Open Access

Guillain‑Barré syndrome associated with Covid‑19: A close relationship or just a coincidence? (Review)

  • Authors:
    • Adina Stoian
    • Rodica Bălașa
    • Bianca Liana Grigorescu
    • Smaranda Maier
    • Sebastian Andone
    • Iuliu Gabriel Cocuz
    • Zoltan Bajko
    • Cristian Rares Filep
    • Mircea Stoian
  • View Affiliations

  • Published online on: June 29, 2021     https://doi.org/10.3892/etm.2021.10348
  • Article Number: 916
  • Copyright: © Stoian et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Several neurological complications affecting the central and peripheral nervous system were described secondary to COVID‑19 infection such as hyposmia, headache, nausea, impaired consciousness, psychosis, neurocognitive syndromes and even cerebrovascular accidents. The mechanism of these complications is not fully understood, but heterogenous mechanisms such as cytokine storm, secondary hypercoagulability and direct neurotropism of the virus are thought to be involved. Guillain‑Barré syndrome is a heterogeneous disease that frequently follows a bacterial or viral infection. During the ongoing SARS‑CoV‑2 pandemic, several isolated case reports and case series have suggested an association between this viral infection and the occurrence of Guillain‑Barré syndrome. The main mechanism of Guillain‑Barré syndrome is probably post‑viral dysregulation of the immune system generated by SARS‑CoV‑2. The clinical characteristics and disease evolution seem to be similar to those observed in Guillain‑Barré syndrome secondary to other etiologies. The aim of the present review is to summarize the relevant literature regarding SARS‑CoV‑2‑related Guillain‑Barré syndrome.
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September-2021
Volume 22 Issue 3

Print ISSN: 1792-0981
Online ISSN:1792-1015

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Spandidos Publications style
Stoian A, Bălașa R, Grigorescu BL, Maier S, Andone S, Cocuz IG, Bajko Z, Filep CR and Stoian M: Guillain‑Barré syndrome associated with Covid‑19: A close relationship or just a coincidence? (Review). Exp Ther Med 22: 916, 2021
APA
Stoian, A., Bălașa, R., Grigorescu, B.L., Maier, S., Andone, S., Cocuz, I.G. ... Stoian, M. (2021). Guillain‑Barré syndrome associated with Covid‑19: A close relationship or just a coincidence? (Review). Experimental and Therapeutic Medicine, 22, 916. https://doi.org/10.3892/etm.2021.10348
MLA
Stoian, A., Bălașa, R., Grigorescu, B. L., Maier, S., Andone, S., Cocuz, I. G., Bajko, Z., Filep, C. R., Stoian, M."Guillain‑Barré syndrome associated with Covid‑19: A close relationship or just a coincidence? (Review)". Experimental and Therapeutic Medicine 22.3 (2021): 916.
Chicago
Stoian, A., Bălașa, R., Grigorescu, B. L., Maier, S., Andone, S., Cocuz, I. G., Bajko, Z., Filep, C. R., Stoian, M."Guillain‑Barré syndrome associated with Covid‑19: A close relationship or just a coincidence? (Review)". Experimental and Therapeutic Medicine 22, no. 3 (2021): 916. https://doi.org/10.3892/etm.2021.10348