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Article Open Access

Long non‑coding RNA HOTAIRM1‑1 silencing in cartilage tissue induces osteoarthritis through microRNA‑125b

Corrigendum in: /10.3892/etm.2022.11327
  • Authors:
    • Wen-Bin Liu
    • Gui-Shi Li
    • Peng Shen
    • Ya-Nan Li
    • Fu-Jiang Zhang
  • View Affiliations / Copyright

    Affiliations: Department of Joint Surgery, Tianjin Hospital, Tianjin 300211, P.R. China, Department of Joint Surgery, Yuhuangding Hospital, Yantai, Shandong 264000, P.R. China, Department of Rheumatology and Immunology, Tianjin First Center Hospital, Tianjin 300192, P.R. China, Department of Orthopedics, Tianjin Dongli Hospital, Tianjin 300300, P.R. China
    Copyright: © Liu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 933
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    Published online on: July 1, 2021
       https://doi.org/10.3892/etm.2021.10365
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Abstract

Aberrations in long noncoding RNA (lncRNA) expression have been recognized in numerous human diseases. In the present study, the of role the long noncoding RNA HOX antisense intergenic RNA myeloid 1 variant (HOTAIRM1‑1) in regulating the pathological progression of osteoarthritis (OA) was investigated. The aberrant expression of HOTAIRM1‑1 in OA was demonstrated, but the molecular mechanisms require further analysis. The aim of the present study was to explore the function of miR‑125b in modulating chondrocyte viability and apoptosis, and to address the functional association between HOTAIRM1‑1 and miR‑125b as potential targets. A miR‑125b inhibitor was used, which laid the foundation for the following investigation. The study confirmed that HOTAIRM1‑1 and miR‑125b are inversely expressed in chondrocytes. The expression of HOTAIRM1‑1 was downregulated and the expression of miR‑125b was upregulated in tissues from patients with OA. HOTAIRM1‑1 directly interacted with miR‑125b in chondrocytes. HOTAIRM1‑1 knockdown was associated with chondrocyte proliferation and extracellular matrix degradation. Furthermore, miR‑125b reversed the effect of HOTAIRM1‑1 on cell proliferation and apoptosis. In conclusion, the present study indicates that the loss of HOTAIRM1‑1 function leads to aberrant increases in the proliferation and apoptosis of chondrocytes. miR‑125b may be a potential downstream mechanism that regulates the function of HOTAIRM1‑1, and this finding provides a therapeutic strategy for OA.
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Copy and paste a formatted citation
Spandidos Publications style
Liu W, Li G, Shen P, Li Y and Zhang F: Long non‑coding RNA HOTAIRM1‑1 silencing in cartilage tissue induces osteoarthritis through microRNA‑125b Corrigendum in /10.3892/etm.2022.11327. Exp Ther Med 22: 933, 2021.
APA
Liu, W., Li, G., Shen, P., Li, Y., & Zhang, F. (2021). Long non‑coding RNA HOTAIRM1‑1 silencing in cartilage tissue induces osteoarthritis through microRNA‑125b Corrigendum in /10.3892/etm.2022.11327. Experimental and Therapeutic Medicine, 22, 933. https://doi.org/10.3892/etm.2021.10365
MLA
Liu, W., Li, G., Shen, P., Li, Y., Zhang, F."Long non‑coding RNA HOTAIRM1‑1 silencing in cartilage tissue induces osteoarthritis through microRNA‑125b Corrigendum in /10.3892/etm.2022.11327". Experimental and Therapeutic Medicine 22.3 (2021): 933.
Chicago
Liu, W., Li, G., Shen, P., Li, Y., Zhang, F."Long non‑coding RNA HOTAIRM1‑1 silencing in cartilage tissue induces osteoarthritis through microRNA‑125b Corrigendum in /10.3892/etm.2022.11327". Experimental and Therapeutic Medicine 22, no. 3 (2021): 933. https://doi.org/10.3892/etm.2021.10365
Copy and paste a formatted citation
x
Spandidos Publications style
Liu W, Li G, Shen P, Li Y and Zhang F: Long non‑coding RNA HOTAIRM1‑1 silencing in cartilage tissue induces osteoarthritis through microRNA‑125b Corrigendum in /10.3892/etm.2022.11327. Exp Ther Med 22: 933, 2021.
APA
Liu, W., Li, G., Shen, P., Li, Y., & Zhang, F. (2021). Long non‑coding RNA HOTAIRM1‑1 silencing in cartilage tissue induces osteoarthritis through microRNA‑125b Corrigendum in /10.3892/etm.2022.11327. Experimental and Therapeutic Medicine, 22, 933. https://doi.org/10.3892/etm.2021.10365
MLA
Liu, W., Li, G., Shen, P., Li, Y., Zhang, F."Long non‑coding RNA HOTAIRM1‑1 silencing in cartilage tissue induces osteoarthritis through microRNA‑125b Corrigendum in /10.3892/etm.2022.11327". Experimental and Therapeutic Medicine 22.3 (2021): 933.
Chicago
Liu, W., Li, G., Shen, P., Li, Y., Zhang, F."Long non‑coding RNA HOTAIRM1‑1 silencing in cartilage tissue induces osteoarthritis through microRNA‑125b Corrigendum in /10.3892/etm.2022.11327". Experimental and Therapeutic Medicine 22, no. 3 (2021): 933. https://doi.org/10.3892/etm.2021.10365
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