Advancement in research on the role of the transient receptor potential vanilloid channel in cerebral ischemic injury (Review)

Xie,Qian; Ma,Rong; Li,Hongyan; Wang,Jian; Guo,Xiaoqing; Chen,Hai

doi:10.3892/etm.2021.10313

Advancement in research on the role of the transient receptor potential vanilloid channel in cerebral ischemic injury (Review)

Authors:
- Qian Xie
- Rong Ma
- Hongyan Li
- Jian Wang
- Xiaoqing Guo
- Hai Chen
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Affiliations: School of Pharmacy and State Key Laboratory of Characteristic Chinese Medicine Resources in Southwest China, Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan 611137, P.R. China
Published online on: June 15, 2021 https://doi.org/10.3892/etm.2021.10313
Article Number: 881
Copyright: © Xie et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Stroke is a common critical disease occurring in middle‑aged and elderly individuals, and is characterized by high morbidity, lethality and mortality. As such, it is of great concern to medical professionals. The aim of the present review was to investigate the effects of transient receptor potential vanilloid (TRPV) subtypes during cerebral ischemia in ischemia‑reperfusion animal models, oxygen glucose deprivation and in other administration cell models in vitro to explore new avenues for stroke research and clinical treatments. TRPV1, TRPV2 and TRPV4 employ different methodologies by which they confer protection against cerebral ischemic injury. TRPV1 and TRPV4 are likely related to the inhibition of inflammatory reactions, neurotoxicity and cell apoptosis, thus promoting nerve growth and regulation of intracellular calcium ions (Ca²⁺). The mechanisms of neuroprotection of TRPV1 are the JNK pathway, N‑methyl‑D‑aspartate (NMDA) receptor and therapeutic hypothermia. The mechanisms of neuroprotection of TRPV4 are the PI3K/Akt pathways, NMDA receptor and p38 MAPK pathway, amongst others. The mechanisms by which TRPV2 confers its protective effects are predominantly connected with the regulation of nerve growth factor, MAPK and JNK pathways, as well as JNK‑dependent pathways. Thus, TRPVs have the potential for improving outcomes associated with cerebral ischemic or reperfusion injuries. The protection conferred by TRPV1 and TRPV4 is closely related to cellular Ca²⁺ influx, while TRPV2 has a different target and mode of action, possibly due to its expression sites. However, in light of certain contradictory research conclusions, further experimentation is required to clarify the mechanisms and specific pathways by which TRPVs act to alleviate nerve injuries.

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