation and Migration and Promotes Cell Apoptosis in Osteosarcoma Cells by Upregulation of MicroRNA-133b. Oncol Res. 25:1463–1470. 2017.PubMed/NCBI View Article : Google Scholar

34 

Jiang W and Wang M: New insights into the immunomodulatory role of exosomes in cardiovascular disease. Rev Cardiovasc Med. 20:153–160. 2019.PubMed/NCBI View Article : Google Scholar

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Copy and paste a formatted citation
Spandidos Publications style
Li D, Gao J, Yang C, Li B, Sun J, Yu M, Wang Y, Wang H and Lu Y: cRGDyK‑modified procaine liposome inhibits the proliferation and motility of glioma cells via the ERK/p38MAPK pathway. Exp Ther Med 22: 859, 2021.
APA
Li, D., Gao, J., Yang, C., Li, B., Sun, J., Yu, M. ... Lu, Y. (2021). cRGDyK‑modified procaine liposome inhibits the proliferation and motility of glioma cells via the ERK/p38MAPK pathway. Experimental and Therapeutic Medicine, 22, 859. https://doi.org/10.3892/etm.2021.10291
MLA
Li, D., Gao, J., Yang, C., Li, B., Sun, J., Yu, M., Wang, Y., Wang, H., Lu, Y."cRGDyK‑modified procaine liposome inhibits the proliferation and motility of glioma cells via the ERK/p38MAPK pathway". Experimental and Therapeutic Medicine 22.2 (2021): 859.
Chicago
Li, D., Gao, J., Yang, C., Li, B., Sun, J., Yu, M., Wang, Y., Wang, H., Lu, Y."cRGDyK‑modified procaine liposome inhibits the proliferation and motility of glioma cells via the ERK/p38MAPK pathway". Experimental and Therapeutic Medicine 22, no. 2 (2021): 859. https://doi.org/10.3892/etm.2021.10291
Copy and paste a formatted citation
x
Spandidos Publications style
Li D, Gao J, Yang C, Li B, Sun J, Yu M, Wang Y, Wang H and Lu Y: cRGDyK‑modified procaine liposome inhibits the proliferation and motility of glioma cells via the ERK/p38MAPK pathway. Exp Ther Med 22: 859, 2021.
APA
Li, D., Gao, J., Yang, C., Li, B., Sun, J., Yu, M. ... Lu, Y. (2021). cRGDyK‑modified procaine liposome inhibits the proliferation and motility of glioma cells via the ERK/p38MAPK pathway. Experimental and Therapeutic Medicine, 22, 859. https://doi.org/10.3892/etm.2021.10291
MLA
Li, D., Gao, J., Yang, C., Li, B., Sun, J., Yu, M., Wang, Y., Wang, H., Lu, Y."cRGDyK‑modified procaine liposome inhibits the proliferation and motility of glioma cells via the ERK/p38MAPK pathway". Experimental and Therapeutic Medicine 22.2 (2021): 859.
Chicago
Li, D., Gao, J., Yang, C., Li, B., Sun, J., Yu, M., Wang, Y., Wang, H., Lu, Y."cRGDyK‑modified procaine liposome inhibits the proliferation and motility of glioma cells via the ERK/p38MAPK pathway". Experimental and Therapeutic Medicine 22, no. 2 (2021): 859. https://doi.org/10.3892/etm.2021.10291
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